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The map label for this gene is macA [H]

Identifier: 114331908

GI number: 114331908

Start: 2047993

End: 2049144

Strand: Direct

Name: macA [H]

Synonym: Neut_1934

Alternate gene names: 114331908

Gene position: 2047993-2049144 (Clockwise)

Preceding gene: 114331907

Following gene: 114331909

Centisome position: 76.96

GC content: 53.21

Gene sequence:

>1152_bases
ATGAAATTCCCACACTTGCAGCGGCGCACGCTAGCATTGCTCGCAGTCATCACATTACTCCTGACGCTGTTTACATATAT
TGCCCTGCAATCCGGGCCACTGGCCCCCATTGTGGTCACTGTAACCACGGTGGAATCACGAAGTATCGTCCCTGCCCTGT
CCGGTATTGGAACGGTGCAGGCACGCTACACTTACAAGATCGGACCGATTTTGCCAGGGCGTGTTAAACATCTGAATGTA
GACGTGGGAGATGTAGTCAAGGCTGGACAGGTTTTGGGTGAGATGGATCCGGTTGATCTGAATGATCGTATCCATGCACA
GGAGGCCGCCATCAAAAGCGCCGAAGCTGATTTGCATCAGGCACAAGCCAGACAACACCATGCACAAGCGCAGCTCAAAC
GCTATGAAAAACTGTTACCCGCTCATGGCACCAGCGAGGAAAGTGTTGCCATCAAACGGGAAGAACTGGCAGTCACCAAA
GCAGCAACCGTGGCAGCACGCGAAAATCTTGGTCGTACACGTGCCAATTTGCAGGCACTGCACACACAACGCAACGATCT
CAAGCTGATAGCGCCTGTGACAGGTCTGGTAACCATACGTGCCGTAGATCCCGGTACTACGCTGGTGACAGGCCAGCCTG
CGGTTGAAATCATTGATACTGCACACTTGTGGATTGATACCCGCTTCGATCAGATCAACGCCGAAGGATTAACCCCGGGA
CTGCCCGCTCAATTCATACTGCGTTCGCAGCAAACTGGAAGCATTACGGGACAGGTACTGCGGGTTGAACCGCTGGCTGA
TACGGTCACAGAAGAAACACTGGCAAAGATCACCTTCGCCATGCCACCCTCGCAATTGCCGCCAGTGGGCGAATTGGCTG
AGGTGACGGTCTACCTGCCGAAACTGCCCATCACACCAACAATCCCCAATGCTGCCATTCGCAACGAGGATGGCGTACCA
GGTGTCTGGAAGCTGGTTGATGGTAAACCTGAGTTTACCCGGATAAAACTGGGACGCGCTGATCTCAATGGCCATGTCCA
GATCAAACACGGATTGGCGGCAGGCGATCAATTTATCGTCTACAGTGAAAAAACACTCACCGCTTTCAGCCGGGTCAGCA
TAGCAAAACGGATTCCCGGTGTATCGCCATGA

Upstream 100 bases:

>100_bases
GACTTGTCATACAATCCATGCTGGCGGGTGAAGTTGCACGAATCCGCCGTGATGCCCCGGGTGTTTTCGCCATCTATTGC
CGTGGCATCAGGAAGGCTCT

Downstream 100 bases:

>100_bases
TCAATCTGGCTGTACGCGATATTCTGCACAATTGGGGCAAGTTCATTTTTACCGGCATTGGCCTCGGCCTCCTCATCGGT
GTAACACTGACCATGGCAGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKFPHLQRRTLALLAVITLLLTLFTYIALQSGPLAPIVVTVTTVESRSIVPALSGIGTVQARYTYKIGPILPGRVKHLNV
DVGDVVKAGQVLGEMDPVDLNDRIHAQEAAIKSAEADLHQAQARQHHAQAQLKRYEKLLPAHGTSEESVAIKREELAVTK
AATVAARENLGRTRANLQALHTQRNDLKLIAPVTGLVTIRAVDPGTTLVTGQPAVEIIDTAHLWIDTRFDQINAEGLTPG
LPAQFILRSQQTGSITGQVLRVEPLADTVTEETLAKITFAMPPSQLPPVGELAEVTVYLPKLPITPTIPNAAIRNEDGVP
GVWKLVDGKPEFTRIKLGRADLNGHVQIKHGLAAGDQFIVYSEKTLTAFSRVSIAKRIPGVSP

Sequences:

>Translated_383_residues
MKFPHLQRRTLALLAVITLLLTLFTYIALQSGPLAPIVVTVTTVESRSIVPALSGIGTVQARYTYKIGPILPGRVKHLNV
DVGDVVKAGQVLGEMDPVDLNDRIHAQEAAIKSAEADLHQAQARQHHAQAQLKRYEKLLPAHGTSEESVAIKREELAVTK
AATVAARENLGRTRANLQALHTQRNDLKLIAPVTGLVTIRAVDPGTTLVTGQPAVEIIDTAHLWIDTRFDQINAEGLTPG
LPAQFILRSQQTGSITGQVLRVEPLADTVTEETLAKITFAMPPSQLPPVGELAEVTVYLPKLPITPTIPNAAIRNEDGVP
GVWKLVDGKPEFTRIKLGRADLNGHVQIKHGLAAGDQFIVYSEKTLTAFSRVSIAKRIPGVSP
>Mature_383_residues
MKFPHLQRRTLALLAVITLLLTLFTYIALQSGPLAPIVVTVTTVESRSIVPALSGIGTVQARYTYKIGPILPGRVKHLNV
DVGDVVKAGQVLGEMDPVDLNDRIHAQEAAIKSAEADLHQAQARQHHAQAQLKRYEKLLPAHGTSEESVAIKREELAVTK
AATVAARENLGRTRANLQALHTQRNDLKLIAPVTGLVTIRAVDPGTTLVTGQPAVEIIDTAHLWIDTRFDQINAEGLTPG
LPAQFILRSQQTGSITGQVLRVEPLADTVTEETLAKITFAMPPSQLPPVGELAEVTVYLPKLPITPTIPNAAIRNEDGVP
GVWKLVDGKPEFTRIKLGRADLNGHVQIKHGLAAGDQFIVYSEKTLTAFSRVSIAKRIPGVSP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=365, Percent_Identity=25.4794520547945, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082036, Length=183, Percent_Identity=27.8688524590164, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41375; Mature: 41375

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPHLQRRTLALLAVITLLLTLFTYIALQSGPLAPIVVTVTTVESRSIVPALSGIGTVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHCCCEEE
ARYTYKIGPILPGRVKHLNVDVGDVVKAGQVLGEMDPVDLNDRIHAQEAAIKSAEADLHQ
EEEEEEECCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AQARQHHAQAQLKRYEKLLPAHGTSEESVAIKREELAVTKAATVAARENLGRTRANLQAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HTQRNDLKLIAPVTGLVTIRAVDPGTTLVTGQPAVEIIDTAHLWIDTRFDQINAEGLTPG
HCCCCCEEEEEEEEEEEEEEEECCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCC
LPAQFILRSQQTGSITGQVLRVEPLADTVTEETLAKITFAMPPSQLPPVGELAEVTVYLP
CCHHHHEECCCCCCCCEEEEEEECCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEC
KLPITPTIPNAAIRNEDGVPGVWKLVDGKPEFTRIKLGRADLNGHVQIKHGLAAGDQFIV
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCCEEEE
YSEKTLTAFSRVSIAKRIPGVSP
EECHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKFPHLQRRTLALLAVITLLLTLFTYIALQSGPLAPIVVTVTTVESRSIVPALSGIGTVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHCCCEEE
ARYTYKIGPILPGRVKHLNVDVGDVVKAGQVLGEMDPVDLNDRIHAQEAAIKSAEADLHQ
EEEEEEECCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AQARQHHAQAQLKRYEKLLPAHGTSEESVAIKREELAVTKAATVAARENLGRTRANLQAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HTQRNDLKLIAPVTGLVTIRAVDPGTTLVTGQPAVEIIDTAHLWIDTRFDQINAEGLTPG
HCCCCCEEEEEEEEEEEEEEEECCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCC
LPAQFILRSQQTGSITGQVLRVEPLADTVTEETLAKITFAMPPSQLPPVGELAEVTVYLP
CCHHHHEECCCCCCCCEEEEEEECCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEC
KLPITPTIPNAAIRNEDGVPGVWKLVDGKPEFTRIKLGRADLNGHVQIKHGLAAGDQFIV
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCCEEEE
YSEKTLTAFSRVSIAKRIPGVSP
EECHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]