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The map label for this gene is ywlC [H]

Identifier: 114332280

GI number: 114332280

Start: 2445525

End: 2446550

Strand: Direct

Name: ywlC [H]

Synonym: Neut_2320

Alternate gene names: 114332280

Gene position: 2445525-2446550 (Clockwise)

Preceding gene: 114332267

Following gene: 114332281

Centisome position: 91.9

GC content: 43.47

Gene sequence:

>1026_bases
ATGTATTACATGTCCAAAACCCATAATCCAGTTCCTGACTTGGTAAACGAGCAAATTACTGCCGCCGTTGCAAGTTTACG
TAAAGGTAATGTTATCGCTTTCCCAACAGAAACGGTTTATGGGCTGGGTGCGGATATTTCTCACCCCCAAGCAATCCAGA
AGATATTTGATATCAAAGGCAGGCCTCCTGACCATCCACTCATAGTTCATTTTGCTAAGTCAGCCGAGCTCGAATTTTGG
GCGGAAAATATACCTACAACAGCACTTATGCTGGCTAAACATTTCTGGCCTGGCCCATTAACCTTAGTCCTGCCCAAAAG
CAGGCATATTCCACTTAGCGTTACAGGAGGGCAAGATACTGTAGGATTACGTGTTCCCAGTCACCCAGTTGCACTCAGGC
TTTTAGAGGAGCTTGGCGGTTATAAAGCAATTGCCGCGCCCTCGGCCAATCGCTTCGGCTTTGTTAGCCCCACATCTGCT
GACCATGTAAAGAAAGAATTTGGGGATCGTATTGATATAATTCTCGACGGCGGATCCTGCGAAGTAGGTCTTGAAAGTAC
AATCGTCAGTTGTATTGATAATGAAGTCGCGATACTGCGCCCTGGTGGAATTTCGGTTTTATCTATTGAAAATGTACTTA
AGCAGAAGATTTTTGTTCGATCTCACGGTAATTCAATTCGGGCTCCAGGATCCTTGACATCACATTACGCAACCACAACA
CCACTTGAAATCTGCCATGGTGAATCTCTTTTTTTACGCTCTTCCATCCTTTTGCAGCAAGGAATACGCACAGCAGTTAT
AGTACGAAGCGTACGCGAAGATTTTGTTCAAGATGCAAATAACAAACTTCACTGTGTTTTTATGCCTAATGATCCGGTTA
GGTTTGGAAGGGATTTATACGCGACTCTGCGTAGACTTGATAATGAAAATTTCCAACAAATTCTAGTTGAAGCACCGCCT
GATAATTTAGAATGGCTAGCCGTTGCTGATCGATTAAATCGAGCCAGCTACTCATTTTATAAATAA

Upstream 100 bases:

>100_bases
TGAAAACTTTGTGGATATAGGTTTTTGCATCTGTCTGCGTGGATAATTTAAACTTACAAAATGTGGAATATATTCCTTCT
ATTGCGGTTATTCTTATTAC

Downstream 100 bases:

>100_bases
ATCTTAAAAAGACAATGGCTCTTTCAGCAGTCCTCTTTGACGTTGACGGTACTCTCGCAGATACTGAGCGGGATGGACAC
CGGCTCGCTTTTAATCAAGC

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MYYMSKTHNPVPDLVNEQITAAVASLRKGNVIAFPTETVYGLGADISHPQAIQKIFDIKGRPPDHPLIVHFAKSAELEFW
AENIPTTALMLAKHFWPGPLTLVLPKSRHIPLSVTGGQDTVGLRVPSHPVALRLLEELGGYKAIAAPSANRFGFVSPTSA
DHVKKEFGDRIDIILDGGSCEVGLESTIVSCIDNEVAILRPGGISVLSIENVLKQKIFVRSHGNSIRAPGSLTSHYATTT
PLEICHGESLFLRSSILLQQGIRTAVIVRSVREDFVQDANNKLHCVFMPNDPVRFGRDLYATLRRLDNENFQQILVEAPP
DNLEWLAVADRLNRASYSFYK

Sequences:

>Translated_341_residues
MYYMSKTHNPVPDLVNEQITAAVASLRKGNVIAFPTETVYGLGADISHPQAIQKIFDIKGRPPDHPLIVHFAKSAELEFW
AENIPTTALMLAKHFWPGPLTLVLPKSRHIPLSVTGGQDTVGLRVPSHPVALRLLEELGGYKAIAAPSANRFGFVSPTSA
DHVKKEFGDRIDIILDGGSCEVGLESTIVSCIDNEVAILRPGGISVLSIENVLKQKIFVRSHGNSIRAPGSLTSHYATTT
PLEICHGESLFLRSSILLQQGIRTAVIVRSVREDFVQDANNKLHCVFMPNDPVRFGRDLYATLRRLDNENFQQILVEAPP
DNLEWLAVADRLNRASYSFYK
>Mature_341_residues
MYYMSKTHNPVPDLVNEQITAAVASLRKGNVIAFPTETVYGLGADISHPQAIQKIFDIKGRPPDHPLIVHFAKSAELEFW
AENIPTTALMLAKHFWPGPLTLVLPKSRHIPLSVTGGQDTVGLRVPSHPVALRLLEELGGYKAIAAPSANRFGFVSPTSA
DHVKKEFGDRIDIILDGGSCEVGLESTIVSCIDNEVAILRPGGISVLSIENVLKQKIFVRSHGNSIRAPGSLTSHYATTT
PLEICHGESLFLRSSILLQQGIRTAVIVRSVREDFVQDANNKLHCVFMPNDPVRFGRDLYATLRRLDNENFQQILVEAPP
DNLEWLAVADRLNRASYSFYK

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=212, Percent_Identity=32.5471698113208, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI2367210, Length=164, Percent_Identity=31.7073170731707, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081864, Length=199, Percent_Identity=28.1407035175879, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537239, Length=193, Percent_Identity=31.6062176165803, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321269, Length=365, Percent_Identity=32.0547945205479, Blast_Score=146, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 37635; Mature: 37635

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYMSKTHNPVPDLVNEQITAAVASLRKGNVIAFPTETVYGLGADISHPQAIQKIFDIKG
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHEECCCCCCCHHHHHHHHHCCC
RPPDHPLIVHFAKSAELEFWAENIPTTALMLAKHFWPGPLTLVLPKSRHIPLSVTGGQDT
CCCCCCEEEEEECCCCEEEHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCE
VGLRVPSHPVALRLLEELGGYKAIAAPSANRFGFVSPTSADHVKKEFGDRIDIILDGGSC
EEEECCCCHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHHHHHCCEEEEEEECCCC
EVGLESTIVSCIDNEVAILRPGGISVLSIENVLKQKIFVRSHGNSIRAPGSLTSHYATTT
CCCHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHHHHEEEECCCCEECCCCCCCCCCCCC
PLEICHGESLFLRSSILLQQGIRTAVIVRSVREDFVQDANNKLHCVFMPNDPVRFGRDLY
CHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
ATLRRLDNENFQQILVEAPPDNLEWLAVADRLNRASYSFYK
HHHHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCC
>Mature Secondary Structure
MYYMSKTHNPVPDLVNEQITAAVASLRKGNVIAFPTETVYGLGADISHPQAIQKIFDIKG
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHEECCCCCCCHHHHHHHHHCCC
RPPDHPLIVHFAKSAELEFWAENIPTTALMLAKHFWPGPLTLVLPKSRHIPLSVTGGQDT
CCCCCCEEEEEECCCCEEEHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCE
VGLRVPSHPVALRLLEELGGYKAIAAPSANRFGFVSPTSADHVKKEFGDRIDIILDGGSC
EEEECCCCHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHHHHHCCEEEEEEECCCC
EVGLESTIVSCIDNEVAILRPGGISVLSIENVLKQKIFVRSHGNSIRAPGSLTSHYATTT
CCCHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHHHHEEEECCCCEECCCCCCCCCCCCC
PLEICHGESLFLRSSILLQQGIRTAVIVRSVREDFVQDANNKLHCVFMPNDPVRFGRDLY
CHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
ATLRRLDNENFQQILVEAPPDNLEWLAVADRLNRASYSFYK
HHHHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]