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The map label for this gene is hda [H]

Identifier: 114332207

GI number: 114332207

Start: 2372758

End: 2373423

Strand: Direct

Name: hda [H]

Synonym: Neut_2247

Alternate gene names: 114332207

Gene position: 2372758-2373423 (Clockwise)

Preceding gene: 114332206

Following gene: 114332208

Centisome position: 89.17

GC content: 45.35

Gene sequence:

>666_bases
ATGAGACAACTTCTCCTTGATATTACTGAAATCGGCCCGCCGTCACTGGACAACTTTATTCCTGAAGGGAACGAAGAGTT
GCTGTACACACTGAGGAATCTGGTTGCCGACAATCGTCAAGATCGTTTTTATTATCTGTGGGGAAATACAGGAAGCGGTA
AAAGCCATCTGCTGCAGGCGGTAACCAATATTTTTATGGAACAGCAGCGCAATACACACTACATTGATTGCAATCAGGCT
GATGAAATTGATTTCAATCTAACCGCAGATTGCATAGCAGTTGATAACATTGAACAACTGGATGATGCTGAACAAATTAG
ACTGTTTAATCTTTATAACCAGATCCGTGAAAGCAAGTATGGGATATTTTTGGCTGGTGGCACCCGACCGCCTGCACAAT
TGGGTTTGCGTCCGGATCTGACTACTCGCCTGGGCTGGGGATTGGTATATCAAGTACACGAATTAACGGATGAAAAAAAA
ATAGAAGTTATGCAAGACTATGCAATCCGTTGCGGATTTGAGTTGCCTCTGGATGTTTGCAACTACTTACTGAAGCATGA
ACAACGGGACTTATCCTCCCTGATCAGGCAGGTCAGCGCGCTGGATCAGCTTTCGCTGACTAGGCAGCGCCCCGTCACCC
TTCCCTTGCTGCGTGAACTGTTATAA

Upstream 100 bases:

>100_bases
CTGCTGCGCAATAACACTGTTTTGATATCCGGACATCTTTAATCTATCAGCATATTGTCTCTTTTATCCCATATGCAAAA
ATAGATTCCAAAAACTGCCA

Downstream 100 bases:

>100_bases
TCAGCACCGGTTTCGGACGATCGTCAATCTCGGAATATCAGATGATTGCAGTTGCTCCGTTCAACTTTGAAACGAATCTG
CTGTTTTTCCTTACACAGCT

Product: DnaA regulatory inactivator Hda

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRQLLLDITEIGPPSLDNFIPEGNEELLYTLRNLVADNRQDRFYYLWGNTGSGKSHLLQAVTNIFMEQQRNTHYIDCNQA
DEIDFNLTADCIAVDNIEQLDDAEQIRLFNLYNQIRESKYGIFLAGGTRPPAQLGLRPDLTTRLGWGLVYQVHELTDEKK
IEVMQDYAIRCGFELPLDVCNYLLKHEQRDLSSLIRQVSALDQLSLTRQRPVTLPLLRELL

Sequences:

>Translated_221_residues
MRQLLLDITEIGPPSLDNFIPEGNEELLYTLRNLVADNRQDRFYYLWGNTGSGKSHLLQAVTNIFMEQQRNTHYIDCNQA
DEIDFNLTADCIAVDNIEQLDDAEQIRLFNLYNQIRESKYGIFLAGGTRPPAQLGLRPDLTTRLGWGLVYQVHELTDEKK
IEVMQDYAIRCGFELPLDVCNYLLKHEQRDLSSLIRQVSALDQLSLTRQRPVTLPLLRELL
>Mature_221_residues
MRQLLLDITEIGPPSLDNFIPEGNEELLYTLRNLVADNRQDRFYYLWGNTGSGKSHLLQAVTNIFMEQQRNTHYIDCNQA
DEIDFNLTADCIAVDNIEQLDDAEQIRLFNLYNQIRESKYGIFLAGGTRPPAQLGLRPDLTTRLGWGLVYQVHELTDEKK
IEVMQDYAIRCGFELPLDVCNYLLKHEQRDLSSLIRQVSALDQLSLTRQRPVTLPLLRELL

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=215, Percent_Identity=35.3488372093023, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367267, Length=230, Percent_Identity=24.7826086956522, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 25540; Mature: 25540

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLLLDITEIGPPSLDNFIPEGNEELLYTLRNLVADNRQDRFYYLWGNTGSGKSHLLQA
CCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
VTNIFMEQQRNTHYIDCNQADEIDFNLTADCIAVDNIEQLDDAEQIRLFNLYNQIRESKY
HHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHCCC
GIFLAGGTRPPAQLGLRPDLTTRLGWGLVYQVHELTDEKKIEVMQDYAIRCGFELPLDVC
CEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHH
NYLLKHEQRDLSSLIRQVSALDQLSLTRQRPVTLPLLRELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
>Mature Secondary Structure
MRQLLLDITEIGPPSLDNFIPEGNEELLYTLRNLVADNRQDRFYYLWGNTGSGKSHLLQA
CCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
VTNIFMEQQRNTHYIDCNQADEIDFNLTADCIAVDNIEQLDDAEQIRLFNLYNQIRESKY
HHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHCCC
GIFLAGGTRPPAQLGLRPDLTTRLGWGLVYQVHELTDEKKIEVMQDYAIRCGFELPLDVC
CEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHH
NYLLKHEQRDLSSLIRQVSALDQLSLTRQRPVTLPLLRELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA