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The map label for this gene is phhA [H]

Identifier: 114798396

GI number: 114798396

Start: 1421958

End: 1422839

Strand: Direct

Name: phhA [H]

Synonym: HNE_1395

Alternate gene names: 114798396

Gene position: 1421958-1422839 (Clockwise)

Preceding gene: 114797692

Following gene: 114800479

Centisome position: 38.38

GC content: 59.75

Gene sequence:

>882_bases
ATGGACACTGCATTTGCCAAGAATCGCTATCATGGCGCCCCCCGCGCGGACGATTACACCATCGACCAGGCGTGGGAGAC
CTATTCCCCCGCCGAGCATGACCGCTGGGACAGGCTGTTCCGCCGCCAGAAGGAGATCGCCACCGGGCGCGCTTCGAAGG
TGGCGCTGGACGCAATGCACAAGCTGGAGCTTTCCCCCTCCGGCATCCCGCATATGGGCCGGCTGTCAGACAAGCTGGAA
AAGATAACCGGCTGGCGCGTGGTGCCTGTGGCTGAGCTTGTGCCCGATGAGGTGTTCTTCGATCACCTCGCCAACCGCCG
CTTTCCGGCAGGCGCCTTCATCCGCCCGGAGGAAGAGTTCGACTATCTTCAGGAGCCGGACATTTTCCACGACATCTTCG
GCCATGTGCCGATGCTGGCAGACCCTGTGTTTGCAGACTTCATGGAAGCCTATGGCAAGGGCGGCCAGCGCGCGATGCGC
CTCGGCCAGCTGCACAATCTGGCGCGCCTTTATTGGTACACGGTCGAGTTCGGCCTGATCCAGGAAGAGGACGGACTGCG
CATCTATGGCGCGGGCATCCTCTCCAGCCCGCATGAAACCGTGTTCGCACTGGAAGACGCCAGCCCCAACCGTATCGGCT
TTGACCTGCAACGCCTTATGCGGACGAAATACATTATTGATGATTTCCAGCAGACCTATTTCGTCATACCCAGCTTCGAG
GCGTTGCTCGAAACCTGCTACAAGGATTTCGGCGATGTTTATGCCGAAGTGAAAGGCCAGCCCGACTATGAAGCCAATGA
GCTTGCGCCGGGCGATGATGTGATCACCCGCGGCACGCTGAAATATTTCAGGGACGGCGGGCGTAAGGCCGGTAAGGCCT
AA

Upstream 100 bases:

>100_bases
ATTGGGCGTCACGCTCTCGGAAATCATCGATTCCCGTCCGGAAGCGGCCTGAATTAGTTACATCTGGAACTAATTTTATT
TCGCGGTTATAATTACCCGC

Downstream 100 bases:

>100_bases
GCCTCGCCCTTGCGCGCCGTCTGCTTGGGATCATGCTTGGGCGCAGGCGCCAGGCGCATCACCTCGGTCTGGAACCGCTC
ATCGTCGCCCGCCAGCAGGA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDTAFAKNRYHGAPRADDYTIDQAWETYSPAEHDRWDRLFRRQKEIATGRASKVALDAMHKLELSPSGIPHMGRLSDKLE
KITGWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEFDYLQEPDIFHDIFGHVPMLADPVFADFMEAYGKGGQRAMR
LGQLHNLARLYWYTVEFGLIQEEDGLRIYGAGILSSPHETVFALEDASPNRIGFDLQRLMRTKYIIDDFQQTYFVIPSFE
ALLETCYKDFGDVYAEVKGQPDYEANELAPGDDVITRGTLKYFRDGGRKAGKA

Sequences:

>Translated_293_residues
MDTAFAKNRYHGAPRADDYTIDQAWETYSPAEHDRWDRLFRRQKEIATGRASKVALDAMHKLELSPSGIPHMGRLSDKLE
KITGWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEFDYLQEPDIFHDIFGHVPMLADPVFADFMEAYGKGGQRAMR
LGQLHNLARLYWYTVEFGLIQEEDGLRIYGAGILSSPHETVFALEDASPNRIGFDLQRLMRTKYIIDDFQQTYFVIPSFE
ALLETCYKDFGDVYAEVKGQPDYEANELAPGDDVITRGTLKYFRDGGRKAGKA
>Mature_293_residues
MDTAFAKNRYHGAPRADDYTIDQAWETYSPAEHDRWDRLFRRQKEIATGRASKVALDAMHKLELSPSGIPHMGRLSDKLE
KITGWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEFDYLQEPDIFHDIFGHVPMLADPVFADFMEAYGKGGQRAMR
LGQLHNLARLYWYTVEFGLIQEEDGLRIYGAGILSSPHETVFALEDASPNRIGFDLQRLMRTKYIIDDFQQTYFVIPSFE
ALLETCYKDFGDVYAEVKGQPDYEANELAPGDDVITRGTLKYFRDGGRKAGKA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=216, Percent_Identity=32.8703703703704, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI31795563, Length=217, Percent_Identity=34.1013824884793, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4759248, Length=173, Percent_Identity=36.4161849710983, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI88900503, Length=216, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI88900505, Length=216, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI88900501, Length=216, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17531391, Length=176, Percent_Identity=39.2045454545455, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=230, Percent_Identity=33.0434782608696, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115533973, Length=230, Percent_Identity=33.0434782608696, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71980736, Length=220, Percent_Identity=30.9090909090909, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24660393, Length=226, Percent_Identity=33.1858407079646, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62472054, Length=226, Percent_Identity=33.1858407079646, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136774, Length=217, Percent_Identity=32.7188940092166, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136776, Length=217, Percent_Identity=32.7188940092166, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24654994, Length=265, Percent_Identity=30.9433962264151, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33541; Mature: 33541

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAFAKNRYHGAPRADDYTIDQAWETYSPAEHDRWDRLFRRQKEIATGRASKVALDAMH
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KLELSPSGIPHMGRLSDKLEKITGWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEF
HHCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
DYLQEPDIFHDIFGHVPMLADPVFADFMEAYGKGGQRAMRLGQLHNLARLYWYTVEFGLI
HHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECEE
QEEDGLRIYGAGILSSPHETVFALEDASPNRIGFDLQRLMRTKYIIDDFQQTYFVIPSFE
ECCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHH
ALLETCYKDFGDVYAEVKGQPDYEANELAPGDDVITRGTLKYFRDGGRKAGKA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDTAFAKNRYHGAPRADDYTIDQAWETYSPAEHDRWDRLFRRQKEIATGRASKVALDAMH
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KLELSPSGIPHMGRLSDKLEKITGWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEF
HHCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
DYLQEPDIFHDIFGHVPMLADPVFADFMEAYGKGGQRAMRLGQLHNLARLYWYTVEFGLI
HHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECEE
QEEDGLRIYGAGILSSPHETVFALEDASPNRIGFDLQRLMRTKYIIDDFQQTYFVIPSFE
ECCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHH
ALLETCYKDFGDVYAEVKGQPDYEANELAPGDDVITRGTLKYFRDGGRKAGKA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]