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The map label for this gene is aceA [H]

Identifier: 114797791

GI number: 114797791

Start: 1260109

End: 1261731

Strand: Direct

Name: aceA [H]

Synonym: HNE_1239

Alternate gene names: 114797791

Gene position: 1260109-1261731 (Clockwise)

Preceding gene: 114800327

Following gene: 114798790

Centisome position: 34.01

GC content: 60.38

Gene sequence:

>1623_bases
ATGTCCAAACGCCCTACCTATGCCGAGCTGCGCGCCCAGGTCCAGAAACGTTACCCCACCGGCCAGGCGCCTGGCGGCGT
GACAGTGGACGACATCGTCCAGCTGAAGATGCAGAACACCTACAACACCCATCTCGACATCGCCCGCGAGATGGCCGTCG
TGATGCGCGCCGATATGGCCGCTTATGACCAGGATCACTCGAAGTTCACCCAGTCGCTTGGCTGCTGGTCGGGCTTCCAT
GCGCAGCAGATGATAAAGGCTGTCAAGCGCATGAAGGGCACCGCCAAGGGCACCTATGTGTACCTTTCCGGCTGGATGGT
CGCTGGCCTGCGTAACCGTTTCGGCCACCTGCCGGACCAGTCGATGCATGAGAAAACTTCGGTCGCAGACCTGATCGAGG
AAATCTACGTCTCCCTGCGCCAGGCTGATGAGGTCGCCCTCAACGATCTCTTCCGTGAGCTGAAAGCTGCCCGTGAAAAA
GGCGCGCCGGCCGATGTGATCGAAACCATCATCCAGCGTATCGACACGTTCGAATCGCATGTCGTGCCGATCATCGCCGA
CATCGATGCCGGCTTCGGCAACGAGCACGCCACCTATCTGCTCGCCAAGGAGCTGATCAAGGCGGGCGCCTGCTGCATCC
AGATCGAAAATCAGGTGTCGGACGCAAAACAGTGCGGCCACCAGGATGGCAAGGTCACCGTGCCGCGCGAAGACTTCATC
GAGAAGCTGCGCGCCTGCCGTCTGGCCTTTGAAGAACTCGGCGTGGATGACGGCGTCATCGTCGCCCGCACAGACAGCCT
TGGCGCTGGCCTGACGCAGAAAGTCCCGGTCTCCCAGCATGCGGGCGATCTCGCCTCGGAATACACTAAATGGCTGGAAG
TCGAAGAAATCACGCCCGCCAATCCGCTGAAAGAGGGCGATCTCGCGCTTCAGCAGAACGGCCGCCTCGTGAAACCCGTT
CGCCTCGCCAACGGCCTCTTCAAGTTCCAGGAAAACACCGGCGCTGACCGCGTCGTGGAAGACTGTATCGCCAACCTGAC
GCTCGGCGGCGCAGACCTCCTCTGGATCGAAACCGACACGCCAGACGTGGACATCATCGCGGGCCTGGTAAACCGCGTGA
AGGAAGCAGTTCCAGATGCGAAGCTCACCTACAACAACTCACCGTCGTTCAACTGGACGCTCAACCTGCGCAAACAGGTC
CGCAAGGCCTGGGCCGCAGAAGGCAAGATTGCCGAGGGCGAGTATCCGGAAGCAGAGCTGATGTCGGCCAAGTTTGACGA
CACCCCACTCGGCCAGGAAGCCGATGCGCGCCTCAAGCGCTTCCAGTATGACATCTCCGACCGCGCCGGCGTGTTCCATA
ACCTGATCACGCTGCCGACCTTCCACATGACGGCCTTCGCCACCGACCAGCTCTCTCGCGGCTATTTCGGGGAAGACAAG
ATGGCCGCCTATGTCAAAACCATTCAGCGCCAGGAAATCCGCAACAACGTTTCGGCTGTCAAACACCAGCACGAAGTCGG
CTCGGACCTTGGCGACACGTTCAAGGAAATGGTTGCCGGTGAGCGCGCCCTGAAAGCCAGCGGCGAGCACAACACGATGA
ACCAGTTCGAGAACGTCGTCTGA

Upstream 100 bases:

>100_bases
AGCTCGCCGACTTCCTGACGCTGCCCGCCTATGAAGCGCTGCGCACCCTTGCATGATCCGTCAACACACTAATCAGAACC
TTCTCCAGGGAGATACTCTC

Downstream 100 bases:

>100_bases
TCCCTTTCCTTGCTGCGTAGGGAAAAACTCCGCCCCATCTGCCTTCGGGCAGGTGGGGTTTTTTTCTCGGTAAGACGCTC
GCTGGCCGACGAGGGCGCAG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSKRPTYAELRAQVQKRYPTGQAPGGVTVDDIVQLKMQNTYNTHLDIAREMAVVMRADMAAYDQDHSKFTQSLGCWSGFH
AQQMIKAVKRMKGTAKGTYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVADLIEEIYVSLRQADEVALNDLFRELKAAREK
GAPADVIETIIQRIDTFESHVVPIIADIDAGFGNEHATYLLAKELIKAGACCIQIENQVSDAKQCGHQDGKVTVPREDFI
EKLRACRLAFEELGVDDGVIVARTDSLGAGLTQKVPVSQHAGDLASEYTKWLEVEEITPANPLKEGDLALQQNGRLVKPV
RLANGLFKFQENTGADRVVEDCIANLTLGGADLLWIETDTPDVDIIAGLVNRVKEAVPDAKLTYNNSPSFNWTLNLRKQV
RKAWAAEGKIAEGEYPEAELMSAKFDDTPLGQEADARLKRFQYDISDRAGVFHNLITLPTFHMTAFATDQLSRGYFGEDK
MAAYVKTIQRQEIRNNVSAVKHQHEVGSDLGDTFKEMVAGERALKASGEHNTMNQFENVV

Sequences:

>Translated_540_residues
MSKRPTYAELRAQVQKRYPTGQAPGGVTVDDIVQLKMQNTYNTHLDIAREMAVVMRADMAAYDQDHSKFTQSLGCWSGFH
AQQMIKAVKRMKGTAKGTYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVADLIEEIYVSLRQADEVALNDLFRELKAAREK
GAPADVIETIIQRIDTFESHVVPIIADIDAGFGNEHATYLLAKELIKAGACCIQIENQVSDAKQCGHQDGKVTVPREDFI
EKLRACRLAFEELGVDDGVIVARTDSLGAGLTQKVPVSQHAGDLASEYTKWLEVEEITPANPLKEGDLALQQNGRLVKPV
RLANGLFKFQENTGADRVVEDCIANLTLGGADLLWIETDTPDVDIIAGLVNRVKEAVPDAKLTYNNSPSFNWTLNLRKQV
RKAWAAEGKIAEGEYPEAELMSAKFDDTPLGQEADARLKRFQYDISDRAGVFHNLITLPTFHMTAFATDQLSRGYFGEDK
MAAYVKTIQRQEIRNNVSAVKHQHEVGSDLGDTFKEMVAGERALKASGEHNTMNQFENVV
>Mature_539_residues
SKRPTYAELRAQVQKRYPTGQAPGGVTVDDIVQLKMQNTYNTHLDIAREMAVVMRADMAAYDQDHSKFTQSLGCWSGFHA
QQMIKAVKRMKGTAKGTYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVADLIEEIYVSLRQADEVALNDLFRELKAAREKG
APADVIETIIQRIDTFESHVVPIIADIDAGFGNEHATYLLAKELIKAGACCIQIENQVSDAKQCGHQDGKVTVPREDFIE
KLRACRLAFEELGVDDGVIVARTDSLGAGLTQKVPVSQHAGDLASEYTKWLEVEEITPANPLKEGDLALQQNGRLVKPVR
LANGLFKFQENTGADRVVEDCIANLTLGGADLLWIETDTPDVDIIAGLVNRVKEAVPDAKLTYNNSPSFNWTLNLRKQVR
KAWAAEGKIAEGEYPEAELMSAKFDDTPLGQEADARLKRFQYDISDRAGVFHNLITLPTFHMTAFATDQLSRGYFGEDKM
AAYVKTIQRQEIRNNVSAVKHQHEVGSDLGDTFKEMVAGERALKASGEHNTMNQFENVV

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=497, Percent_Identity=27.9678068410463, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982926, Length=516, Percent_Identity=26.7441860465116, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17561814, Length=516, Percent_Identity=26.7441860465116, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6325263, Length=511, Percent_Identity=24.26614481409, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320908, Length=177, Percent_Identity=30.5084745762712, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59990; Mature: 59858

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRPTYAELRAQVQKRYPTGQAPGGVTVDDIVQLKMQNTYNTHLDIAREMAVVMRADMA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AYDQDHSKFTQSLGCWSGFHAQQMIKAVKRMKGTAKGTYVYLSGWMVAGLRNRFGHLPDQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCCCH
SMHEKTSVADLIEEIYVSLRQADEVALNDLFRELKAAREKGAPADVIETIIQRIDTFESH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
VVPIIADIDAGFGNEHATYLLAKELIKAGACCIQIENQVSDAKQCGHQDGKVTVPREDFI
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCEEECCHHHHH
EKLRACRLAFEELGVDDGVIVARTDSLGAGLTQKVPVSQHAGDLASEYTKWLEVEEITPA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NPLKEGDLALQQNGRLVKPVRLANGLFKFQENTGADRVVEDCIANLTLGGADLLWIETDT
CCCCCCCCHHHCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCC
PDVDIIAGLVNRVKEAVPDAKLTYNNSPSFNWTLNLRKQVRKAWAAEGKIAEGEYPEAEL
CCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCHHHH
MSAKFDDTPLGQEADARLKRFQYDISDRAGVFHNLITLPTFHMTAFATDQLSRGYFGEDK
HHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
MAAYVKTIQRQEIRNNVSAVKHQHEVGSDLGDTFKEMVAGERALKASGEHNTMNQFENVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure 
SKRPTYAELRAQVQKRYPTGQAPGGVTVDDIVQLKMQNTYNTHLDIAREMAVVMRADMA
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AYDQDHSKFTQSLGCWSGFHAQQMIKAVKRMKGTAKGTYVYLSGWMVAGLRNRFGHLPDQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCCCH
SMHEKTSVADLIEEIYVSLRQADEVALNDLFRELKAAREKGAPADVIETIIQRIDTFESH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
VVPIIADIDAGFGNEHATYLLAKELIKAGACCIQIENQVSDAKQCGHQDGKVTVPREDFI
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCEEECCHHHHH
EKLRACRLAFEELGVDDGVIVARTDSLGAGLTQKVPVSQHAGDLASEYTKWLEVEEITPA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NPLKEGDLALQQNGRLVKPVRLANGLFKFQENTGADRVVEDCIANLTLGGADLLWIETDT
CCCCCCCCHHHCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCC
PDVDIIAGLVNRVKEAVPDAKLTYNNSPSFNWTLNLRKQVRKAWAAEGKIAEGEYPEAEL
CCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCHHHH
MSAKFDDTPLGQEADARLKRFQYDISDRAGVFHNLITLPTFHMTAFATDQLSRGYFGEDK
HHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
MAAYVKTIQRQEIRNNVSAVKHQHEVGSDLGDTFKEMVAGERALKASGEHNTMNQFENVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9395332 [H]