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The map label for this gene is mrdA [H]

Identifier: 114797905

GI number: 114797905

Start: 3091950

End: 3093905

Strand: Reverse

Name: mrdA [H]

Synonym: HNE_2934

Alternate gene names: 114797905

Gene position: 3093905-3091950 (Counterclockwise)

Preceding gene: 114798654

Following gene: 114797109

Centisome position: 83.51

GC content: 65.24

Gene sequence:

>1956_bases
ATGAGCCGGAAAAGTAAAAACGCTGATGAGATGTTCGACCGCCGCATGTTCATGGCGGCCGGTGTAGGCGGTGTTGTCTG
GGCAACCCTCGTCAGCCGCCTGTTTCAGCTGCAGTTTCTTGATGCCGAGCGCTATCAGGATCTGGCCGAAGCCAACCATG
TGAAGCTCGTGCTGGCCCCGCCTGAACGCGGCCAGATCCTTGACCGATTCGGGCGCCCGCTCGCGTCCCAGCGTCAGGCA
GGCCGCGTTTCGGTCATCCCGGAACAGATGAGCGATCCCGAAGCGGTGCTGAACCGTATCTCCAACCTGATCGACCTGCC
CGATGCACGGCGCACGCGCCTGCTGGAGGATATTCGCAATGCACGCCGGCGCAATTCGGCGTTCCTGCCGGTCATCGTGG
CCCAGGAGCTGACATTCGAGGAATTCTCCCGGATGCAGGTCCATGCCGTGGAGATGGCCGGTGTCGACGTGCAGATGGCC
TCGACGCGGTCCTATCCGCGCGGCCGCGATTTCGGCCATGTGCTTGGTTATGTTGCGCGCGCCAGCGGCGAAGACCTTGA
GCGTATGACCACTGGCCTCGCGCCGGAAGACGCGCGCATTTATCAGGAGATGTTCCGCCATCCGGATATGCGGACCGGGC
GTCAGGGGATGGAACGCTTTGCCGAAGACTGGCTGCGCGGCCGTCCCGGGCGGCGCCGTGTCGTGGCCAACGCGCATGGC
CGCCCGCTCTGGGAGCTGCAGCAGGACCCGAGCCAGGCCGCTGTTCCGGGCAAGGACCTTTATGTCACAATCGATTCGGA
GCTTCAGCGCGTCGCGATTGATCGCTTCGAGGGCGAGAGCGGGGCCGCTGTCGTCATCGATATTGAAAATGGCGATGTGC
TGGCAATGGTCTCCACGCCGGCTTTTGATCCCAACGGGTTCGTCAACGGCATTTCCAGCGCCGATTATGCGCTGCTGCGC
GATGATCCGCGCTCGCCGCTGTATCCGCGCGCGCATGGCGGGGTCTATCCGCCCGGCTCGACCTTCAAGATGGTGGTGGC
CACCGCCGCGCTCGAGGCTGGCGTCATCAAGCCGGAAGAACGCATCCGCTGCCCCGGCCATTACCGGTTCGGCAACCGCA
CCTGGCACTGCTGGAAACGCCCCGGCCATGGCGCCATGAACATGCACGACGCCATCAAACAGTCCTGCGACGTGTATTTC
TATGAAATCGCGCGCCGGGCGGGCGTCGAGAAAATCGCTGAAGTCTCGCGCAAGTTCGGCTTTGGCCATACCTGGGTCCT
CGGCATGACCGGCGCCCGTGGCGGCCTGGTGCCAGATCCCGAATGGAAACAGAAAAACCGCGGCGAGCCGTGGTTTGAAG
GCGAAACGCTCAACTTCGGCATCGGGCAGGGGCAGCTGGGCACCACGCCGCTGCAACTTGCCCTGATGACCGCGCGGATC
GCCGCCACCGGCGCGCCCATCCGTCCCCGGATGATCGGCCTCGGCCCAGTGGATGAAGATGACGCGCTGCTCGACGCGCC
GCTCGACACCGAGATCATGGAACGCATGAAGGCGGGCATGTACGGGGTAACATCCGAAGGTGGCGGCACGGCCTATCGTT
CCGGCGATCTTGGCCTCGGCGGTCCGCGCCTGGCCGGCAAGACGGGCACCGCGCAGGTCCGCCGTATCACCGAACAGGAG
CGCCGCTCGGGCGTTCGCGGCGGCGAAGACATTGCCCGCGAGCTGCGCGACCACGCCCTGTTCGTGGCCTATGCGCCTGC
GGACAATCCCAAATATGCCATCTCCGTCATTGTGGAGCATGGCGAAGGCGGCTCGCGTACTGCCGCGCCGGTCGCGCGCG
ACATCCTCGCCGCTGCCATCCGCATGAACAGCGGCCGCACGCCCAATTATGCCCGGCGCGCCGCCACGCGGCCCGAAGTC
GTCCCGCCCGAAATCAACACCGGTGACCCGGCATGA

Upstream 100 bases:

>100_bases
CGATCCTGGCCTCGATCATCACCACAGGGCTTGTCTATCTCGTCGGATACCGCATGTTTGATCTTGGGCGGCGGCCGGGT
GAGCCATCAGGGCAGACGAC

Downstream 100 bases:

>100_bases
GCCGGGACGGCTTTACCGGCTTCACGCGCGGCGAAGCCCGTGTGCGCACCGCGTCGTCTTCCTTGCAATTTGCCGAGCTT
GGCCCGTTCAGCAAGCTGGC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSRKSKNADEMFDRRMFMAAGVGGVVWATLVSRLFQLQFLDAERYQDLAEANHVKLVLAPPERGQILDRFGRPLASQRQA
GRVSVIPEQMSDPEAVLNRISNLIDLPDARRTRLLEDIRNARRRNSAFLPVIVAQELTFEEFSRMQVHAVEMAGVDVQMA
STRSYPRGRDFGHVLGYVARASGEDLERMTTGLAPEDARIYQEMFRHPDMRTGRQGMERFAEDWLRGRPGRRRVVANAHG
RPLWELQQDPSQAAVPGKDLYVTIDSELQRVAIDRFEGESGAAVVIDIENGDVLAMVSTPAFDPNGFVNGISSADYALLR
DDPRSPLYPRAHGGVYPPGSTFKMVVATAALEAGVIKPEERIRCPGHYRFGNRTWHCWKRPGHGAMNMHDAIKQSCDVYF
YEIARRAGVEKIAEVSRKFGFGHTWVLGMTGARGGLVPDPEWKQKNRGEPWFEGETLNFGIGQGQLGTTPLQLALMTARI
AATGAPIRPRMIGLGPVDEDDALLDAPLDTEIMERMKAGMYGVTSEGGGTAYRSGDLGLGGPRLAGKTGTAQVRRITEQE
RRSGVRGGEDIARELRDHALFVAYAPADNPKYAISVIVEHGEGGSRTAAPVARDILAAAIRMNSGRTPNYARRAATRPEV
VPPEINTGDPA

Sequences:

>Translated_651_residues
MSRKSKNADEMFDRRMFMAAGVGGVVWATLVSRLFQLQFLDAERYQDLAEANHVKLVLAPPERGQILDRFGRPLASQRQA
GRVSVIPEQMSDPEAVLNRISNLIDLPDARRTRLLEDIRNARRRNSAFLPVIVAQELTFEEFSRMQVHAVEMAGVDVQMA
STRSYPRGRDFGHVLGYVARASGEDLERMTTGLAPEDARIYQEMFRHPDMRTGRQGMERFAEDWLRGRPGRRRVVANAHG
RPLWELQQDPSQAAVPGKDLYVTIDSELQRVAIDRFEGESGAAVVIDIENGDVLAMVSTPAFDPNGFVNGISSADYALLR
DDPRSPLYPRAHGGVYPPGSTFKMVVATAALEAGVIKPEERIRCPGHYRFGNRTWHCWKRPGHGAMNMHDAIKQSCDVYF
YEIARRAGVEKIAEVSRKFGFGHTWVLGMTGARGGLVPDPEWKQKNRGEPWFEGETLNFGIGQGQLGTTPLQLALMTARI
AATGAPIRPRMIGLGPVDEDDALLDAPLDTEIMERMKAGMYGVTSEGGGTAYRSGDLGLGGPRLAGKTGTAQVRRITEQE
RRSGVRGGEDIARELRDHALFVAYAPADNPKYAISVIVEHGEGGSRTAAPVARDILAAAIRMNSGRTPNYARRAATRPEV
VPPEINTGDPA
>Mature_650_residues
SRKSKNADEMFDRRMFMAAGVGGVVWATLVSRLFQLQFLDAERYQDLAEANHVKLVLAPPERGQILDRFGRPLASQRQAG
RVSVIPEQMSDPEAVLNRISNLIDLPDARRTRLLEDIRNARRRNSAFLPVIVAQELTFEEFSRMQVHAVEMAGVDVQMAS
TRSYPRGRDFGHVLGYVARASGEDLERMTTGLAPEDARIYQEMFRHPDMRTGRQGMERFAEDWLRGRPGRRRVVANAHGR
PLWELQQDPSQAAVPGKDLYVTIDSELQRVAIDRFEGESGAAVVIDIENGDVLAMVSTPAFDPNGFVNGISSADYALLRD
DPRSPLYPRAHGGVYPPGSTFKMVVATAALEAGVIKPEERIRCPGHYRFGNRTWHCWKRPGHGAMNMHDAIKQSCDVYFY
EIARRAGVEKIAEVSRKFGFGHTWVLGMTGARGGLVPDPEWKQKNRGEPWFEGETLNFGIGQGQLGTTPLQLALMTARIA
ATGAPIRPRMIGLGPVDEDDALLDAPLDTEIMERMKAGMYGVTSEGGGTAYRSGDLGLGGPRLAGKTGTAQVRRITEQER
RSGVRGGEDIARELRDHALFVAYAPADNPKYAISVIVEHGEGGSRTAAPVARDILAAAIRMNSGRTPNYARRAATRPEVV
PPEINTGDPA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=603, Percent_Identity=34.3283582089552, Blast_Score=345, Evalue=8e-96,
Organism=Escherichia coli, GI1786272, Length=633, Percent_Identity=24.6445497630332, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71775; Mature: 71644

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKSKNADEMFDRRMFMAAGVGGVVWATLVSRLFQLQFLDAERYQDLAEANHVKLVLAP
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
PERGQILDRFGRPLASQRQAGRVSVIPEQMSDPEAVLNRISNLIDLPDARRTRLLEDIRN
CCCCHHHHHHCCCHHHHHCCCCEEECCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ARRRNSAFLPVIVAQELTFEEFSRMQVHAVEMAGVDVQMASTRSYPRGRDFGHVLGYVAR
HHHCCCCCEEEEEHHHCCHHHHHHHEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHH
ASGEDLERMTTGLAPEDARIYQEMFRHPDMRTGRQGMERFAEDWLRGRPGRRRVVANAHG
CCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
RPLWELQQDPSQAAVPGKDLYVTIDSELQRVAIDRFEGESGAAVVIDIENGDVLAMVSTP
CCCHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECC
AFDPNGFVNGISSADYALLRDDPRSPLYPRAHGGVYPPGSTFKMVVATAALEAGVIKPEE
CCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
RIRCPGHYRFGNRTWHCWKRPGHGAMNMHDAIKQSCDVYFYEIARRAGVEKIAEVSRKFG
HCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FGHTWVLGMTGARGGLVPDPEWKQKNRGEPWFEGETLNFGIGQGQLGTTPLQLALMTARI
CCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
AATGAPIRPRMIGLGPVDEDDALLDAPLDTEIMERMKAGMYGVTSEGGGTAYRSGDLGLG
HHCCCCCCCEEEECCCCCCCCCEECCCCCHHHHHHHHCCCCEEECCCCCCEEECCCCCCC
GPRLAGKTGTAQVRRITEQERRSGVRGGEDIARELRDHALFVAYAPADNPKYAISVIVEH
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEEECCCCCCCEEEEEEEEC
GEGGSRTAAPVARDILAAAIRMNSGRTPNYARRAATRPEVVPPEINTGDPA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRKSKNADEMFDRRMFMAAGVGGVVWATLVSRLFQLQFLDAERYQDLAEANHVKLVLAP
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
PERGQILDRFGRPLASQRQAGRVSVIPEQMSDPEAVLNRISNLIDLPDARRTRLLEDIRN
CCCCHHHHHHCCCHHHHHCCCCEEECCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ARRRNSAFLPVIVAQELTFEEFSRMQVHAVEMAGVDVQMASTRSYPRGRDFGHVLGYVAR
HHHCCCCCEEEEEHHHCCHHHHHHHEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHH
ASGEDLERMTTGLAPEDARIYQEMFRHPDMRTGRQGMERFAEDWLRGRPGRRRVVANAHG
CCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
RPLWELQQDPSQAAVPGKDLYVTIDSELQRVAIDRFEGESGAAVVIDIENGDVLAMVSTP
CCCHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECC
AFDPNGFVNGISSADYALLRDDPRSPLYPRAHGGVYPPGSTFKMVVATAALEAGVIKPEE
CCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
RIRCPGHYRFGNRTWHCWKRPGHGAMNMHDAIKQSCDVYFYEIARRAGVEKIAEVSRKFG
HCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FGHTWVLGMTGARGGLVPDPEWKQKNRGEPWFEGETLNFGIGQGQLGTTPLQLALMTARI
CCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
AATGAPIRPRMIGLGPVDEDDALLDAPLDTEIMERMKAGMYGVTSEGGGTAYRSGDLGLG
HHCCCCCCCEEEECCCCCCCCCEECCCCCHHHHHHHHCCCCEEECCCCCCEEECCCCCCC
GPRLAGKTGTAQVRRITEQERRSGVRGGEDIARELRDHALFVAYAPADNPKYAISVIVEH
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEEECCCCCCCEEEEEEEEC
GEGGSRTAAPVARDILAAAIRMNSGRTPNYARRAATRPEVVPPEINTGDPA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]