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The map label for this gene is ilvD

Identifier: 114797337

GI number: 114797337

Start: 1438809

End: 1440650

Strand: Reverse

Name: ilvD

Synonym: HNE_1411

Alternate gene names: 114797337

Gene position: 1440650-1438809 (Counterclockwise)

Preceding gene: 114798581

Following gene: 114798912

Centisome position: 38.88

GC content: 63.57

Gene sequence:

>1842_bases
ATGATCCCCTACCGTTCACGCACCTCCACCCACGGCCGCAACATGGCCGGTGCCCGCGGCCTCTGGCGCGCGACGGGCAT
GACGGACAGCGATTTCGGCAAGCCGATCATCGCGGTGGTGAACTCGTTCACCCAGTTCGTGCCGGGGCATGTGCACCTGA
AGGATCTCGGCCAGCTTGTAGCCCGGGAAATCGAGGCGGCCGGCGGCGTGGCCAAGGAATTCAACACGATTGCGGTCGAT
GACGGCATCGCCATGGGCCATGACGGGATGCTCTACTCTCTGCCTTCGCGCGAGATCATTGCCGACAGCGTGGAATATAT
GGTCAACGCCCACTGCGCGGACGCGATGGTGTGCATCTCCAATTGCGACAAGATCACGCCCGGCATGATGATGGCCGCGA
TGCGCCTCGACATTCCGGTCGTGTTCGTTTCCGGCGGGCCGATGGAAGCGGGCAAGGTGAACATCGATGGCGAGCTGCGC
GCGGTGGACCTGATCGACGCGATGATCGAAGCGGCAAACCCTGACCGCACGGACGCGGAAGTCGACGAGTTTGAGAAGAA
TGCCTGCCCAACCTGCGGGTCGTGCTCGGGCATGTTTACGGCCAACTCGATGAATTGCCTCGCCGAAGCGCTCGGCCTCG
CGCTGCCGGGCAATGGCTCGACACTGGCGACGCATGCTGACCGCGAGGCGCTGTTCCGGCGCGCGGGACGGCGGATCGTG
GAGCTGACCAAAGCCTATTATGAAGGCGGCGACACCGGCGTTTCGGCGCGCGGGATTGCCACCAAGGCGGCGTTCGAGAA
TGCCATCACGCTGGACATCGCGATGGGCGGATCGACCAATACGATCCTCCACCTGCTGGCGATGGCACGTGAGGGCGAGG
TGGACTTTACGCTCGCCGATATTGACCGGCTGAGCCGGGTGACGCCGTGCCTCTGCAAGGTGGCGCCCGCGGTGCAGAAT
GTGCACATGGAAGATGTTCACCGCGCGGGCGGGATTTTCGGCATCCTCGGAGAACTGGGCCGGGCGGGGAAACTCGATAC
CTCCGTGCGCACGATCCATGAAGACACGATGGCCGAGGCGCTGAGCAAATGGGATATTGCGGTAACGAACAATCCCGAGG
TGCAGGAGCTGTTCCTGGCGGCGCCGGGCGGGGTTCGCACGACGCAGGCGTTCAGCCAGGCGCGCCGGTATAAAGATCTG
GATACGGACCGGGAAAAGGGCGTCATCCGCTCGGCCAAGCATGCCTTCTCGAAGGATGGCGGGCTCGCAGTGCTGTTTGG
CAACATTGCTGAGATGGGCTGCGTGGTGAAGACGGCCGGCGTGGATGACAGCATTCTGAAGTTTTCCGGCCCGGCGGTGA
TCTGCGAGAGCCAGGAAGAGGCGTGCGAGCGCATCCTGAAGAAGCGCGTGAAGGCGGGCGATGTCGTCATCATCCGCTAT
GAAGGCCCGCGCGGTGGCCCCGGCATGCAGGAGATGCTCTATCCGACATCGTATCTCAAGGCGATGCAGCTGGGCAAGGA
ATGTGCTCTGATCACGGACGGACGCTTCTCGGGCGGAACGTCTGGCCTCTCGATCGGGCATGTCAGCCCGGAAGCGGCTG
AAGGCGGGGCGATCGGGCTTCTGCACGAAGGGGATATCATCGAGATCGACATCCCGAACCGGACGATCAATGCGAAGGTT
TCAGCCGAAGAGTTCGCCAAACGCCGCGCCGAGATGGACGCCAAGGGGGCGGCCGCCTGGAAGCCGGTGGAAGAGCGCCC
GCGCAAGGTGAGCCGTGCGCTGAAGGTTTATGCGGCGCATGTGGGGAATGCTTCTCTGGGCGCAGTGCGGCTCGATCCTT
AG

Upstream 100 bases:

>100_bases
TCTTTCCCGCAGATGTTAAAGAGCGGGTGAATTCACCGCTTTCCGGCCCCATTTCCGCTCCGGAAGGCAAAATTTTGCGG
AAACTGCGAGACCTGAGCCC

Downstream 100 bases:

>100_bases
TTTTCCAGGAAAGTCCCTCTACAGAGATTATTACAATTTATAGTCCAAGGGCTGGACTACTCCATACCTAACTTTCGGTT
TGCCATCTATCATAAGCGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MIPYRSRTSTHGRNMAGARGLWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLDIPVVFVSGGPMEAGKVNIDGELR
AVDLIDAMIEAANPDRTDAEVDEFEKNACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHADREALFRRAGRRIV
ELTKAYYEGGDTGVSARGIATKAAFENAITLDIAMGGSTNTILHLLAMAREGEVDFTLADIDRLSRVTPCLCKVAPAVQN
VHMEDVHRAGGIFGILGELGRAGKLDTSVRTIHEDTMAEALSKWDIAVTNNPEVQELFLAAPGGVRTTQAFSQARRYKDL
DTDREKGVIRSAKHAFSKDGGLAVLFGNIAEMGCVVKTAGVDDSILKFSGPAVICESQEEACERILKKRVKAGDVVIIRY
EGPRGGPGMQEMLYPTSYLKAMQLGKECALITDGRFSGGTSGLSIGHVSPEAAEGGAIGLLHEGDIIEIDIPNRTINAKV
SAEEFAKRRAEMDAKGAAAWKPVEERPRKVSRALKVYAAHVGNASLGAVRLDP

Sequences:

>Translated_613_residues
MIPYRSRTSTHGRNMAGARGLWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLDIPVVFVSGGPMEAGKVNIDGELR
AVDLIDAMIEAANPDRTDAEVDEFEKNACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHADREALFRRAGRRIV
ELTKAYYEGGDTGVSARGIATKAAFENAITLDIAMGGSTNTILHLLAMAREGEVDFTLADIDRLSRVTPCLCKVAPAVQN
VHMEDVHRAGGIFGILGELGRAGKLDTSVRTIHEDTMAEALSKWDIAVTNNPEVQELFLAAPGGVRTTQAFSQARRYKDL
DTDREKGVIRSAKHAFSKDGGLAVLFGNIAEMGCVVKTAGVDDSILKFSGPAVICESQEEACERILKKRVKAGDVVIIRY
EGPRGGPGMQEMLYPTSYLKAMQLGKECALITDGRFSGGTSGLSIGHVSPEAAEGGAIGLLHEGDIIEIDIPNRTINAKV
SAEEFAKRRAEMDAKGAAAWKPVEERPRKVSRALKVYAAHVGNASLGAVRLDP
>Mature_613_residues
MIPYRSRTSTHGRNMAGARGLWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLDIPVVFVSGGPMEAGKVNIDGELR
AVDLIDAMIEAANPDRTDAEVDEFEKNACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHADREALFRRAGRRIV
ELTKAYYEGGDTGVSARGIATKAAFENAITLDIAMGGSTNTILHLLAMAREGEVDFTLADIDRLSRVTPCLCKVAPAVQN
VHMEDVHRAGGIFGILGELGRAGKLDTSVRTIHEDTMAEALSKWDIAVTNNPEVQELFLAAPGGVRTTQAFSQARRYKDL
DTDREKGVIRSAKHAFSKDGGLAVLFGNIAEMGCVVKTAGVDDSILKFSGPAVICESQEEACERILKKRVKAGDVVIIRY
EGPRGGPGMQEMLYPTSYLKAMQLGKECALITDGRFSGGTSGLSIGHVSPEAAEGGAIGLLHEGDIIEIDIPNRTINAKV
SAEEFAKRRAEMDAKGAAAWKPVEERPRKVSRALKVYAAHVGNASLGAVRLDP

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=70.327868852459, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=502, Percent_Identity=31.6733067729084, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI1788157, Length=542, Percent_Identity=28.5977859778598, Blast_Score=179, Evalue=7e-46,
Organism=Escherichia coli, GI1786464, Length=557, Percent_Identity=30.5206463195691, Blast_Score=175, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=607, Percent_Identity=37.0675453047776, Blast_Score=336, Evalue=8e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_HYPNA (Q0C2B5)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760128.1
- STRING:   Q0C2B5
- GeneID:   4289415
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1411
- NMPDR:   fig|228405.5.peg.1371
- TIGR:   HNE_1411
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q0C2B5
- BioCyc:   HNEP81032:HNE_1411-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65327; Mature: 65327

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPYRSRTSTHGRNMAGARGLWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLDIPVVFVSGGPMEAGKVNIDGELRAVDLIDAMIEAANPDRTDAE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCH
VDEFEKNACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHADREALFRRAGRRIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHHHHHH
ELTKAYYEGGDTGVSARGIATKAAFENAITLDIAMGGSTNTILHLLAMAREGEVDFTLAD
HHHHHHHCCCCCCCCCCCCCHHHHHCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEHHH
IDRLSRVTPCLCKVAPAVQNVHMEDVHRAGGIFGILGELGRAGKLDTSVRTIHEDTMAEA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LSKWDIAVTNNPEVQELFLAAPGGVRTTQAFSQARRYKDLDTDREKGVIRSAKHAFSKDG
HHHCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
GLAVLFGNIAEMGCVVKTAGVDDSILKFSGPAVICESQEEACERILKKRVKAGDVVIIRY
CEEEEECCHHHHCEEEEECCCCCHHHEECCCEEEECCHHHHHHHHHHHHCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKAMQLGKECALITDGRFSGGTSGLSIGHVSPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
LHEGDIIEIDIPNRTINAKVSAEEFAKRRAEMDAKGAAAWKPVEERPRKVSRALKVYAAH
EECCCEEEEECCCCEEECEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGNASLGAVRLDP
CCCCCCCEEEECC
>Mature Secondary Structure
MIPYRSRTSTHGRNMAGARGLWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLDIPVVFVSGGPMEAGKVNIDGELRAVDLIDAMIEAANPDRTDAE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCH
VDEFEKNACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHADREALFRRAGRRIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHHHHHH
ELTKAYYEGGDTGVSARGIATKAAFENAITLDIAMGGSTNTILHLLAMAREGEVDFTLAD
HHHHHHHCCCCCCCCCCCCCHHHHHCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEHHH
IDRLSRVTPCLCKVAPAVQNVHMEDVHRAGGIFGILGELGRAGKLDTSVRTIHEDTMAEA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LSKWDIAVTNNPEVQELFLAAPGGVRTTQAFSQARRYKDLDTDREKGVIRSAKHAFSKDG
HHHCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
GLAVLFGNIAEMGCVVKTAGVDDSILKFSGPAVICESQEEACERILKKRVKAGDVVIIRY
CEEEEECCHHHHCEEEEECCCCCHHHEECCCEEEECCHHHHHHHHHHHHCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKAMQLGKECALITDGRFSGGTSGLSIGHVSPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
LHEGDIIEIDIPNRTINAKVSAEEFAKRRAEMDAKGAAAWKPVEERPRKVSRALKVYAAH
EECCCEEEEECCCCEEECEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGNASLGAVRLDP
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA