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The map label for this gene is fcs1 [C]

Identifier: 114797895

GI number: 114797895

Start: 153300

End: 155153

Strand: Reverse

Name: fcs1 [C]

Synonym: HNE_0167

Alternate gene names: 114797895

Gene position: 155153-153300 (Counterclockwise)

Preceding gene: 114800209

Following gene: 114798639

Centisome position: 4.19

GC content: 59.76

Gene sequence:

>1854_bases
ATGGCCGAAGGACAAACCCTTCCCCCGTTTCGCCCCCTGCCGCAAAAGTCCCCCGATGTGGAAATGACCCGCAAGGGCGG
CGCAATATATATCAAGTCGCGCCAAGCGCCGGGCTTACGCCCCTCAACCATTCCGCACGCGCTCGCAGAGCGTGCCGCTC
AACATCCGGACCGGGTTTTCATCAAGGAACGTGATCCGGAGACGGATCAATGGGTGGAGGTAACTTACGGGGACGCCAAT
CGTCTGACAGACTCTCTGGCACAAGCCTTCCTTGATCTCGGCGCAGGCCCTGACGCGCCGGTCATGATCTTGTCGGGAAA
CTCTATCCGCGCGGCCCTCGTGATCCTCGCTGCCCAGAAGATCGGTGCGCCTGCGGCGCCCATCTCGGTCCCCTACTCCA
CCATGTCCAATGACTTCGACAAGCTGAAGCATTGCTATGCGTCAGTGAAGCCCGCGATTATATTTGCCGAGCAGCTTGCG
CCCTTTCAACGGGGCATCGCCGCGCTTGGAGCTCAAGACTGTACGATCGTCAGCGCCGCCCCCGGCGGCGACAATTCGGT
CCGTCATTTTGATGACCTGGTTTCAACGCCCCCCACCTCGGCCATTGCCGCAGCGATGTCGACACTGACAGATGACACAA
CTGCGAAATACCTTTTCACGTCCGGCTCAACGGGCATGCCAAAGCCCGTTCCGCAAACGCAGGGGTCGATGTGCGCAATG
ATCGCTGGCCAGGAAGGTTTGCGCGATGATGCCCGCGATCCCGATTATGACCCAGACAAGATCGCCCATGTGCTGGACTG
GCTGCCCTGGAACCATATCTCCGGCTCCAATGTGAACTTCAATGGCGCCCTCTGGAATGGCGCCACGTTCTGGATTGACG
GCGGCAAGCCCACCGCCGCGCTGTTCCATGAGACCATCCGCAACATTCACGAGTGTAGCCCGTCAACTTTCGGGACGGCG
CCAATCGCACTCTCGATGCTGGCGGAAGCGATGGAACAGGATGAAGCGCTGCTGAAAGCCTTCTTCAAGAACATGCGCTC
CATCGGTTATGGCGGAGCCACCCTTTCGGACGATCTTTACGACCGCCTGCAGGCGCTCTCCATCAAAGCCACGGGGCGCC
GCATCCCCATCATCACAATGTATGGTGCGACTGAAACACAAGGCATCACCGTAGTTCACTGGGAAGCCGAGCGGGTTGGC
CTGGTCGGGCTTCCGCTCCCCGGAACGACCCTCAAACTCGTCCCGAACGGTGAAAAGCTGGAGGTGCGCGTTAAAGGCCC
CAGCGTAATGCCGGGCTATCACAACGACCCGAAAAAGAATGCCGAAGTCTTTGACGAAGAAGGCTTCTACTGCCTCGGAG
ATGCGGTGAAATTCGTCGATGAAAGTGATCCAAATCAGGGCCTCATCTTCGATGGCCGGGTGGGCGAGGACTTCAAGCTT
TCCTCCGGCACCTGGGTATCGGTTGGAACACTCAGACCCGACTTTGTCGCCGCCTGCTCACCGCTGATATTTGACGCCGT
CATTTGTGGCCAGGACAAGGACTTTGCGACCGCGCTGGTATGGCCCTCACCCGCAACGGCCGAACAATATGCCAAAGCCG
CCGGGGAGCCAGCCAAGGGCTTTGCCGCGCTTGTCGCCGACCTTGCGCGCAAGGCCAGCGCCTTCAACGCGGGCGAGCCC
GGCTCCTCCCGGCGCATCAAACGTGTTCTCGTGATGACCGAGGCGCCAAGCATCGACGCTGGAGAGATCACCGACAAAGG
CTATGTGAACCAACGTCTGGTCATTTCCCGGCGTGCAAACCTTGTTCAGGCGCTTTACGCTGAGCCTCCAGCGCCCGGCG
TCATACAACTTTAG

Upstream 100 bases:

>100_bases
ACAGCTGAGCCACCCGCTTAGCGCGGCGTCACCTGTTGCGCACTGACGCCGGGCAGCTATCCTTGGATGCAGCTATACCG
ACATCGCCGAGGAATTCATC

Downstream 100 bases:

>100_bases
ATCCGGACGCGCTTTCAAGGCCCTTGCATCACACCTAATGCGCCATCACATCGCCGGAATTGCCCGGCAGATGTGTGGCC
CATGACGTTTGACGATGCCT

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MAEGQTLPPFRPLPQKSPDVEMTRKGGAIYIKSRQAPGLRPSTIPHALAERAAQHPDRVFIKERDPETDQWVEVTYGDAN
RLTDSLAQAFLDLGAGPDAPVMILSGNSIRAALVILAAQKIGAPAAPISVPYSTMSNDFDKLKHCYASVKPAIIFAEQLA
PFQRGIAALGAQDCTIVSAAPGGDNSVRHFDDLVSTPPTSAIAAAMSTLTDDTTAKYLFTSGSTGMPKPVPQTQGSMCAM
IAGQEGLRDDARDPDYDPDKIAHVLDWLPWNHISGSNVNFNGALWNGATFWIDGGKPTAALFHETIRNIHECSPSTFGTA
PIALSMLAEAMEQDEALLKAFFKNMRSIGYGGATLSDDLYDRLQALSIKATGRRIPIITMYGATETQGITVVHWEAERVG
LVGLPLPGTTLKLVPNGEKLEVRVKGPSVMPGYHNDPKKNAEVFDEEGFYCLGDAVKFVDESDPNQGLIFDGRVGEDFKL
SSGTWVSVGTLRPDFVAACSPLIFDAVICGQDKDFATALVWPSPATAEQYAKAAGEPAKGFAALVADLARKASAFNAGEP
GSSRRIKRVLVMTEAPSIDAGEITDKGYVNQRLVISRRANLVQALYAEPPAPGVIQL

Sequences:

>Translated_617_residues
MAEGQTLPPFRPLPQKSPDVEMTRKGGAIYIKSRQAPGLRPSTIPHALAERAAQHPDRVFIKERDPETDQWVEVTYGDAN
RLTDSLAQAFLDLGAGPDAPVMILSGNSIRAALVILAAQKIGAPAAPISVPYSTMSNDFDKLKHCYASVKPAIIFAEQLA
PFQRGIAALGAQDCTIVSAAPGGDNSVRHFDDLVSTPPTSAIAAAMSTLTDDTTAKYLFTSGSTGMPKPVPQTQGSMCAM
IAGQEGLRDDARDPDYDPDKIAHVLDWLPWNHISGSNVNFNGALWNGATFWIDGGKPTAALFHETIRNIHECSPSTFGTA
PIALSMLAEAMEQDEALLKAFFKNMRSIGYGGATLSDDLYDRLQALSIKATGRRIPIITMYGATETQGITVVHWEAERVG
LVGLPLPGTTLKLVPNGEKLEVRVKGPSVMPGYHNDPKKNAEVFDEEGFYCLGDAVKFVDESDPNQGLIFDGRVGEDFKL
SSGTWVSVGTLRPDFVAACSPLIFDAVICGQDKDFATALVWPSPATAEQYAKAAGEPAKGFAALVADLARKASAFNAGEP
GSSRRIKRVLVMTEAPSIDAGEITDKGYVNQRLVISRRANLVQALYAEPPAPGVIQL
>Mature_616_residues
AEGQTLPPFRPLPQKSPDVEMTRKGGAIYIKSRQAPGLRPSTIPHALAERAAQHPDRVFIKERDPETDQWVEVTYGDANR
LTDSLAQAFLDLGAGPDAPVMILSGNSIRAALVILAAQKIGAPAAPISVPYSTMSNDFDKLKHCYASVKPAIIFAEQLAP
FQRGIAALGAQDCTIVSAAPGGDNSVRHFDDLVSTPPTSAIAAAMSTLTDDTTAKYLFTSGSTGMPKPVPQTQGSMCAMI
AGQEGLRDDARDPDYDPDKIAHVLDWLPWNHISGSNVNFNGALWNGATFWIDGGKPTAALFHETIRNIHECSPSTFGTAP
IALSMLAEAMEQDEALLKAFFKNMRSIGYGGATLSDDLYDRLQALSIKATGRRIPIITMYGATETQGITVVHWEAERVGL
VGLPLPGTTLKLVPNGEKLEVRVKGPSVMPGYHNDPKKNAEVFDEEGFYCLGDAVKFVDESDPNQGLIFDGRVGEDFKLS
SGTWVSVGTLRPDFVAACSPLIFDAVICGQDKDFATALVWPSPATAEQYAKAAGEPAKGFAALVADLARKASAFNAGEPG
SSRRIKRVLVMTEAPSIDAGEITDKGYVNQRLVISRRANLVQALYAEPPAPGVIQL

Specific function: Activates The Carboxylate Group Of 2,3-Dihydroxy- Benzoate (2,3-Dhb), Via ATP-Dependent Ppi Exchange Reactions, To The Acyladenylate. Then, Catalyzes The Acylation Of Holo-Entb With 2,3-Dhb Adenylate, Preparing That Molecule For Amide Bond Formation With

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1786810, Length=417, Percent_Identity=21.5827338129496, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556552, Length=423, Percent_Identity=23.8770685579196, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193204819, Length=557, Percent_Identity=22.4416517055655, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17564090, Length=366, Percent_Identity=25.9562841530055, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 66064; Mature: 65932

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGQTLPPFRPLPQKSPDVEMTRKGGAIYIKSRQAPGLRPSTIPHALAERAAQHPDRVF
CCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEE
IKERDPETDQWVEVTYGDANRLTDSLAQAFLDLGAGPDAPVMILSGNSIRAALVILAAQK
EECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHH
IGAPAAPISVPYSTMSNDFDKLKHCYASVKPAIIFAEQLAPFQRGIAALGAQDCTIVSAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHCCCCCEEEEEEC
PGGDNSVRHFDDLVSTPPTSAIAAAMSTLTDDTTAKYLFTSGSTGMPKPVPQTQGSMCAM
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEE
IAGQEGLRDDARDPDYDPDKIAHVLDWLPWNHISGSNVNFNGALWNGATFWIDGGKPTAA
EECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECEEEECCEEEEEECCCCHHH
LFHETIRNIHECSPSTFGTAPIALSMLAEAMEQDEALLKAFFKNMRSIGYGGATLSDDLY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
DRLQALSIKATGRRIPIITMYGATETQGITVVHWEAERVGLVGLPLPGTTLKLVPNGEKL
HHHHHEEEEECCCEEEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCEEEEECCCCEE
EVRVKGPSVMPGYHNDPKKNAEVFDEEGFYCLGDAVKFVDESDPNQGLIFDGRVGEDFKL
EEEECCCCCCCCCCCCCCCCCHHHCCCCCEEECCHHHHHCCCCCCCCEEECCCCCCCEEE
SSGTWVSVGTLRPDFVAACSPLIFDAVICGQDKDFATALVWPSPATAEQYAKAAGEPAKG
CCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHH
FAALVADLARKASAFNAGEPGSSRRIKRVLVMTEAPSIDAGEITDKGYVNQRLVISRRAN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHH
LVQALYAEPPAPGVIQL
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AEGQTLPPFRPLPQKSPDVEMTRKGGAIYIKSRQAPGLRPSTIPHALAERAAQHPDRVF
CCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEE
IKERDPETDQWVEVTYGDANRLTDSLAQAFLDLGAGPDAPVMILSGNSIRAALVILAAQK
EECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHH
IGAPAAPISVPYSTMSNDFDKLKHCYASVKPAIIFAEQLAPFQRGIAALGAQDCTIVSAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHCCCCCEEEEEEC
PGGDNSVRHFDDLVSTPPTSAIAAAMSTLTDDTTAKYLFTSGSTGMPKPVPQTQGSMCAM
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEE
IAGQEGLRDDARDPDYDPDKIAHVLDWLPWNHISGSNVNFNGALWNGATFWIDGGKPTAA
EECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECEEEECCEEEEEECCCCHHH
LFHETIRNIHECSPSTFGTAPIALSMLAEAMEQDEALLKAFFKNMRSIGYGGATLSDDLY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
DRLQALSIKATGRRIPIITMYGATETQGITVVHWEAERVGLVGLPLPGTTLKLVPNGEKL
HHHHHEEEEECCCEEEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCEEEEECCCCEE
EVRVKGPSVMPGYHNDPKKNAEVFDEEGFYCLGDAVKFVDESDPNQGLIFDGRVGEDFKL
EEEECCCCCCCCCCCCCCCCCHHHCCCCCEEECCHHHHHCCCCCCCCEEECCCCCCCEEE
SSGTWVSVGTLRPDFVAACSPLIFDAVICGQDKDFATALVWPSPATAEQYAKAAGEPAKG
CCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHH
FAALVADLARKASAFNAGEPGSSRRIKRVLVMTEAPSIDAGEITDKGYVNQRLVISRRAN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHH
LVQALYAEPPAPGVIQL
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]