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The map label for this gene is nodT [H]

Identifier: 114331918

GI number: 114331918

Start: 2056850

End: 2058331

Strand: Direct

Name: nodT [H]

Synonym: Neut_1945

Alternate gene names: 114331918

Gene position: 2056850-2058331 (Clockwise)

Preceding gene: 114331917

Following gene: 114331919

Centisome position: 77.29

GC content: 46.22

Gene sequence:

>1482_bases
GTGCGCTGGCACTTGATTTTTACTTTCAGATTACTGGTGCTATTTCTTACTGGTTGCGCTGCCGTTGGGCCAGATTATGT
GCCACCAGAAAAAATCACTCCCGAAAAATTTAATGCCGCACTGAGCGAAGATCAGAAAGCTAAATTATCGCTTCCTGAAA
CTGGGCAAGAAGCAGATGAGGCCAAAACGGAATTCACCAAACAAGTAACCCCTGCAATGTTGGTTGACTGGTGGAACACT
CTGGAAGATCCATTATTAACGCGCTTAATTGAATGGGCCATCAGGGGCAATCTTGATCTTCAGCTTGCGCAGTCACGACT
GAGAGAAGAACGCGCTTCGCGGGGAATTGCCAGATCAGGCCTGTTTCCAACCATAGAGGGAGATGCAGCATTTACGCGAA
GAAAAACCAATCTACAATCAGGTGGCATCAGTGAAATTGACCTCTATTCCTTGAGCTTTGATGCTAGTTGGGAAATTGAT
ATGTTTGGCGGCATCAGGCGCTCAATTGAATCGGCACAAGCCTCCGTTGAAGCACGTCAAGAAGAATTAAACGACACGCT
GGTGACTTTGGTGGCTGAAGTCGCTATCAATTATATTGAAATTCGTGCCTTTCAAGCCCGGCTTGAAGCGGCTGTTAACA
ACCTGGAATCTCAAGAAGGGACGTTACAAATTGTTCAGGATCGGTTAGATGCCGGCCTGACAACGACACTGTCACTAGAG
CAGGCGAAATATAATCTGGAAAATAGTAAATCAGAAATTCCAATGTTACAAACCGGTATCGAACAAGGTAAAAATGGTCT
TGCAGTGCTGCTTGGAGAGTTCCCTGGGTCATTGGCAGAAGAATTGGAGCAGTACCAAAAAGTCCCAACGGTGTCAGTTG
AAGTGGTTGTTGGCGTTCCCGCTGATTTGTTGCGTCGCAGGCCGGACGTCCGACGTGCGGAGCGCGAATTAGCAGCGCAA
ACGGCACGGGTTGGTGTGGCTACTGCAGACCTTTATCCAAGACTCTTCTTATTTGGTTCTGTAGGACTGGAATACATTTC
TGCTGCCAGCTTTTTTACAGGACCCGCAGCCGCCTTCCAAATTGGACCGCAAATCAGATGGCCAGTTTTTAATGCTGGTC
GTATCCGACAAAATATAAAAATAGAAGATGAGCGACAAAGTCAGGCGCTGATTCAATACGAGGCTTCGGTATTAACCGCA
GTTAAAGATGTAGAAAATGCTTTAATCGATTTTGCGAATGAACAAGTTCGCAGACAAGCTTTGATAAAATCCACACAATC
AGCAAAATCAGCAGTTAGCCTGTCGCGTGAATTGTACACTGCGGGCCTAACTGATTTTATTGGTGTGCTGGATGCAGAGA
GAGCCTTATTTTCCTTTCAAGATCAGCTGGCAGTGAGTGAAGGAAAGGTTACTTCCAATTTGATTCGTCTGTATAAATCA
TTGGGCGGCGGATGGAAACCACTGATGCAAGATGCACCGTAG

Upstream 100 bases:

>100_bases
GCGAGCGTAAACTCAATACCAACTTGCAACTCATTCATCTGGTATTCTTGGCTCTTTTGCTTAAAAGATTTTGAACAAAT
TCTAAAAGAAACTATTTATT

Downstream 100 bases:

>100_bases
GCAGTTCTAGGTCAACAGCAAACACAATTTGAGGAACGTTGACTTGAAAAAAGTAAAACTGCTTACTTCTCTTCTAGGTC
TTTCTTTGTTGGTCATTGTT

Product: RND efflux system, outer membrane lipoprotein, NodT family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MRWHLIFTFRLLVLFLTGCAAVGPDYVPPEKITPEKFNAALSEDQKAKLSLPETGQEADEAKTEFTKQVTPAMLVDWWNT
LEDPLLTRLIEWAIRGNLDLQLAQSRLREERASRGIARSGLFPTIEGDAAFTRRKTNLQSGGISEIDLYSLSFDASWEID
MFGGIRRSIESAQASVEARQEELNDTLVTLVAEVAINYIEIRAFQARLEAAVNNLESQEGTLQIVQDRLDAGLTTTLSLE
QAKYNLENSKSEIPMLQTGIEQGKNGLAVLLGEFPGSLAEELEQYQKVPTVSVEVVVGVPADLLRRRPDVRRAERELAAQ
TARVGVATADLYPRLFLFGSVGLEYISAASFFTGPAAAFQIGPQIRWPVFNAGRIRQNIKIEDERQSQALIQYEASVLTA
VKDVENALIDFANEQVRRQALIKSTQSAKSAVSLSRELYTAGLTDFIGVLDAERALFSFQDQLAVSEGKVTSNLIRLYKS
LGGGWKPLMQDAP

Sequences:

>Translated_493_residues
MRWHLIFTFRLLVLFLTGCAAVGPDYVPPEKITPEKFNAALSEDQKAKLSLPETGQEADEAKTEFTKQVTPAMLVDWWNT
LEDPLLTRLIEWAIRGNLDLQLAQSRLREERASRGIARSGLFPTIEGDAAFTRRKTNLQSGGISEIDLYSLSFDASWEID
MFGGIRRSIESAQASVEARQEELNDTLVTLVAEVAINYIEIRAFQARLEAAVNNLESQEGTLQIVQDRLDAGLTTTLSLE
QAKYNLENSKSEIPMLQTGIEQGKNGLAVLLGEFPGSLAEELEQYQKVPTVSVEVVVGVPADLLRRRPDVRRAERELAAQ
TARVGVATADLYPRLFLFGSVGLEYISAASFFTGPAAAFQIGPQIRWPVFNAGRIRQNIKIEDERQSQALIQYEASVLTA
VKDVENALIDFANEQVRRQALIKSTQSAKSAVSLSRELYTAGLTDFIGVLDAERALFSFQDQLAVSEGKVTSNLIRLYKS
LGGGWKPLMQDAP
>Mature_493_residues
MRWHLIFTFRLLVLFLTGCAAVGPDYVPPEKITPEKFNAALSEDQKAKLSLPETGQEADEAKTEFTKQVTPAMLVDWWNT
LEDPLLTRLIEWAIRGNLDLQLAQSRLREERASRGIARSGLFPTIEGDAAFTRRKTNLQSGGISEIDLYSLSFDASWEID
MFGGIRRSIESAQASVEARQEELNDTLVTLVAEVAINYIEIRAFQARLEAAVNNLESQEGTLQIVQDRLDAGLTTTLSLE
QAKYNLENSKSEIPMLQTGIEQGKNGLAVLLGEFPGSLAEELEQYQKVPTVSVEVVVGVPADLLRRRPDVRRAERELAAQ
TARVGVATADLYPRLFLFGSVGLEYISAASFFTGPAAAFQIGPQIRWPVFNAGRIRQNIKIEDERQSQALIQYEASVLTA
VKDVENALIDFANEQVRRQALIKSTQSAKSAVSLSRELYTAGLTDFIGVLDAERALFSFQDQLAVSEGKVTSNLIRLYKS
LGGGWKPLMQDAP

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=479, Percent_Identity=28.39248434238, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI2367348, Length=498, Percent_Identity=23.2931726907631, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54601; Mature: 54601

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWHLIFTFRLLVLFLTGCAAVGPDYVPPEKITPEKFNAALSEDQKAKLSLPETGQEADE
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
AKTEFTKQVTPAMLVDWWNTLEDPLLTRLIEWAIRGNLDLQLAQSRLREERASRGIARSG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCC
LFPTIEGDAAFTRRKTNLQSGGISEIDLYSLSFDASWEIDMFGGIRRSIESAQASVEARQ
CCCEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EELNDTLVTLVAEVAINYIEIRAFQARLEAAVNNLESQEGTLQIVQDRLDAGLTTTLSLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHH
QAKYNLENSKSEIPMLQTGIEQGKNGLAVLLGEFPGSLAEELEQYQKVPTVSVEVVVGVP
HHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCC
ADLLRRRPDVRRAERELAAQTARVGVATADLYPRLFLFGSVGLEYISAASFFTGPAAAFQ
HHHHHCCCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
IGPQIRWPVFNAGRIRQNIKIEDERQSQALIQYEASVLTAVKDVENALIDFANEQVRRQA
CCCCEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSTQSAKSAVSLSRELYTAGLTDFIGVLDAERALFSFQDQLAVSEGKVTSNLIRLYKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LGGGWKPLMQDAP
HCCCCCHHCCCCC
>Mature Secondary Structure
MRWHLIFTFRLLVLFLTGCAAVGPDYVPPEKITPEKFNAALSEDQKAKLSLPETGQEADE
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
AKTEFTKQVTPAMLVDWWNTLEDPLLTRLIEWAIRGNLDLQLAQSRLREERASRGIARSG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCC
LFPTIEGDAAFTRRKTNLQSGGISEIDLYSLSFDASWEIDMFGGIRRSIESAQASVEARQ
CCCEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EELNDTLVTLVAEVAINYIEIRAFQARLEAAVNNLESQEGTLQIVQDRLDAGLTTTLSLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHH
QAKYNLENSKSEIPMLQTGIEQGKNGLAVLLGEFPGSLAEELEQYQKVPTVSVEVVVGVP
HHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCC
ADLLRRRPDVRRAERELAAQTARVGVATADLYPRLFLFGSVGLEYISAASFFTGPAAAFQ
HHHHHCCCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
IGPQIRWPVFNAGRIRQNIKIEDERQSQALIQYEASVLTAVKDVENALIDFANEQVRRQA
CCCCEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSTQSAKSAVSLSRELYTAGLTDFIGVLDAERALFSFQDQLAVSEGKVTSNLIRLYKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LGGGWKPLMQDAP
HCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]