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The map label for this gene is ahcY

Identifier: 114798407

GI number: 114798407

Start: 800471

End: 801880

Strand: Reverse

Name: ahcY

Synonym: HNE_0788

Alternate gene names: 114798407

Gene position: 801880-800471 (Counterclockwise)

Preceding gene: 114797641

Following gene: 114797552

Centisome position: 21.64

GC content: 61.42

Gene sequence:

>1410_bases
ATGAGCGCCAAAGCCGCCCCCCAGGACTATTTCGTGAAGGACATCTCGCTGGCAGAGTACGGCCGGAAAGAGATCGCGAT
TGCCGAAACCGAAATGCCGGGCCTGATGGCTGCCCGCGAAGAGTTCGGCCCCAGCCAGCCGCTCAAAGGCGCCCGCATCT
GCGGCTCCCTGCACATGACGATCCAGACCGCCGTGCTGATCCAGACCCTCGAAGCCCTTGGCGCCCAGGTGCGCTGGGTT
TCCTGCAACATCTACTCCACGCAGGACCACGCCGCCGCAGCCATCGCGGACGCCGGCACCGCCGTCTTCGCCTACAAAGG
CGAGACGCTGGAAGAATACTGGGACTACACCGACCGCATGTTCCAATGGCCCGATGGCGAAGGCCCCAACCTCATCCTCG
ATGATGGCGGCGACGCCACGATGTACCTGATCCTCGGCGAAAAGGCCGAATCCGATCCCTCCTTCCTCGAAAAGCCCACC
TCGGAAGAAGAGAAGTATTTCTTTGCCCAGATCAAAAAGCGCCTGACGGCCTCGCCCGGCTGGTTCAAGAAAACCAAGGC
CGGCGTCCGCGGCGTCTCGGAAGAGACCACCACAGGCGTCAACCGCCTCTACCAGCTGGAAAAGCGCGGCGAACTGCCTT
TCCCGGCAATCAACGTCAACGACTCGGTCACCAAGTCGAAGTTCGACAATAAGTATGGCTGTAAAGAGTCGCTCGTCGAC
GCGATCCGCCGCGGCACGGACGTCATGATGGCCGGCAAGAAAGCCTTCGTCGCCGGCTATGGCGATGTCGGCAAAGGCTC
GGCCGCCTCGCTCGCCGGCTCGGGCGCCCGCGTCGGCGTTTCGGAAGTCGATCCGATCTGCGCCCTGCAGGCCGCCATGG
ACGGGTTTGAAGTCCTGACCATGGACGAAGCCGCGCCCAAATTTGACATCTTCGTCACCGCGACCGGTAACAAGGACATC
CTCACCGTCGACCACATGCGCGCCATGAAAGACATGGCCATCGTCTGCAATATCGGCCACTTCGACAACGAAATTCAGGT
CGAAGGCCTGCGCAATTTCCAGTGGACCAACATCAAGCCGCAGGTCGACATGATCACCTTCCCGGACGGGAAACGCATCA
TCCTCCTCTCCGAAGGCCGCCTGGTAAACCTTGGCAACGCCACCGGCCACCCCTCCTTCGTGATGTCGGCCTCCTTCACC
AACCAGACGCTCGCCCAGATCGAGCTTCACCTGCGCGGCAACGAATATGACAACAAGGTCTACACCCTGCCCAAGCACCT
CGACGAGAAAGTCGCCCGTCTCCACCTCGACAAGCTCGGCGTCCAGCTGACCAAGCTGTCGGGTGAACAGGCCGCGTATA
TCGGCGTGGAACAGACCGGCCCGTTCAAGCCGGAACATTACCGCTACTGA

Upstream 100 bases:

>100_bases
ACAGACCATCCGGCCAATTCAACGCAGCTTGCAGCGGCAAAACCTTGCGCGTGCCCACCGGCCATGTTAACCGCAGCCCA
ACATATAAAGGATCGTTGAT

Downstream 100 bases:

>100_bases
TCCGGCAGCGGGGACAGCCTTGTCGCAGACCTTCATCCTTACCCTGAGTTGCCCGGACAGGGTTGGCCTCGTGGCCAGCC
TTGCACGGCTCATGGAGGAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSAKAAPQDYFVKDISLAEYGRKEIAIAETEMPGLMAAREEFGPSQPLKGARICGSLHMTIQTAVLIQTLEALGAQVRWV
SCNIYSTQDHAAAAIADAGTAVFAYKGETLEEYWDYTDRMFQWPDGEGPNLILDDGGDATMYLILGEKAESDPSFLEKPT
SEEEKYFFAQIKKRLTASPGWFKKTKAGVRGVSEETTTGVNRLYQLEKRGELPFPAINVNDSVTKSKFDNKYGCKESLVD
AIRRGTDVMMAGKKAFVAGYGDVGKGSAASLAGSGARVGVSEVDPICALQAAMDGFEVLTMDEAAPKFDIFVTATGNKDI
LTVDHMRAMKDMAIVCNIGHFDNEIQVEGLRNFQWTNIKPQVDMITFPDGKRIILLSEGRLVNLGNATGHPSFVMSASFT
NQTLAQIELHLRGNEYDNKVYTLPKHLDEKVARLHLDKLGVQLTKLSGEQAAYIGVEQTGPFKPEHYRY

Sequences:

>Translated_469_residues
MSAKAAPQDYFVKDISLAEYGRKEIAIAETEMPGLMAAREEFGPSQPLKGARICGSLHMTIQTAVLIQTLEALGAQVRWV
SCNIYSTQDHAAAAIADAGTAVFAYKGETLEEYWDYTDRMFQWPDGEGPNLILDDGGDATMYLILGEKAESDPSFLEKPT
SEEEKYFFAQIKKRLTASPGWFKKTKAGVRGVSEETTTGVNRLYQLEKRGELPFPAINVNDSVTKSKFDNKYGCKESLVD
AIRRGTDVMMAGKKAFVAGYGDVGKGSAASLAGSGARVGVSEVDPICALQAAMDGFEVLTMDEAAPKFDIFVTATGNKDI
LTVDHMRAMKDMAIVCNIGHFDNEIQVEGLRNFQWTNIKPQVDMITFPDGKRIILLSEGRLVNLGNATGHPSFVMSASFT
NQTLAQIELHLRGNEYDNKVYTLPKHLDEKVARLHLDKLGVQLTKLSGEQAAYIGVEQTGPFKPEHYRY
>Mature_468_residues
SAKAAPQDYFVKDISLAEYGRKEIAIAETEMPGLMAAREEFGPSQPLKGARICGSLHMTIQTAVLIQTLEALGAQVRWVS
CNIYSTQDHAAAAIADAGTAVFAYKGETLEEYWDYTDRMFQWPDGEGPNLILDDGGDATMYLILGEKAESDPSFLEKPTS
EEEKYFFAQIKKRLTASPGWFKKTKAGVRGVSEETTTGVNRLYQLEKRGELPFPAINVNDSVTKSKFDNKYGCKESLVDA
IRRGTDVMMAGKKAFVAGYGDVGKGSAASLAGSGARVGVSEVDPICALQAAMDGFEVLTMDEAAPKFDIFVTATGNKDIL
TVDHMRAMKDMAIVCNIGHFDNEIQVEGLRNFQWTNIKPQVDMITFPDGKRIILLSEGRLVNLGNATGHPSFVMSASFTN
QTLAQIELHLRGNEYDNKVYTLPKHLDEKVARLHLDKLGVQLTKLSGEQAAYIGVEQTGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=57.3593073593074, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=57.2727272727273, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=48.7068965517241, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=48.7068965517241, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=48.7068965517241, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=48.7068965517241, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=48.4913793103448, Blast_Score=424, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.7096774193548, Blast_Score=517, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=55.761316872428, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=59.7402597402597, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=465, Percent_Identity=49.0322580645161, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=467, Percent_Identity=49.678800856531, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=466, Percent_Identity=49.5708154506438, Blast_Score=427, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_HYPNA (Q0C427)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759516.1
- ProteinModelPortal:   Q0C427
- SMR:   Q0C427
- STRING:   Q0C427
- GeneID:   4289748
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0788
- NMPDR:   fig|228405.5.peg.770
- TIGR:   HNE_0788
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q0C427
- ProtClustDB:   PRK05476
- BioCyc:   HNEP81032:HNE_0788-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51572; Mature: 51441

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 60-60 BINDING 135-135 BINDING 195-195 BINDING 225-225 BINDING 229-229 BINDING 230-230 BINDING 282-282 BINDING 317-317 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKAAPQDYFVKDISLAEYGRKEIAIAETEMPGLMAAREEFGPSQPLKGARICGSLHMT
CCCCCCCCHHHEECCCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
IQTAVLIQTLEALGAQVRWVSCNIYSTQDHAAAAIADAGTAVFAYKGETLEEYWDYTDRM
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHCHHHHE
FQWPDGEGPNLILDDGGDATMYLILGEKAESDPSFLEKPTSEEEKYFFAQIKKRLTASPG
EECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCC
WFKKTKAGVRGVSEETTTGVNRLYQLEKRGELPFPAINVNDSVTKSKFDNKYGCKESLVD
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHH
AIRRGTDVMMAGKKAFVAGYGDVGKGSAASLAGSGARVGVSEVDPICALQAAMDGFEVLT
HHHCCCCEEEECCEEEEEECCCCCCCCHHHCCCCCCCCCHHHCCHHHHHHHHCCCEEEEE
MDEAAPKFDIFVTATGNKDILTVDHMRAMKDMAIVCNIGHFDNEIQVEGLRNFQWTNIKP
ECCCCCCEEEEEEECCCCCEEEHHHHHHHHCEEEEEECCCCCCEEEEEECCCEEECCCCC
QVDMITFPDGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELHLRGNEYDNKV
CEEEEECCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEE
YTLPKHLDEKVARLHLDKLGVQLTKLSGEQAAYIGVEQTGPFKPEHYRY
EECHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SAKAAPQDYFVKDISLAEYGRKEIAIAETEMPGLMAAREEFGPSQPLKGARICGSLHMT
CCCCCCCHHHEECCCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
IQTAVLIQTLEALGAQVRWVSCNIYSTQDHAAAAIADAGTAVFAYKGETLEEYWDYTDRM
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHCHHHHE
FQWPDGEGPNLILDDGGDATMYLILGEKAESDPSFLEKPTSEEEKYFFAQIKKRLTASPG
EECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCC
WFKKTKAGVRGVSEETTTGVNRLYQLEKRGELPFPAINVNDSVTKSKFDNKYGCKESLVD
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHH
AIRRGTDVMMAGKKAFVAGYGDVGKGSAASLAGSGARVGVSEVDPICALQAAMDGFEVLT
HHHCCCCEEEECCEEEEEECCCCCCCCHHHCCCCCCCCCHHHCCHHHHHHHHCCCEEEEE
MDEAAPKFDIFVTATGNKDILTVDHMRAMKDMAIVCNIGHFDNEIQVEGLRNFQWTNIKP
ECCCCCCEEEEEEECCCCCEEEHHHHHHHHCEEEEEECCCCCCEEEEEECCCEEECCCCC
QVDMITFPDGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELHLRGNEYDNKV
CEEEEECCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEE
YTLPKHLDEKVARLHLDKLGVQLTKLSGEQAAYIGVEQTGPFKPEHYRY
EECHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA