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The map label for this gene is tcmN [H]

Identifier: 114331055

GI number: 114331055

Start: 1093894

End: 1094784

Strand: Direct

Name: tcmN [H]

Synonym: Neut_1057

Alternate gene names: 114331055

Gene position: 1093894-1094784 (Clockwise)

Preceding gene: 114331054

Following gene: 114331064

Centisome position: 41.11

GC content: 53.2

Gene sequence:

>891_bases
ATGTCCCAAGACGAATCCAAGCCCGTTTCAACGGAAGCTCCCCCAGCAACGCAACTGATGCAGATGATTTTTGGATTTGT
TACTACGCAGGCCATCTCTGTAGCGGCGAGACTGAGTTTGGCTGATTTGCTCAAAGATGGACCGAAAAGTATAGAGGAAC
TTGCTCAGGCAACCGGCACCCAGGCAAGCGCTCTCTATCGTATCTTGCGCGAGCTTGCCAGTGTTGGTATCTTTGCTGAA
GATGACGCGGCGCGCTTTAAACTGACCCCCTTGGCCGAACTGCTACGAAGCGATACGCCTGGTAGTGTGCGCGATCTTTC
TATTTTTATCGGAGCGGATTGGCATTGGCGTGCATGGGGCGATCTTTTCGGCAGTGCTCAGTCTGGCCTGCCAGCGTTCG
AAAGAATCCATGGTAAAGCCTTCTTCGAGTATCTAGGCGAAAATTCTGGTCCCGCCCAGATTTTCAACGATGCCATGACC
AGTATGAGTGCTACCGCCAGCGCGGCAATCGTCGACGGCTACGACTTTACGGGAATCAGCAAGCTCGTCGATGTAGGTGG
CGGTCACGGCATGCTTCTTTGCTCAATCCTGGAAAAATTTCCACAAATGAGCGGAATCCTCATCGATGCCCCTTCCGTCA
TTGCTGGAGCAAAGGAGGCTATTGAAGAGCGTGGGCTTTCGAAGCGCTGCGAGGCAGTTGGCGGTGACTTCTTTGCATCG
GTTCCGGCGGGGGGAGACGCCTATATCATGAAGCATATCCTCCATGAATGGAACGATGAACGCGCGTCGACCATCCTCCA
GTGCTGTGCCGGGAAATACCGACAGATGGCAGGCTTCTTGTCGTCGAAATGGTTATTCCGGAAAGGAACGCACCATCGTT
TGGCAAGCTAA

Upstream 100 bases:

>100_bases
AATGATGCGGCACTTTCTTTGTAACACAATGCTCTACTTTATCGTCATTATGGCATGATCAGGTTAGCGTTATTATTGTC
GCCTTTTGAAAGGAAAATAA

Downstream 100 bases:

>100_bases
TGGATCTGGAAATGCTGGTGCTGCTCCACGCTCATGAGCGTACTGAAGCTGGATATCGTGAGTTGTTCAATCGGTCTGGC
TTCCAGTTGACCAGAATCGT

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSQDESKPVSTEAPPATQLMQMIFGFVTTQAISVAARLSLADLLKDGPKSIEELAQATGTQASALYRILRELASVGIFAE
DDAARFKLTPLAELLRSDTPGSVRDLSIFIGADWHWRAWGDLFGSAQSGLPAFERIHGKAFFEYLGENSGPAQIFNDAMT
SMSATASAAIVDGYDFTGISKLVDVGGGHGMLLCSILEKFPQMSGILIDAPSVIAGAKEAIEERGLSKRCEAVGGDFFAS
VPAGGDAYIMKHILHEWNDERASTILQCCAGKYRQMAGFLSSKWLFRKGTHHRLAS

Sequences:

>Translated_296_residues
MSQDESKPVSTEAPPATQLMQMIFGFVTTQAISVAARLSLADLLKDGPKSIEELAQATGTQASALYRILRELASVGIFAE
DDAARFKLTPLAELLRSDTPGSVRDLSIFIGADWHWRAWGDLFGSAQSGLPAFERIHGKAFFEYLGENSGPAQIFNDAMT
SMSATASAAIVDGYDFTGISKLVDVGGGHGMLLCSILEKFPQMSGILIDAPSVIAGAKEAIEERGLSKRCEAVGGDFFAS
VPAGGDAYIMKHILHEWNDERASTILQCCAGKYRQMAGFLSSKWLFRKGTHHRLAS
>Mature_295_residues
SQDESKPVSTEAPPATQLMQMIFGFVTTQAISVAARLSLADLLKDGPKSIEELAQATGTQASALYRILRELASVGIFAED
DAARFKLTPLAELLRSDTPGSVRDLSIFIGADWHWRAWGDLFGSAQSGLPAFERIHGKAFFEYLGENSGPAQIFNDAMTS
MSATASAAIVDGYDFTGISKLVDVGGGHGMLLCSILEKFPQMSGILIDAPSVIAGAKEAIEERGLSKRCEAVGGDFFASV
PAGGDAYIMKHILHEWNDERASTILQCCAGKYRQMAGFLSSKWLFRKGTHHRLAS

Specific function: The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomyci

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291045183, Length=281, Percent_Identity=24.1992882562278, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI117553627, Length=281, Percent_Identity=24.1992882562278, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI291045181, Length=281, Percent_Identity=24.1992882562278, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001077
- InterPro:   IPR005031
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00891 Methyltransf_2; PF03364 Polyketide_cyc [H]

EC number: NA

Molecular weight: Translated: 31871; Mature: 31739

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00362 RIBOSOMAL_S15

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDESKPVSTEAPPATQLMQMIFGFVTTQAISVAARLSLADLLKDGPKSIEELAQATGT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QASALYRILRELASVGIFAEDDAARFKLTPLAELLRSDTPGSVRDLSIFIGADWHWRAWG
HHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHCCCCCCCEEEEEEEECCCCHHHHH
DLFGSAQSGLPAFERIHGKAFFEYLGENSGPAQIFNDAMTSMSATASAAIVDGYDFTGIS
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHH
KLVDVGGGHGMLLCSILEKFPQMSGILIDAPSVIAGAKEAIEERGLSKRCEAVGGDFFAS
HHHHCCCCCHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCEEC
VPAGGDAYIMKHILHEWNDERASTILQCCAGKYRQMAGFLSSKWLFRKGTHHRLAS
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
SQDESKPVSTEAPPATQLMQMIFGFVTTQAISVAARLSLADLLKDGPKSIEELAQATGT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QASALYRILRELASVGIFAEDDAARFKLTPLAELLRSDTPGSVRDLSIFIGADWHWRAWG
HHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHCCCCCCCEEEEEEEECCCCHHHHH
DLFGSAQSGLPAFERIHGKAFFEYLGENSGPAQIFNDAMTSMSATASAAIVDGYDFTGIS
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHH
KLVDVGGGHGMLLCSILEKFPQMSGILIDAPSVIAGAKEAIEERGLSKRCEAVGGDFFAS
HHHHCCCCCHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCEEC
VPAGGDAYIMKHILHEWNDERASTILQCCAGKYRQMAGFLSSKWLFRKGTHHRLAS
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1548230; 2684656 [H]