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The map label for this gene is fumC [H]

Identifier: 114332089

GI number: 114332089

Start: 2251616

End: 2253016

Strand: Direct

Name: fumC [H]

Synonym: Neut_2124

Alternate gene names: 114332089

Gene position: 2251616-2253016 (Clockwise)

Preceding gene: 114332088

Following gene: 114332098

Centisome position: 84.61

GC content: 51.61

Gene sequence:

>1401_bases
ATGGATTCGTATCGCGAAGAACATGATGCAATGGGTACGGTGCAAGTACCTGTCAACGCACTTTGGGGCGCACAGACCCA
GCGATCACTCACCAATTTCACCATTTCCGGAGAACGCATGCCACCAGCACTGATTCATGCGCTGGCAGTGGTCAAACGCG
CAGCTGCCAGTGTCAATCAGGAGCTGGGATTGCTGGAGGAAAACATCGCTCGGGCAATCATCGCCGCTGCTGATGAAGTG
CTGGCAGGCAAGCATGCCAACGAGTTTCCACTGGTCATCTGGCAAACCGGTTCCGGTACGCAAACCAACATGAACATGAA
CGAGGTGCTAGCCAACCGTGCCTCGGAAATTCTGGGTGGTACGCGCGGCAAAGATCGCAAGGTGCACCCCAATGATCATG
TCAACCGAGGACAATCTTCCAATGATGTGTTTCCCACTGCCATGCACGTTGCTGCAGTAGGAGCCATCCGCAGCCGACTG
ATTCCTGCACTGGAAGCATTGCATAATACATTAGCATCCAAGGCAACCGAGTTCTCAGATATTGTCAAGATTGGCCGCAC
CCATTTGCAGGATGCCACCCCATTGACGCTGGGGCAGGAATTTTCAGGTTATGTATCACAGCTCGACCACGGTCTTGCTC
ATCTTGAATCCGCCCTGCCACACTTGCTTGAACTGGCGTTGGGCGGAACTGCCGTGGGAACAGGTCTTAATACCCATCCG
GAATTTGCGCAGCGCGTCGCAGCAGAAATTGCACACCTCACCGGCTATCCTTTTATCACTGCCCCTAATAAATTCGAAGC
GCTGGCCGCACATGATGCATTCGTTCATGCGCATGGCGTGCTAAAAACGCTAGCCGCTGCGCTAATCAAGATCGCTAATG
ATATCCGCTGGCTGGCATCTGGCCCGCGTTGTGGCATCGGCGAGATTTTTATCCCGGAGAATGAACCTGGTAGTTCGATT
ATGCCCGGCAAAATCAACCCCACTCAGGCAGAGGCCGTGGTCATGCTGGCGTGCCAGGTCATGGGCAATGATGTTGCGAT
CAACCTCGGTGGTGCCATGGGAAATTTTGAACTCAACGCTATGAAACCGCTGATTATCCATAATTTTCTGCAAAGCGCAC
GCCTGCTGGCAGATGGCATAAAAAGCTTCAATACGCATTGCGCCGCGGGCATTACCGCCAATACAACACGTATTCAGCAA
CATTTACAAAATTCACTGATGCTGGTTACTGTGCTTAATCCCTACATCGGCTACGACAAGGCATCCGAAATTGCTAAAAA
AGCCCATCATGAGGCACTAACGTTGAAAGAAGCGGCAATCAAGCTCGGCTATGTCACCGCAGAACAATTTGATGCGTGGG
TTGATCCACAAAAAATGGTGGGAAATAAAAGAAGTCTATAA

Upstream 100 bases:

>100_bases
GCCTCCGGTATTTCTGGAATCCTTCGATGAACAGTTCAATACCCGTAGCTAATCGCTTTCTTTCATACAACTCGTCAATC
TCTCTCGGGAAATAGCCATA

Downstream 100 bases:

>100_bases
AACGGAGGAAGTACCACCTACTCTACCGATCAGATAATAACCCGGCTTAATAGCTGAAAAAAATTAGGCATCCTGAATTC
TTGAAATTCAGGATGCCTAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDSYREEHDAMGTVQVPVNALWGAQTQRSLTNFTISGERMPPALIHALAVVKRAAASVNQELGLLEENIARAIIAAADEV
LAGKHANEFPLVIWQTGSGTQTNMNMNEVLANRASEILGGTRGKDRKVHPNDHVNRGQSSNDVFPTAMHVAAVGAIRSRL
IPALEALHNTLASKATEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLAHLESALPHLLELALGGTAVGTGLNTHP
EFAQRVAAEIAHLTGYPFITAPNKFEALAAHDAFVHAHGVLKTLAAALIKIANDIRWLASGPRCGIGEIFIPENEPGSSI
MPGKINPTQAEAVVMLACQVMGNDVAINLGGAMGNFELNAMKPLIIHNFLQSARLLADGIKSFNTHCAAGITANTTRIQQ
HLQNSLMLVTVLNPYIGYDKASEIAKKAHHEALTLKEAAIKLGYVTAEQFDAWVDPQKMVGNKRSL

Sequences:

>Translated_466_residues
MDSYREEHDAMGTVQVPVNALWGAQTQRSLTNFTISGERMPPALIHALAVVKRAAASVNQELGLLEENIARAIIAAADEV
LAGKHANEFPLVIWQTGSGTQTNMNMNEVLANRASEILGGTRGKDRKVHPNDHVNRGQSSNDVFPTAMHVAAVGAIRSRL
IPALEALHNTLASKATEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLAHLESALPHLLELALGGTAVGTGLNTHP
EFAQRVAAEIAHLTGYPFITAPNKFEALAAHDAFVHAHGVLKTLAAALIKIANDIRWLASGPRCGIGEIFIPENEPGSSI
MPGKINPTQAEAVVMLACQVMGNDVAINLGGAMGNFELNAMKPLIIHNFLQSARLLADGIKSFNTHCAAGITANTTRIQQ
HLQNSLMLVTVLNPYIGYDKASEIAKKAHHEALTLKEAAIKLGYVTAEQFDAWVDPQKMVGNKRSL
>Mature_466_residues
MDSYREEHDAMGTVQVPVNALWGAQTQRSLTNFTISGERMPPALIHALAVVKRAAASVNQELGLLEENIARAIIAAADEV
LAGKHANEFPLVIWQTGSGTQTNMNMNEVLANRASEILGGTRGKDRKVHPNDHVNRGQSSNDVFPTAMHVAAVGAIRSRL
IPALEALHNTLASKATEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLAHLESALPHLLELALGGTAVGTGLNTHP
EFAQRVAAEIAHLTGYPFITAPNKFEALAAHDAFVHAHGVLKTLAAALIKIANDIRWLASGPRCGIGEIFIPENEPGSSI
MPGKINPTQAEAVVMLACQVMGNDVAINLGGAMGNFELNAMKPLIIHNFLQSARLLADGIKSFNTHCAAGITANTTRIQQ
HLQNSLMLVTVLNPYIGYDKASEIAKKAHHEALTLKEAAIKLGYVTAEQFDAWVDPQKMVGNKRSL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=464, Percent_Identity=60.7758620689655, Blast_Score=570, Evalue=1e-163,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=46.7532467532467, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787896, Length=465, Percent_Identity=70.752688172043, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=38.961038961039, Blast_Score=345, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=60.8602150537634, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=62.8834355828221, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=58.7473002159827, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=58.3153347732181, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=58.3153347732181, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=57.5431034482759, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=56.3991323210412, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=51.1930585683297, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49966; Mature: 49966

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSYREEHDAMGTVQVPVNALWGAQTQRSLTNFTISGERMPPALIHALAVVKRAAASVNQ
CCCHHHHHHCCCEEEECHHHHHCCHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHH
ELGLLEENIARAIIAAADEVLAGKHANEFPLVIWQTGSGTQTNMNMNEVLANRASEILGG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
TRGKDRKVHPNDHVNRGQSSNDVFPTAMHVAAVGAIRSRLIPALEALHNTLASKATEFSD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLAHLESALPHLLELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EFAQRVAAEIAHLTGYPFITAPNKFEALAAHDAFVHAHGVLKTLAAALIKIANDIRWLAS
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEIFIPENEPGSSIMPGKINPTQAEAVVMLACQVMGNDVAINLGGAMGNFELNA
CCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHC
MKPLIIHNFLQSARLLADGIKSFNTHCAAGITANTTRIQQHLQNSLMLVTVLNPYIGYDK
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCH
ASEIAKKAHHEALTLKEAAIKLGYVTAEQFDAWVDPQKMVGNKRSL
HHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure
MDSYREEHDAMGTVQVPVNALWGAQTQRSLTNFTISGERMPPALIHALAVVKRAAASVNQ
CCCHHHHHHCCCEEEECHHHHHCCHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHH
ELGLLEENIARAIIAAADEVLAGKHANEFPLVIWQTGSGTQTNMNMNEVLANRASEILGG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
TRGKDRKVHPNDHVNRGQSSNDVFPTAMHVAAVGAIRSRLIPALEALHNTLASKATEFSD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLAHLESALPHLLELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EFAQRVAAEIAHLTGYPFITAPNKFEALAAHDAFVHAHGVLKTLAAALIKIANDIRWLAS
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEIFIPENEPGSSIMPGKINPTQAEAVVMLACQVMGNDVAINLGGAMGNFELNA
CCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHC
MKPLIIHNFLQSARLLADGIKSFNTHCAAGITANTTRIQQHLQNSLMLVTVLNPYIGYDK
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCH
ASEIAKKAHHEALTLKEAAIKLGYVTAEQFDAWVDPQKMVGNKRSL
HHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]