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The map label for this gene is gcvPA [H]

Identifier: 114331926

GI number: 114331926

Start: 2066991

End: 2068346

Strand: Reverse

Name: gcvPA [H]

Synonym: Neut_1953

Alternate gene names: 114331926

Gene position: 2068346-2066991 (Counterclockwise)

Preceding gene: 114331927

Following gene: 114331925

Centisome position: 77.73

GC content: 49.34

Gene sequence:

>1356_bases
ATGCCATTTATTCCCCATACAGAAGAAGATGTAACAGAAATGCTTGCCAGCATTGGCGCTACATCTATCGATGAATTATT
CGACGAAATTCCCGCCGAGCTAAAAAACGGGAAATTAACCCAGGTACCGACTGGCATGAGCGAAATGGAAATTTCGCGCC
TCATGTACGAACGTGCGCAGAAAGATGGGTTCTATCTCAGCTTTATCGGCGCAGGTGCTTATGAACATCATATTCCAGCA
GCAGTCTGGCAAATAACAACCCGGGGAGAATTTTATTCTTCCTACACACCTTATCAGGCAGAGGCCAGCCAGGGGACATT
GCAATTGTTGTACGAATACCAGACTATGATGGCGTCGTTGGCCGGAATGGATGTGTCCAATGCCAGTTTGTATGATGGGG
CATCTGCTCTGGCCGAGGCTGCTCTGATGGCTGTGCGCCAGCACAAATCATCCAGACGTATTCTGGTTCCGCAGACTGTG
CACCCAATTTATCGCAGTGTGGTTCGTACCATTGTCAGAAATCAGGCGATCGAGGTGGTTGAGGTTCCATACGATCCTGC
CACTGGGCAGGTGTCCATTGATCAGCTTGACCAGTTTGCACAGGAAGAATTTGCTGCGCTGATTATTCCTCAACCCAATT
TTTTTGGTGTGCTCGAACAGGTCGATACGCTGGCTGATTGGGCACACGACAAGCAATCTCTGGCTATTGCAGTGGTTAAC
CCGACTGCACTTGCCATGTTGAAACCACCAGGAGAATGGGGGCGTCAGGGAGCAGATATCGCTGTCGGAGAAGGACAACC
TCTGGGAATTCCACTTTCCAGTGGCGGGCCATACTTTGGCTTCATGGCCTGCAAACAAGAACTGGTTCGGCAAATGCCGG
GGCGGATCATTGGACGGACTACCGATCTGGAAGGCAAAGAAGGTTTTGCCTTGACATTGCAGGCAAGGGAGCAACATATC
CGTCGTTCGAAAGCAACTTCCAATATTTGTACCAATCAGGGATTGATGGTAACAGCAGCGACAATTTACATGTCGTTACT
GGGGCCTGAAGGATTGTATCGGGTTGCCGCCCAATCTCATGCAAACACTTTGGCGCTGGTGGAACAACTGGAAACACTTC
CCGGCGTGAAGAAAGCATTCCACAGCCCGTTCTTTCACGAAGCAGTGCTTCAGCTATCTGTTCCGGCTGATGAAGTCTTG
AACAAGCTCAAAGCGCAAGGCGTACTTGGAGGTGTACTACTTGAGAATTACTACCCGGATCTGAAGAACACGCTACTGGT
CTGCGCAACAGAAACCAAAATAGCAGAAGATCTGGATAAATATACTGAAATGTTGCGGCAGATACTGAAAGCCTGA

Upstream 100 bases:

>100_bases
CGATGGCAACGCAGAAGTTTTTCACCGCTTTGTTAAAGCTGTTTGCAGTAAATAGACAAGCAGACATAACCTTTAAGTTT
TTTGGATAATACAGTTAATC

Downstream 100 bases:

>100_bases
AATCAGGAGTAAACCGGAAGAGAGCCGCGTTACTTGTTCTGTATTGAATCAATCTCACCAACCTAAGATAAAACATGCTG
ATATTTGAACATTCCCGCAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPFIPHTEEDVTEMLASIGATSIDELFDEIPAELKNGKLTQVPTGMSEMEISRLMYERAQKDGFYLSFIGAGAYEHHIPA
AVWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLAGMDVSNASLYDGASALAEAALMAVRQHKSSRRILVPQTV
HPIYRSVVRTIVRNQAIEVVEVPYDPATGQVSIDQLDQFAQEEFAALIIPQPNFFGVLEQVDTLADWAHDKQSLAIAVVN
PTALAMLKPPGEWGRQGADIAVGEGQPLGIPLSSGGPYFGFMACKQELVRQMPGRIIGRTTDLEGKEGFALTLQAREQHI
RRSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAQSHANTLALVEQLETLPGVKKAFHSPFFHEAVLQLSVPADEVL
NKLKAQGVLGGVLLENYYPDLKNTLLVCATETKIAEDLDKYTEMLRQILKA

Sequences:

>Translated_451_residues
MPFIPHTEEDVTEMLASIGATSIDELFDEIPAELKNGKLTQVPTGMSEMEISRLMYERAQKDGFYLSFIGAGAYEHHIPA
AVWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLAGMDVSNASLYDGASALAEAALMAVRQHKSSRRILVPQTV
HPIYRSVVRTIVRNQAIEVVEVPYDPATGQVSIDQLDQFAQEEFAALIIPQPNFFGVLEQVDTLADWAHDKQSLAIAVVN
PTALAMLKPPGEWGRQGADIAVGEGQPLGIPLSSGGPYFGFMACKQELVRQMPGRIIGRTTDLEGKEGFALTLQAREQHI
RRSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAQSHANTLALVEQLETLPGVKKAFHSPFFHEAVLQLSVPADEVL
NKLKAQGVLGGVLLENYYPDLKNTLLVCATETKIAEDLDKYTEMLRQILKA
>Mature_450_residues
PFIPHTEEDVTEMLASIGATSIDELFDEIPAELKNGKLTQVPTGMSEMEISRLMYERAQKDGFYLSFIGAGAYEHHIPAA
VWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLAGMDVSNASLYDGASALAEAALMAVRQHKSSRRILVPQTVH
PIYRSVVRTIVRNQAIEVVEVPYDPATGQVSIDQLDQFAQEEFAALIIPQPNFFGVLEQVDTLADWAHDKQSLAIAVVNP
TALAMLKPPGEWGRQGADIAVGEGQPLGIPLSSGGPYFGFMACKQELVRQMPGRIIGRTTDLEGKEGFALTLQAREQHIR
RSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAQSHANTLALVEQLETLPGVKKAFHSPFFHEAVLQLSVPADEVLN
KLKAQGVLGGVLLENYYPDLKNTLLVCATETKIAEDLDKYTEMLRQILKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=438, Percent_Identity=35.1598173515982, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1789269, Length=430, Percent_Identity=32.7906976744186, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=434, Percent_Identity=35.9447004608295, Blast_Score=214, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6323843, Length=405, Percent_Identity=32.0987654320988, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24645648, Length=432, Percent_Identity=36.1111111111111, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49512; Mature: 49381

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIPHTEEDVTEMLASIGATSIDELFDEIPAELKNGKLTQVPTGMSEMEISRLMYERAQ
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
KDGFYLSFIGAGAYEHHIPAAVWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASL
CCCEEEEEEECCCHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AGMDVSNASLYDGASALAEAALMAVRQHKSSRRILVPQTVHPIYRSVVRTIVRNQAIEVV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEE
EVPYDPATGQVSIDQLDQFAQEEFAALIIPQPNFFGVLEQVDTLADWAHDKQSLAIAVVN
ECCCCCCCCEEEHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
PTALAMLKPPGEWGRQGADIAVGEGQPLGIPLSSGGPYFGFMACKQELVRQMPGRIIGRT
CCEEEEECCCHHHCCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEECCC
TDLEGKEGFALTLQAREQHIRRSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAQSH
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHC
ANTLALVEQLETLPGVKKAFHSPFFHEAVLQLSVPADEVLNKLKAQGVLGGVLLENYYPD
CHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LKNTLLVCATETKIAEDLDKYTEMLRQILKA
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFIPHTEEDVTEMLASIGATSIDELFDEIPAELKNGKLTQVPTGMSEMEISRLMYERAQ
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
KDGFYLSFIGAGAYEHHIPAAVWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASL
CCCEEEEEEECCCHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AGMDVSNASLYDGASALAEAALMAVRQHKSSRRILVPQTVHPIYRSVVRTIVRNQAIEVV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEE
EVPYDPATGQVSIDQLDQFAQEEFAALIIPQPNFFGVLEQVDTLADWAHDKQSLAIAVVN
ECCCCCCCCEEEHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
PTALAMLKPPGEWGRQGADIAVGEGQPLGIPLSSGGPYFGFMACKQELVRQMPGRIIGRT
CCEEEEECCCHHHCCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEECCC
TDLEGKEGFALTLQAREQHIRRSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAQSH
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHC
ANTLALVEQLETLPGVKKAFHSPFFHEAVLQLSVPADEVLNKLKAQGVLGGVLLENYYPD
CHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LKNTLLVCATETKIAEDLDKYTEMLRQILKA
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]