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The map label for this gene is metC [H]

Identifier: 114798688

GI number: 114798688

Start: 1447108

End: 1448277

Strand: Reverse

Name: metC [H]

Synonym: HNE_1418

Alternate gene names: 114798688

Gene position: 1448277-1447108 (Counterclockwise)

Preceding gene: 114797517

Following gene: 114798581

Centisome position: 39.09

GC content: 64.27

Gene sequence:

>1170_bases
ATGAGCGCACGGGATGACGCCGAGCCCCAGACCCGCCTGATCCACACCCGCGCCGAACGCCTTGGCCGGGTGACCGTGAA
CCCGCCGGTGGAGCGTGCCTCGACCGTGCTATTCCGCACCGAGGCGCAGCTTTACGGGCCCAAGCCCACCTATGGCCGGA
TGGGGCTGACGGTTCACCGCGAACTGGAAGCAGCGATGTGCATTCTGGAGGGGGCAAAGCATACGCGCCTTGCCTCCAAT
GGCCTGCAAGCCTGCGCGCTGGCGATTGCGAGCGTGGTGGAGGCAGGCGGACATTTTCTGTTCACGGACAGTGCCTATGG
CCCCACCGCGCGCTTCTGCGAGAAGCGGCTGAAGGCGATGGGCGTGGAGGCCGAGCGGTTCGATCCGCGCATGGGCGCGG
GCATTGAGCGGCTGTTCCGCGACAATACGCAGGCGATCCTTGTGGAATCGCCCGGCTCTCTGACGTTTGAGATTTCAGAC
CTGCCTGCCATGGCGCAAGTGGCAAAGGCGCGCGGCATACGCATTGTGTGTGACAACACCTGGGGCGCGGGATTGCATTA
CAAGCCGCTGGCGCTGGGGGCGGACCTTTCCGTGCAGGCGCTGACGAAATATGTGGTGGGCCATTCCGACGCCTTTGGCG
GCGCAGTAATGACCAATGAGCTGAGCCTTGCCAACAAGGTGGCCAACTGTTCGGAGGATTGGGGCATTGGCCTCGCGCCG
GATGACGCCTATCTCGCCGTGCGCGGCATTCGCAGCCTGACCACGCGCCTGAAGGCGCATGAGGCGGCGGGGCTGGAGCT
GGCGCAGTGGCTGGAAGGGCGGCCCGAAGTGGCAAGCGTGATCCATCCTGCCCTGCCCTCCCACCCCGATCATGCGCTTT
GGAAGCGGGATTTTACTGGCGCCTGCGGGCTGTTTTCCTTTGTGCTGAAGGATTATCCGGCAGGCGCACTGGAGCGGTTC
TTCGAGGCGCTGAGCTTGTTCGGCATGGGCTTCTCCTGGGGCGGCTTCGAGAGCCTGATCATTCCGTGCGATGACCAGCT
GACCCGCAGCGAAACCTGCTGGACGAAAGACAAGCCCGGCCAGCTGATGCGCGTGCATGTAGGGCTGGAAGCGGTGAGCG
ATCTGAAAGCCGACCTTGAGGCAGGCTTTGCGGCATTGTCCGCAGGCTGA

Upstream 100 bases:

>100_bases
GCGCTGGCGCGCCTCGGAAACTGGGACGTCGCCGTTTATGACGGCTCGTGGACCGAATGGGTGTCTGACCCCGCCCGGCC
AATCGCGAAAGGCTGAAGCG

Downstream 100 bases:

>100_bases
GTTCAGGGCGCCGGGCGCTCAAAGTTCAGGAAAACGAACAGATCGTCGACATCCGTGCCGATCTGCGCCTGGGGCTCTGA
GGGCGGCCAGAGGCGTTGTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSARDDAEPQTRLIHTRAERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHRELEAAMCILEGAKHTRLASN
GLQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAMGVEAERFDPRMGAGIERLFRDNTQAILVESPGSLTFEISD
LPAMAQVAKARGIRIVCDNTWGAGLHYKPLALGADLSVQALTKYVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAP
DDAYLAVRGIRSLTTRLKAHEAAGLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTGACGLFSFVLKDYPAGALERF
FEALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPGQLMRVHVGLEAVSDLKADLEAGFAALSAG

Sequences:

>Translated_389_residues
MSARDDAEPQTRLIHTRAERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHRELEAAMCILEGAKHTRLASN
GLQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAMGVEAERFDPRMGAGIERLFRDNTQAILVESPGSLTFEISD
LPAMAQVAKARGIRIVCDNTWGAGLHYKPLALGADLSVQALTKYVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAP
DDAYLAVRGIRSLTTRLKAHEAAGLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTGACGLFSFVLKDYPAGALERF
FEALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPGQLMRVHVGLEAVSDLKADLEAGFAALSAG
>Mature_388_residues
SARDDAEPQTRLIHTRAERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHRELEAAMCILEGAKHTRLASNG
LQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAMGVEAERFDPRMGAGIERLFRDNTQAILVESPGSLTFEISDL
PAMAQVAKARGIRIVCDNTWGAGLHYKPLALGADLSVQALTKYVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAPD
DAYLAVRGIRSLTTRLKAHEAAGLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTGACGLFSFVLKDYPAGALERFF
EALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPGQLMRVHVGLEAVSDLKADLEAGFAALSAG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=315, Percent_Identity=34.9206349206349, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI299473759, Length=238, Percent_Identity=36.5546218487395, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI25453487, Length=314, Percent_Identity=32.484076433121, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1789383, Length=402, Percent_Identity=40.547263681592, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1790375, Length=368, Percent_Identity=28.804347826087, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17538055, Length=354, Percent_Identity=32.2033898305085, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=361, Percent_Identity=32.409972299169, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=29.4117647058824, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=41.0828025477707, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319307, Length=348, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=26.7942583732057, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=412, Percent_Identity=27.4271844660194, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321904, Length=400, Percent_Identity=23.5, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=31.0077519379845, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42027; Mature: 41896

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARDDAEPQTRLIHTRAERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHR
CCCCCCCCHHHHHHHHHHHHHCEEECCCCHHHHHEEEEEECHHHCCCCCCCCCCCCCHHH
ELEAAMCILEGAKHTRLASNGLQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHC
GVEAERFDPRMGAGIERLFRDNTQAILVESPGSLTFEISDLPAMAQVAKARGIRIVCDNT
CCCHHHCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHCCCEEEEECC
WGAGLHYKPLALGADLSVQALTKYVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAP
CCCCCEECCEEECCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCC
DDAYLAVRGIRSLTTRLKAHEAAGLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTG
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHCCCCC
ACGLFSFVLKDYPAGALERFFEALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
QLMRVHVGLEAVSDLKADLEAGFAALSAG
CEEEEEECHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure 
SARDDAEPQTRLIHTRAERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHR
CCCCCCCHHHHHHHHHHHHHCEEECCCCHHHHHEEEEEECHHHCCCCCCCCCCCCCHHH
ELEAAMCILEGAKHTRLASNGLQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHC
GVEAERFDPRMGAGIERLFRDNTQAILVESPGSLTFEISDLPAMAQVAKARGIRIVCDNT
CCCHHHCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHCCCEEEEECC
WGAGLHYKPLALGADLSVQALTKYVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAP
CCCCCEECCEEECCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCC
DDAYLAVRGIRSLTTRLKAHEAAGLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTG
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHCCCCC
ACGLFSFVLKDYPAGALERFFEALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
QLMRVHVGLEAVSDLKADLEAGFAALSAG
CEEEEEECHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]