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The map label for this gene is gyaR [H]

Identifier: 114798669

GI number: 114798669

Start: 3572930

End: 3573916

Strand: Reverse

Name: gyaR [H]

Synonym: HNE_3433

Alternate gene names: 114798669

Gene position: 3573916-3572930 (Counterclockwise)

Preceding gene: 114797873

Following gene: 114799539

Centisome position: 96.46

GC content: 63.73

Gene sequence:

>987_bases
ATGCCGGCCAGCAAATTGAAAGTCGTCGTCACCCGTAAGCTTCCGGCGCCCGTTGAGCTCCGGATGAAGGAGTTGTTCGA
CGCCCGGCTGAACGAGAGTGACCGGCCGTTTTCTGTAGAAGAACTGGCCCAGGCGATGCAGACCGCCGATGTGCTGGTGC
CCACGGTCACCGACAAGATTGATGGCCGCCTGATGGCGCGGGCAGGCGACCAGCTGCGCCTGATCGCCCAGTTCGGGGCA
GGGGTGGACAATATCGATGTGGCCAGCGCTGTGCAGCGCGGCATCACCGTCACCAACACGCCCGGCGTGCTGACCGATGA
TACGGCAGATGTTGCGATGGCGCTGATCCTGGCGGTGCCCCGCCGGATGCATGAAGGCGTGCAGATCATGGAGGCGGGCA
AGTTTGATGGCTGGACGCCGACCTGGATGATGGGGCGGCGCCTGTCGGGCAAACGCCTCGGCATCATCGGCATGGGCCGG
ATCGGCCAGGCCGTTGCCCGCCGCGCGCGCGCCTTCGGCATGCAGATACATTACCATAACCGCAAGCCGGTCAGCTCGCG
CATCGAGGAAAGCCTGGAGGCGACCTATTGGGATTCGCTCGATCAGATGCTGGCGCGGATGGACATCGTTTCCATCAACT
GCCCGCATACGCCTGCGACGTTCCATCTGATCAATGCGCGGCGTCTGGGCCTGATGAAACCGGAAGCCTACATCATCAAT
ACCGCGCGCGGTGAGGTGATCGATGAGGCCGCCCTTGCGCGCGCCATCCGCGCCGGAAAAATTGCCGGGGCGGGCCTGGA
TGTGTTCGAGCGCGAACCTGCTGTGAACCCGGAGCTGATCGGCCTGCCGAATGTGCTGCTGCTGCCGCATATGGGCTCGG
CCACCATCGAAGGGCGCACCGAGATGGGCGAGAAGGTCATCATCAATATCAAGACCTTCGCTGACGGCCACCGGCCGCCA
GACCGTGTGATCCCCGCGATCCTCTGA

Upstream 100 bases:

>100_bases
GCACCACACCATGAATCCACAGTAAAGCTGTGGGAGATTGGCGTGACGGGTTGGCTCTGCTAAGCCCCCGATAAATAATA
AAAGCACCGATGGGAGTCCC

Downstream 100 bases:

>100_bases
TCTTCAGCAGACGGGCTGAAACTGAAAGCTCAGTTGGTCGGTAGCTCGCTCTCGCTGGCGGGGGCTGCGCCGTGGACGCG
GGCTGTCAGAAAAGCCCGCA

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPASKLKVVVTRKLPAPVELRMKELFDARLNESDRPFSVEELAQAMQTADVLVPTVTDKIDGRLMARAGDQLRLIAQFGA
GVDNIDVASAVQRGITVTNTPGVLTDDTADVAMALILAVPRRMHEGVQIMEAGKFDGWTPTWMMGRRLSGKRLGIIGMGR
IGQAVARRARAFGMQIHYHNRKPVSSRIEESLEATYWDSLDQMLARMDIVSINCPHTPATFHLINARRLGLMKPEAYIIN
TARGEVIDEAALARAIRAGKIAGAGLDVFEREPAVNPELIGLPNVLLLPHMGSATIEGRTEMGEKVIINIKTFADGHRPP
DRVIPAIL

Sequences:

>Translated_328_residues
MPASKLKVVVTRKLPAPVELRMKELFDARLNESDRPFSVEELAQAMQTADVLVPTVTDKIDGRLMARAGDQLRLIAQFGA
GVDNIDVASAVQRGITVTNTPGVLTDDTADVAMALILAVPRRMHEGVQIMEAGKFDGWTPTWMMGRRLSGKRLGIIGMGR
IGQAVARRARAFGMQIHYHNRKPVSSRIEESLEATYWDSLDQMLARMDIVSINCPHTPATFHLINARRLGLMKPEAYIIN
TARGEVIDEAALARAIRAGKIAGAGLDVFEREPAVNPELIGLPNVLLLPHMGSATIEGRTEMGEKVIINIKTFADGHRPP
DRVIPAIL
>Mature_327_residues
PASKLKVVVTRKLPAPVELRMKELFDARLNESDRPFSVEELAQAMQTADVLVPTVTDKIDGRLMARAGDQLRLIAQFGAG
VDNIDVASAVQRGITVTNTPGVLTDDTADVAMALILAVPRRMHEGVQIMEAGKFDGWTPTWMMGRRLSGKRLGIIGMGRI
GQAVARRARAFGMQIHYHNRKPVSSRIEESLEATYWDSLDQMLARMDIVSINCPHTPATFHLINARRLGLMKPEAYIINT
ARGEVIDEAALARAIRAGKIAGAGLDVFEREPAVNPELIGLPNVLLLPHMGSATIEGRTEMGEKVIINIKTFADGHRPPD
RVIPAIL

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=306, Percent_Identity=37.9084967320261, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI23308577, Length=280, Percent_Identity=31.7857142857143, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=35.2490421455939, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=35.2490421455939, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=34.8837209302326, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=34.8837209302326, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=34.8837209302326, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI87082289, Length=329, Percent_Identity=36.4741641337386, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789279, Length=265, Percent_Identity=32.0754716981132, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1787645, Length=337, Percent_Identity=27.0029673590504, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788660, Length=334, Percent_Identity=26.6467065868263, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=28.3898305084746, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=33.2129963898917, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=259, Percent_Identity=38.996138996139, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=249, Percent_Identity=32.5301204819277, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=249, Percent_Identity=31.7269076305221, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=217, Percent_Identity=31.7972350230415, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=35.3333333333333, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=152, Percent_Identity=32.8947368421053, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=152, Percent_Identity=32.2368421052632, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=39.4904458598726, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI45552429, Length=270, Percent_Identity=34.4444444444444, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24585514, Length=269, Percent_Identity=34.5724907063197, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28574282, Length=269, Percent_Identity=34.5724907063197, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28574284, Length=269, Percent_Identity=34.5724907063197, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45551003, Length=269, Percent_Identity=34.5724907063197, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=33.2089552238806, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=33.210332103321, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=36.2204724409449, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=36.2204724409449, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=36.2204724409449, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=36.2204724409449, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24585516, Length=318, Percent_Identity=30.5031446540881, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=36.2204724409449, Blast_Score=147, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35917; Mature: 35786

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASKLKVVVTRKLPAPVELRMKELFDARLNESDRPFSVEELAQAMQTADVLVPTVTDKI
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEECCHHHHC
DGRLMARAGDQLRLIAQFGAGVDNIDVASAVQRGITVTNTPGVLTDDTADVAMALILAVP
CCEEEECCCCCEEEHHHHCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHH
RRMHEGVQIMEAGKFDGWTPTWMMGRRLSGKRLGIIGMGRIGQAVARRARAFGMQIHYHN
HHHHCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEECC
RKPVSSRIEESLEATYWDSLDQMLARMDIVSINCPHTPATFHLINARRLGLMKPEAYIIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECHHHCCCCCCCEEEEE
TARGEVIDEAALARAIRAGKIAGAGLDVFEREPAVNPELIGLPNVLLLPHMGSATIEGRT
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCEECCCCEEEECCCCCCEECCHH
EMGEKVIINIKTFADGHRPPDRVIPAIL
HCCCEEEEEEEECCCCCCCHHHHCCCCC
>Mature Secondary Structure 
PASKLKVVVTRKLPAPVELRMKELFDARLNESDRPFSVEELAQAMQTADVLVPTVTDKI
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEECCHHHHC
DGRLMARAGDQLRLIAQFGAGVDNIDVASAVQRGITVTNTPGVLTDDTADVAMALILAVP
CCEEEECCCCCEEEHHHHCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHH
RRMHEGVQIMEAGKFDGWTPTWMMGRRLSGKRLGIIGMGRIGQAVARRARAFGMQIHYHN
HHHHCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEECC
RKPVSSRIEESLEATYWDSLDQMLARMDIVSINCPHTPATFHLINARRLGLMKPEAYIIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECHHHCCCCCCCEEEEE
TARGEVIDEAALARAIRAGKIAGAGLDVFEREPAVNPELIGLPNVLLLPHMGSATIEGRT
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCEECCCCEEEECCCCCCEECCHH
EMGEKVIINIKTFADGHRPPDRVIPAIL
HCCCEEEEEEEECCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA