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The map label for this gene is atpB

Identifier: 114797617

GI number: 114797617

Start: 1990559

End: 1991320

Strand: Direct

Name: atpB

Synonym: HNE_1919

Alternate gene names: 114797617

Gene position: 1990559-1991320 (Clockwise)

Preceding gene: 114798123

Following gene: 114798825

Centisome position: 53.73

GC content: 60.37

Gene sequence:

>762_bases
ATGCCGGCCATCGCGCTTGACCCGATCCACCAGTTCGAAGTCACCAAATGGCTCGATCTGCGCCTGGGTAATATCGACAT
CTCGTTCACGAACGCCTCGGGCTTCATGCTCCTGGGCGTCGTGCTGGTAATCGGCTTCTTCAGCATGGCCACCCGCAAGG
GCGAGCTTGTGCCCTCGCGCCTCCAGTCGGTCGCAGAGATGGGCTACGGCTTCATCGCCGACATGGTGCGCAGCGCGGCG
GGCGAAGAAGGCCTGAAATTCTTCCCCTTCGTCTTCACGCTGTTCTTCTTCATCCTGTTCGCAAACCTCATCGGCATGGT
GCCGTATGCGTTCACCACTACCAGCCACATCATCGTCACCGGCGCCCTCGCCATGACCGTGATCCTGATGGTCATCGTGG
TCGGCCTGATCAAGAATGGCCTTGGCTTTTTCAAGCTGTTCGCCCCCTCGGGCGCCCCGCTGCCGATCTACATCATTCTC
ACGCCAATCGAGATCATCTCCTTCCTGGCGCGCCCCCTCACGCTCGGCCTGCGTCTCTTCGCAAACATGCTGGCGGGCCA
CATCATGCTGAAACTGTTCGCCGGTTTCACGGTGATGCTGATCGGCGCAGGCGCCATCTACATTCCGGTTGCGGCTCTGG
CATTTGCGATGGGCGTTGCGCTCAACGCGCTGGAGTTCCTCGTCGCGGGCCTTCAGGCCTATGTCTTCGCCATTCTTACA
TGCGTCTACCTCAACGACGCCCTTCACGCGGACGCCCACTAA

Upstream 100 bases:

>100_bases
CAGTCATCCGGGCCTATCATGAGCTGAATGCTCGGGCTCAAAAGCTTTCACCGGGGCCGGCCAAGGCCCCCGACGACGGA
ACGAACGACGCATGAACCTG

Downstream 100 bases:

>100_bases
GGGAGCCGCGGGAGTGCGTCATGATACCCCGCATCAAACTGCTTGACGGCGCCTAACGAACACGCTTCACGGGCGTCAAA
CTACCCTAAACCCTTTTCCC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MPAIALDPIHQFEVTKWLDLRLGNIDISFTNASGFMLLGVVLVIGFFSMATRKGELVPSRLQSVAEMGYGFIADMVRSAA
GEEGLKFFPFVFTLFFFILFANLIGMVPYAFTTTSHIIVTGALAMTVILMVIVVGLIKNGLGFFKLFAPSGAPLPIYIIL
TPIEIISFLARPLTLGLRLFANMLAGHIMLKLFAGFTVMLIGAGAIYIPVAALAFAMGVALNALEFLVAGLQAYVFAILT
CVYLNDALHADAH

Sequences:

>Translated_253_residues
MPAIALDPIHQFEVTKWLDLRLGNIDISFTNASGFMLLGVVLVIGFFSMATRKGELVPSRLQSVAEMGYGFIADMVRSAA
GEEGLKFFPFVFTLFFFILFANLIGMVPYAFTTTSHIIVTGALAMTVILMVIVVGLIKNGLGFFKLFAPSGAPLPIYIIL
TPIEIISFLARPLTLGLRLFANMLAGHIMLKLFAGFTVMLIGAGAIYIPVAALAFAMGVALNALEFLVAGLQAYVFAILT
CVYLNDALHADAH
>Mature_252_residues
PAIALDPIHQFEVTKWLDLRLGNIDISFTNASGFMLLGVVLVIGFFSMATRKGELVPSRLQSVAEMGYGFIADMVRSAAG
EEGLKFFPFVFTLFFFILFANLIGMVPYAFTTTSHIIVTGALAMTVILMVIVVGLIKNGLGFFKLFAPSGAPLPIYIILT
PIEIISFLARPLTLGLRLFANMLAGHIMLKLFAGFTVMLIGAGAIYIPVAALAFAMGVALNALEFLVAGLQAYVFAILTC
VYLNDALHADAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=194, Percent_Identity=30.9278350515464, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1790176, Length=227, Percent_Identity=26.431718061674, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6226527, Length=252, Percent_Identity=35.7142857142857, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_HYPNA (Q0C0X3)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760620.1
- ProteinModelPortal:   Q0C0X3
- SMR:   Q0C0X3
- STRING:   Q0C0X3
- GeneID:   4288639
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1919
- NMPDR:   fig|228405.5.peg.1847
- TIGR:   HNE_1919
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   NISPNAR
- PhylomeDB:   Q0C0X3
- ProtClustDB:   PRK05815
- BioCyc:   HNEP81032:HNE_1919-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27291; Mature: 27160

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13b59ed8)-; HASH(0x14224a20)-; HASH(0x14226ee4)-; HASH(0x13e5fbec)-; HASH(0x1024647c)-; HASH(0x1398f0e8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAIALDPIHQFEVTKWLDLRLGNIDISFTNASGFMLLGVVLVIGFFSMATRKGELVPSR
CCCCCCCCHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LQSVAEMGYGFIADMVRSAAGEEGLKFFPFVFTLFFFILFANLIGMVPYAFTTTSHIIVT
HHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
GALAMTVILMVIVVGLIKNGLGFFKLFAPSGAPLPIYIILTPIEIISFLARPLTLGLRLF
HHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
ANMLAGHIMLKLFAGFTVMLIGAGAIYIPVAALAFAMGVALNALEFLVAGLQAYVFAILT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVYLNDALHADAH
HHHHHHHHCCCCH
>Mature Secondary Structure 
PAIALDPIHQFEVTKWLDLRLGNIDISFTNASGFMLLGVVLVIGFFSMATRKGELVPSR
CCCCCCCHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LQSVAEMGYGFIADMVRSAAGEEGLKFFPFVFTLFFFILFANLIGMVPYAFTTTSHIIVT
HHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
GALAMTVILMVIVVGLIKNGLGFFKLFAPSGAPLPIYIILTPIEIISFLARPLTLGLRLF
HHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
ANMLAGHIMLKLFAGFTVMLIGAGAIYIPVAALAFAMGVALNALEFLVAGLQAYVFAILT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVYLNDALHADAH
HHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA