Click here to switch to the map view.

The map label for this gene is galF [C]

Identifier: 114797511

GI number: 114797511

Start: 1952568

End: 1953293

Strand: Reverse

Name: galF [C]

Synonym: HNE_1885

Alternate gene names: 114797511

Gene position: 1953293-1952568 (Counterclockwise)

Preceding gene: 114798471

Following gene: 114800509

Centisome position: 52.72

GC content: 65.7

Gene sequence:

>726_bases
ATGAGTGTTCCGGTTCCGCATACGGCGATGGTGCTGGCCGCTGGTCTGGGCACGAGGATGCGGCCGCTCACGGATGCTTG
CCCCAAGCCGCTGATTGCGGTGCGCGGGCGCAGGCTGATTGACCGGGTGATCGAGCCGCTGAAGGCGGCAGGCGTTCGCC
GCATCATCGTGAACGTGCATTACCTGCCTGAGCAGATTGAGGACTACCTGAAGGGGCTGACGGACTTTGAGGTGATCGTT
TCCGATGAGCGGGGAGAAGTTCTGGAGACGGGTGGGGGCCTGGCGAAAGCGAGGGGGTTGCTTGGCGACGATCCCGTGTT
CGTGCTGAACACCGACGCGTTCTGGTCTCCCGAGACGGCGGACCCGCTTCTGGCATTGGCAGAGGCCTTTGACCCGGCGC
AGGAGGATGAGCGGCTGCTGGTGGCCGACACTGGCCGCGCGCTGGGCTTTGATGGGCCGGGCGACTTCTTCATGGAGGCC
GATGGCCGCCTCAAGCGGCGGGGCGAGGCGGCGTCTGCGCCCTGGGCGTATGCCGGCGTGCGGATCATGAAGCCTCAGGT
TTATGACGGGCGGCCGGTGGAGCGGTTTTCGGCGGTGAAGGTGTGGGATGAACTGATACCGCAAGGGCGGGCACGCGGGC
TGGCGCTCGATTCCTTCTGGCTTCATGTGGGCGATCCGCAGGCCCTGAAGGATGCGGAGATGTGGGTGGCCTGTCATGGC
GGCTGA

Upstream 100 bases:

>100_bases
GGCAGCTTTCCATTCTTGCCCGCAATCTCGCCCATCCGTCGCTTGCCGGCATGCGGGCGTTTGTTCGCGAGCAGACCCCT
TTCGTCTTTGAGGCCAAGTC

Downstream 100 bases:

>100_bases
TGCGCTGTTCGGGCCGGATGCGCCGCGCATCCGGACGATTGCGCCGGGCACAGCCTTTGTGAAGGAGCTGGCGCGCGCGC
TGGCAGCCGAGACATCTCTG

Product: nucleotidyl transferase family protein

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSVPVPHTAMVLAAGLGTRMRPLTDACPKPLIAVRGRRLIDRVIEPLKAAGVRRIIVNVHYLPEQIEDYLKGLTDFEVIV
SDERGEVLETGGGLAKARGLLGDDPVFVLNTDAFWSPETADPLLALAEAFDPAQEDERLLVADTGRALGFDGPGDFFMEA
DGRLKRRGEAASAPWAYAGVRIMKPQVYDGRPVERFSAVKVWDELIPQGRARGLALDSFWLHVGDPQALKDAEMWVACHG
G

Sequences:

>Translated_241_residues
MSVPVPHTAMVLAAGLGTRMRPLTDACPKPLIAVRGRRLIDRVIEPLKAAGVRRIIVNVHYLPEQIEDYLKGLTDFEVIV
SDERGEVLETGGGLAKARGLLGDDPVFVLNTDAFWSPETADPLLALAEAFDPAQEDERLLVADTGRALGFDGPGDFFMEA
DGRLKRRGEAASAPWAYAGVRIMKPQVYDGRPVERFSAVKVWDELIPQGRARGLALDSFWLHVGDPQALKDAEMWVACHG
G
>Mature_240_residues
SVPVPHTAMVLAAGLGTRMRPLTDACPKPLIAVRGRRLIDRVIEPLKAAGVRRIIVNVHYLPEQIEDYLKGLTDFEVIVS
DERGEVLETGGGLAKARGLLGDDPVFVLNTDAFWSPETADPLLALAEAFDPAQEDERLLVADTGRALGFDGPGDFFMEAD
GRLKRRGEAASAPWAYAGVRIMKPQVYDGRPVERFSAVKVWDELIPQGRARGLALDSFWLHVGDPQALKDAEMWVACHGG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=229, Percent_Identity=30.1310043668122, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI11761619, Length=229, Percent_Identity=30.1310043668122, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=249, Percent_Identity=28.5140562248996, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=231, Percent_Identity=29.8701298701299, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26309; Mature: 26178

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPVPHTAMVLAAGLGTRMRPLTDACPKPLIAVRGRRLIDRVIEPLKAAGVRRIIVNVH
CCCCCCHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
YLPEQIEDYLKGLTDFEVIVSDERGEVLETGGGLAKARGLLGDDPVFVLNTDAFWSPETA
CCHHHHHHHHCCCCCEEEEEECCCCCEECCCCCHHHHCCCCCCCCEEEEECCCCCCCCCC
DPLLALAEAFDPAQEDERLLVADTGRALGFDGPGDFFMEADGRLKRRGEAASAPWAYAGV
CHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCHHHCCCCCCCCHHHCCE
RIMKPQVYDGRPVERFSAVKVWDELIPQGRARGLALDSFWLHVGDPQALKDAEMWVACHG
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHEEEECCCCHHHCCCEEEEEEEC
G
C
>Mature Secondary Structure 
SVPVPHTAMVLAAGLGTRMRPLTDACPKPLIAVRGRRLIDRVIEPLKAAGVRRIIVNVH
CCCCCHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
YLPEQIEDYLKGLTDFEVIVSDERGEVLETGGGLAKARGLLGDDPVFVLNTDAFWSPETA
CCHHHHHHHHCCCCCEEEEEECCCCCEECCCCCHHHHCCCCCCCCEEEEECCCCCCCCCC
DPLLALAEAFDPAQEDERLLVADTGRALGFDGPGDFFMEADGRLKRRGEAASAPWAYAGV
CHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCHHHCCCCCCCCHHHCCE
RIMKPQVYDGRPVERFSAVKVWDELIPQGRARGLALDSFWLHVGDPQALKDAEMWVACHG
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHEEEECCCCHHHCCCEEEEEEEC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA