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The map label for this gene is lepB [H]

Identifier: 114331757

GI number: 114331757

Start: 1884475

End: 1885278

Strand: Reverse

Name: lepB [H]

Synonym: Neut_1780

Alternate gene names: 114331757

Gene position: 1885278-1884475 (Counterclockwise)

Preceding gene: 114331758

Following gene: 114331756

Centisome position: 70.85

GC content: 40.92

Gene sequence:

>804_bases
ATGAATTTTCCTTTGGTGTTGCTTGCTTTATTGGTGGTTACAGGTGGAATTTGGCTGCTTGATTATTTAATACTGCGACA
CCAGCGTACTCCTGATAATGTCGAGCCATGGTGGATTGAGTACCCTAAAAGTTTTTTCCCCATTATTTTGGTTGTATTTT
GTTTGAGATCGTTTCTGGTAGAGCCTTTTAAAATACCTTCCGGTTCCATGATACCGACCTTACTGGTGGGGGATTTTATA
TTGGTCAACAAGTACACCTACGGGATCAGATTGCCTGTAGCAAACCTGAAAATTATCAATATGAATGAGCCCAAACGAGG
CGAAGTCATGGTATTCCGCTTTCCAGAAGATCCATCTATTGACTACATCAAGCGGGTGATTGGTATACCTGGGGATACGG
TCACTTACCGAAACAAACATCTAAGTATCAATAATGTTCCCATTCAATTGGAACCAGCTGGCGACTACAAGTATATTGAA
TCCGGGTTAGCATATATTTATACACAGCGGTTTAAGGAGAGCATGGATGGTAACGAGTATAATGTTTTGATTAATCAGGA
GATGCCCGATATACAGCTATCCGCTGTCCATCATTTTCCCAACCGGGAAAATTGTACTTTTGACCAAACAGGCTTCTCAT
GCAAAATCCCAGAAGGTAATTATTTTACTTTAGGTGATAATCGTGATGGCAGCAGTGATAGCCGCTATTGGGGCTTTGTG
CCGGAAGATCATATTGTTGGTAAAGCTTTCCTGATCTGGTGGAATTTTAATGATCTGAGCAGAATAGGTACGCTAATCAA
GTAA

Upstream 100 bases:

>100_bases
TTGCTATCCTTCAGGTGGATGGTAAGTAAACAATACCGATAAATGACGTGTTTAATATGTTTATCAGTATATCTTTAGAT
CAGATAAGTACCGGGATACT

Downstream 100 bases:

>100_bases
TGATTTGAATCTTTAGTATGCCGCAGGAGAAATTTATGTATTCATCATTATATTCCTCGACAAACAGAGGGCAGCAAGGG
ATAAGTCTGCCCGGGCTACT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNFPLVLLALLVVTGGIWLLDYLILRHQRTPDNVEPWWIEYPKSFFPIILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANLKIINMNEPKRGEVMVFRFPEDPSIDYIKRVIGIPGDTVTYRNKHLSINNVPIQLEPAGDYKYIE
SGLAYIYTQRFKESMDGNEYNVLINQEMPDIQLSAVHHFPNRENCTFDQTGFSCKIPEGNYFTLGDNRDGSSDSRYWGFV
PEDHIVGKAFLIWWNFNDLSRIGTLIK

Sequences:

>Translated_267_residues
MNFPLVLLALLVVTGGIWLLDYLILRHQRTPDNVEPWWIEYPKSFFPIILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANLKIINMNEPKRGEVMVFRFPEDPSIDYIKRVIGIPGDTVTYRNKHLSINNVPIQLEPAGDYKYIE
SGLAYIYTQRFKESMDGNEYNVLINQEMPDIQLSAVHHFPNRENCTFDQTGFSCKIPEGNYFTLGDNRDGSSDSRYWGFV
PEDHIVGKAFLIWWNFNDLSRIGTLIK
>Mature_267_residues
MNFPLVLLALLVVTGGIWLLDYLILRHQRTPDNVEPWWIEYPKSFFPIILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANLKIINMNEPKRGEVMVFRFPEDPSIDYIKRVIGIPGDTVTYRNKHLSINNVPIQLEPAGDYKYIE
SGLAYIYTQRFKESMDGNEYNVLINQEMPDIQLSAVHHFPNRENCTFDQTGFSCKIPEGNYFTLGDNRDGSSDSRYWGFV
PEDHIVGKAFLIWWNFNDLSRIGTLIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=325, Percent_Identity=36, Blast_Score=183, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 30864; Mature: 30864

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPLVLLALLVVTGGIWLLDYLILRHQRTPDNVEPWWIEYPKSFFPIILVVFCLRSFLV
CCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKYTYGIRLPVANLKIINMNEPKRGEVMVFRFPEDPSI
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCEEEEECCCCCCCCEEEEECCCCCCH
DYIKRVIGIPGDTVTYRNKHLSINNVPIQLEPAGDYKYIESGLAYIYTQRFKESMDGNEY
HHHHHHHCCCCCEEEEECCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEE
NVLINQEMPDIQLSAVHHFPNRENCTFDQTGFSCKIPEGNYFTLGDNRDGSSDSRYWGFV
EEEECCCCCCEEEEEEECCCCCCCCEECCCCCEEECCCCCEEEECCCCCCCCCCCEECCC
PEDHIVGKAFLIWWNFNDLSRIGTLIK
CCCCEEEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MNFPLVLLALLVVTGGIWLLDYLILRHQRTPDNVEPWWIEYPKSFFPIILVVFCLRSFLV
CCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKYTYGIRLPVANLKIINMNEPKRGEVMVFRFPEDPSI
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCEEEEECCCCCCCCEEEEECCCCCCH
DYIKRVIGIPGDTVTYRNKHLSINNVPIQLEPAGDYKYIESGLAYIYTQRFKESMDGNEY
HHHHHHHCCCCCEEEEECCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEE
NVLINQEMPDIQLSAVHHFPNRENCTFDQTGFSCKIPEGNYFTLGDNRDGSSDSRYWGFV
EEEECCCCCCEEEEEEECCCCCCCCEECCCCCEEECCCCCEEEECCCCCCCCCCCEECCC
PEDHIVGKAFLIWWNFNDLSRIGTLIK
CCCCEEEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]