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The map label for this gene is mmsB [H]

Identifier: 114798417

GI number: 114798417

Start: 1884138

End: 1885028

Strand: Reverse

Name: mmsB [H]

Synonym: HNE_1826

Alternate gene names: 114798417

Gene position: 1885028-1884138 (Counterclockwise)

Preceding gene: 114797149

Following gene: 114799178

Centisome position: 50.88

GC content: 59.71

Gene sequence:

>891_bases
ATGACCAAGATCGCCTTCATCGGCCTCGGCAACATGGGCGGTGGCATGTGCGCCAACCTCGTGAAGGCGGGACATGCGGT
GGCCGCCTTTGACCTGAACGGAGAAGCGGTGGCGGCAGCCGCGGCCAAAGGCGCGCGCGCCGCAGCGTCTGTCGCCGACG
CAGTCAAAGACGCAGACGTTATCGTCAGTATGCTACCGGCTGGAAAGCATGTTCTCGGCGTATATTTTGGCCCTGATGGT
GTTGGCGCACATGCTGCAAAAGGTACGTTGCTGATTGATTGCTCCACCATTGCGGTGACAGATGCGCGTGAAGCGCATTC
GCAGGCGGAGCAGGCGGGCTTTCTGATGGTGGATGCACCGGTATCCGGCGGTGTGGCAGCTGCTGAAGCTGGCACGCTCA
CATTCATGGCCGGCGGCACAGCAGCGGCTTACGAAAGGGCAGCGCCGATTCTGAAGGCGATGGGCAAGAACATCTTCCAT
GCAGGTGGCGCCGGAAACGGCCAGGCCGCCAAGATCGCCAACAATATGCTGCTTGGCATTTCGATGATCGGAACCTGTGA
AGCGTTCAATCTTGCTGAAAAGCTCGGGCTGGATGCGGAGACCTTCTTCAGGATTTCATCGGTGTCGTCCGGCCAATGCT
GGTCGATGACGAGTTATTGCCCGGCGCCAGGACCGGTGCCCACGTCCCCGGCCAATCGGGATTACAAACCGGGGTTTGCG
GTCGCCATGATGTTGAAAGACCTGCATCTGGCAGCCGACGCCGCAAAAGCGGCGGGCGCGGACATTCGCCTGGGGGAAAT
GGCCGAGGGTATATATCAGAATCTTTCGGAGCGCGGCTTCGATGGCCTGGATTTTTCGGGCGTTATGAAAGATCTGAAGG
GCGAGCTTTGA

Upstream 100 bases:

>100_bases
GAACGCCGCCTGTTCCAGGGCCTGTTTGGCACTGCCGACCAGAAAGAAGGCATGAGCGCATTCAGTGAGAAGCGCCCTGC
AAAGTTTGAGGACAAGTAAG

Downstream 100 bases:

>100_bases
ACCATGCAGCAGGCTGAGGACTTCCGCGCTGAGAGCCGTGCCCTGCACGAGTTGATTTCCGAGACTGCGCCGATCCGGTA
TCGCGAACCCACACAGTTCA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTKIAFIGLGNMGGGMCANLVKAGHAVAAFDLNGEAVAAAAAKGARAAASVADAVKDADVIVSMLPAGKHVLGVYFGPDG
VGAHAAKGTLLIDCSTIAVTDAREAHSQAEQAGFLMVDAPVSGGVAAAEAGTLTFMAGGTAAAYERAAPILKAMGKNIFH
AGGAGNGQAAKIANNMLLGISMIGTCEAFNLAEKLGLDAETFFRISSVSSGQCWSMTSYCPAPGPVPTSPANRDYKPGFA
VAMMLKDLHLAADAAKAAGADIRLGEMAEGIYQNLSERGFDGLDFSGVMKDLKGEL

Sequences:

>Translated_296_residues
MTKIAFIGLGNMGGGMCANLVKAGHAVAAFDLNGEAVAAAAAKGARAAASVADAVKDADVIVSMLPAGKHVLGVYFGPDG
VGAHAAKGTLLIDCSTIAVTDAREAHSQAEQAGFLMVDAPVSGGVAAAEAGTLTFMAGGTAAAYERAAPILKAMGKNIFH
AGGAGNGQAAKIANNMLLGISMIGTCEAFNLAEKLGLDAETFFRISSVSSGQCWSMTSYCPAPGPVPTSPANRDYKPGFA
VAMMLKDLHLAADAAKAAGADIRLGEMAEGIYQNLSERGFDGLDFSGVMKDLKGEL
>Mature_295_residues
TKIAFIGLGNMGGGMCANLVKAGHAVAAFDLNGEAVAAAAAKGARAAASVADAVKDADVIVSMLPAGKHVLGVYFGPDGV
GAHAAKGTLLIDCSTIAVTDAREAHSQAEQAGFLMVDAPVSGGVAAAEAGTLTFMAGGTAAAYERAAPILKAMGKNIFHA
GGAGNGQAAKIANNMLLGISMIGTCEAFNLAEKLGLDAETFFRISSVSSGQCWSMTSYCPAPGPVPTSPANRDYKPGFAV
AMMLKDLHLAADAAKAAGADIRLGEMAEGIYQNLSERGFDGLDFSGVMKDLKGEL

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=42.8571428571429, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI40556376, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=36.6101694915254, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=34.965034965035, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=30.9278350515464, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=31.3993174061433, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=41.4141414141414, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=45.4237288135593, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=45.4237288135593, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI28574115, Length=285, Percent_Identity=23.859649122807, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=46.031746031746, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29830; Mature: 29699

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAFIGLGNMGGGMCANLVKAGHAVAAFDLNGEAVAAAAAKGARAAASVADAVKDADV
CCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHH
IVSMLPAGKHVLGVYFGPDGVGAHAAKGTLLIDCSTIAVTDAREAHSQAEQAGFLMVDAP
HHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEECEEEEECCHHHHHHHHHCCEEEEECC
VSGGVAAAEAGTLTFMAGGTAAAYERAAPILKAMGKNIFHAGGAGNGQAAKIANNMLLGI
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCEEEEE
SMIGTCEAFNLAEKLGLDAETFFRISSVSSGQCWSMTSYCPAPGPVPTSPANRDYKPGFA
HHHCCHHHHHHHHHHCCCHHHHEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHH
VAMMLKDLHLAADAAKAAGADIRLGEMAEGIYQNLSERGFDGLDFSGVMKDLKGEL
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TKIAFIGLGNMGGGMCANLVKAGHAVAAFDLNGEAVAAAAAKGARAAASVADAVKDADV
CEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHH
IVSMLPAGKHVLGVYFGPDGVGAHAAKGTLLIDCSTIAVTDAREAHSQAEQAGFLMVDAP
HHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEECEEEEECCHHHHHHHHHCCEEEEECC
VSGGVAAAEAGTLTFMAGGTAAAYERAAPILKAMGKNIFHAGGAGNGQAAKIANNMLLGI
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCEEEEE
SMIGTCEAFNLAEKLGLDAETFFRISSVSSGQCWSMTSYCPAPGPVPTSPANRDYKPGFA
HHHCCHHHHHHHHHHCCCHHHHEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHH
VAMMLKDLHLAADAAKAAGADIRLGEMAEGIYQNLSERGFDGLDFSGVMKDLKGEL
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]