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The map label for this gene is folE

Identifier: 114797723

GI number: 114797723

Start: 3376545

End: 3377165

Strand: Direct

Name: folE

Synonym: HNE_3203

Alternate gene names: 114797723

Gene position: 3376545-3377165 (Clockwise)

Preceding gene: 114799006

Following gene: 114799190

Centisome position: 91.13

GC content: 58.62

Gene sequence:

>621_bases
ATGGACGCCGTTACTCCAAAAAAAGACATTCCGCGCCCGGATTCCGTGCGCCGCCCCTCTCAACAGGAAGCCGAAGAAGC
CGTGCGCACGCTCATCGCGTGGGCAGGGGATGATCCGGCCCGTGAAGGCCTGATCGACACGCCCAAGCGCGTCGTCAACG
CCTATAAAGAGTGGTTTGAAGGCTATGGCGAAGACCCGGTAAAATATCTCAGCCGGACCTTCGAGGATGTGCAGGGCTAT
GACGACATCGTCATGCTGCGCAACATCGAGGTGGAAAGCCATTGCGAGCACCATATCGCGCCCTTCATCGGCAAGGCGTT
CATCGCCTATAAGCCGTCGACGGCGGTTGTGGGCATTTCAAAGCTTGCCCGCGTGGTCGAGATCTTCGCCAAGCGCCTGC
AGACGCAGGAAACGATGACGGCGCAGATTTGCGATGCCATCACCGAAAGCCTAGCGCCAATGGGAACAGCCGTGTTCATC
GAAGCCGAGCATCAGTGCATGTCCACCCGCGGCGTTCACCACAAGCATGTGACCACGATCACCACGCAGTTTACCGGCGT
GTTCAAATCCGATGCGGATTTGCGCAACCGGTTCCTGAACATGTGCGGCCAGACGGTCTGA

Upstream 100 bases:

>100_bases
ACTCCGGGCGGGCGTTAAGTCCGGGCAAGAGAGCGTCAAAGACTCTCAAGGGATGCCCCGGCTCGACCCCCGTCCCTCAG
TGAAGGAAAATGCAGTGGCT

Downstream 100 bases:

>100_bases
ATTTCAGGCGCAGCCAAATTTTCAAACGCCCTGCCCGCGCGGCAGGGCGTTTTTCGTTCGGGCTCAGACGTGCGCCGCCA
GCAATCTCTCATATGTGGCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFEGYGEDPVKYLSRTFEDVQGY
DDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGISKLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFI
EAEHQCMSTRGVHHKHVTTITTQFTGVFKSDADLRNRFLNMCGQTV

Sequences:

>Translated_206_residues
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFEGYGEDPVKYLSRTFEDVQGY
DDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGISKLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFI
EAEHQCMSTRGVHHKHVTTITTQFTGVFKSDADLRNRFLNMCGQTV
>Mature_206_residues
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFEGYGEDPVKYLSRTFEDVQGY
DDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGISKLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFI
EAEHQCMSTRGVHHKHVTTITTQFTGVFKSDADLRNRFLNMCGQTV

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=226, Percent_Identity=36.7256637168142, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI4503949, Length=226, Percent_Identity=36.7256637168142, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI66932970, Length=197, Percent_Identity=35.0253807106599, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI66932972, Length=187, Percent_Identity=36.3636363636364, Blast_Score=121, Evalue=5e-28,
Organism=Escherichia coli, GI1788476, Length=195, Percent_Identity=35.8974358974359, Blast_Score=107, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=195, Percent_Identity=38.974358974359, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6321706, Length=183, Percent_Identity=38.7978142076503, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656782, Length=201, Percent_Identity=38.8059701492537, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24656796, Length=201, Percent_Identity=38.8059701492537, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24656791, Length=201, Percent_Identity=38.8059701492537, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_HYPNA (Q0BXB5)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761878.1
- ProteinModelPortal:   Q0BXB5
- SMR:   Q0BXB5
- STRING:   Q0BXB5
- GeneID:   4289238
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3203
- NMPDR:   fig|228405.5.peg.3067
- TIGR:   HNE_3203
- eggNOG:   COG0302
- HOGENOM:   HBG370191
- OMA:   LTTTFTG
- PhylomeDB:   Q0BXB5
- ProtClustDB:   PRK09347
- BioCyc:   HNEP81032:HNE_3203-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 23142; Mature: 23142

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHH
GYGEDPVKYLSRTFEDVQGYDDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
KLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFIEAEHQCMSTRGVHHKHVTTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCHHHHHHH
TTQFTGVFKSDADLRNRFLNMCGQTV
HHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHH
GYGEDPVKYLSRTFEDVQGYDDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
KLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFIEAEHQCMSTRGVHHKHVTTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCHHHHHHH
TTQFTGVFKSDADLRNRFLNMCGQTV
HHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA