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The map label for this gene is proA

Identifier: 114332069

GI number: 114332069

Start: 2227870

End: 2229138

Strand: Reverse

Name: proA

Synonym: Neut_2104

Alternate gene names: 114332069

Gene position: 2229138-2227870 (Counterclockwise)

Preceding gene: 114332070

Following gene: 114332068

Centisome position: 83.77

GC content: 49.17

Gene sequence:

>1269_bases
ATGGAAAAAAACGAAAAAATACACGCTGATATGCAGGCTCTCGGGCGTGCGGCGTGTGCGGCAGCGCGGATAGTTGCAAA
AGCAGATACCGCTACTAAAAATCATGCACTTGCTATGATGGCTCGTGCTATTCGTCGTGATGAGGCATTATTGCTAGCGG
CTAATGCCAAAGATGTAGCGCAGGCCAGAAATAAAGGTTTGGAATCAGCCATGATTGATCGCCTGACATTGACTTCGAGA
GGGGTTGTCAGTATGGCCACCGGTCTAGAACAGATTGCCACACTACCTGATCCGATTGGAGCGATGACAGATCTGGATTA
TCGTCCATCCGGTATTCAGGTAGGTAAAATGCGGGTGCCACTGGGGGTAATCGGTATTATTTATGAGGCACGCCCGAACG
TGACGGCGGATGCTGCCGGTCTATGCTTGAAAGCGGGTAATGCAGCAATTTTGCGTGGGGGATCTGAGGCGATACAAAGT
AATCAGGCCATTGCCATTTGCGTAAGAGAGGGACTTAGATCGGCGGGCCTGCCTGAACAGACTATGCAGGTGGTGGAGAC
GACAGATCGTGCGGCGGTGAGCGCGCTGATTACCATGAGTGAATATGTGGATGTGATTGTTCCACGAGGTGGTAAGGGGT
TGATCGAACGGATTACTAATGAAGCGCGTGTTCCGGTTATCAAGCATCTGGATGGCGTGTGTCATGTATACGTTGATTTG
TCAGCAGATCTGGAAAAAGCGGTGCGTGTTGCAGATAATGCTAAAACTCAGCGTTACGGCACATGCAACACCATGGAGAC
GTTACTGGTGCATACTGGGATTGCTGAACAATTTTTACCACGCATCTGCCAAATATTTTTGGAAAAAGAGGTGGAATTAC
GGGGGGATGAGGCAGCATGTGCACTTGTTTCCCGAATGAAACCGGCTGTGGAGGAAGACTGGTATGCTGAATATCTCGCG
CCGATTCTGAGTGTTCGTATTGTGGCTGATATTGATGAGGCCATTACGCATATTGCCACCTATGGATCACAACATACCGA
TACTATCGTGACAGAAAATTATTCGCGTGCGCGACAATTTCTGCGTGAAGTAGATTCCAGTTCGGTCATGGTGAATGCTT
CAACCCGTTTTGCTGACGGATTTGAATATGGTCTGGGAGCGGAAATTGGTATTTCTACAGATAAGTTGCACGCACGTGGC
CCAGTGGGGCTGGAAGGACTGACCAGCCAGAAGTTTATCGTGCTGGGTGATGGCCATATCAGGGAATAA

Upstream 100 bases:

>100_bases
GGCGGGGATCGACTGCCAAAGATTCCAGTAAATAATGATTCTGGAAAATTCCTGCCGATTCACCAGATTACCCTTGATAA
CCGATTGACTGACATTTCTC

Downstream 100 bases:

>100_bases
GAAGATGACACAATTTACAACAATAGTTTTGCCTGATATTGGCGATTTTAAGGATGTTCCAGTCATAGAAACTCTGGTTA
AACCGGGGGATCGGGTAGAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEKNEKIHADMQALGRAACAAARIVAKADTATKNHALAMMARAIRRDEALLLAANAKDVAQARNKGLESAMIDRLTLTSR
GVVSMATGLEQIATLPDPIGAMTDLDYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIQS
NQAIAICVREGLRSAGLPEQTMQVVETTDRAAVSALITMSEYVDVIVPRGGKGLIERITNEARVPVIKHLDGVCHVYVDL
SADLEKAVRVADNAKTQRYGTCNTMETLLVHTGIAEQFLPRICQIFLEKEVELRGDEAACALVSRMKPAVEEDWYAEYLA
PILSVRIVADIDEAITHIATYGSQHTDTIVTENYSRARQFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARG
PVGLEGLTSQKFIVLGDGHIRE

Sequences:

>Translated_422_residues
MEKNEKIHADMQALGRAACAAARIVAKADTATKNHALAMMARAIRRDEALLLAANAKDVAQARNKGLESAMIDRLTLTSR
GVVSMATGLEQIATLPDPIGAMTDLDYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIQS
NQAIAICVREGLRSAGLPEQTMQVVETTDRAAVSALITMSEYVDVIVPRGGKGLIERITNEARVPVIKHLDGVCHVYVDL
SADLEKAVRVADNAKTQRYGTCNTMETLLVHTGIAEQFLPRICQIFLEKEVELRGDEAACALVSRMKPAVEEDWYAEYLA
PILSVRIVADIDEAITHIATYGSQHTDTIVTENYSRARQFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARG
PVGLEGLTSQKFIVLGDGHIRE
>Mature_422_residues
MEKNEKIHADMQALGRAACAAARIVAKADTATKNHALAMMARAIRRDEALLLAANAKDVAQARNKGLESAMIDRLTLTSR
GVVSMATGLEQIATLPDPIGAMTDLDYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIQS
NQAIAICVREGLRSAGLPEQTMQVVETTDRAAVSALITMSEYVDVIVPRGGKGLIERITNEARVPVIKHLDGVCHVYVDL
SADLEKAVRVADNAKTQRYGTCNTMETLLVHTGIAEQFLPRICQIFLEKEVELRGDEAACALVSRMKPAVEEDWYAEYLA
PILSVRIVADIDEAITHIATYGSQHTDTIVTENYSRARQFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARG
PVGLEGLTSQKFIVLGDGHIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=411, Percent_Identity=35.036496350365, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=35.6796116504854, Blast_Score=251, Evalue=8e-67,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=46.0240963855422, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17569967, Length=378, Percent_Identity=35.978835978836, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17569969, Length=378, Percent_Identity=35.978835978836, Blast_Score=260, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=35.5813953488372, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21357643, Length=392, Percent_Identity=39.5408163265306, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_NITEC (Q0AEA6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748291.1
- ProteinModelPortal:   Q0AEA6
- SMR:   Q0AEA6
- STRING:   Q0AEA6
- GeneID:   4271986
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2104
- NMPDR:   fig|335283.3.peg.130
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q0AEA6
- ProtClustDB:   PRK00197
- BioCyc:   NEUT335283:NEUT_2104-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45466; Mature: 45466

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNEKIHADMQALGRAACAAARIVAKADTATKNHALAMMARAIRRDEALLLAANAKDVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHH
QARNKGLESAMIDRLTLTSRGVVSMATGLEQIATLPDPIGAMTDLDYRPSGIQVGKMRVP
HHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECC
LGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIQSNQAIAICVREGLRSAGLPEQ
CEEEEEEEECCCCCCCCCCCCEEECCCEEEEECCHHHHHCCCEEEEEEHHHHHHCCCCHH
TMQVVETTDRAAVSALITMSEYVDVIVPRGGKGLIERITNEARVPVIKHLDGVCHVYVDL
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCHHHHCCCEEEEEEEC
SADLEKAVRVADNAKTQRYGTCNTMETLLVHTGIAEQFLPRICQIFLEKEVELRGDEAAC
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALVSRMKPAVEEDWYAEYLAPILSVRIVADIDEAITHIATYGSQHTDTIVTENYSRARQF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHH
LREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSQKFIVLGDGHI
HHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCC
RE
CC
>Mature Secondary Structure
MEKNEKIHADMQALGRAACAAARIVAKADTATKNHALAMMARAIRRDEALLLAANAKDVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHH
QARNKGLESAMIDRLTLTSRGVVSMATGLEQIATLPDPIGAMTDLDYRPSGIQVGKMRVP
HHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECC
LGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIQSNQAIAICVREGLRSAGLPEQ
CEEEEEEEECCCCCCCCCCCCEEECCCEEEEECCHHHHHCCCEEEEEEHHHHHHCCCCHH
TMQVVETTDRAAVSALITMSEYVDVIVPRGGKGLIERITNEARVPVIKHLDGVCHVYVDL
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCHHHHCCCEEEEEEEC
SADLEKAVRVADNAKTQRYGTCNTMETLLVHTGIAEQFLPRICQIFLEKEVELRGDEAAC
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALVSRMKPAVEEDWYAEYLAPILSVRIVADIDEAITHIATYGSQHTDTIVTENYSRARQF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHH
LREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSQKFIVLGDGHI
HHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCC
RE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA