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The map label for this gene is iscA [H]

Identifier: 114798611

GI number: 114798611

Start: 2771264

End: 2771623

Strand: Reverse

Name: iscA [H]

Synonym: HNE_2612

Alternate gene names: 114798611

Gene position: 2771623-2771264 (Counterclockwise)

Preceding gene: 114799313

Following gene: 114797714

Centisome position: 74.81

GC content: 61.39

Gene sequence:

>360_bases
ATGGCCCGTAGACCTCGTCCGAAACCTGTCCGCCTGTCTGACGCCGCTGCCGAGCGGGTCAAAGACATCATGGCTGAACG
CGGCATGGGCTATCTGCGCGTGGGCGTCACCAATGGTGGCTGCGCGGGCATGGAATACGTTATGGACTATGCCTCTGAGC
CTGCTGCCCTCGATGAGGTGGTGGAGGACAATGGCGTCACCATCCTGATCGACGCCAAGGCTGTGCTGTTCCTGCTGGGC
AGTGAACTCGACTACGAAACCACGCTGCTTCACGAGAAATTCGTGTTCCGGAACCCCAACCAGACCGATGCCTGCGGCTG
CGGCGAGAGCGTGACGATCGTGCCGGCAGCGGCTGAATAG

Upstream 100 bases:

>100_bases
TCGATCCGCCCTGGGACCCGTCCCGCATGTCGGATGAAGCCCGCCTCGCGCTGAACATGCTTTGATTGAAGGAGGGGCTT
CGCGCCCCTATCTACAGACC

Downstream 100 bases:

>100_bases
CCAAAACGCTGGCGCCGCCGATGCAGATTCGAGGTTTCCCCCCGATTGCTGCCCCCGATGCTGAAATCCTGATCCTGGGC
AGTATGCCCGGCATCGCCTC

Product: iron-sulfur cluster assembly accessory protein

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MARRPRPKPVRLSDAAAERVKDIMAERGMGYLRVGVTNGGCAGMEYVMDYASEPAALDEVVEDNGVTILIDAKAVLFLLG
SELDYETTLLHEKFVFRNPNQTDACGCGESVTIVPAAAE

Sequences:

>Translated_119_residues
MARRPRPKPVRLSDAAAERVKDIMAERGMGYLRVGVTNGGCAGMEYVMDYASEPAALDEVVEDNGVTILIDAKAVLFLLG
SELDYETTLLHEKFVFRNPNQTDACGCGESVTIVPAAAE
>Mature_118_residues
ARRPRPKPVRLSDAAAERVKDIMAERGMGYLRVGVTNGGCAGMEYVMDYASEPAALDEVVEDNGVTILIDAKAVLFLLGS
ELDYETTLLHEKFVFRNPNQTDACGCGESVTIVPAAAE

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=111, Percent_Identity=36.9369369369369, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI160420328, Length=105, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788877, Length=105, Percent_Identity=47.6190476190476, Blast_Score=105, Evalue=6e-25,
Organism=Escherichia coli, GI1787974, Length=105, Percent_Identity=37.1428571428571, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1786351, Length=107, Percent_Identity=34.5794392523364, Blast_Score=77, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25146411, Length=111, Percent_Identity=41.4414414414414, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193209025, Length=103, Percent_Identity=43.6893203883495, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323001, Length=104, Percent_Identity=42.3076923076923, Blast_Score=100, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24642263, Length=110, Percent_Identity=43.6363636363636, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 12851; Mature: 12720

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRPRPKPVRLSDAAAERVKDIMAERGMGYLRVGVTNGGCAGMEYVMDYASEPAALDEV
CCCCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHH
VEDNGVTILIDAKAVLFLLGSELDYETTLLHEKFVFRNPNQTDACGCGESVTIVPAAAE
HCCCCCEEEEEHHEEEHHHCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
ARRPRPKPVRLSDAAAERVKDIMAERGMGYLRVGVTNGGCAGMEYVMDYASEPAALDEV
CCCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHH
VEDNGVTILIDAKAVLFLLGSELDYETTLLHEKFVFRNPNQTDACGCGESVTIVPAAAE
HCCCCCEEEEEHHEEEHHHCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA