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The map label for this gene is icd [H]

Identifier: 114332011

GI number: 114332011

Start: 2161043

End: 2162290

Strand: Direct

Name: icd [H]

Synonym: Neut_2045

Alternate gene names: 114332011

Gene position: 2161043-2162290 (Clockwise)

Preceding gene: 114332010

Following gene: 114332013

Centisome position: 81.21

GC content: 45.59

Gene sequence:

>1248_bases
ATGTATCAACATATCAAGGTACCGGCCATCGGCAGCAAAATTCAGGTAAAAAATGACTCTACCCTGATCGTACCAGATAA
CCCGATCATCCCTTTTATTGAGGGAGATGGTACAGGTATAGATATCACACCCGTCATGATCAAAGTGATCGATGGCGCAG
TAAAAAAAGCATATGGTGATTCCCGGAAAATTTCCTGGATGGAAATTTACGCGGGTGAGAAATCGACTCGCGTCTATGGA
CAGGATGTCTGGCTGCCAGACGAAACCTTGCAAGCAGCAAAGGAATTTGTGGTATCCATCAAGGGGCCATTGACCACACC
AGTAAGCGGTGGCATTCGGTCAATCAATGTAGCATTACGCCAACTGCTGGATCTGTATGTTTGTCTGCGCCCGGTACGGT
ATTTCCAAGGGGTTCCCAGCCCGGTCAAACAACCGGAGAAAGTAGATATGATCATATTTCGCGAAAACTCGGAAGATATC
TATGCGGGCATCGAATGGGAAGCTGGAACAGCAGCTGTTGGAAAAGTAATTAATTTCCTGACAACAGAAATGGAAATCAC
CAAGATCCGATTTCCTCAATCTTCTGCGATCGGGATAAAACCGGTTTCAAAAGAAGGCAGCGAACGTTTGATCAGGAAAG
CCATTCAGTATGCGATTGACCATAAACGGCGCTCTGTCACCTTGGTGCACAAAGGAAATATTATGAAATTCACAGAAGGG
GCTTTCAAGAAATGGGGTTACGAACTAGCAGCAAAAGAATTTGGCGCAGAATTACTGGATGGCGGTCCGTGGATGAAACT
GCGGTATGATGGTAATGAAATTACCATCAAGGATGTTATTGCTGATGCCTTCCTCCAGCAAATCTTGCTGCGTCCGGATG
AATACGATGTTATCGCCACACTTAATTTAAATGGTGACTATATTTCTGACGCTCTGGCTGCACAGGTGGGTGGTATCGGA
ATCGCTCCCGGAGCAAATTTGAGCGACAGCATAGCGATATTTGAGGCGACACACGGCACAGCACCAAAGTACGCTGGCAA
GGATCAAGTCAATCCAGGATCAATCATCCTGTCAGCAGAAATGATGCTCAGATACATTAACTGGCACGAAGCAGCCGATA
TCATTATCAGCTCAATGGAGAAAACGATACAAGACAAAATCATGACCTATGATCTGGCAAGACTTACACCGAATGCCAGG
CAGGCCACTTCTTCAGAATTTGGGAGTGCAATGATACAAAGAATGTAA

Upstream 100 bases:

>100_bases
TATCTGCAGAGGAAAAGTTAAACGATCAGAGAATAGATCAAGAGTCCGGCGAGTCCAGCATTCATGAGTCAATATAATTT
TTTAACTTCTTGGAGACACG

Downstream 100 bases:

>100_bases
TAGAACTTATTAGACTGATATTCTCTGTAACATTTACTTCAGTCAGCTTATTTCAGAAATCAACCCCCGGCCTGGCATTA
TAAAAACTTCAGGCCGGGGG

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MYQHIKVPAIGSKIQVKNDSTLIVPDNPIIPFIEGDGTGIDITPVMIKVIDGAVKKAYGDSRKISWMEIYAGEKSTRVYG
QDVWLPDETLQAAKEFVVSIKGPLTTPVSGGIRSINVALRQLLDLYVCLRPVRYFQGVPSPVKQPEKVDMIIFRENSEDI
YAGIEWEAGTAAVGKVINFLTTEMEITKIRFPQSSAIGIKPVSKEGSERLIRKAIQYAIDHKRRSVTLVHKGNIMKFTEG
AFKKWGYELAAKEFGAELLDGGPWMKLRYDGNEITIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAQVGGIG
IAPGANLSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRYINWHEAADIIISSMEKTIQDKIMTYDLARLTPNAR
QATSSEFGSAMIQRM

Sequences:

>Translated_415_residues
MYQHIKVPAIGSKIQVKNDSTLIVPDNPIIPFIEGDGTGIDITPVMIKVIDGAVKKAYGDSRKISWMEIYAGEKSTRVYG
QDVWLPDETLQAAKEFVVSIKGPLTTPVSGGIRSINVALRQLLDLYVCLRPVRYFQGVPSPVKQPEKVDMIIFRENSEDI
YAGIEWEAGTAAVGKVINFLTTEMEITKIRFPQSSAIGIKPVSKEGSERLIRKAIQYAIDHKRRSVTLVHKGNIMKFTEG
AFKKWGYELAAKEFGAELLDGGPWMKLRYDGNEITIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAQVGGIG
IAPGANLSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRYINWHEAADIIISSMEKTIQDKIMTYDLARLTPNAR
QATSSEFGSAMIQRM
>Mature_415_residues
MYQHIKVPAIGSKIQVKNDSTLIVPDNPIIPFIEGDGTGIDITPVMIKVIDGAVKKAYGDSRKISWMEIYAGEKSTRVYG
QDVWLPDETLQAAKEFVVSIKGPLTTPVSGGIRSINVALRQLLDLYVCLRPVRYFQGVPSPVKQPEKVDMIIFRENSEDI
YAGIEWEAGTAAVGKVINFLTTEMEITKIRFPQSSAIGIKPVSKEGSERLIRKAIQYAIDHKRRSVTLVHKGNIMKFTEG
AFKKWGYELAAKEFGAELLDGGPWMKLRYDGNEITIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAQVGGIG
IAPGANLSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRYINWHEAADIIISSMEKTIQDKIMTYDLARLTPNAR
QATSSEFGSAMIQRM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=389, Percent_Identity=29.5629820051414, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4758582, Length=323, Percent_Identity=30.030959752322, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI28178821, Length=350, Percent_Identity=27.1428571428571, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI28178816, Length=350, Percent_Identity=27.1428571428571, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI28178838, Length=264, Percent_Identity=31.4393939393939, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI28178819, Length=179, Percent_Identity=32.9608938547486, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=69.5443645083933, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1788101, Length=374, Percent_Identity=27.5401069518717, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081683, Length=382, Percent_Identity=25.6544502617801, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71986051, Length=360, Percent_Identity=32.5, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=308, Percent_Identity=32.1428571428571, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=310, Percent_Identity=30.6451612903226, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550882, Length=392, Percent_Identity=24.4897959183673, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=416, Percent_Identity=31.0096153846154, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322097, Length=374, Percent_Identity=29.144385026738, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324291, Length=389, Percent_Identity=25.706940874036, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24661184, Length=388, Percent_Identity=33.2474226804124, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643270, Length=389, Percent_Identity=32.133676092545, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24643268, Length=389, Percent_Identity=32.133676092545, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161078633, Length=310, Percent_Identity=28.7096774193548, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24650122, Length=310, Percent_Identity=28.7096774193548, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161078639, Length=310, Percent_Identity=28.7096774193548, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161078637, Length=310, Percent_Identity=28.7096774193548, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161078635, Length=310, Percent_Identity=28.7096774193548, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281362242, Length=324, Percent_Identity=29.0123456790123, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648872, Length=324, Percent_Identity=29.0123456790123, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130355, Length=326, Percent_Identity=24.8466257668712, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45830; Mature: 45830

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAIGSKIQVKNDSTLIVPDNPIIPFIEGDGTGIDITPVMIKVIDGAVKKAYGD
CCCEEECCCCCCEEEECCCCEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
SRKISWMEIYAGEKSTRVYGQDVWLPDETLQAAKEFVVSIKGPLTTPVSGGIRSINVALR
CCCEEEEEEECCCCCCEEECCEECCCHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHH
QLLDLYVCLRPVRYFQGVPSPVKQPEKVDMIIFRENSEDIYAGIEWEAGTAAVGKVINFL
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHH
TTEMEITKIRFPQSSAIGIKPVSKEGSERLIRKAIQYAIDHKRRSVTLVHKGNIMKFTEG
HCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCH
AFKKWGYELAAKEFGAELLDGGPWMKLRYDGNEITIKDVIADAFLQQILLRPDEYDVIAT
HHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYISDALAAQVGGIGIAPGANLSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAE
EECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHH
MMLRYINWHEAADIIISSMEKTIQDKIMTYDLARLTPNARQATSSEFGSAMIQRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQHIKVPAIGSKIQVKNDSTLIVPDNPIIPFIEGDGTGIDITPVMIKVIDGAVKKAYGD
CCCEEECCCCCCEEEECCCCEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
SRKISWMEIYAGEKSTRVYGQDVWLPDETLQAAKEFVVSIKGPLTTPVSGGIRSINVALR
CCCEEEEEEECCCCCCEEECCEECCCHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHH
QLLDLYVCLRPVRYFQGVPSPVKQPEKVDMIIFRENSEDIYAGIEWEAGTAAVGKVINFL
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHH
TTEMEITKIRFPQSSAIGIKPVSKEGSERLIRKAIQYAIDHKRRSVTLVHKGNIMKFTEG
HCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCH
AFKKWGYELAAKEFGAELLDGGPWMKLRYDGNEITIKDVIADAFLQQILLRPDEYDVIAT
HHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYISDALAAQVGGIGIAPGANLSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAE
EECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHH
MMLRYINWHEAADIIISSMEKTIQDKIMTYDLARLTPNARQATSSEFGSAMIQRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]