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The map label for this gene is yngG [H]

Identifier: 114797911

GI number: 114797911

Start: 1086898

End: 1087848

Strand: Direct

Name: yngG [H]

Synonym: HNE_1080

Alternate gene names: 114797911

Gene position: 1086898-1087848 (Clockwise)

Preceding gene: 114799245

Following gene: 114798589

Centisome position: 29.34

GC content: 66.14

Gene sequence:

>951_bases
ATGAGCAGCGTATTGATCAGCGAAGTTGGACCGCGAGACGGGCTTCAGAACTGTAAGGCCGTGATGCCGACCGAGGCTAA
GAAGCGCTGGATTGCGGCGCTGGCGGATGCGGGCGTGCAGGAAATCGAGATCGGGTCGTTTGTGTCGCCCAAGCTGCTGC
CGCAGATGGCGGATACGGGCGAGATCCTGGATTTTGCCGTGACGATTCCGGGGCTGACCGTGGCGGTGCTGGTGCCCAAC
CTGAAGGGCGCGGAGGCGGCGATTGCCGGCGGGGCGCACAAGATCACCCTGCCGCTTTCGGTTTCGGAGACCCATTCGCT
GCGCAACATCCGGCGCACGCATGCGCAGGTGATCGACGAGGCGCGGGCGATTGCGGCGCTGGTGAAATCCCTCCCGGAGA
GGAAGCGGCCGCATTTTGAAGGGTCGCTGTCGACGGCGTTTGGCTGCACGCTGGAGGGGCCGGTGCCGGAGGCGACGACC
CTGCGCTGCGCCGAGCAGCTGATGGCAGCGGGCTGCGATGAGGTGGGCCTGTCGGACACGACGGGGTATGGCGATCCGGC
GTCTGTGAGGCGGCTGATCCGGGCGGTTCGGGGTGTGATCGGGGCGGAAAACCTGACCGGCGTGCACCTGCACAACACCC
GCGGGCTGGGCCTTGCCAATGCGCTGGCCGCCTATGATGAGGGCATCACGACGTTTGATGGCTCGCTCGGCGGGCTGGGC
GGGTGCCCGACGGCGCCGGGCGCCAGCGGGAATGTTGTGACCGAGGACATGGTGTTCATGTTTGAGGCGATGGGCATTTC
GACGGGCATTGATCTGCGCAAGCTGATGGCGACGCGCGAGATGGTGGCAGAGGCGTTGCCGGGCGAGGAGCTTTATGGCT
TCACCCCGAAGGCGGGTCTGCCGCTGGGATTTAAAGGTGAGCCGGTGCCGGCTCCGGTGGCAGCTGGCTAA

Upstream 100 bases:

>100_bases
CTGAAGTTCCTGCCCGCGATGATTGCCATTACTTGCTCAAATGATATATCTTTTCAAGTTAGGGCATACATTCTTTGATA
TAACAATCAGGTGGAATTCG

Downstream 100 bases:

>100_bases
AAAAGCGGGGGCGGGGTGCGGGCAAATCTTCCAGCGCTGATTACGCTGATAGTCTATGCGGTGTTGCTTGTAGGTGTCAG
CCTGTGGGCGAGCCGCAAGG

Product: putative hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSSVLISEVGPRDGLQNCKAVMPTEAKKRWIAALADAGVQEIEIGSFVSPKLLPQMADTGEILDFAVTIPGLTVAVLVPN
LKGAEAAIAGGAHKITLPLSVSETHSLRNIRRTHAQVIDEARAIAALVKSLPERKRPHFEGSLSTAFGCTLEGPVPEATT
LRCAEQLMAAGCDEVGLSDTTGYGDPASVRRLIRAVRGVIGAENLTGVHLHNTRGLGLANALAAYDEGITTFDGSLGGLG
GCPTAPGASGNVVTEDMVFMFEAMGISTGIDLRKLMATREMVAEALPGEELYGFTPKAGLPLGFKGEPVPAPVAAG

Sequences:

>Translated_316_residues
MSSVLISEVGPRDGLQNCKAVMPTEAKKRWIAALADAGVQEIEIGSFVSPKLLPQMADTGEILDFAVTIPGLTVAVLVPN
LKGAEAAIAGGAHKITLPLSVSETHSLRNIRRTHAQVIDEARAIAALVKSLPERKRPHFEGSLSTAFGCTLEGPVPEATT
LRCAEQLMAAGCDEVGLSDTTGYGDPASVRRLIRAVRGVIGAENLTGVHLHNTRGLGLANALAAYDEGITTFDGSLGGLG
GCPTAPGASGNVVTEDMVFMFEAMGISTGIDLRKLMATREMVAEALPGEELYGFTPKAGLPLGFKGEPVPAPVAAG
>Mature_315_residues
SSVLISEVGPRDGLQNCKAVMPTEAKKRWIAALADAGVQEIEIGSFVSPKLLPQMADTGEILDFAVTIPGLTVAVLVPNL
KGAEAAIAGGAHKITLPLSVSETHSLRNIRRTHAQVIDEARAIAALVKSLPERKRPHFEGSLSTAFGCTLEGPVPEATTL
RCAEQLMAAGCDEVGLSDTTGYGDPASVRRLIRAVRGVIGAENLTGVHLHNTRGLGLANALAAYDEGITTFDGSLGGLGG
CPTAPGASGNVVTEDMVFMFEAMGISTGIDLRKLMATREMVAEALPGEELYGFTPKAGLPLGFKGEPVPAPVAAG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=283, Percent_Identity=40.9893992932862, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI109150422, Length=284, Percent_Identity=40.1408450704225, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI109150427, Length=284, Percent_Identity=40.1408450704225, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI260654708, Length=122, Percent_Identity=42.6229508196721, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786261, Length=296, Percent_Identity=23.6486486486486, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17510563, Length=281, Percent_Identity=38.4341637010676, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24582381, Length=305, Percent_Identity=38.3606557377049, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32746; Mature: 32615

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVLISEVGPRDGLQNCKAVMPTEAKKRWIAALADAGVQEIEIGSFVSPKLLPQMADTG
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHCCCC
EILDFAVTIPGLTVAVLVPNLKGAEAAIAGGAHKITLPLSVSETHSLRNIRRTHAQVIDE
CCEEEEEECCCEEEEEEECCCCCCCHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
ARAIAALVKSLPERKRPHFEGSLSTAFGCTLEGPVPEATTLRCAEQLMAAGCDEVGLSDT
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCC
TGYGDPASVRRLIRAVRGVIGAENLTGVHLHNTRGLGLANALAAYDEGITTFDGSLGGLG
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCC
GCPTAPGASGNVVTEDMVFMFEAMGISTGIDLRKLMATREMVAEALPGEELYGFTPKAGL
CCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
PLGFKGEPVPAPVAAG
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSVLISEVGPRDGLQNCKAVMPTEAKKRWIAALADAGVQEIEIGSFVSPKLLPQMADTG
CCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHCCCC
EILDFAVTIPGLTVAVLVPNLKGAEAAIAGGAHKITLPLSVSETHSLRNIRRTHAQVIDE
CCEEEEEECCCEEEEEEECCCCCCCHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
ARAIAALVKSLPERKRPHFEGSLSTAFGCTLEGPVPEATTLRCAEQLMAAGCDEVGLSDT
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCC
TGYGDPASVRRLIRAVRGVIGAENLTGVHLHNTRGLGLANALAAYDEGITTFDGSLGGLG
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCC
GCPTAPGASGNVVTEDMVFMFEAMGISTGIDLRKLMATREMVAEALPGEELYGFTPKAGL
CCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
PLGFKGEPVPAPVAAG
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]