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The map label for this gene is accC [H]

Identifier: 114331874

GI number: 114331874

Start: 2014594

End: 2015952

Strand: Reverse

Name: accC [H]

Synonym: Neut_1899

Alternate gene names: 114331874

Gene position: 2015952-2014594 (Counterclockwise)

Preceding gene: 114331875

Following gene: 114331873

Centisome position: 75.76

GC content: 48.42

Gene sequence:

>1359_bases
ATGTTTGAAAAAATATTAATCGCAAATCGTGGAGAAATAGCATTGCGCGTCCAGCGAGCGTGCCGGACTATGGGTATCAA
GACCGTAGCGGTTCATTCGGAAGCGGATGCCGAAGCAAAATATGTCAAGCTGGCCGATGAATCAGTCTGTATCGGCCCGG
CAGCTTCTGCGCAAAGTTACTTGAATATCCCCGCTATCATTAGTGCTGCTGAAGTAACGGATGCGGAAGCCATTCATCCG
GGTTACGGTTTTTTATCCGAGAATGCGGATTTTGCAGAGAGGGTGGAAAAGAGCGGTTTTTTCTTTATCGGCCCCCGACC
GGATACAATCCGGTTGATGGGAGATAAGGTCTCTGCAAAACACGCGATGCTGCAGGCAGGTGTTCCCTGTGTACCAGGCT
CAGAGGGTGCGTTGCCGGATTCACTTGATGAAGTAAGGAAAATTATCAAGGAGATCGGTTACCCAGTCATTATCAAGGCA
GCCGGAGGAGGTGGGGGGCGCGGGATGCGCGTCGTGTACACTGAAGCGGCGCTCTCGAATGCGGTGATTACAACGCGTAA
TGAAGCGCAGGCGGCATTTGGTAACCCGGTGGTTTACGCAGAAAAATACCTGGAAAATCCGCGTCATATTGAATTCCAGA
TACTGGCTGACGAATACGGCAATACCGTTCATCTGGGGGAGAGGGATTGCTCCATGCAGCGCCGTCACCAGAAGATTATT
GAAGAGGCGCCGGCGCGAGGTATTTCGATCAAGTTGCGCAATCAAATTGGTGAGCGATGTGTCGAGGCTTGCAAGCGTAT
TAATTACAGAGGGGTAGGAACTTTCGAGTTTCTTTATGAGAACAATGAATTTTATTTCATTGAAATGAATACCCGGCTTC
AGGTTGAGCATCCGGTGACAGAAGCCGTTACTGGTATTGACCTGGTTCAAGCACAGATTCGTGTGGCGGCAGGGGAAAAA
CTGTCAGTGCAGCAAAAAGATATTGTGACCAGAGGACATGCCATAGAATGCCGCATCAATGCGGAAGATCCCTATAAGCT
GACTCCCTCAGCCGGACGTATTACACAGTACCATGCTCCAGGCGGTCCCGGGATCCGAGTCGATTCCCATATTTACCATA
ATTATCGCGTGCCACCTTACTATGATTCCATGATCGCCAAGGTAATTGCCTATGGTGACAATCGTGATCTCGCTATTGCG
CGTATGCGTATTGCGCTTACCGAAATGATCATTGAAGGAATCAAAACCAATATTCCGTTACATCTGGATCTTTTGGCGGA
CTGTAACTTTGTATCCGATTCTGTCTCTATTCACTATCTTGAAAACAAGCTTGCACTGTATAACAAAAAAACGACTTGA

Upstream 100 bases:

>100_bases
ATGGCGAGCCGTTATTTATTATCGAATAATAATCTTTCGAGAAATAATGCTCTGAATTTTCAGGAATCTATCCGGATCTG
GTTTTCATCGTTTAATTTAT

Downstream 100 bases:

>100_bases
TGTGATCGTGATAAAACCTGTTACACAGATCAGCTATGTCCTGGCTCTCTCTGACTTTTAAAGTTGGGTCCGATTACGTT
GATTCGGTAAGTGATCAGTT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFEKILIANRGEIALRVQRACRTMGIKTVAVHSEADAEAKYVKLADESVCIGPAASAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFFFIGPRPDTIRLMGDKVSAKHAMLQAGVPCVPGSEGALPDSLDEVRKIIKEIGYPVIIKA
AGGGGGRGMRVVYTEAALSNAVITTRNEAQAAFGNPVVYAEKYLENPRHIEFQILADEYGNTVHLGERDCSMQRRHQKII
EEAPARGISIKLRNQIGERCVEACKRINYRGVGTFEFLYENNEFYFIEMNTRLQVEHPVTEAVTGIDLVQAQIRVAAGEK
LSVQQKDIVTRGHAIECRINAEDPYKLTPSAGRITQYHAPGGPGIRVDSHIYHNYRVPPYYDSMIAKVIAYGDNRDLAIA
RMRIALTEMIIEGIKTNIPLHLDLLADCNFVSDSVSIHYLENKLALYNKKTT

Sequences:

>Translated_452_residues
MFEKILIANRGEIALRVQRACRTMGIKTVAVHSEADAEAKYVKLADESVCIGPAASAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFFFIGPRPDTIRLMGDKVSAKHAMLQAGVPCVPGSEGALPDSLDEVRKIIKEIGYPVIIKA
AGGGGGRGMRVVYTEAALSNAVITTRNEAQAAFGNPVVYAEKYLENPRHIEFQILADEYGNTVHLGERDCSMQRRHQKII
EEAPARGISIKLRNQIGERCVEACKRINYRGVGTFEFLYENNEFYFIEMNTRLQVEHPVTEAVTGIDLVQAQIRVAAGEK
LSVQQKDIVTRGHAIECRINAEDPYKLTPSAGRITQYHAPGGPGIRVDSHIYHNYRVPPYYDSMIAKVIAYGDNRDLAIA
RMRIALTEMIIEGIKTNIPLHLDLLADCNFVSDSVSIHYLENKLALYNKKTT
>Mature_452_residues
MFEKILIANRGEIALRVQRACRTMGIKTVAVHSEADAEAKYVKLADESVCIGPAASAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFFFIGPRPDTIRLMGDKVSAKHAMLQAGVPCVPGSEGALPDSLDEVRKIIKEIGYPVIIKA
AGGGGGRGMRVVYTEAALSNAVITTRNEAQAAFGNPVVYAEKYLENPRHIEFQILADEYGNTVHLGERDCSMQRRHQKII
EEAPARGISIKLRNQIGERCVEACKRINYRGVGTFEFLYENNEFYFIEMNTRLQVEHPVTEAVTGIDLVQAQIRVAAGEK
LSVQQKDIVTRGHAIECRINAEDPYKLTPSAGRITQYHAPGGPGIRVDSHIYHNYRVPPYYDSMIAKVIAYGDNRDLAIA
RMRIALTEMIIEGIKTNIPLHLDLLADCNFVSDSVSIHYLENKLALYNKKTT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=48.314606741573, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.314606741573, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.314606741573, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=46.9387755102041, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=453, Percent_Identity=45.2538631346578, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=453, Percent_Identity=45.2538631346578, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=453, Percent_Identity=45.2538631346578, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=30.9941520467836, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=30.9941520467836, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=30.9941520467836, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=30.9941520467836, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=30.9941520467836, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=29.9610894941634, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=67.260579064588, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1786216, Length=253, Percent_Identity=25.6916996047431, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.1783295711061, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=48.6425339366516, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=458, Percent_Identity=44.3231441048035, Blast_Score=357, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=28.6298568507157, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=27.431906614786, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=27.431906614786, Blast_Score=191, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6319695, Length=454, Percent_Identity=44.0528634361233, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=41.123595505618, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=454, Percent_Identity=44.9339207048458, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=508, Percent_Identity=30.3149606299213, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=31.25, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=45.7399103139013, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=455, Percent_Identity=46.5934065934066, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=44.7432762836186, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=29.9009900990099, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=29.9009900990099, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=29.9009900990099, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=29.9009900990099, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49952; Mature: 49952

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRVQRACRTMGIKTVAVHSEADAEAKYVKLADESVCIGPAASAQSY
CCCEEEEECCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFFFIGPRPDTIRLMGDKVSAK
CCCCHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCHHHH
HAMLQAGVPCVPGSEGALPDSLDEVRKIIKEIGYPVIIKAAGGGGGRGMRVVYTEAALSN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEHHHCC
AVITTRNEAQAAFGNPVVYAEKYLENPRHIEFQILADEYGNTVHLGERDCSMQRRHQKII
CEEEECCCCHHHCCCCEEEEHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPARGISIKLRNQIGERCVEACKRINYRGVGTFEFLYENNEFYFIEMNTRLQVEHPVT
HHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEECCEEEECCCHH
EAVTGIDLVQAQIRVAAGEKLSVQQKDIVTRGHAIECRINAEDPYKLTPSAGRITQYHAP
HHHHHHHHHHHEEEEECCCCCCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEECC
GGPGIRVDSHIYHNYRVPPYYDSMIAKVIAYGDNRDLAIARMRIALTEMIIEGIKTNIPL
CCCCEEECCEEEECCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCE
HLDLLADCNFVSDSVSIHYLENKLALYNKKTT
EEEEEECCCCCCCCEEEEEEECEEEEEECCCC
>Mature Secondary Structure
MFEKILIANRGEIALRVQRACRTMGIKTVAVHSEADAEAKYVKLADESVCIGPAASAQSY
CCCEEEEECCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFFFIGPRPDTIRLMGDKVSAK
CCCCHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCHHHH
HAMLQAGVPCVPGSEGALPDSLDEVRKIIKEIGYPVIIKAAGGGGGRGMRVVYTEAALSN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEHHHCC
AVITTRNEAQAAFGNPVVYAEKYLENPRHIEFQILADEYGNTVHLGERDCSMQRRHQKII
CEEEECCCCHHHCCCCEEEEHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPARGISIKLRNQIGERCVEACKRINYRGVGTFEFLYENNEFYFIEMNTRLQVEHPVT
HHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEECCEEEECCCHH
EAVTGIDLVQAQIRVAAGEKLSVQQKDIVTRGHAIECRINAEDPYKLTPSAGRITQYHAP
HHHHHHHHHHHEEEEECCCCCCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEECC
GGPGIRVDSHIYHNYRVPPYYDSMIAKVIAYGDNRDLAIARMRIALTEMIIEGIKTNIPL
CCCCEEECCEEEECCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCE
HLDLLADCNFVSDSVSIHYLENKLALYNKKTT
EEEEEECCCCCCCCEEEEEEECEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]