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The map label for this gene is tpm

Identifier: 114332232

GI number: 114332232

Start: 2395688

End: 2396350

Strand: Direct

Name: tpm

Synonym: Neut_2272

Alternate gene names: 114332232

Gene position: 2395688-2396350 (Clockwise)

Preceding gene: 114332231

Following gene: 114332233

Centisome position: 90.03

GC content: 50.98

Gene sequence:

>663_bases
ATGGAACATGAATTCTGGCTACAAAGCTGGCACGAAGGGCGTACCGGTTTTCATCAACTACGCGTACAGCCGTTACTGCA
GAAATACTGGCCAACACTTGATCTACCAACTGGCAGCAAGATATTTGTTCCACTGACTGGCAAATCATTGGATATGGCTT
GGCTGGCTGCGCAAGGCTACCGTGTATTGGGTGTAGAGCTTTCACTACTGGCAGTACAGCAGTTTTTTGCCGAGCATGGC
CTGAAACCTGCGGTGAGAGAATCTCACTATGGCACACATTACACAGCCAGGAACATTGAGGTGATCTGCGGCGATACTTT
TGCGCTGGATGCAGCGCTGCTTTCCGATTGTAGCGGTATCTACGATCGTGCTGCGCTGATCGCTCTGCCACCCGAGCTGC
GCGTACCCTATATAAACGAACTCATGACATGTCTGCCGGCTGGTTGTAGCGGTTTGCTGATCACACTTGAATATCAGCAG
CAGGAAATGGTTGGGCCACCGTTTTCAGTTGAAGAAGCCGAGGTACTGAAGTGCTATTCACCCCGCTGGTGTGTCAAGCT
GCTGGAACGAAACGATATCCTTCCCCAAGAACCTGGTTTTGCTGCACGTGGCCTGACAAAACTTGCCACAGCAGTGTACC
AACTCCAACGACTGGCTGTATAA

Upstream 100 bases:

>100_bases
GATCGGCAAAGTATTGGATCTGTTCACTCCGGAGGAGTGTGCCAACTACTTCGCTTCATGTGGATATGTAAACAAGTAAA
CCAAAAATACTCTAAACACA

Downstream 100 bases:

>100_bases
ATCAACAAACGGCGTGGGGAACAAGCTGGAAGTCAAATTTTTTGATATGTTTCTTGAGGTGGAGCACAGTACATTCGCAA
TAACATTCCTTGCAATAACC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MEHEFWLQSWHEGRTGFHQLRVQPLLQKYWPTLDLPTGSKIFVPLTGKSLDMAWLAAQGYRVLGVELSLLAVQQFFAEHG
LKPAVRESHYGTHYTARNIEVICGDTFALDAALLSDCSGIYDRAALIALPPELRVPYINELMTCLPAGCSGLLITLEYQQ
QEMVGPPFSVEEAEVLKCYSPRWCVKLLERNDILPQEPGFAARGLTKLATAVYQLQRLAV

Sequences:

>Translated_220_residues
MEHEFWLQSWHEGRTGFHQLRVQPLLQKYWPTLDLPTGSKIFVPLTGKSLDMAWLAAQGYRVLGVELSLLAVQQFFAEHG
LKPAVRESHYGTHYTARNIEVICGDTFALDAALLSDCSGIYDRAALIALPPELRVPYINELMTCLPAGCSGLLITLEYQQ
QEMVGPPFSVEEAEVLKCYSPRWCVKLLERNDILPQEPGFAARGLTKLATAVYQLQRLAV
>Mature_220_residues
MEHEFWLQSWHEGRTGFHQLRVQPLLQKYWPTLDLPTGSKIFVPLTGKSLDMAWLAAQGYRVLGVELSLLAVQQFFAEHG
LKPAVRESHYGTHYTARNIEVICGDTFALDAALLSDCSGIYDRAALIALPPELRVPYINELMTCLPAGCSGLLITLEYQQ
QEMVGPPFSVEEAEVLKCYSPRWCVKLLERNDILPQEPGFAARGLTKLATAVYQLQRLAV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=199, Percent_Identity=32.6633165829146, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_NITEC (Q0ADU3)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748454.1
- ProteinModelPortal:   Q0ADU3
- SMR:   Q0ADU3
- STRING:   Q0ADU3
- GeneID:   4274036
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2272
- NMPDR:   fig|335283.3.peg.73
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   NEUT335283:NEUT_2272-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24704; Mature: 24704

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHEFWLQSWHEGRTGFHQLRVQPLLQKYWPTLDLPTGSKIFVPLTGKSLDMAWLAAQGY
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHCCC
RVLGVELSLLAVQQFFAEHGLKPAVRESHYGTHYTARNIEVICGDTFALDAALLSDCSGI
EEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHH
YDRAALIALPPELRVPYINELMTCLPAGCSGLLITLEYQQQEMVGPPFSVEEAEVLKCYS
HHCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECHHHHCCCCCCCCHHHHHHHCC
PRWCVKLLERNDILPQEPGFAARGLTKLATAVYQLQRLAV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHEFWLQSWHEGRTGFHQLRVQPLLQKYWPTLDLPTGSKIFVPLTGKSLDMAWLAAQGY
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHCCC
RVLGVELSLLAVQQFFAEHGLKPAVRESHYGTHYTARNIEVICGDTFALDAALLSDCSGI
EEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHH
YDRAALIALPPELRVPYINELMTCLPAGCSGLLITLEYQQQEMVGPPFSVEEAEVLKCYS
HHCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECHHHHCCCCCCCCHHHHHHHCC
PRWCVKLLERNDILPQEPGFAARGLTKLATAVYQLQRLAV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA