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The map label for this gene is moaB2 [H]

Identifier: 114797493

GI number: 114797493

Start: 1576419

End: 1576955

Strand: Direct

Name: moaB2 [H]

Synonym: HNE_1551

Alternate gene names: 114797493

Gene position: 1576419-1576955 (Clockwise)

Preceding gene: 114799331

Following gene: 114799818

Centisome position: 42.55

GC content: 60.89

Gene sequence:

>537_bases
ATGCCGGGCATTGACGAGAGCCTTGCCTTTTACCCGCTGAACATCGCTGTACTGACGGTATCCGATACCCGAAATACCGA
AACAGATACTTCTGGCGGCCTGCTCATCGAGCGGGCCCGGGCGGCGGGTCATAACGTGGTCGAGCGCGCCATCGTCAGGG
ATGAGGTGGCGGATATCCGTGCAGTTGTCTCGCGATGGATCGCCGAACCGGGGATCGACGTGGTGCTGACGACGGGTGGA
ACAGGATTCTCTCCTCGCGATGTGACCCCTGAAGCCGTCAAACCGCTGTTCCGGCGCGAGATGGATGGCTTTTCCGTCGT
CTTTCACCAGGTGAGCCTTGGCACGGTGGGCGTTTCCACCCTGCAGTCCCGTGCTTTCGCGGGGCAAGCGGGCGAGACAT
TCATTTTCTGTGTTCCAGGTTCAACCGGCGCCTGCCGGGACGCATGGGACCATGTGTTCGCCCTGGAGTTCGATAGCAGG
TTCCGGCCGTGCTCCCTGGTCGGTCAGATTGAACGCTATCGGGGAATCTGTCCGTGA

Upstream 100 bases:

>100_bases
GAAGCCGTCTTCTGGAAGCGCGAACTCGGACCGTTTGGCGAGCGCTGGATAGAGCCTACAGATCGAGACAGAATGGACTT
GGAGAGATGGAATGAAAAAA

Downstream 100 bases:

>100_bases
CGAAGCTGACCCACCTCGATTCTGATGGCCGCGTTCATATGGTGGATGTGAGCGAGAAGGCCGCAAGTGTGCGCCGCGCG
GTGGCGAGCGGGCGCGTGCG

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MPGIDESLAFYPLNIAVLTVSDTRNTETDTSGGLLIERARAAGHNVVERAIVRDEVADIRAVVSRWIAEPGIDVVLTTGG
TGFSPRDVTPEAVKPLFRREMDGFSVVFHQVSLGTVGVSTLQSRAFAGQAGETFIFCVPGSTGACRDAWDHVFALEFDSR
FRPCSLVGQIERYRGICP

Sequences:

>Translated_178_residues
MPGIDESLAFYPLNIAVLTVSDTRNTETDTSGGLLIERARAAGHNVVERAIVRDEVADIRAVVSRWIAEPGIDVVLTTGG
TGFSPRDVTPEAVKPLFRREMDGFSVVFHQVSLGTVGVSTLQSRAFAGQAGETFIFCVPGSTGACRDAWDHVFALEFDSR
FRPCSLVGQIERYRGICP
>Mature_177_residues
PGIDESLAFYPLNIAVLTVSDTRNTETDTSGGLLIERARAAGHNVVERAIVRDEVADIRAVVSRWIAEPGIDVVLTTGGT
GFSPRDVTPEAVKPLFRREMDGFSVVFHQVSLGTVGVSTLQSRAFAGQAGETFIFCVPGSTGACRDAWDHVFALEFDSRF
RPCSLVGQIERYRGICP

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=35.1351351351351, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=35.1351351351351, Blast_Score=87, Evalue=8e-18,
Organism=Escherichia coli, GI1787000, Length=166, Percent_Identity=50.6024096385542, Blast_Score=167, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17564954, Length=146, Percent_Identity=37.6712328767123, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136978, Length=153, Percent_Identity=38.562091503268, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24638841, Length=153, Percent_Identity=38.562091503268, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19290; Mature: 19159

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIDESLAFYPLNIAVLTVSDTRNTETDTSGGLLIERARAAGHNVVERAIVRDEVADIR
CCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHH
AVVSRWIAEPGIDVVLTTGGTGFSPRDVTPEAVKPLFRREMDGFSVVFHQVSLGTVGVST
HHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHH
LQSRAFAGQAGETFIFCVPGSTGACRDAWDHVFALEFDSRFRPCSLVGQIERYRGICP
HHHHHHCCCCCCEEEEEECCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PGIDESLAFYPLNIAVLTVSDTRNTETDTSGGLLIERARAAGHNVVERAIVRDEVADIR
CCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHH
AVVSRWIAEPGIDVVLTTGGTGFSPRDVTPEAVKPLFRREMDGFSVVFHQVSLGTVGVST
HHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHH
LQSRAFAGQAGETFIFCVPGSTGACRDAWDHVFALEFDSRFRPCSLVGQIERYRGICP
HHHHHHCCCCCCEEEEEECCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]