Click here to switch to the map view.

The map label for this gene is sdaA [H]

Identifier: 114331737

GI number: 114331737

Start: 1860886

End: 1862271

Strand: Reverse

Name: sdaA [H]

Synonym: Neut_1760

Alternate gene names: 114331737

Gene position: 1862271-1860886 (Counterclockwise)

Preceding gene: 114331742

Following gene: 114331734

Centisome position: 69.98

GC content: 49.93

Gene sequence:

>1386_bases
ATGTTTATAAGCGTTCTTGATCTGTTTAAAATCGGTATTGGCCCCTCCAGTTCGCACACGATGGGGCCAATGGCGGCAGC
AAATGTTTTTCGTGATGATATTGACCAGCTGATTTTACAAACTCCGGATAATCGCAACCATCGTGTTTATTGCGTACTCA
AGGGCTCACTCGCATTTACTGGAAGAGGGCACGCAACAGATAGGGCTGTAACTTTGGGATTGCATGGCTATAGCCCTGCA
TCCCTCGCCGGGCAGGATGTCAATGCGCTGACTGCAAAGCTCTGGGCGACCAATACTGTGCAGCTTGCCAGCGGCAGACA
CATTGATTTCAATCCGGAGGATGACATTGTCTTTGATAAATCTGATCCGTTACCGCAACATCCTAACGGAATGATTTTTT
ATCTTCTGGATGAGGAGGGAAAGAAAGTTCTGTCAGAAACATTCTTTTCCATCGGGGGTGGATTTATCTGTACGCTTGCA
GAAATTAGCCAGCTGGATGCTCCGCTTAAAATTGAATTTGCTGGTACTTATCCATACCCGTTTGATTCAGCAGACAGTAT
GCTTGAGATGTCGCGGCAAAGTGGCTTATCCATTGCGGAAATGAAACGCGCCAATGAATTAACCAGGATGTCGGAACAAG
ATCTTGATCAGGGACTGGACAGTATCTGGCAGGCTATGTGTCATTGTGTTGAACAGGGACTGACGGCAGAAGGCCGCCTC
CCAGGTATCCTGGGGATACGCCGGCGTGCAAAAGATCTATTCAAGCAACTGGAAACAAATCCGGAAAAAGGTACGCTGAA
TGACTGGTTATGCGCCTATGCCATGGCGGTGAATGAAGAGAATGCTGCGGGTCACATGGTTGTGACAGCGCCTACCAATG
GCGCTGCCGGGGTTATTCCGGCAGTTATTTACTATCTGCTTAAGCATGAAGGTGGGACTCTGCAGCAAGTACGGGATTTT
CTACTGACTGCTGCCGCAATTGGTGGGTTGATCAAGCATCGTAGCTCTATTTCCGGGGCGGAAGTAGGCTGTCAGGGAGA
AGTGGGTTCGGCAGCAGCAATGGCTGCAGCTGGTCTTTCCGCGGTGCGGGGAGGGACCACTGAGCAAATCGAGAATGCGG
CTGAAATTGCATTGGAACACCATTTGGGTATGACTTGCGATCCGGTTGGCGGGCTAGTTCAGGTGCCCTGTATTGAACGT
AATGGTTTTGGCGCAATCAAGGCCCATACCGCTGCTGCACTTGCTTGCCGCGGTACGGGCGAGCATTTTATATCACTCGA
CAACTGCATTAACGCGATGAAGCAGACGGGTCTGGAGATGTCACACAAATACAAGGAAACTTCATTGGGTGGCCTGGCTG
TCAGTGTCAGCATTACCGAATGCTGA

Upstream 100 bases:

>100_bases
CTGTGAAGCGGATTTGCTCAATCCACTATAATACAATCTTGGCAATTACAACAAACTGTCGGGGCAATTTTCTTCTTAAT
ACCAATCAAAAAATTATCCT

Downstream 100 bases:

>100_bases
GAATGGGATTCGAATAATCATTGGAAATGACGTATATAAGGGAGTATTGGATTTATGGATCTCTAAAACACCCGGTTTTC
TACCCGTTTTTTGAAATGTC

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MFISVLDLFKIGIGPSSSHTMGPMAAANVFRDDIDQLILQTPDNRNHRVYCVLKGSLAFTGRGHATDRAVTLGLHGYSPA
SLAGQDVNALTAKLWATNTVQLASGRHIDFNPEDDIVFDKSDPLPQHPNGMIFYLLDEEGKKVLSETFFSIGGGFICTLA
EISQLDAPLKIEFAGTYPYPFDSADSMLEMSRQSGLSIAEMKRANELTRMSEQDLDQGLDSIWQAMCHCVEQGLTAEGRL
PGILGIRRRAKDLFKQLETNPEKGTLNDWLCAYAMAVNEENAAGHMVVTAPTNGAAGVIPAVIYYLLKHEGGTLQQVRDF
LLTAAAIGGLIKHRSSISGAEVGCQGEVGSAAAMAAAGLSAVRGGTTEQIENAAEIALEHHLGMTCDPVGGLVQVPCIER
NGFGAIKAHTAAALACRGTGEHFISLDNCINAMKQTGLEMSHKYKETSLGGLAVSVSITEC

Sequences:

>Translated_461_residues
MFISVLDLFKIGIGPSSSHTMGPMAAANVFRDDIDQLILQTPDNRNHRVYCVLKGSLAFTGRGHATDRAVTLGLHGYSPA
SLAGQDVNALTAKLWATNTVQLASGRHIDFNPEDDIVFDKSDPLPQHPNGMIFYLLDEEGKKVLSETFFSIGGGFICTLA
EISQLDAPLKIEFAGTYPYPFDSADSMLEMSRQSGLSIAEMKRANELTRMSEQDLDQGLDSIWQAMCHCVEQGLTAEGRL
PGILGIRRRAKDLFKQLETNPEKGTLNDWLCAYAMAVNEENAAGHMVVTAPTNGAAGVIPAVIYYLLKHEGGTLQQVRDF
LLTAAAIGGLIKHRSSISGAEVGCQGEVGSAAAMAAAGLSAVRGGTTEQIENAAEIALEHHLGMTCDPVGGLVQVPCIER
NGFGAIKAHTAAALACRGTGEHFISLDNCINAMKQTGLEMSHKYKETSLGGLAVSVSITEC
>Mature_461_residues
MFISVLDLFKIGIGPSSSHTMGPMAAANVFRDDIDQLILQTPDNRNHRVYCVLKGSLAFTGRGHATDRAVTLGLHGYSPA
SLAGQDVNALTAKLWATNTVQLASGRHIDFNPEDDIVFDKSDPLPQHPNGMIFYLLDEEGKKVLSETFFSIGGGFICTLA
EISQLDAPLKIEFAGTYPYPFDSADSMLEMSRQSGLSIAEMKRANELTRMSEQDLDQGLDSIWQAMCHCVEQGLTAEGRL
PGILGIRRRAKDLFKQLETNPEKGTLNDWLCAYAMAVNEENAAGHMVVTAPTNGAAGVIPAVIYYLLKHEGGTLQQVRDF
LLTAAAIGGLIKHRSSISGAEVGCQGEVGSAAAMAAAGLSAVRGGTTEQIENAAEIALEHHLGMTCDPVGGLVQVPCIER
NGFGAIKAHTAAALACRGTGEHFISLDNCINAMKQTGLEMSHKYKETSLGGLAVSVSITEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=461, Percent_Identity=45.7700650759219, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1789161, Length=465, Percent_Identity=45.5913978494624, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1788116, Length=461, Percent_Identity=44.0347071583514, Blast_Score=355, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49211; Mature: 49211

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISVLDLFKIGIGPSSSHTMGPMAAANVFRDDIDQLILQTPDNRNHRVYCVLKGSLAFT
CEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEC
GRGHATDRAVTLGLHGYSPASLAGQDVNALTAKLWATNTVQLASGRHIDFNPEDDIVFDK
CCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECC
SDPLPQHPNGMIFYLLDEEGKKVLSETFFSIGGGFICTLAEISQLDAPLKIEFAGTYPYP
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCC
FDSADSMLEMSRQSGLSIAEMKRANELTRMSEQDLDQGLDSIWQAMCHCVEQGLTAEGRL
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PGILGIRRRAKDLFKQLETNPEKGTLNDWLCAYAMAVNEENAAGHMVVTAPTNGAAGVIP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHH
AVIYYLLKHEGGTLQQVRDFLLTAAAIGGLIKHRSSISGAEVGCQGEVGSAAAMAAAGLS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AVRGGTTEQIENAAEIALEHHLGMTCDPVGGLVQVPCIERNGFGAIKAHTAAALACRGTG
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECEECCCCCCCEEHHHHHEEEECCCC
EHFISLDNCINAMKQTGLEMSHKYKETSLGGLAVSVSITEC
CCEEEHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEECC
>Mature Secondary Structure
MFISVLDLFKIGIGPSSSHTMGPMAAANVFRDDIDQLILQTPDNRNHRVYCVLKGSLAFT
CEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEC
GRGHATDRAVTLGLHGYSPASLAGQDVNALTAKLWATNTVQLASGRHIDFNPEDDIVFDK
CCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECC
SDPLPQHPNGMIFYLLDEEGKKVLSETFFSIGGGFICTLAEISQLDAPLKIEFAGTYPYP
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCC
FDSADSMLEMSRQSGLSIAEMKRANELTRMSEQDLDQGLDSIWQAMCHCVEQGLTAEGRL
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PGILGIRRRAKDLFKQLETNPEKGTLNDWLCAYAMAVNEENAAGHMVVTAPTNGAAGVIP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHH
AVIYYLLKHEGGTLQQVRDFLLTAAAIGGLIKHRSSISGAEVGCQGEVGSAAAMAAAGLS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AVRGGTTEQIENAAEIALEHHLGMTCDPVGGLVQVPCIERNGFGAIKAHTAAALACRGTG
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECEECCCCCCCEEHHHHHEEEECCCC
EHFISLDNCINAMKQTGLEMSHKYKETSLGGLAVSVSITEC
CCEEEHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]