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The map label for this gene is csgA [H]

Identifier: 114331869

GI number: 114331869

Start: 2010288

End: 2010986

Strand: Direct

Name: csgA [H]

Synonym: Neut_1894

Alternate gene names: 114331869

Gene position: 2010288-2010986 (Clockwise)

Preceding gene: 114331865

Following gene: 114331870

Centisome position: 75.54

GC content: 49.07

Gene sequence:

>699_bases
ATGAATACTGTTTTGATTACCGGCGCCAATCGGGGAATCGGATTGGAATTTGCCACACAATATGCGGCAGACGGGTGGCA
GGTAGTCGCCTGCTGCCGGCAACCGCAACAGGCCATGGCGCTCAATCAGCTGGCTGAGCAGTACAAAGATCATTTTTCCA
TTTACCAGCTTGATGTACGTGAGCTTGCCGAAATAGATCAGTTGTCACAAAAGCTGCATGATTTGTCCATTGATGTGCTG
ATTAATAACGCAGGCGTTTATCCACCTGCACAAAATGGGGAGTTTGGTCATATCAACTATGATGACTGGATGGAGGCCTT
CAGGGTCAATACATTCGCCCCCCTCAGAATGGCAGAAGCCCTGGTGAAACAGGTTGCTCGCAGCAAATTGAAAGTTATCG
CCACCATCACCAGCAAAATGGCCAGTATCGACGATAACCAGCGTGGCGGCAGTTATATTTACCGATCCAGCAAAACTGCC
GTAAACATGGTGGTAAAAAGTCTTGCCATTGATCTGCAGCCTCGCGGTATTATTTCAGTGCTGCTACATCCAGGCTGGGT
ACAGACTGATATGGGTGGACGTGGCGCGTTAATCACAGCAAAGCAGAGTGTGACCGGCATGAAAGGCATCCTGGATAAAA
TCACCCATACGGATACAGGCAAATTTCTTGCCTACGATGGACAGCACATCCCTTGGTAG

Upstream 100 bases:

>100_bases
CCTGCCTAGATCAGGTAATGCGGATGCAATAATCTGTCATTTTTTCATCTCAATGCTCCCGGAAAATGCCGATTATTTTG
ACCATGTACAGGAGTTTTCC

Downstream 100 bases:

>100_bases
TCTTTTTTACCTGCCTTTCAAGCAACAAACTTTCACTGGTAACCAAATGCGCTCATCTTATGTTGTGCAACTCGACGATG
AAGCAGCAACTTTGTTCCTG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNTVLITGANRGIGLEFATQYAADGWQVVACCRQPQQAMALNQLAEQYKDHFSIYQLDVRELAEIDQLSQKLHDLSIDVL
INNAGVYPPAQNGEFGHINYDDWMEAFRVNTFAPLRMAEALVKQVARSKLKVIATITSKMASIDDNQRGGSYIYRSSKTA
VNMVVKSLAIDLQPRGIISVLLHPGWVQTDMGGRGALITAKQSVTGMKGILDKITHTDTGKFLAYDGQHIPW

Sequences:

>Translated_232_residues
MNTVLITGANRGIGLEFATQYAADGWQVVACCRQPQQAMALNQLAEQYKDHFSIYQLDVRELAEIDQLSQKLHDLSIDVL
INNAGVYPPAQNGEFGHINYDDWMEAFRVNTFAPLRMAEALVKQVARSKLKVIATITSKMASIDDNQRGGSYIYRSSKTA
VNMVVKSLAIDLQPRGIISVLLHPGWVQTDMGGRGALITAKQSVTGMKGILDKITHTDTGKFLAYDGQHIPW
>Mature_232_residues
MNTVLITGANRGIGLEFATQYAADGWQVVACCRQPQQAMALNQLAEQYKDHFSIYQLDVRELAEIDQLSQKLHDLSIDVL
INNAGVYPPAQNGEFGHINYDDWMEAFRVNTFAPLRMAEALVKQVARSKLKVIATITSKMASIDDNQRGGSYIYRSSKTA
VNMVVKSLAIDLQPRGIISVLLHPGWVQTDMGGRGALITAKQSVTGMKGILDKITHTDTGKFLAYDGQHIPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=206, Percent_Identity=28.1553398058252, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI7657478, Length=198, Percent_Identity=31.3131313131313, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=190, Percent_Identity=27.3684210526316, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=242, Percent_Identity=31.404958677686, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193207563, Length=242, Percent_Identity=29.3388429752066, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558990, Length=253, Percent_Identity=29.2490118577075, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17558992, Length=243, Percent_Identity=30.0411522633745, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559964, Length=248, Percent_Identity=29.8387096774194, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI72001658, Length=211, Percent_Identity=32.7014218009479, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559962, Length=209, Percent_Identity=31.5789473684211, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558996, Length=253, Percent_Identity=28.0632411067194, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532177, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17541382, Length=255, Percent_Identity=28.6274509803922, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17542178, Length=238, Percent_Identity=27.7310924369748, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=194, Percent_Identity=29.8969072164948, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322067, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24643142, Length=189, Percent_Identity=32.2751322751323, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25667; Mature: 25667

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVLITGANRGIGLEFATQYAADGWQVVACCRQPQQAMALNQLAEQYKDHFSIYQLDVR
CCEEEEECCCCCCCHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHEEEEECHH
ELAEIDQLSQKLHDLSIDVLINNAGVYPPAQNGEFGHINYDDWMEAFRVNTFAPLRMAEA
HHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
LVKQVARSKLKVIATITSKMASIDDNQRGGSYIYRSSKTAVNMVVKSLAIDLQPRGIISV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEE
LLHPGWVQTDMGGRGALITAKQSVTGMKGILDKITHTDTGKFLAYDGQHIPW
EECCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MNTVLITGANRGIGLEFATQYAADGWQVVACCRQPQQAMALNQLAEQYKDHFSIYQLDVR
CCEEEEECCCCCCCHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHEEEEECHH
ELAEIDQLSQKLHDLSIDVLINNAGVYPPAQNGEFGHINYDDWMEAFRVNTFAPLRMAEA
HHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
LVKQVARSKLKVIATITSKMASIDDNQRGGSYIYRSSKTAVNMVVKSLAIDLQPRGIISV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEE
LLHPGWVQTDMGGRGALITAKQSVTGMKGILDKITHTDTGKFLAYDGQHIPW
EECCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]