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The map label for this gene is cyoE

Identifier: 114798218

GI number: 114798218

Start: 1050186

End: 1051142

Strand: Direct

Name: cyoE

Synonym: HNE_1040

Alternate gene names: 114798218

Gene position: 1050186-1051142 (Clockwise)

Preceding gene: 114799015

Following gene: 114800186

Centisome position: 28.34

GC content: 65.52

Gene sequence:

>957_bases
ATGACAGAGCTGACCGCCGCAACCCCCACCAAGCGCCCCGCTACGGCGACTGACTATGTGAACCTGATGAAGCCCCGCAT
CATGATGCTGGTGGTGTTCACGGCCGTAGCAGGTCTCGCCGCTGCCAGCGGTATGACCGGCATCACCATGCACCCGGCCA
TGGCGGCAATTGCCGTGCTGGCCGTTGCGCTCGGCTCGGGCGCGGCCGGCGCCATCAACATGTGGTATGACGCCGACATC
GACGCCATCATGAGCCGCACCTCGACGCGCCCCATCCCGTCGGGCGCCGTGCCCAAGGAAGAGGCCCTCACAATGGGCCT
CATCATGTCGGGCGTCTCGGTGATGCTGATGTGGCTGGCGTCCAACTGGCTCGCCGCCGCGCTGCTGGCCTTCTCGATCT
TCTACTATGGCGTCATCTATACGATGTGGCTGAAGCGGGCGACGCCGCAGAATATCGTCATCGGCGGCGGGGCAGGCGCG
TTCCCTCCGGTCATCGGCTGGGCCGCCGTCACCGGCAATACGCCGCTCGACGCCTGGATTCTCTTCGCCATCATCTTCTT
CTGGACGCCCCCGCATTTCTGGGCGCTGTCGCTGCTGGCGCACAAGGAATACGCCAAGGTCTCCGTGCCCATGCTGCCGG
TCACCCACGGCGCCAAGGCCACGCGGTTCCAGATCCTCGTCTATACGCTGGTGCTGATCCCGGTCTCGCTTGCCCCTCTG
GCCACCGGTCTGGGCGGCTGGATCTATGGCGCAGTCGCCGGCGGTCTGGGACTGGTCTTCCTGGCTTATGCGGTCGCCAT
CCTGCGCTCGAAGGCGGGCGATGACGGCGCCCCGGCGGGCGACATGAAACTCGCCCGCACTGCGTTCCTCTTCTCGATTC
TCTACCTCTTCGCCCTATTTGGCGCAGTGCTGGTGGAGCATGCTGCCGGGCTGCACTTCCCGGTCTTTGGAGCCTGA

Upstream 100 bases:

>100_bases
GGCCCGCCGCACCGGGCTGGAGAATTGAACCAACCGGGGCGGCCCTCGCGCATCAGCGTGCGGGCCGCTTCGTTTAAAAC
GGCCTGAGAGAGGCCCGGAG

Downstream 100 bases:

>100_bases
TATGGAAGACCCCACGCTGAAGCCGGATGTCCGCCGGTTCACGCCGGAAGAACTGGCCGCCCGCAAGAAGCGCAATGTCT
GGCTCGGCCTGGCGCTGGGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTELTAATPTKRPATATDYVNLMKPRIMMLVVFTAVAGLAAASGMTGITMHPAMAAIAVLAVALGSGAAGAINMWYDADI
DAIMSRTSTRPIPSGAVPKEEALTMGLIMSGVSVMLMWLASNWLAAALLAFSIFYYGVIYTMWLKRATPQNIVIGGGAGA
FPPVIGWAAVTGNTPLDAWILFAIIFFWTPPHFWALSLLAHKEYAKVSVPMLPVTHGAKATRFQILVYTLVLIPVSLAPL
ATGLGGWIYGAVAGGLGLVFLAYAVAILRSKAGDDGAPAGDMKLARTAFLFSILYLFALFGAVLVEHAAGLHFPVFGA

Sequences:

>Translated_318_residues
MTELTAATPTKRPATATDYVNLMKPRIMMLVVFTAVAGLAAASGMTGITMHPAMAAIAVLAVALGSGAAGAINMWYDADI
DAIMSRTSTRPIPSGAVPKEEALTMGLIMSGVSVMLMWLASNWLAAALLAFSIFYYGVIYTMWLKRATPQNIVIGGGAGA
FPPVIGWAAVTGNTPLDAWILFAIIFFWTPPHFWALSLLAHKEYAKVSVPMLPVTHGAKATRFQILVYTLVLIPVSLAPL
ATGLGGWIYGAVAGGLGLVFLAYAVAILRSKAGDDGAPAGDMKLARTAFLFSILYLFALFGAVLVEHAAGLHFPVFGA
>Mature_317_residues
TELTAATPTKRPATATDYVNLMKPRIMMLVVFTAVAGLAAASGMTGITMHPAMAAIAVLAVALGSGAAGAINMWYDADID
AIMSRTSTRPIPSGAVPKEEALTMGLIMSGVSVMLMWLASNWLAAALLAFSIFYYGVIYTMWLKRATPQNIVIGGGAGAF
PPVIGWAAVTGNTPLDAWILFAIIFFWTPPHFWALSLLAHKEYAKVSVPMLPVTHGAKATRFQILVYTLVLIPVSLAPLA
TGLGGWIYGAVAGGLGLVFLAYAVAILRSKAGDDGAPAGDMKLARTAFLFSILYLFALFGAVLVEHAAGLHFPVFGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=202, Percent_Identity=34.6534653465347, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786631, Length=284, Percent_Identity=29.9295774647887, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=223, Percent_Identity=32.2869955156951, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325085, Length=297, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19921064, Length=286, Percent_Identity=30.4195804195804, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_HYPNA (Q0C3D1)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759762.1
- STRING:   Q0C3D1
- GeneID:   4288599
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1040
- NMPDR:   fig|228405.5.peg.1013
- TIGR:   HNE_1040
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q0C3D1
- ProtClustDB:   PRK04375
- BioCyc:   HNEP81032:HNE_1040-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33421; Mature: 33290

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00943 UBIA; PS00046 HISTONE_H2A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x121ad34c)-; HASH(0x126c6fa4)-; HASH(0x12949864)-; HASH(0x100145cc)-; HASH(0x1248c618)-; HASH(0x12384154)-; HASH(0x1226e858)-; HASH(0x1244f9a0)-; HASH(0x1248c240)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTAATPTKRPATATDYVNLMKPRIMMLVVFTAVAGLAAASGMTGITMHPAMAAIAVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AVALGSGAAGAINMWYDADIDAIMSRTSTRPIPSGAVPKEEALTMGLIMSGVSVMLMWLA
HHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SNWLAAALLAFSIFYYGVIYTMWLKRATPQNIVIGGGAGAFPPVIGWAAVTGNTPLDAWI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHEECCCCCHHHHH
LFAIIFFWTPPHFWALSLLAHKEYAKVSVPMLPVTHGAKATRFQILVYTLVLIPVSLAPL
HHHHHHHHCCHHHHHHHHHHHHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ATGLGGWIYGAVAGGLGLVFLAYAVAILRSKAGDDGAPAGDMKLARTAFLFSILYLFALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAVLVEHAAGLHFPVFGA
HHHHHHHHCCCCCCCCCH
>Mature Secondary Structure 
TELTAATPTKRPATATDYVNLMKPRIMMLVVFTAVAGLAAASGMTGITMHPAMAAIAVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AVALGSGAAGAINMWYDADIDAIMSRTSTRPIPSGAVPKEEALTMGLIMSGVSVMLMWLA
HHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SNWLAAALLAFSIFYYGVIYTMWLKRATPQNIVIGGGAGAFPPVIGWAAVTGNTPLDAWI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHEECCCCCHHHHH
LFAIIFFWTPPHFWALSLLAHKEYAKVSVPMLPVTHGAKATRFQILVYTLVLIPVSLAPL
HHHHHHHHCCHHHHHHHHHHHHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ATGLGGWIYGAVAGGLGLVFLAYAVAILRSKAGDDGAPAGDMKLARTAFLFSILYLFALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAVLVEHAAGLHFPVFGA
HHHHHHHHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA