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The map label for this gene is nrdA [H]

Identifier: 114798532

GI number: 114798532

Start: 889593

End: 891374

Strand: Direct

Name: nrdA [H]

Synonym: HNE_0869

Alternate gene names: 114798532

Gene position: 889593-891374 (Clockwise)

Preceding gene: 114798777

Following gene: 114797589

Centisome position: 24.01

GC content: 61.9

Gene sequence:

>1782_bases
GTGCCGGTCAACCAGGTGGTGACCGATCCGTCCCGCGATTCGCTGCTGACCGATTTCGGCAAGAAGACGCTCGACGACCG
TTACCTGCTGCCCGGCGAGACCTATCAGGACATGTTCGCCCGCGTCGCCACCGCCTATGCGGACGATGCCGAGCATGGCC
AGCGCATCTATGACTATATTTCGCGCCTCTGGTTCATGCCCGCAACGCCTGTGCTCTCCAATGGCGGCGCCGATCGCGGC
CTGCCGATTTCCTGCTTCCTCAACCAGGTCGGCGATTCGCTCGACGACATCGTCGAGACCTGGACCGAGAATGTCTGGCT
CGCCTCCAATGGCGGCGGCATCGGCACCTATTGGGGCAATGTCCGCTCCATCGGTGAGAAAGTCGGCCAGAACGGTCAGA
CCTCCGGCATCATCCCCTTCATCCGCGTGATGGATTCGCTCACCCTTGCGATCAGCCAGGGCTCGCTGCGCCGTGGCTCG
GCTGCCTGCTATCTCGACATCCACCACCCGGAAATCGAAGAATTCCTGGAAATCCGCAAAACCTCGGGCGACTTCAACCG
CAAGTCCCTGAACCTCCATCACGGCATCAACATCACCGACGCCTTCATGGAAGCGGTCCGCAATGACGAAGAGTTCGGAC
TCATCAGCCCGAAATCGGGTGAAGTGCTGAAATACGTCAATGCCCGCAAGCTCTGGCAGAAACTGCTCGAGCTGCGCATG
CAGACCGGCGAGCCCTACCTGCTGTTCACCGACACCGTGAACAACGCGCTGCCCGCCCACCAGAAGCGCCTCGGCCTCAA
GGTTACCCAGTCGAACCTCTGCTCGGAAATCACCCTGCCGACCGGCGTCGACCATCGCGGCACCGACCGCACGGCTGTCT
GCTGCCTGTCCTCGGTGAACGCTGAAACCTTCCTCGAATGGTCGAAGGAGCCGATGTTCCTGGAAGACATCTTCCGCTTC
CTCGACAACGTGCTGGAAGACTTCATCCAGCGCGCCCCGCCGGAAATGGCCCGCGCGGTCTATTCCGCCAAGCGCGAGCG
CTCGGTCGGCCTCGGCGTCATGGGCTTCCACTCCTTCCTCCAGGCGATGAATGTCTCCATGGAAAGCGCGACCGCCAAGT
CGCTCAACCTGAAGATCTTCAAGCACATCCGCCAGGGCGCAGACGCGGCCTCGGTGAAGCTCGCCAAGGAACGTGGCCCC
TGTGAAGACGCCCGCGATGTCGGCATGATGGCCCGCTTCTCCAACAAGATGGCCGTCGCCCCCACCGCGTCGATCTCGAT
CATCTGCGGCGGCACCTCGGCCGGCATCGAGCCGATCCCGGCCAACGTCTACACCCACAAGACCCTCTCGGGCTCCTTCA
CGGTGAAGAACCAGCAGCTGGAAACCCTGCTCGATACGAAAGGTCTCAACACCAACGAGATCTGGACCTCGATCCTCGAG
CATGAAGGCTCGGTCCAGCACCTCGATTGCCTCGACGCGCATGAGAAGGATGTCTTCAAGACCGCCTTCGAACTTGACCA
GCGCTGGATCATCGAGCTGGCGGCCGACCGCACGCCGTTCATCTGCCAGTCTCAGTCGCTGAACCTCTTCCTGCCCGGCG
ACATCAATAAATGGGACCTTCACATGCTGCACTGGACGGCATGGGAGCGGGGCCTGAAGTCGCTCTACTATTGCCGCTCG
AAATCCGTGCAGCGCGCCGCCTTCGCCGGGTCGGAAAAGGCGGAAGCCTCGACGCTGGAAGTCGCGCGCACCGACTATGA
CGAGTGCCTTGCCTGCCAGTAA

Upstream 100 bases:

>100_bases
GAGGAGGGTCGCCATGTCGGCAACCAACGCTAAATCCGTCGCCAGTGAAGCCGCCCGCAAAGGCAAGCCGAAAGCTGGTG
GGGGCGCGAAAGTGGCGCTC

Downstream 100 bases:

>100_bases
GGCAGGGCTGCCTCAACCGGCATCATTCTATCAAAGGGCGCCCGCTGATTCGGCTGGCGCCCTTTTTCGTTGCGGGAAGT
AAACGCCGCATTCGCCCCTG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MPVNQVVTDPSRDSLLTDFGKKTLDDRYLLPGETYQDMFARVATAYADDAEHGQRIYDYISRLWFMPATPVLSNGGADRG
LPISCFLNQVGDSLDDIVETWTENVWLASNGGGIGTYWGNVRSIGEKVGQNGQTSGIIPFIRVMDSLTLAISQGSLRRGS
AACYLDIHHPEIEEFLEIRKTSGDFNRKSLNLHHGINITDAFMEAVRNDEEFGLISPKSGEVLKYVNARKLWQKLLELRM
QTGEPYLLFTDTVNNALPAHQKRLGLKVTQSNLCSEITLPTGVDHRGTDRTAVCCLSSVNAETFLEWSKEPMFLEDIFRF
LDNVLEDFIQRAPPEMARAVYSAKRERSVGLGVMGFHSFLQAMNVSMESATAKSLNLKIFKHIRQGADAASVKLAKERGP
CEDARDVGMMARFSNKMAVAPTASISIICGGTSAGIEPIPANVYTHKTLSGSFTVKNQQLETLLDTKGLNTNEIWTSILE
HEGSVQHLDCLDAHEKDVFKTAFELDQRWIIELAADRTPFICQSQSLNLFLPGDINKWDLHMLHWTAWERGLKSLYYCRS
KSVQRAAFAGSEKAEASTLEVARTDYDECLACQ

Sequences:

>Translated_593_residues
MPVNQVVTDPSRDSLLTDFGKKTLDDRYLLPGETYQDMFARVATAYADDAEHGQRIYDYISRLWFMPATPVLSNGGADRG
LPISCFLNQVGDSLDDIVETWTENVWLASNGGGIGTYWGNVRSIGEKVGQNGQTSGIIPFIRVMDSLTLAISQGSLRRGS
AACYLDIHHPEIEEFLEIRKTSGDFNRKSLNLHHGINITDAFMEAVRNDEEFGLISPKSGEVLKYVNARKLWQKLLELRM
QTGEPYLLFTDTVNNALPAHQKRLGLKVTQSNLCSEITLPTGVDHRGTDRTAVCCLSSVNAETFLEWSKEPMFLEDIFRF
LDNVLEDFIQRAPPEMARAVYSAKRERSVGLGVMGFHSFLQAMNVSMESATAKSLNLKIFKHIRQGADAASVKLAKERGP
CEDARDVGMMARFSNKMAVAPTASISIICGGTSAGIEPIPANVYTHKTLSGSFTVKNQQLETLLDTKGLNTNEIWTSILE
HEGSVQHLDCLDAHEKDVFKTAFELDQRWIIELAADRTPFICQSQSLNLFLPGDINKWDLHMLHWTAWERGLKSLYYCRS
KSVQRAAFAGSEKAEASTLEVARTDYDECLACQ
>Mature_592_residues
PVNQVVTDPSRDSLLTDFGKKTLDDRYLLPGETYQDMFARVATAYADDAEHGQRIYDYISRLWFMPATPVLSNGGADRGL
PISCFLNQVGDSLDDIVETWTENVWLASNGGGIGTYWGNVRSIGEKVGQNGQTSGIIPFIRVMDSLTLAISQGSLRRGSA
ACYLDIHHPEIEEFLEIRKTSGDFNRKSLNLHHGINITDAFMEAVRNDEEFGLISPKSGEVLKYVNARKLWQKLLELRMQ
TGEPYLLFTDTVNNALPAHQKRLGLKVTQSNLCSEITLPTGVDHRGTDRTAVCCLSSVNAETFLEWSKEPMFLEDIFRFL
DNVLEDFIQRAPPEMARAVYSAKRERSVGLGVMGFHSFLQAMNVSMESATAKSLNLKIFKHIRQGADAASVKLAKERGPC
EDARDVGMMARFSNKMAVAPTASISIICGGTSAGIEPIPANVYTHKTLSGSFTVKNQQLETLLDTKGLNTNEIWTSILEH
EGSVQHLDCLDAHEKDVFKTAFELDQRWIIELAADRTPFICQSQSLNLFLPGDINKWDLHMLHWTAWERGLKSLYYCRSK
SVQRAAFAGSEKAEASTLEVARTDYDECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=618, Percent_Identity=31.5533980582524, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1789030, Length=624, Percent_Identity=25.3205128205128, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI2367133, Length=652, Percent_Identity=24.8466257668712, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17555242, Length=657, Percent_Identity=30.8980213089802, Blast_Score=264, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6320914, Length=623, Percent_Identity=31.9422150882825, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6322123, Length=623, Percent_Identity=30.8186195826645, Blast_Score=253, Evalue=7e-68,
Organism=Drosophila melanogaster, GI17352481, Length=649, Percent_Identity=29.4298921417565, Blast_Score=249, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 66161; Mature: 66030

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVNQVVTDPSRDSLLTDFGKKTLDDRYLLPGETYQDMFARVATAYADDAEHGQRIYDYI
CCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
SRLWFMPATPVLSNGGADRGLPISCFLNQVGDSLDDIVETWTENVWLASNGGGIGTYWGN
HHHHCCCCCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCEECHHHH
VRSIGEKVGQNGQTSGIIPFIRVMDSLTLAISQGSLRRGSAACYLDIHHPEIEEFLEIRK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHH
TSGDFNRKSLNLHHGINITDAFMEAVRNDEEFGLISPKSGEVLKYVNARKLWQKLLELRM
CCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
QTGEPYLLFTDTVNNALPAHQKRLGLKVTQSNLCSEITLPTGVDHRGTDRTAVCCLSSVN
CCCCCEEEEECCCCCCCCCHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCC
AETFLEWSKEPMFLEDIFRFLDNVLEDFIQRAPPEMARAVYSAKRERSVGLGVMGFHSFL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
QAMNVSMESATAKSLNLKIFKHIRQGADAASVKLAKERGPCEDARDVGMMARFSNKMAVA
HHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHCCCCCHHHHHHHHHHHCCCEEEC
PTASISIICGGTSAGIEPIPANVYTHKTLSGSFTVKNQQLETLLDTKGLNTNEIWTSILE
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCCHHHHHHHHHH
HEGSVQHLDCLDAHEKDVFKTAFELDQRWIIELAADRTPFICQSQSLNLFLPGDINKWDL
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCEE
HMLHWTAWERGLKSLYYCRSKSVQRAAFAGSEKAEASTLEVARTDYDECLACQ
EEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
PVNQVVTDPSRDSLLTDFGKKTLDDRYLLPGETYQDMFARVATAYADDAEHGQRIYDYI
CCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
SRLWFMPATPVLSNGGADRGLPISCFLNQVGDSLDDIVETWTENVWLASNGGGIGTYWGN
HHHHCCCCCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEEECCCCEECHHHH
VRSIGEKVGQNGQTSGIIPFIRVMDSLTLAISQGSLRRGSAACYLDIHHPEIEEFLEIRK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHH
TSGDFNRKSLNLHHGINITDAFMEAVRNDEEFGLISPKSGEVLKYVNARKLWQKLLELRM
CCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
QTGEPYLLFTDTVNNALPAHQKRLGLKVTQSNLCSEITLPTGVDHRGTDRTAVCCLSSVN
CCCCCEEEEECCCCCCCCCHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCC
AETFLEWSKEPMFLEDIFRFLDNVLEDFIQRAPPEMARAVYSAKRERSVGLGVMGFHSFL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
QAMNVSMESATAKSLNLKIFKHIRQGADAASVKLAKERGPCEDARDVGMMARFSNKMAVA
HHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHCCCCCHHHHHHHHHHHCCCEEEC
PTASISIICGGTSAGIEPIPANVYTHKTLSGSFTVKNQQLETLLDTKGLNTNEIWTSILE
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCCHHHHHHHHHH
HEGSVQHLDCLDAHEKDVFKTAFELDQRWIIELAADRTPFICQSQSLNLFLPGDINKWDL
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCEE
HMLHWTAWERGLKSLYYCRSKSVQRAAFAGSEKAEASTLEVARTDYDECLACQ
EEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]