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The map label for this gene is copA [H]

Identifier: 114331847

GI number: 114331847

Start: 1984980

End: 1986689

Strand: Direct

Name: copA [H]

Synonym: Neut_1872

Alternate gene names: 114331847

Gene position: 1984980-1986689 (Clockwise)

Preceding gene: 114331840

Following gene: 114331848

Centisome position: 74.59

GC content: 46.02

Gene sequence:

>1710_bases
ATGTCTAATTTTATTCGCACTATCATAATAATTGTTTATCTGGTGTGTGCCTCTGGCGGTGCCTATGCATCCTTAAAATT
ACCTGAAACAATCCGAGTTGAGCCCACCGCACTCACATCTGAACCGCCTTGTGATCTCAAAATTCCACCAGCCTGGCGTG
ATGCGCAAGTTATTGAAGGCGTGGAAATTGACGCAGATCCAGGTTGCAGCCCGGATAATCCTGCCTGGATTGCCGTTGCT
GTTAAAGGAACCAATAACGTTTCCATGGATACGCTCATGCAGACGCACTTTTCTCCAGACGCCATCATCAAGACAGATGA
TCTGGATGGAGACGGTGATCCTGATCGTATCGTTATCAAGTTGGAAATCATGGAATTAAATGGAAAATCCCCTGATTTTC
CCGGCCAGGTTCCCACCTTTGATATCGCTCCTGGCGTACAACCCGGTGCCTGGGTTTTTGCCCCAAAAACCAGCGGCATG
TCAACTGAAAATTTTGAAAGTGTGCGAGCCACTCCGCTGATTAGATTGCCATCGCCGGTAATCCGGGTTGAGCAGGGAGA
TATCGTACAGATCGTGCTGGAAAATACGCATTATTTTCCGCACAGTATCCATTTACATGGCGTGGATCACCCTTTCCATT
ATGAGTTTAATGGTAACGATGGCGTACCTCAAACCAGTGAAATGGAGCTGATGCCTGGTGAACGCCGTATTTATCAATTC
CAGGCACGTGAAACCGGCACCATGTTTTATCACTGTCACGTCCAAACACATACTCATTTGTCGATGGGCCTGGCGGGAAT
AATCGTTGTTGAAGAAAACCGGCCCAATAACTGGCTGCAAACATTGAATATTGGCGGTGGCCACGTACGGCACCGATCAG
TTGCGATCAAGGAGGATTTTGATCGGGAATATGACTTGCACTACCATTCAATGGACAAGGAACTGGGTGACATTATTAAG
GAATACAACGACCCACGTTTGACTGCGCGCGACATGAACCGACGCTACCAAATCAATAATGCTACCGAAGATTATTTTAC
AATTAATGGATTATCATTTCCTTATTCACTCAGAGAATCACTGATCATAGTTGATCCAGACGAGAAAATTAAATTACGTT
TACTCAACAGTGGCAGTGAATCAATCGCGATTCACACACATGGGCATCATGCCATGATTACGCACTATGACGGAGTGGAG
CATAATCCTATAGCACAAATCATGCGTGACGTGTTTGATCTAGCCCCGGCGCAACGTCTGGATCTGAAACTGGAAACCAT
CAATGACGGCAGACACAGTTATGGTGAAGGTGACTGGCTGATCCATGATCACCGTGAAAAAGGAATTACGACAAACGGTA
TGGCTGAAGGTGGCAGCATGAGTTCCATTGTGTACACTTCGTATCTTGGTGAAAACGGCTTGCCGGATACGAGTCACTTT
GGTGTTAATCTCGACCATTTTTTCACCAAGGAATATTGGGAAAGAAAGGTTCCCGTTTGGCAAGACCTGGATGAAGCCGC
TACTTTTGGAGCTGCCGCAGGCAGAACAATCAATCTTGACACCGCAACTCGTAACATTTTGCTCTATGCTTTAGGAGGAT
TGTTGGCTGGATTGCTCCTGTATTCGATCTTTGTCGGACGTAGTCATATCAAGCAATATGCTGCAGCATTAATTTCACGA
ATCAGAGGCGAAAAAGGGGGTAAAGCGTAA

Upstream 100 bases:

>100_bases
AGAAATCGCCATAAGCTTGCGTAAAACTGAAAAAATTACCGTACGGTTCAAGCAAGAGCGCTCTTTTGTTAAACTCCATA
AAGGATAAATTGAGAGAGAC

Downstream 100 bases:

>100_bases
TGAAAGCAAGATTCACGATCATTTTTCTGCTGGCTGCCACTTTGCCATTCTGTTTCAATGCTATGGCGCAACAGCAGGCC
ACACCCGATGAACACGATCA

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSNFIRTIIIIVYLVCASGGAYASLKLPETIRVEPTALTSEPPCDLKIPPAWRDAQVIEGVEIDADPGCSPDNPAWIAVA
VKGTNNVSMDTLMQTHFSPDAIIKTDDLDGDGDPDRIVIKLEIMELNGKSPDFPGQVPTFDIAPGVQPGAWVFAPKTSGM
STENFESVRATPLIRLPSPVIRVEQGDIVQIVLENTHYFPHSIHLHGVDHPFHYEFNGNDGVPQTSEMELMPGERRIYQF
QARETGTMFYHCHVQTHTHLSMGLAGIIVVEENRPNNWLQTLNIGGGHVRHRSVAIKEDFDREYDLHYHSMDKELGDIIK
EYNDPRLTARDMNRRYQINNATEDYFTINGLSFPYSLRESLIIVDPDEKIKLRLLNSGSESIAIHTHGHHAMITHYDGVE
HNPIAQIMRDVFDLAPAQRLDLKLETINDGRHSYGEGDWLIHDHREKGITTNGMAEGGSMSSIVYTSYLGENGLPDTSHF
GVNLDHFFTKEYWERKVPVWQDLDEAATFGAAAGRTINLDTATRNILLYALGGLLAGLLLYSIFVGRSHIKQYAAALISR
IRGEKGGKA

Sequences:

>Translated_569_residues
MSNFIRTIIIIVYLVCASGGAYASLKLPETIRVEPTALTSEPPCDLKIPPAWRDAQVIEGVEIDADPGCSPDNPAWIAVA
VKGTNNVSMDTLMQTHFSPDAIIKTDDLDGDGDPDRIVIKLEIMELNGKSPDFPGQVPTFDIAPGVQPGAWVFAPKTSGM
STENFESVRATPLIRLPSPVIRVEQGDIVQIVLENTHYFPHSIHLHGVDHPFHYEFNGNDGVPQTSEMELMPGERRIYQF
QARETGTMFYHCHVQTHTHLSMGLAGIIVVEENRPNNWLQTLNIGGGHVRHRSVAIKEDFDREYDLHYHSMDKELGDIIK
EYNDPRLTARDMNRRYQINNATEDYFTINGLSFPYSLRESLIIVDPDEKIKLRLLNSGSESIAIHTHGHHAMITHYDGVE
HNPIAQIMRDVFDLAPAQRLDLKLETINDGRHSYGEGDWLIHDHREKGITTNGMAEGGSMSSIVYTSYLGENGLPDTSHF
GVNLDHFFTKEYWERKVPVWQDLDEAATFGAAAGRTINLDTATRNILLYALGGLLAGLLLYSIFVGRSHIKQYAAALISR
IRGEKGGKA
>Mature_568_residues
SNFIRTIIIIVYLVCASGGAYASLKLPETIRVEPTALTSEPPCDLKIPPAWRDAQVIEGVEIDADPGCSPDNPAWIAVAV
KGTNNVSMDTLMQTHFSPDAIIKTDDLDGDGDPDRIVIKLEIMELNGKSPDFPGQVPTFDIAPGVQPGAWVFAPKTSGMS
TENFESVRATPLIRLPSPVIRVEQGDIVQIVLENTHYFPHSIHLHGVDHPFHYEFNGNDGVPQTSEMELMPGERRIYQFQ
ARETGTMFYHCHVQTHTHLSMGLAGIIVVEENRPNNWLQTLNIGGGHVRHRSVAIKEDFDREYDLHYHSMDKELGDIIKE
YNDPRLTARDMNRRYQINNATEDYFTINGLSFPYSLRESLIIVDPDEKIKLRLLNSGSESIAIHTHGHHAMITHYDGVEH
NPIAQIMRDVFDLAPAQRLDLKLETINDGRHSYGEGDWLIHDHREKGITTNGMAEGGSMSSIVYTSYLGENGLPDTSHFG
VNLDHFFTKEYWERKVPVWQDLDEAATFGAAAGRTINLDTATRNILLYALGGLLAGLLLYSIFVGRSHIKQYAAALISRI
RGEKGGKA

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 63526; Mature: 63394

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFIRTIIIIVYLVCASGGAYASLKLPETIRVEPTALTSEPPCDLKIPPAWRDAQVIEG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCCCEECCCCCCCCHHHCC
VEIDADPGCSPDNPAWIAVAVKGTNNVSMDTLMQTHFSPDAIIKTDDLDGDGDPDRIVIK
EEECCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEE
LEIMELNGKSPDFPGQVPTFDIAPGVQPGAWVFAPKTSGMSTENFESVRATPLIRLPSPV
EEEEEECCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCHHCCCEEEECCCCE
IRVEQGDIVQIVLENTHYFPHSIHLHGVDHPFHYEFNGNDGVPQTSEMELMPGERRIYQF
EEECCCCEEEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCEEECCCCCEEEEE
QARETGTMFYHCHVQTHTHLSMGLAGIIVVEENRPNNWLQTLNIGGGHVRHRSVAIKEDF
ECCCCCEEEEEEEEEECCEEECCEEEEEEEECCCCCCCEEEEECCCCEEEEEEEEEHHCC
DREYDLHYHSMDKELGDIIKEYNDPRLTARDMNRRYQINNATEDYFTINGLSFPYSLRES
CCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCCCCCEEEEECCCCCHHHCCC
LIIVDPDEKIKLRLLNSGSESIAIHTHGHHAMITHYDGVEHNPIAQIMRDVFDLAPAQRL
EEEECCCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHH
DLKLETINDGRHSYGEGDWLIHDHREKGITTNGMAEGGSMSSIVYTSYLGENGLPDTSHF
EEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
GVNLDHFFTKEYWERKVPVWQDLDEAATFGAAAGRTINLDTATRNILLYALGGLLAGLLL
CCCHHHHHHHHHHHCCCCCHHCHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
YSIFVGRSHIKQYAAALISRIRGEKGGKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNFIRTIIIIVYLVCASGGAYASLKLPETIRVEPTALTSEPPCDLKIPPAWRDAQVIEG
CHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCCCEECCCCCCCCHHHCC
VEIDADPGCSPDNPAWIAVAVKGTNNVSMDTLMQTHFSPDAIIKTDDLDGDGDPDRIVIK
EEECCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEE
LEIMELNGKSPDFPGQVPTFDIAPGVQPGAWVFAPKTSGMSTENFESVRATPLIRLPSPV
EEEEEECCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCHHCCCEEEECCCCE
IRVEQGDIVQIVLENTHYFPHSIHLHGVDHPFHYEFNGNDGVPQTSEMELMPGERRIYQF
EEECCCCEEEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCEEECCCCCEEEEE
QARETGTMFYHCHVQTHTHLSMGLAGIIVVEENRPNNWLQTLNIGGGHVRHRSVAIKEDF
ECCCCCEEEEEEEEEECCEEECCEEEEEEEECCCCCCCEEEEECCCCEEEEEEEEEHHCC
DREYDLHYHSMDKELGDIIKEYNDPRLTARDMNRRYQINNATEDYFTINGLSFPYSLRES
CCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCCCCCEEEEECCCCCHHHCCC
LIIVDPDEKIKLRLLNSGSESIAIHTHGHHAMITHYDGVEHNPIAQIMRDVFDLAPAQRL
EEEECCCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHH
DLKLETINDGRHSYGEGDWLIHDHREKGITTNGMAEGGSMSSIVYTSYLGENGLPDTSHF
EEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
GVNLDHFFTKEYWERKVPVWQDLDEAATFGAAAGRTINLDTATRNILLYALGGLLAGLLL
CCCHHHHHHHHHHHCCCCCHHCHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
YSIFVGRSHIKQYAAALISRIRGEKGGKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]