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The map label for this gene is nuoM [H]

Identifier: 114797733

GI number: 114797733

Start: 1798362

End: 1799864

Strand: Direct

Name: nuoM [H]

Synonym: HNE_1757

Alternate gene names: 114797733

Gene position: 1798362-1799864 (Clockwise)

Preceding gene: 114798733

Following gene: 114800320

Centisome position: 48.54

GC content: 56.09

Gene sequence:

>1503_bases
ATGGGCGGTTTCCCCATTCTTACCGCGATGACGTTCCTGCCGTTGATCGGCGCGTTGCTCATCGTTCTCGTCCGCGCGGC
CACTGCAGGAAGCCGCGCTGCGGCGGATGATGGTCGTCAAAACCGTGCCATCCTCATGGCTTCGCTGATTATTTCAGCAG
CGACTTTCGTGCTGTCTGTTGCGGCGTTTCTGTCGTTCGATCCAGGGCAGATGGGTTATCAGCTGGTCGAACAGCACGCG
TGGTATGGTCCGATAAGCTATAAGCTCGGTATCGACGGGCTTTCCATGTCGCTGATCCTGCTCACGACGTTTCTGACGCC
GATCTGCCTTCTGGCGAGCTGGAATTCCATCGACAAGCGCGTGACTGAATATGTCGTCGCATTTCTGGTGCTCGAGACAT
TCATGATTGGTGTCTTTACGGCGCTCGATCTGGTGCTGTTCTACATATTCTTCGAGGCTGGCCTGATCCCGATGTTCCTC
ATCATCGGTATCTGGGGTGGGAAAGACCGTATCTATGCCTCGTTCAAGTTCTTCCTCTACACGCTGATCGGCTCACTGCT
GCTTCTGGTGGCCGCGATCTACATGATCCAGGTGGCCGGTTCAGCCGACTTCGAAGTGCTCGAGCAGTTTGCGTTTGATC
CGGGCGTTCAGACCTGGCTCTGGCTTGCCTTCTTGGCGTCGTTTGCCGTCAAGCTGCCGATGTGGCCGGTTCACACATGG
TTGCCGGATGCGCACGTTCAGGCGCCAACGGCCGGGTCGGTTGTCCTCGCCGGTGTCCTGCTGAAAATGGGCGGCTACGG
CATGCTGCGCTTTTCATTGCCGATGTTTCCCGATGCCAGCGCATACTTCCAACCGATGATGTTTGCCCTTGCGGTCATCG
CGATCATTTACACGTCGCTTGTCGCCTGGCGTCAGACGGACATGAAAAAACTCATCGCCTATTCGTCGGTCGCGCATATG
GGCTTTGTTACGCTCGGTATTTTTGCCTTCAATGAAACGGGGATACAGGGCGCCATCTTTCAGATGCTGAGCCACGGCCT
GATTTCCGGCGCGCTGTTCCTGATCGTGGGTGTCGTCTACGACCGCATGCACACTCGCGAGATTGCAGCCTATGGCGGCC
TGGTTGGCCGCATGCCGATCTATGCCGGCTTCTTCATGTTGTTCACCATGGCCAACGTAGGTTTGCCCGGAACAAGCGGG
TTCGTAGGAGAAATTCTTACGATGATAGGTGGCTTCCAGGCAGCAACATGGGCAGCCTTTGGCGCGGCATTCGGTGTGAT
CTTTTCTGCCGTCTACATGCTGACGCTTTATCGCCGCACCGTCTTCGGTGAGATAACCAATCCACTGCTTGAAGACATCA
AGGACATGAACCGGATCGAATGGGTCTGCATTGCACCGCTTGCAGTCCTCACAGTTCTTTTTGGTGTTGCCCCCAACCTC
ATTTTCGCCGTCACCAATGGTGCTACAGGGCGCATTATCGCGCTCATGGCGGGAGGCCAGTAA

Upstream 100 bases:

>100_bases
AAATGCACACGGGTTATCTGTATCACTATGCCTTCGTGATCATCGGGGCGGCCATCGTATTTGGCGCGATCCTGTGGTTG
CGGGCAGGAGGGGCCAACTG

Downstream 100 bases:

>100_bases
GCCGATGCTTGATACTCAATCCATCATACAGGCCATGGCTCCAGAGCTTTGGCTCGCCGCATCCGGTCTCATGCTGGTGC
TCGTGGGGGCAATCGTTGGA

Product: NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGGFPILTAMTFLPLIGALLIVLVRAATAGSRAAADDGRQNRAILMASLIISAATFVLSVAAFLSFDPGQMGYQLVEQHA
WYGPISYKLGIDGLSMSLILLTTFLTPICLLASWNSIDKRVTEYVVAFLVLETFMIGVFTALDLVLFYIFFEAGLIPMFL
IIGIWGGKDRIYASFKFFLYTLIGSLLLLVAAIYMIQVAGSADFEVLEQFAFDPGVQTWLWLAFLASFAVKLPMWPVHTW
LPDAHVQAPTAGSVVLAGVLLKMGGYGMLRFSLPMFPDASAYFQPMMFALAVIAIIYTSLVAWRQTDMKKLIAYSSVAHM
GFVTLGIFAFNETGIQGAIFQMLSHGLISGALFLIVGVVYDRMHTREIAAYGGLVGRMPIYAGFFMLFTMANVGLPGTSG
FVGEILTMIGGFQAATWAAFGAAFGVIFSAVYMLTLYRRTVFGEITNPLLEDIKDMNRIEWVCIAPLAVLTVLFGVAPNL
IFAVTNGATGRIIALMAGGQ

Sequences:

>Translated_500_residues
MGGFPILTAMTFLPLIGALLIVLVRAATAGSRAAADDGRQNRAILMASLIISAATFVLSVAAFLSFDPGQMGYQLVEQHA
WYGPISYKLGIDGLSMSLILLTTFLTPICLLASWNSIDKRVTEYVVAFLVLETFMIGVFTALDLVLFYIFFEAGLIPMFL
IIGIWGGKDRIYASFKFFLYTLIGSLLLLVAAIYMIQVAGSADFEVLEQFAFDPGVQTWLWLAFLASFAVKLPMWPVHTW
LPDAHVQAPTAGSVVLAGVLLKMGGYGMLRFSLPMFPDASAYFQPMMFALAVIAIIYTSLVAWRQTDMKKLIAYSSVAHM
GFVTLGIFAFNETGIQGAIFQMLSHGLISGALFLIVGVVYDRMHTREIAAYGGLVGRMPIYAGFFMLFTMANVGLPGTSG
FVGEILTMIGGFQAATWAAFGAAFGVIFSAVYMLTLYRRTVFGEITNPLLEDIKDMNRIEWVCIAPLAVLTVLFGVAPNL
IFAVTNGATGRIIALMAGGQ
>Mature_499_residues
GGFPILTAMTFLPLIGALLIVLVRAATAGSRAAADDGRQNRAILMASLIISAATFVLSVAAFLSFDPGQMGYQLVEQHAW
YGPISYKLGIDGLSMSLILLTTFLTPICLLASWNSIDKRVTEYVVAFLVLETFMIGVFTALDLVLFYIFFEAGLIPMFLI
IGIWGGKDRIYASFKFFLYTLIGSLLLLVAAIYMIQVAGSADFEVLEQFAFDPGVQTWLWLAFLASFAVKLPMWPVHTWL
PDAHVQAPTAGSVVLAGVLLKMGGYGMLRFSLPMFPDASAYFQPMMFALAVIAIIYTSLVAWRQTDMKKLIAYSSVAHMG
FVTLGIFAFNETGIQGAIFQMLSHGLISGALFLIVGVVYDRMHTREIAAYGGLVGRMPIYAGFFMLFTMANVGLPGTSGF
VGEILTMIGGFQAATWAAFGAAFGVIFSAVYMLTLYRRTVFGEITNPLLEDIKDMNRIEWVCIAPLAVLTVLFGVAPNLI
FAVTNGATGRIIALMAGGQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=370, Percent_Identity=35.4054054054054, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI251831117, Length=426, Percent_Identity=23.4741784037559, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788613, Length=420, Percent_Identity=41.4285714285714, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1788827, Length=271, Percent_Identity=28.0442804428044, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788831, Length=289, Percent_Identity=27.681660899654, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788614, Length=421, Percent_Identity=26.8408551068884, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693160, Length=364, Percent_Identity=25.2747252747253, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367154, Length=323, Percent_Identity=25.077399380805, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788829, Length=415, Percent_Identity=24.578313253012, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54279; Mature: 54148

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEECCCCCEEEEEEECCC
>Mature Secondary Structure 
GGFPILTAMTFLPLIGALLIVLVRAATAGSRAAADDGRQNRAILMASLIISAATFVLSV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AAFLSFDPGQMGYQLVEQHAWYGPISYKLGIDGLSMSLILLTTFLTPICLLASWNSIDKR
HHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
VTEYVVAFLVLETFMIGVFTALDLVLFYIFFEAGLIPMFLIIGIWGGKDRIYASFKFFLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TLIGSLLLLVAAIYMIQVAGSADFEVLEQFAFDPGVQTWLWLAFLASFAVKLPMWPVHTW
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHC
LPDAHVQAPTAGSVVLAGVLLKMGGYGMLRFSLPMFPDASAYFQPMMFALAVIAIIYTSL
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAWRQTDMKKLIAYSSVAHMGFVTLGIFAFNETGIQGAIFQMLSHGLISGALFLIVGVVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DRMHTREIAAYGGLVGRMPIYAGFFMLFTMANVGLPGTSGFVGEILTMIGGFQAATWAAF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHH
GAAFGVIFSAVYMLTLYRRTVFGEITNPLLEDIKDMNRIEWVCIAPLAVLTVLFGVAPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IFAVTNGATGRIIALMAGGQ
EEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]