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The map label for this gene is pepP [H]

Identifier: 114332060

GI number: 114332060

Start: 2218627

End: 2220009

Strand: Reverse

Name: pepP [H]

Synonym: Neut_2095

Alternate gene names: 114332060

Gene position: 2220009-2218627 (Counterclockwise)

Preceding gene: 114332064

Following gene: 114332059

Centisome position: 83.43

GC content: 48.08

Gene sequence:

>1383_bases
GTGGTCTGGCAAATTCCCGACTGTTTTCTGAAACTATTACTGGAATCCGGTGACATGATTCCAGTCCAGACGTATATCGA
TCGCAGAAAACAACTGCTGTCACACATTCAGCAAGGTGTTGCTGTAATTGCTACTTCACCGGAGAAATACCGTAACCGTG
ATACAAATTATCCCTATCGTTACGATAGCTACTTCTACTATTTAACCGGTTTCCAGGAGCCTGAAGCGGTTTTGTTATTG
GTTGCTACCGGGGATGAAAACACATCGCAACAGATTTTATTCTGTCGGGACAAGGATAGTGAACATGAAATATGGAATGG
GTTTCGTTATGGGCCGGATGCGGCACGAGAAGCATTTTGTTTTGACGCAGCTTATCCCATTACCCGGCTGGATGAGCTTG
TCGGTGAGCTGCTAGCGAATCAACCTGTGGTATTTCATGCATTCGGTCATGATGTTTCCTGGGATCAGCGTGTGATCGGG
TGGATCAGCCGTGTGCGAGAACAGATCAGGAAAGGCATATCAGCACCGGCAGAAATACGAGATATCCGCCATTTACTCGA
TGAAATGCGCTTGGTCAAGGATGATCATGAACTGGCGGTGATGCGGGAAGCAGCCAGGATTTCAGCTGATGCACACAAGC
GCGCCATGCAGGCGACTCGTCCCGGTAAGCATGAATATGAAATAGAAGCTGAACTGCTCTATGAATTTCGTCAGCAAGGT
GCTCAGTCTCCCGCTTATACATCTATTGTGGCGGGCGGTGCGAATGCATGTGTATTGCACTATGTTCAGAATGACGCACG
GCTGAAAGCAGGTGATTTGTTGTTGATTGACGCTGCCTGTGAATTGCATGGTTATGCAGCGGATATTACACGTACTTTTC
CGATAAATGGTAGCTTTTCGGCTGCACAGAAAGATGTTTATCAGTTGGTACTTGCTGCCCAGCTGACTGCCATTGATGCA
GTTCGGCCGGGTAATAATTGGGATATGCCGCATCAGGCAGCTTTGCGGGTACTGGTACAAGGATTGATTGACTTGCGCTT
ATGCGAAGGTAGCCCGGATGCAGTGATGGAAACGGAATCCTACAAACGATTCTATATGCACCGGACCGGTCACTGGTTAG
GGTTGGATGTACATGATGCGGGAGAATACAAGCAGGCCGGACAGTGGCGTACACTGGTTTCTGGGATGACGCTGACTGTA
GAGCCAGGTTGTTATATTCGCCCCGCCGAAGATATCCCGGAGCATTTCTGGAATATTGGTATAAGAATCGAGGATGATGT
AGCTGTTACATCGACCGGGCATGAAGTGCTTACCCGGTCAGTGCCTAAAAGTGTGGTTGAGATAGAGGAGTGGATGCAAT
GCATGACGACTACAGAAAAATAA

Upstream 100 bases:

>100_bases
AAATGTTACATTTTAACCATAAAAAGAAACCGGGAGTTAATAATGCTTTTGTATCCATACGGGTTTTTCATATTATCGAT
GTCTGGAAGATACATGGTCG

Downstream 100 bases:

>100_bases
TTATTAGAAGGATTATTCATCAGGGGCAAGCTGATCCGACAGGTGAATCACTGAATACATCGCCGATTAACCGGTGGGCA
TTTTATCTGACGCTGATACC

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MVWQIPDCFLKLLLESGDMIPVQTYIDRRKQLLSHIQQGVAVIATSPEKYRNRDTNYPYRYDSYFYYLTGFQEPEAVLLL
VATGDENTSQQILFCRDKDSEHEIWNGFRYGPDAAREAFCFDAAYPITRLDELVGELLANQPVVFHAFGHDVSWDQRVIG
WISRVREQIRKGISAPAEIRDIRHLLDEMRLVKDDHELAVMREAARISADAHKRAMQATRPGKHEYEIEAELLYEFRQQG
AQSPAYTSIVAGGANACVLHYVQNDARLKAGDLLLIDAACELHGYAADITRTFPINGSFSAAQKDVYQLVLAAQLTAIDA
VRPGNNWDMPHQAALRVLVQGLIDLRLCEGSPDAVMETESYKRFYMHRTGHWLGLDVHDAGEYKQAGQWRTLVSGMTLTV
EPGCYIRPAEDIPEHFWNIGIRIEDDVAVTSTGHEVLTRSVPKSVVEIEEWMQCMTTTEK

Sequences:

>Translated_460_residues
MVWQIPDCFLKLLLESGDMIPVQTYIDRRKQLLSHIQQGVAVIATSPEKYRNRDTNYPYRYDSYFYYLTGFQEPEAVLLL
VATGDENTSQQILFCRDKDSEHEIWNGFRYGPDAAREAFCFDAAYPITRLDELVGELLANQPVVFHAFGHDVSWDQRVIG
WISRVREQIRKGISAPAEIRDIRHLLDEMRLVKDDHELAVMREAARISADAHKRAMQATRPGKHEYEIEAELLYEFRQQG
AQSPAYTSIVAGGANACVLHYVQNDARLKAGDLLLIDAACELHGYAADITRTFPINGSFSAAQKDVYQLVLAAQLTAIDA
VRPGNNWDMPHQAALRVLVQGLIDLRLCEGSPDAVMETESYKRFYMHRTGHWLGLDVHDAGEYKQAGQWRTLVSGMTLTV
EPGCYIRPAEDIPEHFWNIGIRIEDDVAVTSTGHEVLTRSVPKSVVEIEEWMQCMTTTEK
>Mature_460_residues
MVWQIPDCFLKLLLESGDMIPVQTYIDRRKQLLSHIQQGVAVIATSPEKYRNRDTNYPYRYDSYFYYLTGFQEPEAVLLL
VATGDENTSQQILFCRDKDSEHEIWNGFRYGPDAAREAFCFDAAYPITRLDELVGELLANQPVVFHAFGHDVSWDQRVIG
WISRVREQIRKGISAPAEIRDIRHLLDEMRLVKDDHELAVMREAARISADAHKRAMQATRPGKHEYEIEAELLYEFRQQG
AQSPAYTSIVAGGANACVLHYVQNDARLKAGDLLLIDAACELHGYAADITRTFPINGSFSAAQKDVYQLVLAAQLTAIDA
VRPGNNWDMPHQAALRVLVQGLIDLRLCEGSPDAVMETESYKRFYMHRTGHWLGLDVHDAGEYKQAGQWRTLVSGMTLTV
EPGCYIRPAEDIPEHFWNIGIRIEDDVAVTSTGHEVLTRSVPKSVVEIEEWMQCMTTTEK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=456, Percent_Identity=31.359649122807, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI149589008, Length=485, Percent_Identity=31.340206185567, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI260593665, Length=333, Percent_Identity=36.036036036036, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI260593663, Length=326, Percent_Identity=31.5950920245399, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1789275, Length=434, Percent_Identity=44.0092165898618, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1788728, Length=322, Percent_Identity=31.3664596273292, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790282, Length=322, Percent_Identity=31.6770186335404, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17508215, Length=489, Percent_Identity=31.9018404907975, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71989583, Length=393, Percent_Identity=26.2086513994911, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320922, Length=460, Percent_Identity=28.695652173913, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321118, Length=462, Percent_Identity=30.952380952381, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19920384, Length=414, Percent_Identity=34.5410628019324, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21357079, Length=441, Percent_Identity=31.0657596371882, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 52252; Mature: 52252

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWQIPDCFLKLLLESGDMIPVQTYIDRRKQLLSHIQQGVAVIATSPEKYRNRDTNYPYR
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCCCCEE
YDSYFYYLTGFQEPEAVLLLVATGDENTSQQILFCRDKDSEHEIWNGFRYGPDAAREAFC
ECCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCCHHHHHHEE
FDAAYPITRLDELVGELLANQPVVFHAFGHDVSWDQRVIGWISRVREQIRKGISAPAEIR
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
DIRHLLDEMRLVKDDHELAVMREAARISADAHKRAMQATRPGKHEYEIEAELLYEFRQQG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCC
AQSPAYTSIVAGGANACVLHYVQNDARLKAGDLLLIDAACELHGYAADITRTFPINGSFS
CCCCCHHHEEECCCCEEEEEEECCCCEEECCCEEEEEEHHHHCCEEECCEEEECCCCCCH
AAQKDVYQLVLAAQLTAIDAVRPGNNWDMPHQAALRVLVQGLIDLRLCEGSPDAVMETES
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCEECHHH
YKRFYMHRTGHWLGLDVHDAGEYKQAGQWRTLVSGMTLTVEPGCYIRPAEDIPEHFWNIG
HHHHHHHCCCCEEEEEECCCCCHHHCCCHHHHHCCCEEEECCCCEECCHHHHHHHHHHCC
IRIEDDVAVTSTGHEVLTRSVPKSVVEIEEWMQCMTTTEK
CEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVWQIPDCFLKLLLESGDMIPVQTYIDRRKQLLSHIQQGVAVIATSPEKYRNRDTNYPYR
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCCCCEE
YDSYFYYLTGFQEPEAVLLLVATGDENTSQQILFCRDKDSEHEIWNGFRYGPDAAREAFC
ECCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCCHHHHHHEE
FDAAYPITRLDELVGELLANQPVVFHAFGHDVSWDQRVIGWISRVREQIRKGISAPAEIR
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
DIRHLLDEMRLVKDDHELAVMREAARISADAHKRAMQATRPGKHEYEIEAELLYEFRQQG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCC
AQSPAYTSIVAGGANACVLHYVQNDARLKAGDLLLIDAACELHGYAADITRTFPINGSFS
CCCCCHHHEEECCCCEEEEEEECCCCEEECCCEEEEEEHHHHCCEEECCEEEECCCCCCH
AAQKDVYQLVLAAQLTAIDAVRPGNNWDMPHQAALRVLVQGLIDLRLCEGSPDAVMETES
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCEECHHH
YKRFYMHRTGHWLGLDVHDAGEYKQAGQWRTLVSGMTLTVEPGCYIRPAEDIPEHFWNIG
HHHHHHHCCCCEEEEEECCCCCHHHCCCHHHHHCCCEEEECCCCEECCHHHHHHHHHHCC
IRIEDDVAVTSTGHEVLTRSVPKSVVEIEEWMQCMTTTEK
CEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]