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The map label for this gene is aprX [H]

Identifier: 114331839

GI number: 114331839

Start: 1974247

End: 1976646

Strand: Reverse

Name: aprX [H]

Synonym: Neut_1864

Alternate gene names: 114331839

Gene position: 1976646-1974247 (Counterclockwise)

Preceding gene: 114331841

Following gene: 114331837

Centisome position: 74.28

GC content: 52.96

Gene sequence:

>2400_bases
ATGGCCACAGAAAAACGAGGTTCCCGTTCCAATAGTAAAACAGGCGGTAGTAAATCATCCAGCCCCTTCATGGTACTTTT
TCGCTCTGGGGCCAACTTAACCGTAGAGTTTCCGTCAATATTGAACAAGGAAGGTAGCTCACCGGAAATCGGTACGGTGG
TCTATATCCATGGTATTGACAACAAACCGATAGCATCAGTCCTGAAGTGCCAATGGGATACGGCCTTGTTTGGCGCACCA
ATGGGAGATCGCACTCGCATGGCGTATTGGGTGGATCGTAATCGTTATCCTGAACCTGAAAAAGGTAGTTGTGCCGACAA
AGACACGCTCTCGGGGAGTGTGGACAGAATGAGCGCACAAGCTCTGCAGGAACTTGGTCTGGAGCCGGAAACCAAGCTGA
GCTCTGCTGAGCGCAAGATCATGACAGCCTTGGAAGAGCGGTTGCGCAAAGGGGAAAAACAACCCGGCGGAGTTGATGTG
AAGGTGCTGCCGTTACCGGAAAGTGTACGGTTGTGGATCACCCGGCGTATTACCAAATTATTTCTCAAGGATGTACAGGA
TTTCTTTTTTGATGAGCACAAGCGCGGCCTGATGGAACAATCGTTACGCGATCGTCTGGACGTGGGCGGCGGCCCCTTTA
TTGTGATCGGCCACAGCCAGGGTTCAATGATCGCCTACCATGTATTGCGCCAGTTGAAGAAGGCTGACTGTGATGTGCGC
CTGTTCATCACTATTGGCTCGCCGCTGGGCATTCAGGAAGTGCAGGATGTGCTGGGCAAAATCGACCCCGGCAAGCCGCT
TGCGGTACCGGAATGTGTTGATCACTGGCTGAATGTTGCCGAGCGTCTTGATCCGGTCGCACTCGATTCACATCTGGAAA
ACGATTATCAGCCCAACAGTCGTGACGTGAAAGTTGAAAATCACGCCGGACTGATGATTAACCCGGACTGGGAATCCAAT
CCGCATTCGGGTACAGGCTATCTGTCGCTTGATATCGTTCGCCAGACTGTTCGCCAGACCGCCGGGCCCACCTTTAGTAA
CCCGGTGGGCCGCAATATTCTGATGAAAGATCTGGTTGACGATATCGAAGATAGTCATCGCGAACAAAGACACCCAACGC
TGATTCAGCTGGTTTCGGATGATAGCAATGGCACGCCGCTGGACGAGGTACGTAGCCGCCTTGAAACCCTGATCAATGAA
GTGCTGGAGTTCAATGGTGCCAAACGTGAAGATGGCCGCATCCAGCTCATGCAGCGCTTTATTTCGGCTGATTTGACTCG
CAGCGAAATCGAGCAATTGCGTTCACACTGCGGCACACTGAAAATTGACCGCGTCTGGCGCAATGCTGTCAAACGTGCAC
TGCTTTATCAGTCGGTACACACCATTCAGGTACGCCCGGCTAATCTCGGTTATAGTGCTTGTGGCCGGAATATCGCCTGG
GCGGTGCTCGATACCGGAATCGCTGCCAACCACCCGCATTTCAAGGCACACAGCAACGTCATTGCACAGTGGGATTGCAC
AGGCAGTGGCAGTCCCAGGCAACTGAAACCAGGAGATAGCGGTTTTGGCACGCTGGATGGCAATGGCCATGGTACCCACG
TCGCTGCAATCATCGCCGGTGGATTGACACTGCCGCGTGACGCAAAAGACCCGACCTCCATAGATCAGCAGGGCATGGCA
CCCGAGGCAAAGCTGTATGGTTTCAAGGTATTCAAGGACAGCGGCAGCGGGGAAGATGCTTTTATCATCAAAGCACTCGA
TACCATTGCAGAACTGAATGAACGAGCCGGTAAATTGATAATTCACGGTGTGAATCTCAGTTTGGGTGGTAATTTCGATC
CCAGTGTATTTGGATGTGGTCATACCCCGCTGTGCCAGGAGCTGCGGCGGCTCTGGCGTCAGGGAGTGCTGGTATGCCTT
GCGGCTGGCAACGAAGGCTATGCGCTGCTCGATTCAGTCAATGGTGTGATATCGGCCAACATGGATCTTTCTATCGGTGA
TCCGGCTAACCTTGAGGAAGCCATCGCCGTCGGCTCGGTGCATAAAACCAATCCTCATACCTACGGTATTTCCTACTTTT
CTTCACGTGGCCCGACAGCGGACGGACGCATGAAGCCAGATCTGGTCGCACCGGGCGAAAATATTCTTTCAGCAAGGCAT
CAGTGGCCGAAGGGCAAGCTCACCGTGCGCAATGCTTACGTGGAAATGAGTGGTACCAGCATGGCCACTCCGCATGTCTC
GGGGTTGCTGGCAGCTTTTCTTTCCGCCCGGCGAGAATTTATCGGCTATCCCGATCGTGTCAAGGCGCTGCTACTGCAGC
ACTGCACTGATCTGGCCCGTGATCCTTACATTCAAGGGAAAGGCATACCTAATCTGGTGAAAATGATCATGAATACCTGA

Upstream 100 bases:

>100_bases
ATTCCTGTCTGTCACGGACAGGGCGTATTATTTGATTGGCATTATTTCGACCAGATGGCTCTGGTAGCAATCAGGGCAAT
TCAGATAGAGAGAAAAGACC

Downstream 100 bases:

>100_bases
TTGTGAATGGATCATATTGCAGAACTTATTTGGATTGTTTTAGGGTTGTCTAAAAAACATTTAGACACAACATTGCAAAG
CGATATTGCCCGTATTGGAT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MATEKRGSRSNSKTGGSKSSSPFMVLFRSGANLTVEFPSILNKEGSSPEIGTVVYIHGIDNKPIASVLKCQWDTALFGAP
MGDRTRMAYWVDRNRYPEPEKGSCADKDTLSGSVDRMSAQALQELGLEPETKLSSAERKIMTALEERLRKGEKQPGGVDV
KVLPLPESVRLWITRRITKLFLKDVQDFFFDEHKRGLMEQSLRDRLDVGGGPFIVIGHSQGSMIAYHVLRQLKKADCDVR
LFITIGSPLGIQEVQDVLGKIDPGKPLAVPECVDHWLNVAERLDPVALDSHLENDYQPNSRDVKVENHAGLMINPDWESN
PHSGTGYLSLDIVRQTVRQTAGPTFSNPVGRNILMKDLVDDIEDSHREQRHPTLIQLVSDDSNGTPLDEVRSRLETLINE
VLEFNGAKREDGRIQLMQRFISADLTRSEIEQLRSHCGTLKIDRVWRNAVKRALLYQSVHTIQVRPANLGYSACGRNIAW
AVLDTGIAANHPHFKAHSNVIAQWDCTGSGSPRQLKPGDSGFGTLDGNGHGTHVAAIIAGGLTLPRDAKDPTSIDQQGMA
PEAKLYGFKVFKDSGSGEDAFIIKALDTIAELNERAGKLIIHGVNLSLGGNFDPSVFGCGHTPLCQELRRLWRQGVLVCL
AAGNEGYALLDSVNGVISANMDLSIGDPANLEEAIAVGSVHKTNPHTYGISYFSSRGPTADGRMKPDLVAPGENILSARH
QWPKGKLTVRNAYVEMSGTSMATPHVSGLLAAFLSARREFIGYPDRVKALLLQHCTDLARDPYIQGKGIPNLVKMIMNT

Sequences:

>Translated_799_residues
MATEKRGSRSNSKTGGSKSSSPFMVLFRSGANLTVEFPSILNKEGSSPEIGTVVYIHGIDNKPIASVLKCQWDTALFGAP
MGDRTRMAYWVDRNRYPEPEKGSCADKDTLSGSVDRMSAQALQELGLEPETKLSSAERKIMTALEERLRKGEKQPGGVDV
KVLPLPESVRLWITRRITKLFLKDVQDFFFDEHKRGLMEQSLRDRLDVGGGPFIVIGHSQGSMIAYHVLRQLKKADCDVR
LFITIGSPLGIQEVQDVLGKIDPGKPLAVPECVDHWLNVAERLDPVALDSHLENDYQPNSRDVKVENHAGLMINPDWESN
PHSGTGYLSLDIVRQTVRQTAGPTFSNPVGRNILMKDLVDDIEDSHREQRHPTLIQLVSDDSNGTPLDEVRSRLETLINE
VLEFNGAKREDGRIQLMQRFISADLTRSEIEQLRSHCGTLKIDRVWRNAVKRALLYQSVHTIQVRPANLGYSACGRNIAW
AVLDTGIAANHPHFKAHSNVIAQWDCTGSGSPRQLKPGDSGFGTLDGNGHGTHVAAIIAGGLTLPRDAKDPTSIDQQGMA
PEAKLYGFKVFKDSGSGEDAFIIKALDTIAELNERAGKLIIHGVNLSLGGNFDPSVFGCGHTPLCQELRRLWRQGVLVCL
AAGNEGYALLDSVNGVISANMDLSIGDPANLEEAIAVGSVHKTNPHTYGISYFSSRGPTADGRMKPDLVAPGENILSARH
QWPKGKLTVRNAYVEMSGTSMATPHVSGLLAAFLSARREFIGYPDRVKALLLQHCTDLARDPYIQGKGIPNLVKMIMNT
>Mature_798_residues
ATEKRGSRSNSKTGGSKSSSPFMVLFRSGANLTVEFPSILNKEGSSPEIGTVVYIHGIDNKPIASVLKCQWDTALFGAPM
GDRTRMAYWVDRNRYPEPEKGSCADKDTLSGSVDRMSAQALQELGLEPETKLSSAERKIMTALEERLRKGEKQPGGVDVK
VLPLPESVRLWITRRITKLFLKDVQDFFFDEHKRGLMEQSLRDRLDVGGGPFIVIGHSQGSMIAYHVLRQLKKADCDVRL
FITIGSPLGIQEVQDVLGKIDPGKPLAVPECVDHWLNVAERLDPVALDSHLENDYQPNSRDVKVENHAGLMINPDWESNP
HSGTGYLSLDIVRQTVRQTAGPTFSNPVGRNILMKDLVDDIEDSHREQRHPTLIQLVSDDSNGTPLDEVRSRLETLINEV
LEFNGAKREDGRIQLMQRFISADLTRSEIEQLRSHCGTLKIDRVWRNAVKRALLYQSVHTIQVRPANLGYSACGRNIAWA
VLDTGIAANHPHFKAHSNVIAQWDCTGSGSPRQLKPGDSGFGTLDGNGHGTHVAAIIAGGLTLPRDAKDPTSIDQQGMAP
EAKLYGFKVFKDSGSGEDAFIIKALDTIAELNERAGKLIIHGVNLSLGGNFDPSVFGCGHTPLCQELRRLWRQGVLVCLA
AGNEGYALLDSVNGVISANMDLSIGDPANLEEAIAVGSVHKTNPHTYGISYFSSRGPTADGRMKPDLVAPGENILSARHQ
WPKGKLTVRNAYVEMSGTSMATPHVSGLLAAFLSARREFIGYPDRVKALLLQHCTDLARDPYIQGKGIPNLVKMIMNT

Specific function: Displays serine protease activity. Seems to have a broad substrate specificity [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasm (Probable). Note=Is leaked to the culture medium during the late stationary phase owing to cell lysis [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=360, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320775, Length=318, Percent_Identity=28.9308176100629, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324576, Length=318, Percent_Identity=27.6729559748428, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319893, Length=285, Percent_Identity=29.1228070175439, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 87639; Mature: 87508

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEKRGSRSNSKTGGSKSSSPFMVLFRSGANLTVEFPSILNKEGSSPEIGTVVYIHGID
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCEEEEEEECCC
NKPIASVLKCQWDTALFGAPMGDRTRMAYWVDRNRYPEPEKGSCADKDTLSGSVDRMSAQ
CCHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCHHHHHHH
ALQELGLEPETKLSSAERKIMTALEERLRKGEKQPGGVDVKVLPLPESVRLWITRRITKL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FLKDVQDFFFDEHKRGLMEQSLRDRLDVGGGPFIVIGHSQGSMIAYHVLRQLKKADCDVR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
LFITIGSPLGIQEVQDVLGKIDPGKPLAVPECVDHWLNVAERLDPVALDSHLENDYQPNS
EEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
RDVKVENHAGLMINPDWESNPHSGTGYLSLDIVRQTVRQTAGPTFSNPVGRNILMKDLVD
CCEEEECCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DIEDSHREQRHPTLIQLVSDDSNGTPLDEVRSRLETLINEVLEFNGAKREDGRIQLMQRF
HHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ISADLTRSEIEQLRSHCGTLKIDRVWRNAVKRALLYQSVHTIQVRPANLGYSACGRNIAW
HHCCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHCCCEEE
AVLDTGIAANHPHFKAHSNVIAQWDCTGSGSPRQLKPGDSGFGTLDGNGHGTHVAAIIAG
EEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEHCC
GLTLPRDAKDPTSIDQQGMAPEAKLYGFKVFKDSGSGEDAFIIKALDTIAELNERAGKLI
CCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCEEE
IHGVNLSLGGNFDPSVFGCGHTPLCQELRRLWRQGVLVCLAAGNEGYALLDSVNGVISAN
EEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCEEECC
MDLSIGDPANLEEAIAVGSVHKTNPHTYGISYFSSRGPTADGRMKPDLVAPGENILSARH
CEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QWPKGKLTVRNAYVEMSGTSMATPHVSGLLAAFLSARREFIGYPDRVKALLLQHCTDLAR
CCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
DPYIQGKGIPNLVKMIMNT
CCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ATEKRGSRSNSKTGGSKSSSPFMVLFRSGANLTVEFPSILNKEGSSPEIGTVVYIHGID
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCEEEEEEECCC
NKPIASVLKCQWDTALFGAPMGDRTRMAYWVDRNRYPEPEKGSCADKDTLSGSVDRMSAQ
CCHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCHHHHHHH
ALQELGLEPETKLSSAERKIMTALEERLRKGEKQPGGVDVKVLPLPESVRLWITRRITKL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FLKDVQDFFFDEHKRGLMEQSLRDRLDVGGGPFIVIGHSQGSMIAYHVLRQLKKADCDVR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
LFITIGSPLGIQEVQDVLGKIDPGKPLAVPECVDHWLNVAERLDPVALDSHLENDYQPNS
EEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
RDVKVENHAGLMINPDWESNPHSGTGYLSLDIVRQTVRQTAGPTFSNPVGRNILMKDLVD
CCEEEECCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DIEDSHREQRHPTLIQLVSDDSNGTPLDEVRSRLETLINEVLEFNGAKREDGRIQLMQRF
HHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ISADLTRSEIEQLRSHCGTLKIDRVWRNAVKRALLYQSVHTIQVRPANLGYSACGRNIAW
HHCCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHCCCEEE
AVLDTGIAANHPHFKAHSNVIAQWDCTGSGSPRQLKPGDSGFGTLDGNGHGTHVAAIIAG
EEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEHCC
GLTLPRDAKDPTSIDQQGMAPEAKLYGFKVFKDSGSGEDAFIIKALDTIAELNERAGKLI
CCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCEEE
IHGVNLSLGGNFDPSVFGCGHTPLCQELRRLWRQGVLVCLAAGNEGYALLDSVNGVISAN
EEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCEEECC
MDLSIGDPANLEEAIAVGSVHKTNPHTYGISYFSSRGPTADGRMKPDLVAPGENILSARH
CEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QWPKGKLTVRNAYVEMSGTSMATPHVSGLLAAFLSARREFIGYPDRVKALLLQHCTDLAR
CCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
DPYIQGKGIPNLVKMIMNT
CCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]