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The map label for this gene is clpA [H]

Identifier: 114332014

GI number: 114332014

Start: 2163319

End: 2165589

Strand: Direct

Name: clpA [H]

Synonym: Neut_2048

Alternate gene names: 114332014

Gene position: 2163319-2165589 (Clockwise)

Preceding gene: 114332013

Following gene: 114332015

Centisome position: 81.3

GC content: 48.52

Gene sequence:

>2271_bases
ATGATTGCGCAAGAATTGGAAGTAAGTTTGCATATGGCTTTCGTCGAGTCACGACAAAAACGTCACGAATTCATTACGGT
TGAACACCTGCTACTGGCTCTGCTAGATAATCCCAGCGCTATAAAAGTGTTGCTTGCCTGTACAGTTGATATCGAGGATT
TGCGCAAGTCCCTGCAGGATCATATTGCCCGCCATACACCAGTAGTAGAAGGATCTGGGGATGTTGACACCCAGCCTACT
CTGGGCTTTCAGCGGGTCATCCAAAGAGCGATTCTCCATGTCCAATCCTCCGGCAAAAAAGAAGTCACCGGTGCTAACGT
CCTGGTCGCAATTTTTGGCGAGAAAGATTCACACGCAGTTTATTTTTTACAGCAGAAAGGCGCAACACGACTGGATGTGG
TGAATTATATTTCCCACAAGATAGACAAGACAGCACAGAACAGCGAATCTGAAAAAAATGAGGACAGTACTGACAGCGAG
CAACGGGATTCAGGCAGCCCGCTGGAAAGCTACACCATCAATCTGAACAGCCAGGCAGCTGCTAACCGAATAGATCCTCT
GATTGGACGTGAAAAAGAGGTTGAACGAGTCATTCAGACATTATGTCGTCGCCGCAAAAACAACCCGCTGCTGGTTGGTG
AGGCTGGTGTAGGAAAAACTGCCATTGCCGAAGGGCTGGCCAGAAGAATTACTGAAAATCGAGTACCGGATGTACTTGCC
AATCATCAGGTCTATGCCCTGGACATGGGGGCGTTACTGGCCGGAACAAAATATCGGGGCGATTTTGAACAGCGGCTGAA
GGCGGTATTAAAACAGCTCACTGACAACCCCAAAGCAATTCTGTTCATCGACGAAATTCATACTCTGATCGGTGCTGGTG
CTGCATCGGGCGGTACGCTGGATGCATCCAATCTGCTCAAACCCGCACTCAGCTCCGGACAGCTTAAATGTATCGGGGCC
ACTACCTACAACGAATATCGTGGCATTTTTGAGAAGGATCACGCCTTGTCTCGCCGCTTCCAGAAAATTGATATCTCTGA
ACCTGATATCAGCGAAACCGTGGAGATTCTGCGCGGGCTAAAATCCCGCTACGAAAAACATCATAATGTTAGATACACTG
AAGTCGCGCTAACAGCAGCCGCAGAATTGTCCGCACGTTTCATTAATGATCGTCACTTACCAGACAAGGCAATTGATGTC
ATCGATGAAGCCGGCGCTGCCCAGCGAGTGCTCCCCAAATCCAGACAGCGGAAAATTATCGGCAAACAGGAAATCGAGCA
TGTTATTGCTGGAATAGCGCGGATACCGCCACAGAATGTTTCCAATGATGACCGCAATAAACTGAAAACACTGGATCGTG
ACCTCAAGGCCATCGTTTTCGGGCAGGATGCAGCAATTGATGCGCTCACTGCTGCCATTAAAATGGCACGCAGTGGACTG
GGAAATACCGGCAAGCCTATTGGTTCCTTCCTGTTTTCCGGACCAACCGGCGTAGGAAAAACTGAAGTGGCACGTCAGCT
TGCCTATATACTCGGAATCCCTCTGCATCGCTTTGATATGTCCGAATACATGGAACGCCATGCGGTTTCAAGACTGGTCG
GTGCACCGCCGGGCTACGTTGGATTCGATCAGGGAGGCCTGCTGACTGAAACGATCATCAAACAACCACACGCTGTACTG
CTATTTGATGAGATTGAAAAAGCACACCCTGATATCTTCAACGTCATGCTCCAGATCATGGATTATGGAACATTAACGGA
TAACAATGGGCGCAAGGCTGATTTTCGTAACGTGATCATCATCATGACGACTAACGCGGGTGCCGATACGCTCACCAAGA
CAGTAATTGGATTTACCAAACACGCAAAATCCGGAGATGAAATGATTGAAATCAAACGGCTGTTCACGCCCGAGTTTCGT
AACCGGCTGGACGCTATTATCTCGTTTGCACCACTGGGAGAAGCCATTATATTGCGCGTTGTTGACAAGTTCCTGATAGA
GCTCGAAGCACAACTGCAAGAAAAGAAAGTGGATGTTACATTCACCGACAACCTGCGCAGTCATCTTGCCAGCCATGGAT
TTGACCCGCTAATGGGTGCTCGCCCCATGGCTCGGCTTATTCAAGATATTATCCGCCGGGCACTTGCTGATGAATTGTTA
TTCGGGCAACTGGTTAACGGTGGCAAGGTAACCGTAGATATTGGTGAAGACGGCAAAGCTGTTCTCACATTTGAAAATAA
GGAAAATGTAGCTGCACCCATCCCATCTTGA

Upstream 100 bases:

>100_bases
ACTTATCCTGGCGATATTGCAGCCACAAAAGTACAACAGGTCAATGAATTCTCAAAACAAAATCAGCATCCACTCATGTG
TGTGATGGAGAAGGAATAAT

Downstream 100 bases:

>100_bases
AAACCAAAAGAATAAAATGAACCTTCGGATACGCTTCCGTACATTCTTCATTGCACTTCTTATTTTCGTATACCCCCTGA
CTGCTGATGCAGACGCCACG

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPSAIKVLLACTVDIEDLRKSLQDHIARHTPVVEGSGDVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLQQKGATRLDVVNYISHKIDKTAQNSESEKNEDSTDSE
QRDSGSPLESYTINLNSQAAANRIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRITENRVPDVLA
NHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLTDNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCIGA
TTYNEYRGIFEKDHALSRRFQKIDISEPDISETVEILRGLKSRYEKHHNVRYTEVALTAAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSRQRKIIGKQEIEHVIAGIARIPPQNVSNDDRNKLKTLDRDLKAIVFGQDAAIDALTAAIKMARSGL
GNTGKPIGSFLFSGPTGVGKTEVARQLAYILGIPLHRFDMSEYMERHAVSRLVGAPPGYVGFDQGGLLTETIIKQPHAVL
LFDEIEKAHPDIFNVMLQIMDYGTLTDNNGRKADFRNVIIIMTTNAGADTLTKTVIGFTKHAKSGDEMIEIKRLFTPEFR
NRLDAIISFAPLGEAIILRVVDKFLIELEAQLQEKKVDVTFTDNLRSHLASHGFDPLMGARPMARLIQDIIRRALADELL
FGQLVNGGKVTVDIGEDGKAVLTFENKENVAAPIPS

Sequences:

>Translated_756_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPSAIKVLLACTVDIEDLRKSLQDHIARHTPVVEGSGDVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLQQKGATRLDVVNYISHKIDKTAQNSESEKNEDSTDSE
QRDSGSPLESYTINLNSQAAANRIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRITENRVPDVLA
NHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLTDNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCIGA
TTYNEYRGIFEKDHALSRRFQKIDISEPDISETVEILRGLKSRYEKHHNVRYTEVALTAAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSRQRKIIGKQEIEHVIAGIARIPPQNVSNDDRNKLKTLDRDLKAIVFGQDAAIDALTAAIKMARSGL
GNTGKPIGSFLFSGPTGVGKTEVARQLAYILGIPLHRFDMSEYMERHAVSRLVGAPPGYVGFDQGGLLTETIIKQPHAVL
LFDEIEKAHPDIFNVMLQIMDYGTLTDNNGRKADFRNVIIIMTTNAGADTLTKTVIGFTKHAKSGDEMIEIKRLFTPEFR
NRLDAIISFAPLGEAIILRVVDKFLIELEAQLQEKKVDVTFTDNLRSHLASHGFDPLMGARPMARLIQDIIRRALADELL
FGQLVNGGKVTVDIGEDGKAVLTFENKENVAAPIPS
>Mature_756_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPSAIKVLLACTVDIEDLRKSLQDHIARHTPVVEGSGDVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLQQKGATRLDVVNYISHKIDKTAQNSESEKNEDSTDSE
QRDSGSPLESYTINLNSQAAANRIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRITENRVPDVLA
NHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLTDNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCIGA
TTYNEYRGIFEKDHALSRRFQKIDISEPDISETVEILRGLKSRYEKHHNVRYTEVALTAAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSRQRKIIGKQEIEHVIAGIARIPPQNVSNDDRNKLKTLDRDLKAIVFGQDAAIDALTAAIKMARSGL
GNTGKPIGSFLFSGPTGVGKTEVARQLAYILGIPLHRFDMSEYMERHAVSRLVGAPPGYVGFDQGGLLTETIIKQPHAVL
LFDEIEKAHPDIFNVMLQIMDYGTLTDNNGRKADFRNVIIIMTTNAGADTLTKTVIGFTKHAKSGDEMIEIKRLFTPEFR
NRLDAIISFAPLGEAIILRVVDKFLIELEAQLQEKKVDVTFTDNLRSHLASHGFDPLMGARPMARLIQDIIRRALADELL
FGQLVNGGKVTVDIGEDGKAVLTFENKENVAAPIPS

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=31.5436241610738, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1787109, Length=745, Percent_Identity=62.2818791946309, Blast_Score=945, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=392, Percent_Identity=45.1530612244898, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=276, Percent_Identity=52.1739130434783, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323002, Length=299, Percent_Identity=47.4916387959866, Blast_Score=264, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83346; Mature: 83346

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPSAIKVLLACTVDIEDLRKSLQD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHEECCHHHHHHHHHH
HIARHTPVVEGSGDVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLQQKGATRLDVVNYISHKIDKTAQNSESEKNEDSTDSEQRDSGSPLESYTINLNSQAA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCHHH
ANRIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRITENRVPDVLA
HHHCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHH
NHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLTDNPKAILFIDEIHTLIGAGAASGGTL
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCC
DASNLLKPALSSGQLKCIGATTYNEYRGIFEKDHALSRRFQKIDISEPDISETVEILRGL
CHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
KSRYEKHHNVRYTEVALTAAAELSARFINDRHLPDKAIDVIDEAGAAQRVLPKSRQRKII
HHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHC
GKQEIEHVIAGIARIPPQNVSNDDRNKLKTLDRDLKAIVFGQDAAIDALTAAIKMARSGL
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
GNTGKPIGSFLFSGPTGVGKTEVARQLAYILGIPLHRFDMSEYMERHAVSRLVGAPPGYV
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTETIIKQPHAVLLFDEIEKAHPDIFNVMLQIMDYGTLTDNNGRKADFRNVII
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCCCEEE
IMTTNAGADTLTKTVIGFTKHAKSGDEMIEIKRLFTPEFRNRLDAIISFAPLGEAIILRV
EEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
VDKFLIELEAQLQEKKVDVTFTDNLRSHLASHGFDPLMGARPMARLIQDIIRRALADELL
HHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FGQLVNGGKVTVDIGEDGKAVLTFENKENVAAPIPS
HHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPSAIKVLLACTVDIEDLRKSLQD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHEECCHHHHHHHHHH
HIARHTPVVEGSGDVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLQQKGATRLDVVNYISHKIDKTAQNSESEKNEDSTDSEQRDSGSPLESYTINLNSQAA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCHHH
ANRIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRITENRVPDVLA
HHHCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHH
NHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLTDNPKAILFIDEIHTLIGAGAASGGTL
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCC
DASNLLKPALSSGQLKCIGATTYNEYRGIFEKDHALSRRFQKIDISEPDISETVEILRGL
CHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
KSRYEKHHNVRYTEVALTAAAELSARFINDRHLPDKAIDVIDEAGAAQRVLPKSRQRKII
HHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHC
GKQEIEHVIAGIARIPPQNVSNDDRNKLKTLDRDLKAIVFGQDAAIDALTAAIKMARSGL
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
GNTGKPIGSFLFSGPTGVGKTEVARQLAYILGIPLHRFDMSEYMERHAVSRLVGAPPGYV
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTETIIKQPHAVLLFDEIEKAHPDIFNVMLQIMDYGTLTDNNGRKADFRNVII
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCCCEEE
IMTTNAGADTLTKTVIGFTKHAKSGDEMIEIKRLFTPEFRNRLDAIISFAPLGEAIILRV
EEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
VDKFLIELEAQLQEKKVDVTFTDNLRSHLASHGFDPLMGARPMARLIQDIIRRALADELL
HHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FGQLVNGGKVTVDIGEDGKAVLTFENKENVAAPIPS
HHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]