Click here to switch to the map view.

The map label for this gene is ivd2 [H]

Identifier: 114798575

GI number: 114798575

Start: 1301577

End: 1302749

Strand: Direct

Name: ivd2 [H]

Synonym: HNE_1272

Alternate gene names: 114798575

Gene position: 1301577-1302749 (Clockwise)

Preceding gene: 114797826

Following gene: 114799414

Centisome position: 35.13

GC content: 61.98

Gene sequence:

>1173_bases
ATGCTGACGAACACATATCCCTCTCTGAACTTCGATCTCGGTGAAACTGCGGACATGATCCGCGAGACCGTGAAAAACTT
TGCCCAGAACGAGATTGCGCCGCGCGCCGCCGAGATTGACCGGACGGACAAGTTTCCGCGCGACCTTCTGCCGAAGATGG
GGGAGCTTGGCCTCCTCGGCATCACGGTGGAAGAGGAATGGGGCGGCACGGGCCTTGGATACCTTGAGCATGTCGTGGCG
ATGGAGGAAATCTCCCGCGCGTCGGCCTCGGTTGGCCTATCTTACGGGGCGCACTCAAACCTTTGCGTCAACCAGCTGCG
CCGCTGGGGCAATGACCAGCAGAAAGCGCGCTACCTGCCCAAGCTGATCTCGGGCGAGCATCTGGGCAGCCTCGCGATGA
GCGAGAGCGGTGCGGGCTCGGACGTGGTGTCCATGAAGCTGCGCGCTGACAAGAAGGGCGACCACTATGTGCTCAACGGC
ACCAAGATGTGGATCACCAATGCGCCGGATGCGGACACTCTGGTGGTCTATGCCAAGACCGACCCGAATGGCGGCTCTAA
GGGCATCACGGCCTTCCTGATCGAGCGGGGCTTCAAGGGATTTTCGGTGGCGCAGAAGCTCGACAAGCTGGGCATGCGCG
GATCGGAAACCGGCGAGCTGGTGTTTGAAGATTGCGAAGTGCCTGAAGAGAATGTGATGGGACCGGTGGGCGCCGGGGCG
CGCATTCTGATGAGCGGGCTCGACTATGAGCGCGCGGTCCTCTCGGCCGGGCCGACGGGCATCATGCAGGCATGCCTGGA
TGTGGTGATCCCCTACATTCATGACCGCAAACAGTTTGGCCAGTCCATCGGCGAGTTCCAGCTGGTGCAGGGCAAGCTGG
CGGACATGTATGTGCAGATGAATGCGGCGAAGGCCTATGTCTATGCGGTCGCCAAGGCGTGCGATCGGGGCGAGACGGCC
CGCAAGGATGCGGCCGGCGCTATTCTGTATGCGGCAGAAACGGCGACGAAGCTGGCGCTGGACGCGATCCAGCTGCTCGG
TGGCAACGGGTATATCAATGAATACCCTACAGGCCGCCTGCTGCGCGACGCCAAGCTCTATGAGATTGGCGCGGGCACGA
GCGAGATCCGCCGCTGGCTGATCGGGCGGGAGCTGTTTTCGGAGACGGCTTGA

Upstream 100 bases:

>100_bases
CGGGTTCCTGTTTGTGGTGGCCACGTATTACCTTTACCGGGCGATGACGCAGGACGAGTGAGCCGGTGACAGGCAGGCAG
GGCCTTGCTAGGAAAGGGCC

Downstream 100 bases:

>100_bases
AAATTCAATTATTCACTTTTCTGGCAGTCGTATCAGTCTCTTGCGCAGCGAGCCCGCAAACGACAACCTCCATATTGGCT
GAAGATGATGGTTCTTGCGG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLTNTYPSLNFDLGETADMIRETVKNFAQNEIAPRAAEIDRTDKFPRDLLPKMGELGLLGITVEEEWGGTGLGYLEHVVA
MEEISRASASVGLSYGAHSNLCVNQLRRWGNDQQKARYLPKLISGEHLGSLAMSESGAGSDVVSMKLRADKKGDHYVLNG
TKMWITNAPDADTLVVYAKTDPNGGSKGITAFLIERGFKGFSVAQKLDKLGMRGSETGELVFEDCEVPEENVMGPVGAGA
RILMSGLDYERAVLSAGPTGIMQACLDVVIPYIHDRKQFGQSIGEFQLVQGKLADMYVQMNAAKAYVYAVAKACDRGETA
RKDAAGAILYAAETATKLALDAIQLLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRWLIGRELFSETA

Sequences:

>Translated_390_residues
MLTNTYPSLNFDLGETADMIRETVKNFAQNEIAPRAAEIDRTDKFPRDLLPKMGELGLLGITVEEEWGGTGLGYLEHVVA
MEEISRASASVGLSYGAHSNLCVNQLRRWGNDQQKARYLPKLISGEHLGSLAMSESGAGSDVVSMKLRADKKGDHYVLNG
TKMWITNAPDADTLVVYAKTDPNGGSKGITAFLIERGFKGFSVAQKLDKLGMRGSETGELVFEDCEVPEENVMGPVGAGA
RILMSGLDYERAVLSAGPTGIMQACLDVVIPYIHDRKQFGQSIGEFQLVQGKLADMYVQMNAAKAYVYAVAKACDRGETA
RKDAAGAILYAAETATKLALDAIQLLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRWLIGRELFSETA
>Mature_390_residues
MLTNTYPSLNFDLGETADMIRETVKNFAQNEIAPRAAEIDRTDKFPRDLLPKMGELGLLGITVEEEWGGTGLGYLEHVVA
MEEISRASASVGLSYGAHSNLCVNQLRRWGNDQQKARYLPKLISGEHLGSLAMSESGAGSDVVSMKLRADKKGDHYVLNG
TKMWITNAPDADTLVVYAKTDPNGGSKGITAFLIERGFKGFSVAQKLDKLGMRGSETGELVFEDCEVPEENVMGPVGAGA
RILMSGLDYERAVLSAGPTGIMQACLDVVIPYIHDRKQFGQSIGEFQLVQGKLADMYVQMNAAKAYVYAVAKACDRGETA
RKDAAGAILYAAETATKLALDAIQLLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRWLIGRELFSETA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=63.2, Blast_Score=500, Evalue=1e-141,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=65.4867256637168, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=41.3793103448276, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI4501859, Length=370, Percent_Identity=39.1891891891892, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=37.2031662269129, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=37.2031662269129, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=35.4005167958656, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI7656849, Length=386, Percent_Identity=33.160621761658, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=32.4396782841823, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=33.5064935064935, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=33.5064935064935, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=31.3829787234043, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=32.171581769437, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=27.5261324041812, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=27.5261324041812, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=379, Percent_Identity=21.8997361477573, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI218563752, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=28.4595300261097, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=26.509186351706, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081702, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=61.3157894736842, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17506239, Length=387, Percent_Identity=35.6589147286822, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=36.6233766233766, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17570075, Length=393, Percent_Identity=35.8778625954198, Blast_Score=250, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=35.5437665782493, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.9331619537275, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=34.7708894878706, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=38.4353741496599, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.2857142857143, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.4014598540146, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.961038961039, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17534353, Length=365, Percent_Identity=29.041095890411, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=310, Percent_Identity=33.5483870967742, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.1827956989247, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.2452316076294, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=30.327868852459, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI86563381, Length=268, Percent_Identity=27.6119402985075, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=268, Percent_Identity=27.6119402985075, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=63.7075718015666, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=42.3280423280423, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=39.6276595744681, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=36.604774535809, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=37.1052631578947, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=33.8983050847458, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=29.5336787564767, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42307; Mature: 42307

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNTYPSLNFDLGETADMIRETVKNFAQNEIAPRAAEIDRTDKFPRDLLPKMGELGLLG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHCCCCCEEE
ITVEEEWGGTGLGYLEHVVAMEEISRASASVGLSYGAHSNLCVNQLRRWGNDQQKARYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHLGSLAMSESGAGSDVVSMKLRADKKGDHYVLNGTKMWITNAPDADTLVVYAKT
HHHCCCHHCHHHHCCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEEE
DPNGGSKGITAFLIERGFKGFSVAQKLDKLGMRGSETGELVFEDCEVPEENVMGPVGAGA
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCH
RILMSGLDYERAVLSAGPTGIMQACLDVVIPYIHDRKQFGQSIGEFQLVQGKLADMYVQM
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEH
NAAKAYVYAVAKACDRGETARKDAAGAILYAAETATKLALDAIQLLGGNGYINEYPTGRL
HHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRWLIGRELFSETA
HHCCCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTNTYPSLNFDLGETADMIRETVKNFAQNEIAPRAAEIDRTDKFPRDLLPKMGELGLLG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHCCCCCEEE
ITVEEEWGGTGLGYLEHVVAMEEISRASASVGLSYGAHSNLCVNQLRRWGNDQQKARYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHLGSLAMSESGAGSDVVSMKLRADKKGDHYVLNGTKMWITNAPDADTLVVYAKT
HHHCCCHHCHHHHCCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEEE
DPNGGSKGITAFLIERGFKGFSVAQKLDKLGMRGSETGELVFEDCEVPEENVMGPVGAGA
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCH
RILMSGLDYERAVLSAGPTGIMQACLDVVIPYIHDRKQFGQSIGEFQLVQGKLADMYVQM
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEH
NAAKAYVYAVAKACDRGETARKDAAGAILYAAETATKLALDAIQLLGGNGYINEYPTGRL
HHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRWLIGRELFSETA
HHCCCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]