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The map label for this gene is yisK [H]

Identifier: 114798406

GI number: 114798406

Start: 859665

End: 860498

Strand: Direct

Name: yisK [H]

Synonym: HNE_0839

Alternate gene names: 114798406

Gene position: 859665-860498 (Clockwise)

Preceding gene: 114798093

Following gene: 114797619

Centisome position: 23.2

GC content: 61.75

Gene sequence:

>834_bases
ATGCGTCTGGTGCGGTTTGAAGCCGAAGGGCACGTCCGGTTTGGCCATCTGGAAGGCGATACTGTCGTGCCTGTTGCAGG
AGACAGCTTTATCGACGCGCTGGAGGGCCGCGAGAAGGGCGCGCCCCTGGCGCTCAGCGTCGTGCGCCTGCTCGCCCCGG
TGCCCCGTCCCCGAAAAATCCTGGGGATAGGTGTGAATTATGCCGCCCACGCCGCCGAGAGCGTGAGCTTCATCAACACC
GCCAAACCCGAGGTGCAGAAATGGTTCAACAAACAGGCAACGGCGGTGAACGGACCCTATGATCCGGTCCACCTTCCCAG
GGTTTCCAGCCAGCTCGATTATGAGGGTGAGCTGGTCGCGGTGATCGGCAAGCATGGCCGGCATGTGCCCGCTGAAAGGG
CCATGGAAATCGTTGCAGGCTTCTGTATCGGTTGCGATTATTCGGTGCGCGACTGGCAGAAGGCCAGCCAGACGATGATC
ATGGGCAAGGGCTTTGACACGCACGCGCCGTTTGGCCCCGCGCTGGTGACGCCGGATGAGCTGGGCGATATTTCAGACCT
CGAAATCCGCAGCTTCGTGAACGGCGAATTGCGCCAGTCCGGCCGCCCGCGGGACATGATCCACGATGTTGGCGCCCAGA
TTGCACATCTTACGGCGGCCTTTACGCTTGAGCCTGGGGATGTGATCTTCACTGGAACCCCGGCCGGAGTCGGCGCGGGG
TTCGATCCGCCGAAATGGCTGAAGGCAGGTGACCGTGTACGCATCGAGATCGACAGGCTGGGCCACATCGAGAACGCCAT
CGTTCCCGAGCCTGACACAATGCGAATCGGTTGA

Upstream 100 bases:

>100_bases
TCTACTCGCCCCCTCCCTAGCCCTTGCCAAAGCGGTCCACAACGCGAGATGAACACCCTGCAAGGTTGTTTGGGCAGTAG
TGTGACAGGAGAGTAACGAT

Downstream 100 bases:

>100_bases
TCGGAAGCGCCGGTTTGGGGGGCAGTCTGAGGGTCGGTCCGGGGGGCAGTCTGAGGGAACGACGGGGCCTCGCCTTTTGG
GCAAGGCCCCCGTCTCCCCC

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MRLVRFEAEGHVRFGHLEGDTVVPVAGDSFIDALEGREKGAPLALSVVRLLAPVPRPRKILGIGVNYAAHAAESVSFINT
AKPEVQKWFNKQATAVNGPYDPVHLPRVSSQLDYEGELVAVIGKHGRHVPAERAMEIVAGFCIGCDYSVRDWQKASQTMI
MGKGFDTHAPFGPALVTPDELGDISDLEIRSFVNGELRQSGRPRDMIHDVGAQIAHLTAAFTLEPGDVIFTGTPAGVGAG
FDPPKWLKAGDRVRIEIDRLGHIENAIVPEPDTMRIG

Sequences:

>Translated_277_residues
MRLVRFEAEGHVRFGHLEGDTVVPVAGDSFIDALEGREKGAPLALSVVRLLAPVPRPRKILGIGVNYAAHAAESVSFINT
AKPEVQKWFNKQATAVNGPYDPVHLPRVSSQLDYEGELVAVIGKHGRHVPAERAMEIVAGFCIGCDYSVRDWQKASQTMI
MGKGFDTHAPFGPALVTPDELGDISDLEIRSFVNGELRQSGRPRDMIHDVGAQIAHLTAAFTLEPGDVIFTGTPAGVGAG
FDPPKWLKAGDRVRIEIDRLGHIENAIVPEPDTMRIG
>Mature_277_residues
MRLVRFEAEGHVRFGHLEGDTVVPVAGDSFIDALEGREKGAPLALSVVRLLAPVPRPRKILGIGVNYAAHAAESVSFINT
AKPEVQKWFNKQATAVNGPYDPVHLPRVSSQLDYEGELVAVIGKHGRHVPAERAMEIVAGFCIGCDYSVRDWQKASQTMI
MGKGFDTHAPFGPALVTPDELGDISDLEIRSFVNGELRQSGRPRDMIHDVGAQIAHLTAAFTLEPGDVIFTGTPAGVGAG
FDPPKWLKAGDRVRIEIDRLGHIENAIVPEPDTMRIG

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=228, Percent_Identity=45.6140350877193, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI40786394, Length=228, Percent_Identity=44.2982456140351, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI215422413, Length=216, Percent_Identity=32.8703703703704, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13654274, Length=185, Percent_Identity=35.1351351351351, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI66348062, Length=185, Percent_Identity=35.1351351351351, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI1787428, Length=208, Percent_Identity=33.6538461538462, Blast_Score=104, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17557057, Length=183, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324161, Length=237, Percent_Identity=29.957805907173, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28572127, Length=274, Percent_Identity=38.6861313868613, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24663695, Length=221, Percent_Identity=35.2941176470588, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571789, Length=210, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 30009; Mature: 30009

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVRFEAEGHVRFGHLEGDTVVPVAGDSFIDALEGREKGAPLALSVVRLLAPVPRPRKI
CEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEE
LGIGVNYAAHAAESVSFINTAKPEVQKWFNKQATAVNGPYDPVHLPRVSSQLDYEGELVA
EEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VIGKHGRHVPAERAMEIVAGFCIGCDYSVRDWQKASQTMIMGKGFDTHAPFGPALVTPDE
EEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCEECHHH
LGDISDLEIRSFVNGELRQSGRPRDMIHDVGAQIAHLTAAFTLEPGDVIFTGTPAGVGAG
CCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCC
FDPPKWLKAGDRVRIEIDRLGHIENAIVPEPDTMRIG
CCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MRLVRFEAEGHVRFGHLEGDTVVPVAGDSFIDALEGREKGAPLALSVVRLLAPVPRPRKI
CEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEE
LGIGVNYAAHAAESVSFINTAKPEVQKWFNKQATAVNGPYDPVHLPRVSSQLDYEGELVA
EEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VIGKHGRHVPAERAMEIVAGFCIGCDYSVRDWQKASQTMIMGKGFDTHAPFGPALVTPDE
EEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCEECHHH
LGDISDLEIRSFVNGELRQSGRPRDMIHDVGAQIAHLTAAFTLEPGDVIFTGTPAGVGAG
CCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCC
FDPPKWLKAGDRVRIEIDRLGHIENAIVPEPDTMRIG
CCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]