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The map label for this gene is ppx [H]

Identifier: 114331807

GI number: 114331807

Start: 1939103

End: 1940638

Strand: Direct

Name: ppx [H]

Synonym: Neut_1831

Alternate gene names: 114331807

Gene position: 1939103-1940638 (Clockwise)

Preceding gene: 114331806

Following gene: 114331814

Centisome position: 72.87

GC content: 51.17

Gene sequence:

>1536_bases
ATGCACGCATACTCAACGCTCGCTGCCGTTGATCTGGGTTCCAACAGTTTTCATCTGCAGGTCGCCAGGGTAGAAGAAAA
GCAACTCTACCTGCTGGATAATCTGAAAGAAATGGTACAGCTTGCAGCGGGATTATCCGAAGATCAGACGCTGGACGAGG
CATCACAAAACCGTGCACTCGCCTGCCTGGAACGGTTTGGCGAGCGTTTACGGGGACTGCCGTATCATGCCGTCAGAGTG
GTGGGCACAAACTCGCTGCGTGTTGCCAGAAATGCAGCAGGTTTTTTGCAAAAAGCTGAAAATGCACTGGGCTTTCCTAT
CGAAATCATTGCAGGCTACGAAGAAGCCCGGTTGATTTTTCTTGGTGTGGCGCACAGCTTGCCTCCTTCGGATGACGCTC
TGCTCGTCGTCGATATTGGTGGTGGCTCCACCGAACTGATCATCGGCAGCCAACTGAAATCCAGCAAACTGGAAAGTCTT
CCCATTGGTTGTATCAGCTACAGCCAGTATTTTTTTCCTGATGGGAAGCTCACCAAAGACTCGCTGAGATATGCCGAGCT
GGCCGCACGTTCCGAAATACAGGCCGCCACCGCTGAGTTCTCCTCATCATACTGGCAAAAAGCCTATGGCTCTTCCGGCA
CCGCGCGCGCACTGGCACACATCCTCGCAATAAACGGCTATAACGACAGCGATGATGCAGAAATCATCACACTCGCAGGG
TTGGAAAAACTGCGCGAATTCCTGCTTAAAACAGGTGATCTCAGAAAGCTGGCAATTCCAGGCTTAAACCCCAGCCGCAG
AATAATTATTGCGGGTGGATTTGCCATCATGAGCGCTATTTTTACAGAGCTGAAGATCAAGCGTATGGAAATTGCCAGCG
GCGCACTGCGTCAGGGTGTACTCTACGACATGCTGGGGCGCTTTCACAAAGAAGATATGCGTGAAGTCTCCGTACAGGAA
TTCATGCAGCGCTACCGGGTGGATTTGCAGCAGGCAACCCGGATTGAATCACTTGCGATTTTGCTTGGCAAACAACTCCT
GGCGGATTACCCCGATCAGGAAAAAGCTGAGAATGCACTGAAATTGCTTTCCTGGGCAGCGCGTTTACATGAAATCGGCA
TTTCGGTGGCCCATACCGGCTACCACAAACATTCTGCTTATATTCTCGATAACGCCGATATGCCTGGCTTTTCCAGAATG
GAGCAATCCCAGTTAGGTCAGCTGGTGCTATCGCACCATGGCTCGCTTGCCAAAACCGGGGATTTCCTTAGCCACCCCAT
TAACCTTGCTCGTTCAGTTGCCTTGCGTATCGCTACAATTTTTTACCGCAGCCGTACCCAGGTTGATTTGCCAGCCTTGA
TGCTATCCATGAGTGGAAGGCGTTGCACATTACGCATTCCGCAAACCTGGCTGGAACGCTATCCGCTGACCGATACGCTA
CTGAATAATGAAATCAAGACCTGGGCAAAAGTTGATGTTGACCTGCGTATTGAAAACCTGACTGAACATCATCGCACCCG
ATCGGGTGCAGCCTGA

Upstream 100 bases:

>100_bases
ATTGTCTACCTGGTTAAGGGGAAGGATGTCCGCCATGTATCGGCGGATGAAATTGAACGCGAAGTCAGTAAATAAACCGT
TCAGAACCAGCCCCCGCATC

Downstream 100 bases:

>100_bases
TAGCTTATTTACTGCCAGCATTTGGCAATAGCTTCTGCTCCTGTCACTCCGCCTGCTCCTCGCACACCTGTATGAGTCAA
CGACAAGGTACCGCAGGTAT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MHAYSTLAAVDLGSNSFHLQVARVEEKQLYLLDNLKEMVQLAAGLSEDQTLDEASQNRALACLERFGERLRGLPYHAVRV
VGTNSLRVARNAAGFLQKAENALGFPIEIIAGYEEARLIFLGVAHSLPPSDDALLVVDIGGGSTELIIGSQLKSSKLESL
PIGCISYSQYFFPDGKLTKDSLRYAELAARSEIQAATAEFSSSYWQKAYGSSGTARALAHILAINGYNDSDDAEIITLAG
LEKLREFLLKTGDLRKLAIPGLNPSRRIIIAGGFAIMSAIFTELKIKRMEIASGALRQGVLYDMLGRFHKEDMREVSVQE
FMQRYRVDLQQATRIESLAILLGKQLLADYPDQEKAENALKLLSWAARLHEIGISVAHTGYHKHSAYILDNADMPGFSRM
EQSQLGQLVLSHHGSLAKTGDFLSHPINLARSVALRIATIFYRSRTQVDLPALMLSMSGRRCTLRIPQTWLERYPLTDTL
LNNEIKTWAKVDVDLRIENLTEHHRTRSGAA

Sequences:

>Translated_511_residues
MHAYSTLAAVDLGSNSFHLQVARVEEKQLYLLDNLKEMVQLAAGLSEDQTLDEASQNRALACLERFGERLRGLPYHAVRV
VGTNSLRVARNAAGFLQKAENALGFPIEIIAGYEEARLIFLGVAHSLPPSDDALLVVDIGGGSTELIIGSQLKSSKLESL
PIGCISYSQYFFPDGKLTKDSLRYAELAARSEIQAATAEFSSSYWQKAYGSSGTARALAHILAINGYNDSDDAEIITLAG
LEKLREFLLKTGDLRKLAIPGLNPSRRIIIAGGFAIMSAIFTELKIKRMEIASGALRQGVLYDMLGRFHKEDMREVSVQE
FMQRYRVDLQQATRIESLAILLGKQLLADYPDQEKAENALKLLSWAARLHEIGISVAHTGYHKHSAYILDNADMPGFSRM
EQSQLGQLVLSHHGSLAKTGDFLSHPINLARSVALRIATIFYRSRTQVDLPALMLSMSGRRCTLRIPQTWLERYPLTDTL
LNNEIKTWAKVDVDLRIENLTEHHRTRSGAA
>Mature_511_residues
MHAYSTLAAVDLGSNSFHLQVARVEEKQLYLLDNLKEMVQLAAGLSEDQTLDEASQNRALACLERFGERLRGLPYHAVRV
VGTNSLRVARNAAGFLQKAENALGFPIEIIAGYEEARLIFLGVAHSLPPSDDALLVVDIGGGSTELIIGSQLKSSKLESL
PIGCISYSQYFFPDGKLTKDSLRYAELAARSEIQAATAEFSSSYWQKAYGSSGTARALAHILAINGYNDSDDAEIITLAG
LEKLREFLLKTGDLRKLAIPGLNPSRRIIIAGGFAIMSAIFTELKIKRMEIASGALRQGVLYDMLGRFHKEDMREVSVQE
FMQRYRVDLQQATRIESLAILLGKQLLADYPDQEKAENALKLLSWAARLHEIGISVAHTGYHKHSAYILDNADMPGFSRM
EQSQLGQLVLSHHGSLAKTGDFLSHPINLARSVALRIATIFYRSRTQVDLPALMLSMSGRRCTLRIPQTWLERYPLTDTL
LNNEIKTWAKVDVDLRIENLTEHHRTRSGAA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=497, Percent_Identity=38.6317907444668, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI48994966, Length=489, Percent_Identity=36.8098159509202, Blast_Score=300, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56667; Mature: 56667

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAYSTLAAVDLGSNSFHLQVARVEEKQLYLLDNLKEMVQLAAGLSEDQTLDEASQNRAL
CCCHHCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHH
ACLERFGERLRGLPYHAVRVVGTNSLRVARNAAGFLQKAENALGFPIEIIAGYEEARLIF
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
LGVAHSLPPSDDALLVVDIGGGSTELIIGSQLKSSKLESLPIGCISYSQYFFPDGKLTKD
EEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCEECCCCCCCHH
SLRYAELAARSEIQAATAEFSSSYWQKAYGSSGTARALAHILAINGYNDSDDAEIITLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEHHH
LEKLREFLLKTGDLRKLAIPGLNPSRRIIIAGGFAIMSAIFTELKIKRMEIASGALRQGV
HHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYDMLGRFHKEDMREVSVQEFMQRYRVDLQQATRIESLAILLGKQLLADYPDQEKAENAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KLLSWAARLHEIGISVAHTGYHKHSAYILDNADMPGFSRMEQSQLGQLVLSHHGSLAKTG
HHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHCC
DFLSHPINLARSVALRIATIFYRSRTQVDLPALMLSMSGRRCTLRIPQTWLERYPLTDTL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHHHHHCCCCHHHH
LNNEIKTWAKVDVDLRIENLTEHHRTRSGAA
HCCCHHHHEEEEEEEEEHHHHHHHHHCCCCC
>Mature Secondary Structure
MHAYSTLAAVDLGSNSFHLQVARVEEKQLYLLDNLKEMVQLAAGLSEDQTLDEASQNRAL
CCCHHCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHH
ACLERFGERLRGLPYHAVRVVGTNSLRVARNAAGFLQKAENALGFPIEIIAGYEEARLIF
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
LGVAHSLPPSDDALLVVDIGGGSTELIIGSQLKSSKLESLPIGCISYSQYFFPDGKLTKD
EEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCEECCCCCCCHH
SLRYAELAARSEIQAATAEFSSSYWQKAYGSSGTARALAHILAINGYNDSDDAEIITLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEHHH
LEKLREFLLKTGDLRKLAIPGLNPSRRIIIAGGFAIMSAIFTELKIKRMEIASGALRQGV
HHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYDMLGRFHKEDMREVSVQEFMQRYRVDLQQATRIESLAILLGKQLLADYPDQEKAENAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KLLSWAARLHEIGISVAHTGYHKHSAYILDNADMPGFSRMEQSQLGQLVLSHHGSLAKTG
HHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHCC
DFLSHPINLARSVALRIATIFYRSRTQVDLPALMLSMSGRRCTLRIPQTWLERYPLTDTL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHHHHHCCCCHHHH
LNNEIKTWAKVDVDLRIENLTEHHRTRSGAA
HCCCHHHHEEEEEEEEEHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]