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The map label for this gene is rppH

Identifier: 114331244

GI number: 114331244

Start: 1304661

End: 1305224

Strand: Direct

Name: rppH

Synonym: Neut_1248

Alternate gene names: 114331244

Gene position: 1304661-1305224 (Clockwise)

Preceding gene: 114331241

Following gene: 114331245

Centisome position: 49.03

GC content: 49.11

Gene sequence:

>564_bases
ATGATCGACCGTAATGGATATAGAGCAAATGTCGGTATTATCCTTCTGAACTCAAAAAGCCAGGTGTTCTGGGGAAAACG
TGCCCGACAGAATTCATGGCAATTTCCGCAAGGCGGAATTAAATCAGGCGAAACACCAACGCAGGCAATGTACCGGGAAC
TGGCTGAAGAAACAGGCTTGCAGCCTGTTCATGTGGAAATTTTGGGCCGGACACGAGAATGGTTACGTTACGATGTACCC
GCCTGCTGGACTCGCCGCGACTGGCGCAAGAACTATCGTGGCCAGAAACAAATCTGGTTTCTGTTGCGTATGCTGGGAAG
AGATTGTGATGTATCACTCAAAACTTGTGCGCATCCCGAATTTGATGCCTGGCGCTGGAACCAGTATTGGGTTGAACTGG
AATCTGTGGTTGAATTCAAGCGACAGGTCTATCGCCTGGCGCTGACAGAACTTTCACGATTACTGGATCATGAGACCTGC
CTGGGTAATGATCAAGCCTACAGGGAGCCACTGGAACCAGTTAAAGAACTTGAGGAGAAATCTTCTGATGCCAGACAGGG
TTGA

Upstream 100 bases:

>100_bases
TGATGCTCCTACTGAGAGTAGCAGCTGTAAATCACACTCAAAATATGGAAAAATTATCGGAAATTCACTGTAAATCAAGC
TAAATTGACAGATAAATTGT

Downstream 100 bases:

>100_bases
TTCAGTATCTTGGAGTCCTGACTCCGGTCCGGCAACAAAAAATTCAAGGCGTAAGCGGCTGCGCCACGTTAGCCGTTACT
ATTTTCAAACCTTAAGGAGA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MIDRNGYRANVGIILLNSKSQVFWGKRARQNSWQFPQGGIKSGETPTQAMYRELAEETGLQPVHVEILGRTREWLRYDVP
ACWTRRDWRKNYRGQKQIWFLLRMLGRDCDVSLKTCAHPEFDAWRWNQYWVELESVVEFKRQVYRLALTELSRLLDHETC
LGNDQAYREPLEPVKELEEKSSDARQG

Sequences:

>Translated_187_residues
MIDRNGYRANVGIILLNSKSQVFWGKRARQNSWQFPQGGIKSGETPTQAMYRELAEETGLQPVHVEILGRTREWLRYDVP
ACWTRRDWRKNYRGQKQIWFLLRMLGRDCDVSLKTCAHPEFDAWRWNQYWVELESVVEFKRQVYRLALTELSRLLDHETC
LGNDQAYREPLEPVKELEEKSSDARQG
>Mature_187_residues
MIDRNGYRANVGIILLNSKSQVFWGKRARQNSWQFPQGGIKSGETPTQAMYRELAEETGLQPVHVEILGRTREWLRYDVP
ACWTRRDWRKNYRGQKQIWFLLRMLGRDCDVSLKTCAHPEFDAWRWNQYWVELESVVEFKRQVYRLALTELSRLLDHETC
LGNDQAYREPLEPVKELEEKSSDARQG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=172, Percent_Identity=47.6744186046512, Blast_Score=164, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_NITEC (Q0AGN1)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747466.1
- ProteinModelPortal:   Q0AGN1
- SMR:   Q0AGN1
- STRING:   Q0AGN1
- GeneID:   4272192
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1248
- NMPDR:   fig|335283.3.peg.1958
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   Q0AGN1
- ProtClustDB:   PRK00714
- BioCyc:   NEUT335283:NEUT_1248-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 22221; Mature: 22221

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRNGYRANVGIILLNSKSQVFWGKRARQNSWQFPQGGIKSGETPTQAMYRELAEETGL
CCCCCCCEEEEEEEEECCCCCCHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPVHVEILGRTREWLRYDVPACWTRRDWRKNYRGQKQIWFLLRMLGRDCDVSLKTCAHPE
CEEEHHHHHHHHHHHHHCCCCHHCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCC
FDAWRWNQYWVELESVVEFKRQVYRLALTELSRLLDHETCLGNDQAYREPLEPVKELEEK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SSDARQG
HCCCCCC
>Mature Secondary Structure
MIDRNGYRANVGIILLNSKSQVFWGKRARQNSWQFPQGGIKSGETPTQAMYRELAEETGL
CCCCCCCEEEEEEEEECCCCCCHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPVHVEILGRTREWLRYDVPACWTRRDWRKNYRGQKQIWFLLRMLGRDCDVSLKTCAHPE
CEEEHHHHHHHHHHHHHCCCCHHCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCC
FDAWRWNQYWVELESVVEFKRQVYRLALTELSRLLDHETCLGNDQAYREPLEPVKELEEK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SSDARQG
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA