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The map label for this gene is degP [H]

Identifier: 114331760

GI number: 114331760

Start: 1887698

End: 1889170

Strand: Reverse

Name: degP [H]

Synonym: Neut_1783

Alternate gene names: 114331760

Gene position: 1889170-1887698 (Counterclockwise)

Preceding gene: 114331761

Following gene: 114331759

Centisome position: 70.99

GC content: 43.04

Gene sequence:

>1473_bases
ATGATCTCTCAAAGTAACCCCTACCCAAACGCAGGATTAATATTGATCGTGGCTACGATTAAAAATACATGGCAGAAGAT
AGCATTTATAATTTTCCTGTGTTGGTCCGCATTTATGCTGCCTGTTTCATTGCAGGCAAAAGATTTGCCGGACTTTACTG
ATCTGGTAGAAAAGCACGGACAGGCGGTTGTCAATATCAGTACAGTTCAGACTCAGCAAGTAGGGGTTGGTCAGTTTTTG
CCAGAAATTCCTAATATTCCGGAAGATTCTCCTTTCTATGAATTTTTTCGCAGACATATCCAACCTTTCTCAGGCCCGAG
AAAATATGAATCTCGTTCACTTGGTTCAGGTTTTATTATCAGTAAAGATGGGTATATCCTGACCAATGCACATGTGGTTG
AGGCGGCCAATGAAATTACCGTCCGATTGACAGATAAGCGTGAATTCAGCGCAAAAGTAATTGGAGCTGATCAAAAAACA
GATATTGCATTGCTTAAAATAGATGCAAATGATCTACCGGTAGTGACCCAAGGTAGCCCTGAGCAACTCAAGGTTGGAGA
ATGGGTAGTTGCCATTGGCGCTCCCTTTGGCTTCGAGAACACGGTTACAGCGGGAATTGTGAGTGCAAAAGGACGTTCGC
TTGCCCAGGAAAACTATGTTCCTTTTATACAAACTGATGTGGCGATTAATCCGGGTAATTCAGGTGGACCGCTGTTTAAT
ATGAAGGGTGAGGTTGTGGGTATCAACTCCCAGATTTACAGCAGAACGGGTGGGTTTATGGGTCTTTCTTTTGCCATTCC
GATTGATGTCGCGATGGATATTGCCGATCAACTCAAGACCTATGGCAAGATCTCACGCGGAAAGATTGGTGTCATGATAC
AGGAAATGACAGACGAGTTGGCCGAGTCTTTCAGTCTGGACAAGTCACGCGGTGCACTAGTGGTTTCAGTAGAAAAAGGC
GGGCCGGCTGACAAAGCTGGCATAAAGATAAGAGACGTTATTCTGAAATTTGATGGTAAAGATATCGAGGCTTCAAGTGA
TTTGCCACGCATTGTTGGGAACACGAAACCTGGCTCCAAGGTGCCTGTTGAAATATGGCGTAGTGGTTCGGTCAAAAAAA
TGACTATTTCAGTAGGAGAAATGCCTGCAGATGGCAATATTGTTAATCAAAAACAAAGCAAATCAGGAGATGCAACCAGT
CGGCTTGGTCTTGTTCTAAGGGAGCTTTCTGCTAACCAGAAAAATCAGCTTGGTATAGAGAATGGCTTGCTGGTTGATGA
AGTTTATGACGGAATAGCCAGTAGCTCGGGTATTCGTCCCGGAGATATTATCTTGGGATTTAATAATCAAGATATAAAAT
CCATCAGACAGTTCAATAAGTTGCTGAATGATGCTCCCAAAGGTCGGAATATTGCGCTGCTAATAAGAAGAGGGGATGTT
GCGACTTTCATTACCATAAAAATAGATGAATAA

Upstream 100 bases:

>100_bases
AGCTTGTGGGGAATTGATATGACGATATTTTGGCTACGGTAATGTGGACTTACTTCTGTAAGCGCCAATAATTCTTAATT
ATGATTATATATTTATCATC

Downstream 100 bases:

>100_bases
TCGGGCAGAGCTCAGAAAATTAATTGTATATGGGAGAGAAGGCTGTCATCTCTGCGAGGATATGATTGCTTCCCTCGGTG
ATCTGCAAAAGGAATTTCGA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MISQSNPYPNAGLILIVATIKNTWQKIAFIIFLCWSAFMLPVSLQAKDLPDFTDLVEKHGQAVVNISTVQTQQVGVGQFL
PEIPNIPEDSPFYEFFRRHIQPFSGPRKYESRSLGSGFIISKDGYILTNAHVVEAANEITVRLTDKREFSAKVIGADQKT
DIALLKIDANDLPVVTQGSPEQLKVGEWVVAIGAPFGFENTVTAGIVSAKGRSLAQENYVPFIQTDVAINPGNSGGPLFN
MKGEVVGINSQIYSRTGGFMGLSFAIPIDVAMDIADQLKTYGKISRGKIGVMIQEMTDELAESFSLDKSRGALVVSVEKG
GPADKAGIKIRDVILKFDGKDIEASSDLPRIVGNTKPGSKVPVEIWRSGSVKKMTISVGEMPADGNIVNQKQSKSGDATS
RLGLVLRELSANQKNQLGIENGLLVDEVYDGIASSSGIRPGDIILGFNNQDIKSIRQFNKLLNDAPKGRNIALLIRRGDV
ATFITIKIDE

Sequences:

>Translated_490_residues
MISQSNPYPNAGLILIVATIKNTWQKIAFIIFLCWSAFMLPVSLQAKDLPDFTDLVEKHGQAVVNISTVQTQQVGVGQFL
PEIPNIPEDSPFYEFFRRHIQPFSGPRKYESRSLGSGFIISKDGYILTNAHVVEAANEITVRLTDKREFSAKVIGADQKT
DIALLKIDANDLPVVTQGSPEQLKVGEWVVAIGAPFGFENTVTAGIVSAKGRSLAQENYVPFIQTDVAINPGNSGGPLFN
MKGEVVGINSQIYSRTGGFMGLSFAIPIDVAMDIADQLKTYGKISRGKIGVMIQEMTDELAESFSLDKSRGALVVSVEKG
GPADKAGIKIRDVILKFDGKDIEASSDLPRIVGNTKPGSKVPVEIWRSGSVKKMTISVGEMPADGNIVNQKQSKSGDATS
RLGLVLRELSANQKNQLGIENGLLVDEVYDGIASSSGIRPGDIILGFNNQDIKSIRQFNKLLNDAPKGRNIALLIRRGDV
ATFITIKIDE
>Mature_490_residues
MISQSNPYPNAGLILIVATIKNTWQKIAFIIFLCWSAFMLPVSLQAKDLPDFTDLVEKHGQAVVNISTVQTQQVGVGQFL
PEIPNIPEDSPFYEFFRRHIQPFSGPRKYESRSLGSGFIISKDGYILTNAHVVEAANEITVRLTDKREFSAKVIGADQKT
DIALLKIDANDLPVVTQGSPEQLKVGEWVVAIGAPFGFENTVTAGIVSAKGRSLAQENYVPFIQTDVAINPGNSGGPLFN
MKGEVVGINSQIYSRTGGFMGLSFAIPIDVAMDIADQLKTYGKISRGKIGVMIQEMTDELAESFSLDKSRGALVVSVEKG
GPADKAGIKIRDVILKFDGKDIEASSDLPRIVGNTKPGSKVPVEIWRSGSVKKMTISVGEMPADGNIVNQKQSKSGDATS
RLGLVLRELSANQKNQLGIENGLLVDEVYDGIASSSGIRPGDIILGFNNQDIKSIRQFNKLLNDAPKGRNIALLIRRGDV
ATFITIKIDE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=278, Percent_Identity=38.1294964028777, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=38.8, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI22129776, Length=283, Percent_Identity=36.7491166077738, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI7019477, Length=275, Percent_Identity=37.0909090909091, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1786356, Length=471, Percent_Identity=37.1549893842887, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789629, Length=460, Percent_Identity=36.304347826087, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1789630, Length=281, Percent_Identity=37.7224199288256, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24646839, Length=273, Percent_Identity=37.3626373626374, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53109; Mature: 53109

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISQSNPYPNAGLILIVATIKNTWQKIAFIIFLCWSAFMLPVSLQAKDLPDFTDLVEKHG
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCC
QAVVNISTVQTQQVGVGQFLPEIPNIPEDSPFYEFFRRHIQPFSGPRKYESRSLGSGFII
CEEEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
SKDGYILTNAHVVEAANEITVRLTDKREFSAKVIGADQKTDIALLKIDANDLPVVTQGSP
ECCCEEEECCCEEECCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCEEECCCC
EQLKVGEWVVAIGAPFGFENTVTAGIVSAKGRSLAQENYVPFIQTDVAINPGNSGGPLFN
CCEEECCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEEEECCCCCCCCEEE
MKGEVVGINSQIYSRTGGFMGLSFAIPIDVAMDIADQLKTYGKISRGKIGVMIQEMTDEL
CCCCEEEECHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHH
AESFSLDKSRGALVVSVEKGGPADKAGIKIRDVILKFDGKDIEASSDLPRIVGNTKPGSK
HHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHCCCCCCCC
VPVEIWRSGSVKKMTISVGEMPADGNIVNQKQSKSGDATSRLGLVLRELSANQKNQLGIE
CCCEEECCCCEEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NGLLVDEVYDGIASSSGIRPGDIILGFNNQDIKSIRQFNKLLNDAPKGRNIALLIRRGDV
CCEEHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCE
ATFITIKIDE
EEEEEEEECC
>Mature Secondary Structure
MISQSNPYPNAGLILIVATIKNTWQKIAFIIFLCWSAFMLPVSLQAKDLPDFTDLVEKHG
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCC
QAVVNISTVQTQQVGVGQFLPEIPNIPEDSPFYEFFRRHIQPFSGPRKYESRSLGSGFII
CEEEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
SKDGYILTNAHVVEAANEITVRLTDKREFSAKVIGADQKTDIALLKIDANDLPVVTQGSP
ECCCEEEECCCEEECCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCEEECCCC
EQLKVGEWVVAIGAPFGFENTVTAGIVSAKGRSLAQENYVPFIQTDVAINPGNSGGPLFN
CCEEECCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEEEECCCCCCCCEEE
MKGEVVGINSQIYSRTGGFMGLSFAIPIDVAMDIADQLKTYGKISRGKIGVMIQEMTDEL
CCCCEEEECHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHH
AESFSLDKSRGALVVSVEKGGPADKAGIKIRDVILKFDGKDIEASSDLPRIVGNTKPGSK
HHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHCCCCCCCC
VPVEIWRSGSVKKMTISVGEMPADGNIVNQKQSKSGDATSRLGLVLRELSANQKNQLGIE
CCCEEECCCCEEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NGLLVDEVYDGIASSSGIRPGDIILGFNNQDIKSIRQFNKLLNDAPKGRNIALLIRRGDV
CCEEHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCE
ATFITIKIDE
EEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]