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The map label for this gene is fbp [H]

Identifier: 114332246

GI number: 114332246

Start: 2411967

End: 2412425

Strand: Direct

Name: fbp [H]

Synonym: Neut_2286

Alternate gene names: 114332246

Gene position: 2411967-2412425 (Clockwise)

Preceding gene: 114332245

Following gene: 114332250

Centisome position: 90.64

GC content: 46.19

Gene sequence:

>459_bases
ATGAATGTAAAAAAACTATTGGGCATCGTTCTTTCAGGATGTCTATTTTTATCGATAAATGCCCAGGCTGCCGGGGAACA
CATGACACCACACTACGTAAATGTTGCAGATGTAACAACACTGGAAAAAATAGATACCAAGGTTGGTACTGGAGAAGAAG
CCGATATTGGCAAAACCGCCAATGTGCACTATACAGGCTGGTTGTATGATCCCACTGCGGAAGACCATAAAGGCATAAAA
TTTGACAGTTCTCACGATCGTGGCACTCCCTTTTCATTCCTGCTTGGTGCTGGACGGGTTATCAAAGGATGGGATCAGGG
AGTACTGGGTATGAAAGTTGGTGGAAAACGTACCTTGATTATCCCCTCCGCCATGGCATACGGTACCCATGGCGCCGGAG
GTGTTATCCCTCCCGATTCAGCACTGATATTTGATGTGGAATTGATCGGCCTGGAGTAA

Upstream 100 bases:

>100_bases
TCTGCTGTTCGGAATGGTGCTGTGAAACGGGTAAATTCCACCAGCAAATCTCGAATTATCCAATCTACCAAGCTGTGAAT
ACTACTTTTTAGAGGTAATA

Downstream 100 bases:

>100_bases
CCAGGGGCTGGGCCCGGCGGGAAAACAGACAAATACCACCTGTCGGGTTATTTATCGCCAGCTTCCTTTGTTTACCTCCC
TCCAGGGAGGGATTCCTTTA

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MNVKKLLGIVLSGCLFLSINAQAAGEHMTPHYVNVADVTTLEKIDTKVGTGEEADIGKTANVHYTGWLYDPTAEDHKGIK
FDSSHDRGTPFSFLLGAGRVIKGWDQGVLGMKVGGKRTLIIPSAMAYGTHGAGGVIPPDSALIFDVELIGLE

Sequences:

>Translated_152_residues
MNVKKLLGIVLSGCLFLSINAQAAGEHMTPHYVNVADVTTLEKIDTKVGTGEEADIGKTANVHYTGWLYDPTAEDHKGIK
FDSSHDRGTPFSFLLGAGRVIKGWDQGVLGMKVGGKRTLIIPSAMAYGTHGAGGVIPPDSALIFDVELIGLE
>Mature_152_residues
MNVKKLLGIVLSGCLFLSINAQAAGEHMTPHYVNVADVTTLEKIDTKVGTGEEADIGKTANVHYTGWLYDPTAEDHKGIK
FDSSHDRGTPFSFLLGAGRVIKGWDQGVLGMKVGGKRTLIIPSAMAYGTHGAGGVIPPDSALIFDVELIGLE

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=96, Percent_Identity=51.0416666666667, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI4503725, Length=96, Percent_Identity=51.0416666666667, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI206725530, Length=96, Percent_Identity=50, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI17149844, Length=96, Percent_Identity=50, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI17149842, Length=96, Percent_Identity=50, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4758380, Length=96, Percent_Identity=47.9166666666667, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4503729, Length=136, Percent_Identity=39.7058823529412, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI150010552, Length=106, Percent_Identity=43.3962264150943, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI224809329, Length=108, Percent_Identity=46.2962962962963, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI224809327, Length=108, Percent_Identity=46.2962962962963, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4758384, Length=108, Percent_Identity=46.2962962962963, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI192448443, Length=109, Percent_Identity=39.4495412844037, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI224809331, Length=111, Percent_Identity=45.045045045045, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=43.1578947368421, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=46.7391304347826, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI206725547, Length=95, Percent_Identity=41.0526315789474, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI7706131, Length=132, Percent_Identity=38.6363636363636, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI31317231, Length=96, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87082390, Length=148, Percent_Identity=35.8108108108108, Blast_Score=73, Evalue=9e-15,
Organism=Escherichia coli, GI1789745, Length=106, Percent_Identity=43.3962264150943, Blast_Score=70, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=122, Percent_Identity=42.6229508196721, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993519, Length=95, Percent_Identity=47.3684210526316, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=93, Percent_Identity=48.3870967741936, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561778, Length=103, Percent_Identity=41.747572815534, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=56.25, Blast_Score=107, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=48.1818181818182, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=43.5185185185185, Blast_Score=81, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=108, Percent_Identity=42.5925925925926, Blast_Score=78, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281363946, Length=111, Percent_Identity=51.3513513513513, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17352457, Length=111, Percent_Identity=51.3513513513513, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24647110, Length=105, Percent_Identity=51.4285714285714, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24655568, Length=96, Percent_Identity=51.0416666666667, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21356629, Length=97, Percent_Identity=54.639175257732, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=45.7142857142857, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16122; Mature: 16122

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKKLLGIVLSGCLFLSINAQAAGEHMTPHYVNVADVTTLEKIDTKVGTGEEADIGKTA
CCHHHHHHHHHHCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
NVHYTGWLYDPTAEDHKGIKFDSSHDRGTPFSFLLGAGRVIKGWDQGVLGMKVGGKRTLI
CEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHCCCCEEECCCCCEEEEEECCCEEEE
IPSAMAYGTHGAGGVIPPDSALIFDVELIGLE
EECHHHCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MNVKKLLGIVLSGCLFLSINAQAAGEHMTPHYVNVADVTTLEKIDTKVGTGEEADIGKTA
CCHHHHHHHHHHCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
NVHYTGWLYDPTAEDHKGIKFDSSHDRGTPFSFLLGAGRVIKGWDQGVLGMKVGGKRTLI
CEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHCCCCEEECCCCCEEEEEECCCEEEE
IPSAMAYGTHGAGGVIPPDSALIFDVELIGLE
EECHHHCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]