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The map label for this gene is cysM [H]

Identifier: 114332037

GI number: 114332037

Start: 2189374

End: 2190252

Strand: Reverse

Name: cysM [H]

Synonym: Neut_2071

Alternate gene names: 114332037

Gene position: 2190252-2189374 (Counterclockwise)

Preceding gene: 114332038

Following gene: 114332036

Centisome position: 82.31

GC content: 49.26

Gene sequence:

>879_bases
ATGTATAAAACTATCGAACATTTCATCGGACATACCCCCTTGGTCCAGCTTAAACGTATCCCGGGGAAAACCAGCAATAT
TATTCTGGCAAAACTGGAAGGTAATAATCCGGCGGGGTCAGTCAAAGATCGGCCAGCCTACTCCATGATCATACGAGCTC
AGCAGCGTGGAGATATTCAGCCGGGAGATACGTTGATTGAGGCAACTAGCGGCAACACCGGGATTGCATTGGCTATGTCG
GCAGCAATACTAGGCTATCACATGATTCTGGTCATGCCGGAAAATCAGAGTCTGGAGCGTCGTCAAGTGATGGCTGCGTA
CGGTGCCAAAATTATTCTGACAGAAAATATGGAGGAAGCACGGGATGTCGCCGGACAATTGTGCGAGGCTGGCAAGGGTT
TTATTCTTGATCAGTTTTCCAATCCCGATAATCCGTTGGCACATTACGAAGGTACTGCTCCCGAAATCTGGCAGGATACT
GCGGGCAAGATTACTCATTTTGTAAGCAGTATGGGAACGACTGGCACAATCATGGGTTGTGCCCGCTACTTCCGAGAAAA
AGAGCGGAAGGTGGAAATTGTAGGTGTACAGCCGCAAGAAGGTGCCCAGATTCCCGGAATCCGCAAATGGCCGGAAGCTT
ATTTGCCTAAAATTTATCAGTCGGAACTTGTTGATCGTATTTTGCTGGTATCCCAGCAAGAGGCCGAGATCATGGCGCGT
CGATTGGCATCAGAAGAGGGAGTATTCGCTGGCATTTCTTCCGGGGGGGCACTGGCAGCAGTGCTGAAACTTTCTGCTCA
AGTAAGAAACGCGGTGATTGTTTCTATTGTGTGTGACCGTGGGGATCGTTACCTGTCAACCGGAGTTTTTCCTTCCTGA

Upstream 100 bases:

>100_bases
GCTAATCCTTGACTGAACCCCTTGTGAATTCCTTTCACAAGGGGTTTTTTGTATGTGTATGAGATAATCCTGATTTATTT
GTGGCAGCACGTATCTGGTC

Downstream 100 bases:

>100_bases
AGAGCATGGAGCCGAGGTATCTCTGGTTTCGTCGTGTCAGTATTCCGGTTTGTATCTGCAGGCTTGCCACACGCCTCTGG
CTGTTTTTTCTACTTTACGC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MYKTIEHFIGHTPLVQLKRIPGKTSNIILAKLEGNNPAGSVKDRPAYSMIIRAQQRGDIQPGDTLIEATSGNTGIALAMS
AAILGYHMILVMPENQSLERRQVMAAYGAKIILTENMEEARDVAGQLCEAGKGFILDQFSNPDNPLAHYEGTAPEIWQDT
AGKITHFVSSMGTTGTIMGCARYFREKERKVEIVGVQPQEGAQIPGIRKWPEAYLPKIYQSELVDRILLVSQQEAEIMAR
RLASEEGVFAGISSGGALAAVLKLSAQVRNAVIVSIVCDRGDRYLSTGVFPS

Sequences:

>Translated_292_residues
MYKTIEHFIGHTPLVQLKRIPGKTSNIILAKLEGNNPAGSVKDRPAYSMIIRAQQRGDIQPGDTLIEATSGNTGIALAMS
AAILGYHMILVMPENQSLERRQVMAAYGAKIILTENMEEARDVAGQLCEAGKGFILDQFSNPDNPLAHYEGTAPEIWQDT
AGKITHFVSSMGTTGTIMGCARYFREKERKVEIVGVQPQEGAQIPGIRKWPEAYLPKIYQSELVDRILLVSQQEAEIMAR
RLASEEGVFAGISSGGALAAVLKLSAQVRNAVIVSIVCDRGDRYLSTGVFPS
>Mature_292_residues
MYKTIEHFIGHTPLVQLKRIPGKTSNIILAKLEGNNPAGSVKDRPAYSMIIRAQQRGDIQPGDTLIEATSGNTGIALAMS
AAILGYHMILVMPENQSLERRQVMAAYGAKIILTENMEEARDVAGQLCEAGKGFILDQFSNPDNPLAHYEGTAPEIWQDT
AGKITHFVSSMGTTGTIMGCARYFREKERKVEIVGVQPQEGAQIPGIRKWPEAYLPKIYQSELVDRILLVSQQEAEIMAR
RLASEEGVFAGISSGGALAAVLKLSAQVRNAVIVSIVCDRGDRYLSTGVFPS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=38.1578947368421, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=38.1578947368421, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=38.1578947368421, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI2367138, Length=290, Percent_Identity=59.6551724137931, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=42.483660130719, Blast_Score=201, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=310, Percent_Identity=40.3225806451613, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=40.5405405405405, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=41.2371134020619, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=40.4040404040404, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=37.9194630872483, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=35.8490566037736, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=37.8947368421053, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17534315, Length=307, Percent_Identity=34.8534201954397, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.5796178343949, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=31.1728395061728, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643623, Length=306, Percent_Identity=38.2352941176471, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20129101, Length=306, Percent_Identity=38.2352941176471, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31802; Mature: 31802

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00901 CYS_SYNTHASE ; PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKTIEHFIGHTPLVQLKRIPGKTSNIILAKLEGNNPAGSVKDRPAYSMIIRAQQRGDIQ
CCCCHHHHHCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHEEHHHCCCCC
PGDTLIEATSGNTGIALAMSAAILGYHMILVMPENQSLERRQVMAAYGAKIILTENMEEA
CCCEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCEEEEECCHHHH
RDVAGQLCEAGKGFILDQFSNPDNPLAHYEGTAPEIWQDTAGKITHFVSSMGTTGTIMGC
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARYFREKERKVEIVGVQPQEGAQIPGIRKWPEAYLPKIYQSELVDRILLVSQQEAEIMAR
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLASEEGVFAGISSGGALAAVLKLSAQVRNAVIVSIVCDRGDRYLSTGVFPS
HHHCCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MYKTIEHFIGHTPLVQLKRIPGKTSNIILAKLEGNNPAGSVKDRPAYSMIIRAQQRGDIQ
CCCCHHHHHCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHEEHHHCCCCC
PGDTLIEATSGNTGIALAMSAAILGYHMILVMPENQSLERRQVMAAYGAKIILTENMEEA
CCCEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCEEEEECCHHHH
RDVAGQLCEAGKGFILDQFSNPDNPLAHYEGTAPEIWQDTAGKITHFVSSMGTTGTIMGC
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARYFREKERKVEIVGVQPQEGAQIPGIRKWPEAYLPKIYQSELVDRILLVSQQEAEIMAR
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLASEEGVFAGISSGGALAAVLKLSAQVRNAVIVSIVCDRGDRYLSTGVFPS
HHHCCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]