Click here to switch to the map view.

The map label for this gene is dcp [H]

Identifier: 114797980

GI number: 114797980

Start: 3449649

End: 3451829

Strand: Direct

Name: dcp [H]

Synonym: HNE_3288

Alternate gene names: 114797980

Gene position: 3449649-3451829 (Clockwise)

Preceding gene: 114797225

Following gene: 114800010

Centisome position: 93.11

GC content: 61.94

Gene sequence:

>2181_bases
ATGACTGATGCCCTGAAGGGCGGCGCTGCCGCTCTCGTACTCGCCGCCACGGCTGCCTGCGGCGCCCCGGAAACCACCAC
ACCGGAAGCCGAAGCCGCCAGCAGCCAGAGCGAGCTGCCTGAAATCACCGTCACCGACGCCGAGCTGGAAGGAAACCCCT
TCCGCGCCGAATGGACCGGCGCCTATGGCGCGCCCCCCTTCGCCCAGATCACCGACGCGCACTACATGCCGGCGGTCAAG
AAGGGCATCCTCGAGATGCGCGCCGAGATCGACGCCATCGTCAACACCGAAGAAGAGCCCACCTTCGAGAACACCATCCT
GGCGCTGGAAAAATCCGGCAAGGCGCTGGAGCGGGTCATGCTGGTGTTCGGCAACATCACCAACACCGATACCAATGACG
CGCTCACGGCCCTGGAAGGCGAAATCTACCCCATGCTCACACGTGAGCAGGATGCGGTGACCTTCAATCCGGAACTCTTT
GCCCGCGTGCAGGCCGTTTACGACCAACGCGACCGTCTCGGCCTCGACGAGCAGGAAGCCCGCCTGCTGGAGCTGACGCA
TCGCAATTTCGTCCGCGCCGGCGCCAGCCTCGCGCCGGAAGTCCAGGCAGAGATCGGCCAGCTGAACGCCGAAATCTCCG
CCCTGACGACCACCTATGGCCAGAACCTTCTCAACGCCACCAACGCCTTCAAGCTGGAAATCACCGATCCGGCCCGCCTC
GGCGGCCTGTCGGATGACTTCAAGAACGCCATCAAGGTGGACGGCGAAGACAAATGGGTGGTCGGCATCAGCCGCTCCTT
CTTCGAAGGCTTCATGGCCAGCGCCGAAGACCGCGAGCTGCGCAGCCAGCTGTTTGACGGCTATCGCACTGTCGCCTCCT
CCGGCGAGTTCGATAACGGCCCGCTTGCCATCAAGCTCGCCCAGCTGCGCGCCAAACGCGCCGAGCTGATGGGCTATCCC
AGCCACGCGCATTATGTGCTCGAGGAGCGCATGGCGCACACCCCCGATGCCGCGCTCGAATTCCTAGGCAAAGTGCTGGA
GCCCGGCCTCGCCCGCGCCGCAGAAGAAGAAGCCGACATGGAGACGATCGCCGGACACGAGATCCTCGGCCATGACTGGT
GGTTCTATTCGGAAAAGGTCCGTGCCGAGAAGTACGCCTTCGACGAAAACCAGCTGCGCCCCTATTTCGAACTGGGCGCG
TCCACCGACGGCGCGTTTGAAGTTGCCTCGCGCCTCTTCAACATCACCCTGGAAGAAGTGCCCGTCGAGGCGTGGAACCC
GGCTGTCAAATCCTATGACGTGAAGGATTCCGAAAGCGGCGAACATCTCGGCCTGCTGATGATCGACAATTTCGCCCGCG
ACACCAAGCGCGGCGGCGCCTGGATGAGCACCTACCGCTCTTCTTCGGATATGGATGGCAACACCATCCGCCCGATCATC
ACCAACAACATGAACCTGGTTCCGCCCGCAGCGGGCCAGCCGGCCCTGCTCTCGCCGACTGAAGTGGAAACTCTGTTCCA
CGAATTCGGCCACGGCCTGCACGGCCTGCTCACTCAGATCCGCTATCCGAGCTTCTCGGGCGTCTATGGCGGCCCGGACT
ATGTCGAGCTGCCCTCCCAGATCATGGAACACTGGGTGACCGAGCCTCAGGTGCTGGCGATGTATGCCCGCCACCATGAA
ACCGGCGAGATCATTCCTCAGGAACTGGTCGACAAGATGAACAAGGCCTCGACCTTCAATCAGGGCTTCAAGACGACCGA
GTACATCGCTGCCTCGCTGATCGACCTTCACTGGCACATGCTGTCTTCGGAAGAAGCCGCCGAGATCACCGATGCCCGCG
AGTTTGAAAAATCCGTACTCGCCCAATACAACATCCCGGAAATCATCGAGCCACGGTATCGCTCGACCTATTTCTCCCAC
ATCTTCGCGGGCGGCTACGCGGCCGGCTACTACTCATACCTCTGGGCAGAAATTCTGGATGCGGATGGCTTTGACGCCTT
CAAACAATCCGGCGACATCTTCAATCCGGAAGTCGCTGCGAAGCTGAAACAATGGGTGTTCGAATCCGGCGGCCTGCGGG
AGACCGATGAACTCTACCGCAATTTCCGCGGGTCTGATCCGGGCATCGAGCCGCTGCTGCGCAATCGCGGCTTTGCCGAG
CCCTCCCCTGCCGAAGGCTGA

Upstream 100 bases:

>100_bases
CGGGGGCAAAACCGCCCCCTTCTGCCCGTTTCTCTGGAAATCTGCGCCCCCCACAGGTAAACCCTCTGCAATCTTCATTG
CCAGAGGAAGCATGATGAAA

Downstream 100 bases:

>100_bases
TCCGTTCAGCTCCCAAACAAAAACCCCGCCTCCTGGAGGCGGGGTTTTTTTGTGGCGCAGGATGGTTTCAGGCCAGATCA
GCCCCCGACGACCGGGTCCT

Product: peptidyl-dipeptidase

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MTDALKGGAAALVLAATAACGAPETTTPEAEAASSQSELPEITVTDAELEGNPFRAEWTGAYGAPPFAQITDAHYMPAVK
KGILEMRAEIDAIVNTEEEPTFENTILALEKSGKALERVMLVFGNITNTDTNDALTALEGEIYPMLTREQDAVTFNPELF
ARVQAVYDQRDRLGLDEQEARLLELTHRNFVRAGASLAPEVQAEIGQLNAEISALTTTYGQNLLNATNAFKLEITDPARL
GGLSDDFKNAIKVDGEDKWVVGISRSFFEGFMASAEDRELRSQLFDGYRTVASSGEFDNGPLAIKLAQLRAKRAELMGYP
SHAHYVLEERMAHTPDAALEFLGKVLEPGLARAAEEEADMETIAGHEILGHDWWFYSEKVRAEKYAFDENQLRPYFELGA
STDGAFEVASRLFNITLEEVPVEAWNPAVKSYDVKDSESGEHLGLLMIDNFARDTKRGGAWMSTYRSSSDMDGNTIRPII
TNNMNLVPPAAGQPALLSPTEVETLFHEFGHGLHGLLTQIRYPSFSGVYGGPDYVELPSQIMEHWVTEPQVLAMYARHHE
TGEIIPQELVDKMNKASTFNQGFKTTEYIAASLIDLHWHMLSSEEAAEITDAREFEKSVLAQYNIPEIIEPRYRSTYFSH
IFAGGYAAGYYSYLWAEILDADGFDAFKQSGDIFNPEVAAKLKQWVFESGGLRETDELYRNFRGSDPGIEPLLRNRGFAE
PSPAEG

Sequences:

>Translated_726_residues
MTDALKGGAAALVLAATAACGAPETTTPEAEAASSQSELPEITVTDAELEGNPFRAEWTGAYGAPPFAQITDAHYMPAVK
KGILEMRAEIDAIVNTEEEPTFENTILALEKSGKALERVMLVFGNITNTDTNDALTALEGEIYPMLTREQDAVTFNPELF
ARVQAVYDQRDRLGLDEQEARLLELTHRNFVRAGASLAPEVQAEIGQLNAEISALTTTYGQNLLNATNAFKLEITDPARL
GGLSDDFKNAIKVDGEDKWVVGISRSFFEGFMASAEDRELRSQLFDGYRTVASSGEFDNGPLAIKLAQLRAKRAELMGYP
SHAHYVLEERMAHTPDAALEFLGKVLEPGLARAAEEEADMETIAGHEILGHDWWFYSEKVRAEKYAFDENQLRPYFELGA
STDGAFEVASRLFNITLEEVPVEAWNPAVKSYDVKDSESGEHLGLLMIDNFARDTKRGGAWMSTYRSSSDMDGNTIRPII
TNNMNLVPPAAGQPALLSPTEVETLFHEFGHGLHGLLTQIRYPSFSGVYGGPDYVELPSQIMEHWVTEPQVLAMYARHHE
TGEIIPQELVDKMNKASTFNQGFKTTEYIAASLIDLHWHMLSSEEAAEITDAREFEKSVLAQYNIPEIIEPRYRSTYFSH
IFAGGYAAGYYSYLWAEILDADGFDAFKQSGDIFNPEVAAKLKQWVFESGGLRETDELYRNFRGSDPGIEPLLRNRGFAE
PSPAEG
>Mature_725_residues
TDALKGGAAALVLAATAACGAPETTTPEAEAASSQSELPEITVTDAELEGNPFRAEWTGAYGAPPFAQITDAHYMPAVKK
GILEMRAEIDAIVNTEEEPTFENTILALEKSGKALERVMLVFGNITNTDTNDALTALEGEIYPMLTREQDAVTFNPELFA
RVQAVYDQRDRLGLDEQEARLLELTHRNFVRAGASLAPEVQAEIGQLNAEISALTTTYGQNLLNATNAFKLEITDPARLG
GLSDDFKNAIKVDGEDKWVVGISRSFFEGFMASAEDRELRSQLFDGYRTVASSGEFDNGPLAIKLAQLRAKRAELMGYPS
HAHYVLEERMAHTPDAALEFLGKVLEPGLARAAEEEADMETIAGHEILGHDWWFYSEKVRAEKYAFDENQLRPYFELGAS
TDGAFEVASRLFNITLEEVPVEAWNPAVKSYDVKDSESGEHLGLLMIDNFARDTKRGGAWMSTYRSSSDMDGNTIRPIIT
NNMNLVPPAAGQPALLSPTEVETLFHEFGHGLHGLLTQIRYPSFSGVYGGPDYVELPSQIMEHWVTEPQVLAMYARHHET
GEIIPQELVDKMNKASTFNQGFKTTEYIAASLIDLHWHMLSSEEAAEITDAREFEKSVLAQYNIPEIIEPRYRSTYFSHI
FAGGYAAGYYSYLWAEILDADGFDAFKQSGDIFNPEVAAKLKQWVFESGGLRETDELYRNFRGSDPGIEPLLRNRGFAEP
SPAEG

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=589, Percent_Identity=27.8438030560272, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI14149738, Length=640, Percent_Identity=28.59375, Blast_Score=223, Evalue=6e-58,
Organism=Homo sapiens, GI156105687, Length=657, Percent_Identity=24.3531202435312, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=40.4411764705882, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1789913, Length=671, Percent_Identity=31.892697466468, Blast_Score=329, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI71999758, Length=643, Percent_Identity=23.0171073094868, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32565901, Length=514, Percent_Identity=23.9299610894942, Blast_Score=89, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=442, Percent_Identity=26.9230769230769, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322715, Length=672, Percent_Identity=23.6607142857143, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21356111, Length=482, Percent_Identity=26.3485477178423, Blast_Score=159, Evalue=8e-39,
Organism=Drosophila melanogaster, GI20129717, Length=557, Percent_Identity=24.0574506283662, Blast_Score=146, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 80389; Mature: 80258

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDALKGGAAALVLAATAACGAPETTTPEAEAASSQSELPEITVTDAELEGNPFRAEWTG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCHHCCCEEEEECCCCCCCCCEEEECC
AYGAPPFAQITDAHYMPAVKKGILEMRAEIDAIVNTEEEPTFENTILALEKSGKALERVM
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEHHCCHHHHHHH
LVFGNITNTDTNDALTALEGEIYPMLTREQDAVTFNPELFARVQAVYDQRDRLGLDEQEA
HHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCHHHH
RLLELTHRNFVRAGASLAPEVQAEIGQLNAEISALTTTYGQNLLNATNAFKLEITDPARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHH
GGLSDDFKNAIKVDGEDKWVVGISRSFFEGFMASAEDRELRSQLFDGYRTVASSGEFDNG
CCCCHHHHHHEEECCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PLAIKLAQLRAKRAELMGYPSHAHYVLEERMAHTPDAALEFLGKVLEPGLARAAEEEADM
CEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHH
ETIAGHEILGHDWWFYSEKVRAEKYAFDENQLRPYFELGASTDGAFEVASRLFNITLEEV
HHHCCCHHHCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHC
PVEAWNPAVKSYDVKDSESGEHLGLLMIDNFARDTKRGGAWMSTYRSSSDMDGNTIRPII
CCHHCCCCHHCCCCCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHCCCCCCCCCCCCCEE
TNNMNLVPPAAGQPALLSPTEVETLFHEFGHGLHGLLTQIRYPSFSGVYGGPDYVELPSQ
ECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IMEHWVTEPQVLAMYARHHETGEIIPQELVDKMNKASTFNQGFKTTEYIAASLIDLHWHM
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LSSEEAAEITDAREFEKSVLAQYNIPEIIEPRYRSTYFSHIFAGGYAAGYYSYLWAEILD
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
ADGFDAFKQSGDIFNPEVAAKLKQWVFESGGLRETDELYRNFRGSDPGIEPLLRNRGFAE
CCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHCCCCCC
PSPAEG
CCCCCC
>Mature Secondary Structure 
TDALKGGAAALVLAATAACGAPETTTPEAEAASSQSELPEITVTDAELEGNPFRAEWTG
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCHHCCCEEEEECCCCCCCCCEEEECC
AYGAPPFAQITDAHYMPAVKKGILEMRAEIDAIVNTEEEPTFENTILALEKSGKALERVM
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEHHCCHHHHHHH
LVFGNITNTDTNDALTALEGEIYPMLTREQDAVTFNPELFARVQAVYDQRDRLGLDEQEA
HHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCHHHH
RLLELTHRNFVRAGASLAPEVQAEIGQLNAEISALTTTYGQNLLNATNAFKLEITDPARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHH
GGLSDDFKNAIKVDGEDKWVVGISRSFFEGFMASAEDRELRSQLFDGYRTVASSGEFDNG
CCCCHHHHHHEEECCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PLAIKLAQLRAKRAELMGYPSHAHYVLEERMAHTPDAALEFLGKVLEPGLARAAEEEADM
CEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHH
ETIAGHEILGHDWWFYSEKVRAEKYAFDENQLRPYFELGASTDGAFEVASRLFNITLEEV
HHHCCCHHHCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHC
PVEAWNPAVKSYDVKDSESGEHLGLLMIDNFARDTKRGGAWMSTYRSSSDMDGNTIRPII
CCHHCCCCHHCCCCCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHCCCCCCCCCCCCCEE
TNNMNLVPPAAGQPALLSPTEVETLFHEFGHGLHGLLTQIRYPSFSGVYGGPDYVELPSQ
ECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IMEHWVTEPQVLAMYARHHETGEIIPQELVDKMNKASTFNQGFKTTEYIAASLIDLHWHM
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LSSEEAAEITDAREFEKSVLAQYNIPEIIEPRYRSTYFSHIFAGGYAAGYYSYLWAEILD
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
ADGFDAFKQSGDIFNPEVAAKLKQWVFESGGLRETDELYRNFRGSDPGIEPLLRNRGFAE
CCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHCCCCCC
PSPAEG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]