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The map label for this gene is tetA [H]

Identifier: 114797216

GI number: 114797216

Start: 484964

End: 486217

Strand: Reverse

Name: tetA [H]

Synonym: HNE_0492

Alternate gene names: 114797216

Gene position: 486217-484964 (Counterclockwise)

Preceding gene: 114799118

Following gene: 114800219

Centisome position: 13.12

GC content: 65.63

Gene sequence:

>1254_bases
ATGACCGACACCGCGCCCGCCCGCCTTCCCGGCAAAAACGCTTTCTTCTTCGTGCTGGTGACGGTCTTCATCGATCACCT
CGCCTTTGGCCTGATCATCCCGGTCCTGCCCACGCTGATCCAGGATCTCGCCAACGTGCCCGCCTCCGGCGCCACCCTCT
GGATCGGCGGTCTCGCGGCCACCTATGCCGTGATGACGTTCCTGTTCGGCCCGCTGATCGGCGCCCTGTCCGACAAGTTC
GGCCGCCGCCCGGTCCTGCTCGTCTCGATGGCGATGCTGGGGCTCGACTTTCTGCTGATGGCGCTGGCCCCCAACATCTG
GATACTCTTCCTCGGCCGCGCGCTCGCGGGCATATCGGGCGCCACCTACTCAACCGCCAACGCCTACATTGCCGATACGA
CGACCCCGGAGGAACGCGGCCGCGCCTTCGGCTTTATCGGCGCCTCCTTCGGCCTCGGCTTCATTTTCGGCCCGGTGATC
GGCGGCCTGCTCGGCGAGCTTGGCCCCCGCATACCCTTCTTTGCCGCCGTGGGCCTCGCCTTCCTCAACTTCCTCTACGG
CGTATTCGTGCTGCCCGAATCCCTCCCCAAGGCGCGCCGCCGCAATCTGAACCTTAAGCGCGCCAACCCCCTCGGCGCCG
CCCGCCACTTCTCAAAGCTCCCCAAAGTCTCCTGGTTCCTCATCGCGAGCGGCATTTTCTTCCTCGCCCACACAGTCTTC
CCTGCCACCTGGTCGGTGCATGGCGAGATCCGGTATGACTGGTCGCCCATGCAGATCGGCCTCTCGCTCGGCCTCGTGGG
CGTCGGTGCCGCCACCGTCCAAGCGGGCCTCATGGGCTTTATCCTCAAACGCCTCGGCAGTGTGCGCACCATCATGTTCG
GCTATTGCGTCACCATCATCGCGATGACCGGCTTTGCCTTTGCGGGCCAGCCGCTCTTTGCCTATCTCATCATCCCGTTC
AGCGCGCTCGGCGGCGTCACCATGCCCGCCGCCAACGCCCTGATGTCCAGCCTCACTCCGCCTGACGCGCAGGGCGAGCT
GCAAGGCGCTGCCTCCAGCCTCAATGCGCTGGGCATGATCATCGGCCCCCTGATCATGAGCGGTGCATTGTTCAGCTTCT
CCCGCGAAGACGCGCCTTTGCAATTTGGCGGCGCAGCATTCCTGCTCGCGGCCATTCTCACTGCGCTGGCGTTTCTGCCC
TTCCTGCGCGGGGTCGCCGCCAACCGAGACGTTCTGCCCGCCGCAGCGCCCTGA

Upstream 100 bases:

>100_bases
CCGCCCAGAATCGCAGCTTTCTCGCGCCCCCGCCAGCCCTGCCCCGCCCGCGTCAATAATTTCGTTTGACGCCGCCCGCG
CCTTGCTGACAGTCCCGCGC

Downstream 100 bases:

>100_bases
TCAGGACGCCGCCGCTTTACCGGGCTTTTCGGGCACGTTGTCTTCAATAGGTTTCCGGCGATCTTCCACAGGTTCGGTCT
GCGACATTACGGGCTTCAGG

Product: tetracycline-efflux transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTDTAPARLPGKNAFFFVLVTVFIDHLAFGLIIPVLPTLIQDLANVPASGATLWIGGLAATYAVMTFLFGPLIGALSDKF
GRRPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISGATYSTANAYIADTTTPEERGRAFGFIGASFGLGFIFGPVI
GGLLGELGPRIPFFAAVGLAFLNFLYGVFVLPESLPKARRRNLNLKRANPLGAARHFSKLPKVSWFLIASGIFFLAHTVF
PATWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFILKRLGSVRTIMFGYCVTIIAMTGFAFAGQPLFAYLIIPF
SALGGVTMPAANALMSSLTPPDAQGELQGAASSLNALGMIIGPLIMSGALFSFSREDAPLQFGGAAFLLAAILTALAFLP
FLRGVAANRDVLPAAAP

Sequences:

>Translated_417_residues
MTDTAPARLPGKNAFFFVLVTVFIDHLAFGLIIPVLPTLIQDLANVPASGATLWIGGLAATYAVMTFLFGPLIGALSDKF
GRRPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISGATYSTANAYIADTTTPEERGRAFGFIGASFGLGFIFGPVI
GGLLGELGPRIPFFAAVGLAFLNFLYGVFVLPESLPKARRRNLNLKRANPLGAARHFSKLPKVSWFLIASGIFFLAHTVF
PATWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFILKRLGSVRTIMFGYCVTIIAMTGFAFAGQPLFAYLIIPF
SALGGVTMPAANALMSSLTPPDAQGELQGAASSLNALGMIIGPLIMSGALFSFSREDAPLQFGGAAFLLAAILTALAFLP
FLRGVAANRDVLPAAAP
>Mature_416_residues
TDTAPARLPGKNAFFFVLVTVFIDHLAFGLIIPVLPTLIQDLANVPASGATLWIGGLAATYAVMTFLFGPLIGALSDKFG
RRPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISGATYSTANAYIADTTTPEERGRAFGFIGASFGLGFIFGPVIG
GLLGELGPRIPFFAAVGLAFLNFLYGVFVLPESLPKARRRNLNLKRANPLGAARHFSKLPKVSWFLIASGIFFLAHTVFP
ATWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFILKRLGSVRTIMFGYCVTIIAMTGFAFAGQPLFAYLIIPFS
ALGGVTMPAANALMSSLTPPDAQGELQGAASSLNALGMIIGPLIMSGALFSFSREDAPLQFGGAAFLLAAILTALAFLPF
LRGVAANRDVLPAAAP

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=381, Percent_Identity=24.9343832020997, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI94721311, Length=410, Percent_Identity=24.6341463414634, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI225703104, Length=334, Percent_Identity=26.6467065868263, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI225703102, Length=334, Percent_Identity=26.6467065868263, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI217416366, Length=212, Percent_Identity=29.2452830188679, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87081738, Length=195, Percent_Identity=31.7948717948718, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787291, Length=188, Percent_Identity=30.8510638297872, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71996331, Length=391, Percent_Identity=27.6214833759591, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17551570, Length=391, Percent_Identity=24.8081841432225, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357569, Length=374, Percent_Identity=27.5401069518717, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161080926, Length=363, Percent_Identity=28.099173553719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161080924, Length=363, Percent_Identity=28.099173553719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656463, Length=363, Percent_Identity=28.099173553719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656468, Length=363, Percent_Identity=28.099173553719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221513297, Length=381, Percent_Identity=27.5590551181102, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24667561, Length=216, Percent_Identity=30.5555555555556, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17738085, Length=168, Percent_Identity=32.7380952380952, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24667557, Length=196, Percent_Identity=30.1020408163265, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43866; Mature: 43734

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTAPARLPGKNAFFFVLVTVFIDHLAFGLIIPVLPTLIQDLANVPASGATLWIGGLAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHH
TYAVMTFLFGPLIGALSDKFGRRPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
ATYSTANAYIADTTTPEERGRAFGFIGASFGLGFIFGPVIGGLLGELGPRIPFFAAVGLA
CCCCCCCEEEECCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLNFLYGVFVLPESLPKARRRNLNLKRANPLGAARHFSKLPKVSWFLIASGIFFLAHTVF
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PATWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFILKRLGSVRTIMFGYCVTII
CCCEEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMTGFAFAGQPLFAYLIIPFSALGGVTMPAANALMSSLTPPDAQGELQGAASSLNALGMI
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
IGPLIMSGALFSFSREDAPLQFGGAAFLLAAILTALAFLPFLRGVAANRDVLPAAAP
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDTAPARLPGKNAFFFVLVTVFIDHLAFGLIIPVLPTLIQDLANVPASGATLWIGGLAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHH
TYAVMTFLFGPLIGALSDKFGRRPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
ATYSTANAYIADTTTPEERGRAFGFIGASFGLGFIFGPVIGGLLGELGPRIPFFAAVGLA
CCCCCCCEEEECCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLNFLYGVFVLPESLPKARRRNLNLKRANPLGAARHFSKLPKVSWFLIASGIFFLAHTVF
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PATWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFILKRLGSVRTIMFGYCVTII
CCCEEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMTGFAFAGQPLFAYLIIPFSALGGVTMPAANALMSSLTPPDAQGELQGAASSLNALGMI
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
IGPLIMSGALFSFSREDAPLQFGGAAFLLAAILTALAFLPFLRGVAANRDVLPAAAP
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]