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The map label for this gene is nuoN [H]

Identifier: 114797124

GI number: 114797124

Start: 746933

End: 748441

Strand: Direct

Name: nuoN [H]

Synonym: HNE_0736

Alternate gene names: 114797124

Gene position: 746933-748441 (Clockwise)

Preceding gene: 114800322

Following gene: 114798330

Centisome position: 20.16

GC content: 61.37

Gene sequence:

>1509_bases
ATGAACCCGGAAACCCTCATTGCCTCGATCCTTGTTCTGCCGCTGCTGATTGCGGCAGGCATCGCCGCGACGGGCAAGTT
CCCGAATATTCGTGAGGGCGTGACGATCCTCGGCTCGATCGCGCTGTTTGTGCTGGTCGTGCAGCTTGTCATGATGGTGT
CTTCGGGCGCCCGGCCTGAGCTCTTTGTCGGGCAGGCAGCGCCGGGCCTGGCGATCGCTTTCAAGGTTGAGCCCCTTGGC
GCTCTGTTCGCGATCGTGGCCAGCGGCCTGTGGATCGTGAACTCGTTCTATTCCATCGGCTACATGCGCGGGAACCGCGA
GCGTAACCAGACGCGCTTCTACATTTGCTTTGCCATCGCCATCTGCGGCGCCATGGGCGTGGCGACGGCAGGCAACCTGT
TCACGCTGTTCATTTTCTATGAAGTGCTGACCCTGTCGACCTATCCGCTGGTGGCCCATAAGGGCGATGCGGCGGCCCAG
CGCGGCGCGCGTATCTATCTGCTGACGCTGCTCGGCACATCGATTGGCCTCTTCCTGACCGCGATCATGTGGACCTGGGT
CGTAGCGGGCCAGCGCCTGGATTTCGTTGACGGCGGCCTGCTCGCCAATGTCGAGATTTCACCGGCTGTTGCCAGCGCCC
TGTTGCTCCTGTTTGTCTTCGGGATCGGCAAGGCGGCGCTGATGCCGTTCCATTTCTGGCTACCCAACGCGATGGTCGCG
CCAACGCCCGTATCGGCGCTCCTGCACGCCGTGGCGGTTGTGAAGGCGGGTGTGTTCACCGTCCTCAAAGTGTCGATGTA
TATCTTTGGGGCGGACCTTCTGAACGCCACGCCCTCGCGTGAATTCCTGATGGATGTGGCCTGTATCACCATTGTCGTGG
CCTCGCTGATTGCGTTGACCAAAGACAATCTGAAGGCACGCCTTGCCTATTCGACCATCGCCCAGCTGGCCTATGTCACG
CTCGGCGCGATGCTGGCTGACAAGGCCGGTTTCATGGGCGGATCGTTGCAGATCGCGGCGCACGCGGTGGCCAAGATCAC
GCTGTTCATGTGCGCGGGCGCAATCTACGTGGCCACGGGCCTCACCAACATCTCAGACATGCGCGGTCTCGGCCGCAAGA
TGCCTTGGGTCTTTGTCGCCTTCTTCATGGCGTCTCTGTCCATTATCGGAGTGCCGCCATTTGCTGGTGACTGGCCGAAA
TATGAGCTGATGCAGGGCGCAATCGACCGCGGGGCAGACTGGGTGCCGTTCATCCTGATCGCATCGTCGGTGTTGAACAT
TGCCTACCTGTTGCCGATTGCGATTCTGGGGCTGATGCCGCCTGGGCCGGAAGAGCCTGTGAAGGAATTCAAGCGGCCGG
GCGGGGCGCCTGCGCTGACCGTTGCGGCGCCCGTGTTCACGGCGTTCCTCTGTCTGATCCTATTCCTGCTCATTGATCCG
ATCGGTGACTTCCTCTCGCCCGCCATAAATGCGGCCACAACCACAGTTCAGGAGGCCGCGCTGCCATGA

Upstream 100 bases:

>100_bases
TACTTGCGCTCGCCAACCTTTATTTCGGCATCGCCGCTGACTTCCCGCTGGGACTTGCCCAGGACGGCGCAGTGGCTGCC
CTCGGACTGGAGGCGTTCCG

Downstream 100 bases:

>100_bases
GCAACGACACGACCCCTCCGGTCCGGGATAATTCGGGCCGCTTTGTGAAAACGGCCGCCGAGAAGGTCAACGCCATGAGC
CGCACACCCGAGGACGGTGT

Product: putative NADH-quinone oxidoreductase

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MNPETLIASILVLPLLIAAGIAATGKFPNIREGVTILGSIALFVLVVQLVMMVSSGARPELFVGQAAPGLAIAFKVEPLG
ALFAIVASGLWIVNSFYSIGYMRGNRERNQTRFYICFAIAICGAMGVATAGNLFTLFIFYEVLTLSTYPLVAHKGDAAAQ
RGARIYLLTLLGTSIGLFLTAIMWTWVVAGQRLDFVDGGLLANVEISPAVASALLLLFVFGIGKAALMPFHFWLPNAMVA
PTPVSALLHAVAVVKAGVFTVLKVSMYIFGADLLNATPSREFLMDVACITIVVASLIALTKDNLKARLAYSTIAQLAYVT
LGAMLADKAGFMGGSLQIAAHAVAKITLFMCAGAIYVATGLTNISDMRGLGRKMPWVFVAFFMASLSIIGVPPFAGDWPK
YELMQGAIDRGADWVPFILIASSVLNIAYLLPIAILGLMPPGPEEPVKEFKRPGGAPALTVAAPVFTAFLCLILFLLIDP
IGDFLSPAINAATTTVQEAALP

Sequences:

>Translated_502_residues
MNPETLIASILVLPLLIAAGIAATGKFPNIREGVTILGSIALFVLVVQLVMMVSSGARPELFVGQAAPGLAIAFKVEPLG
ALFAIVASGLWIVNSFYSIGYMRGNRERNQTRFYICFAIAICGAMGVATAGNLFTLFIFYEVLTLSTYPLVAHKGDAAAQ
RGARIYLLTLLGTSIGLFLTAIMWTWVVAGQRLDFVDGGLLANVEISPAVASALLLLFVFGIGKAALMPFHFWLPNAMVA
PTPVSALLHAVAVVKAGVFTVLKVSMYIFGADLLNATPSREFLMDVACITIVVASLIALTKDNLKARLAYSTIAQLAYVT
LGAMLADKAGFMGGSLQIAAHAVAKITLFMCAGAIYVATGLTNISDMRGLGRKMPWVFVAFFMASLSIIGVPPFAGDWPK
YELMQGAIDRGADWVPFILIASSVLNIAYLLPIAILGLMPPGPEEPVKEFKRPGGAPALTVAAPVFTAFLCLILFLLIDP
IGDFLSPAINAATTTVQEAALP
>Mature_502_residues
MNPETLIASILVLPLLIAAGIAATGKFPNIREGVTILGSIALFVLVVQLVMMVSSGARPELFVGQAAPGLAIAFKVEPLG
ALFAIVASGLWIVNSFYSIGYMRGNRERNQTRFYICFAIAICGAMGVATAGNLFTLFIFYEVLTLSTYPLVAHKGDAAAQ
RGARIYLLTLLGTSIGLFLTAIMWTWVVAGQRLDFVDGGLLANVEISPAVASALLLLFVFGIGKAALMPFHFWLPNAMVA
PTPVSALLHAVAVVKAGVFTVLKVSMYIFGADLLNATPSREFLMDVACITIVVASLIALTKDNLKARLAYSTIAQLAYVT
LGAMLADKAGFMGGSLQIAAHAVAKITLFMCAGAIYVATGLTNISDMRGLGRKMPWVFVAFFMASLSIIGVPPFAGDWPK
YELMQGAIDRGADWVPFILIASSVLNIAYLLPIAILGLMPPGPEEPVKEFKRPGGAPALTVAAPVFTAFLCLILFLLIDP
IGDFLSPAINAATTTVQEAALP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=370, Percent_Identity=30, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1788829, Length=391, Percent_Identity=31.4578005115089, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788827, Length=351, Percent_Identity=29.0598290598291, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788614, Length=344, Percent_Identity=29.3604651162791, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788831, Length=378, Percent_Identity=27.5132275132275, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI2367154, Length=346, Percent_Identity=26.3005780346821, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693160, Length=409, Percent_Identity=26.4058679706601, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788613, Length=306, Percent_Identity=25.4901960784314, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53124; Mature: 53124

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPETLIASILVLPLLIAAGIAATGKFPNIREGVTILGSIALFVLVVQLVMMVSSGARPE
CCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LFVGQAAPGLAIAFKVEPLGALFAIVASGLWIVNSFYSIGYMRGNRERNQTRFYICFAIA
EEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ICGAMGVATAGNLFTLFIFYEVLTLSTYPLVAHKGDAAAQRGARIYLLTLLGTSIGLFLT
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCEEEEHHHHHHHHHHHHH
AIMWTWVVAGQRLDFVDGGLLANVEISPAVASALLLLFVFGIGKAALMPFHFWLPNAMVA
HHHHHHHHCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
PTPVSALLHAVAVVKAGVFTVLKVSMYIFGADLLNATPSREFLMDVACITIVVASLIALT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KDNLKARLAYSTIAQLAYVTLGAMLADKAGFMGGSLQIAAHAVAKITLFMCAGAIYVATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LTNISDMRGLGRKMPWVFVAFFMASLSIIGVPPFAGDWPKYELMQGAIDRGADWVPFILI
CCCHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
ASSVLNIAYLLPIAILGLMPPGPEEPVKEFKRPGGAPALTVAAPVFTAFLCLILFLLIDP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IGDFLSPAINAATTTVQEAALP
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPETLIASILVLPLLIAAGIAATGKFPNIREGVTILGSIALFVLVVQLVMMVSSGARPE
CCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LFVGQAAPGLAIAFKVEPLGALFAIVASGLWIVNSFYSIGYMRGNRERNQTRFYICFAIA
EEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ICGAMGVATAGNLFTLFIFYEVLTLSTYPLVAHKGDAAAQRGARIYLLTLLGTSIGLFLT
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCEEEEHHHHHHHHHHHHH
AIMWTWVVAGQRLDFVDGGLLANVEISPAVASALLLLFVFGIGKAALMPFHFWLPNAMVA
HHHHHHHHCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
PTPVSALLHAVAVVKAGVFTVLKVSMYIFGADLLNATPSREFLMDVACITIVVASLIALT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KDNLKARLAYSTIAQLAYVTLGAMLADKAGFMGGSLQIAAHAVAKITLFMCAGAIYVATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LTNISDMRGLGRKMPWVFVAFFMASLSIIGVPPFAGDWPKYELMQGAIDRGADWVPFILI
CCCHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
ASSVLNIAYLLPIAILGLMPPGPEEPVKEFKRPGGAPALTVAAPVFTAFLCLILFLLIDP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IGDFLSPAINAATTTVQEAALP
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA