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The map label for this gene is nuoH [H]

Identifier: 114330932

GI number: 114330932

Start: 955745

End: 956842

Strand: Direct

Name: nuoH [H]

Synonym: Neut_0929

Alternate gene names: 114330932

Gene position: 955745-956842 (Clockwise)

Preceding gene: 114330931

Following gene: 114330933

Centisome position: 35.92

GC content: 42.26

Gene sequence:

>1098_bases
ATGGATAGTTTTCAACCATTATTTGAACAATTATTTGGCAGCGAGTGGGGTGTTTCCCTCTTTCTATTGGCAAAGAATCT
GCTGTTGATTCTGGCAATCATTATTCCATTATTGCTGGCAGTCGCATATCTTACTTTTGCAGAGAGAAAGATTATTGCAT
TCATGCAAGTCAGAGTAGGGCCAAACCGGGTAACATTTTTTGGTATTCCTTGGTTGGGTGGATGGGGGCAGCCTATTGCC
GATGCGGTTAAGGCTATCATGAAGGAAATCATTATTCCGACCGGTGCCAATAAATTTCTATTTCTCCTTGCGCCAATACT
TGCTATAACGCCTGCATTAGCGGCATGGGCTGTCGTTCCCTTCTCACCAGAACTAGTATTGGCTGATATCAATGCTGCAC
TGCTATATATTCTGGCTATGACATCTCTGGGTGTCTATGGTGTCATTATTGCTGGATGGGCATCTAATTCAAAATATGCT
TTCTTGGGTGCCATGCGTTCTGCTGCACAGGTTATTTCATATGAATTAGCTATGGGATTTGCCTTGGTTTGTGTGTTGAT
GATGTCCTCTAGTCTCAACTTGGGAGATATCGTAGCGGGGCAACAGGGAGGGAGTTTTCTTAATTGGTACATGATTCCAT
TATTTCCGATGTTTCTAGTTTATTTTATCTCTGGAGTAGCCGAAACTAATCGATTACCTTTTGATGTGGCTGAAGGAGAA
TCGGAAATCGTGGCTGGTTTCCATGTGGATTATTCGGGAATGGCTTTTACCATATTTTTTCTTGCCGAGTATGCAAACAT
GATTCTGGTTGCAACCTTAGCCAGTATCATGTTCCTTGGAGGGTGGTTGCCCCCGGTAGATATCATTCCCTTCAATCTGA
TCCCGGGTGTAGTTTGGTTGTTGTTAAAGATAGCCATCATGTTGTTTTTCTTTCTTTGGTTCCGTGCTACTTTTCCTCGT
TATCGCTATGATCAAATTATGCGGTTGGGGTGGAAGGTATTTATTCCAATTACGTTAATCTGGATTGTTTTATTGGGCGC
AGTAATGCAATTGCCTGAAGCTGCATTGCAAAGCTTTCCATTGAATCTTTGGTTCTAG

Upstream 100 bases:

>100_bases
TCGTTTGGCATGCGCTCACCCGCAAATATCCAGACTGGGAACGATGTTTGGTGAAATCAAACTGGAAAAATTATAAGAAC
CTGGATTTGGAATCTGATCA

Downstream 100 bases:

>100_bases
TCAAGAGGAATTTCAAAATGGAACGCATTAAACGGTTTTTAAAATCCTTTTTGCTATTTGAGTTGTTAAAGGGAATGAAA
GTAACTGGACGCTATTTGTT

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVGPNRVTFFGIPWLGGWGQPIA
DAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVPFSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYA
FLGAMRSAAQVISYELAMGFALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGE
SEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWLLLKIAIMLFFFLWFRATFPR
YRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFPLNLWF

Sequences:

>Translated_365_residues
MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVGPNRVTFFGIPWLGGWGQPIA
DAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVPFSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYA
FLGAMRSAAQVISYELAMGFALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGE
SEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWLLLKIAIMLFFFLWFRATFPR
YRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFPLNLWF
>Mature_365_residues
MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVGPNRVTFFGIPWLGGWGQPIA
DAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVPFSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYA
FLGAMRSAAQVISYELAMGFALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGE
SEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWLLLKIAIMLFFFLWFRATFPR
YRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFPLNLWF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=300, Percent_Identity=42.3333333333333, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788618, Length=329, Percent_Identity=41.6413373860182, Blast_Score=251, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 40482; Mature: 40482

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVG
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PNRVTFFGIPWLGGWGQPIADAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVP
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECC
FSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYAFLGAMRSAAQVISYELAMGF
CCCCEEEEHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGE
HHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
SEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWL
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LLKIAIMLFFFLWFRATFPRYRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
LNLWF
CCCCC
>Mature Secondary Structure
MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVG
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PNRVTFFGIPWLGGWGQPIADAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVP
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECC
FSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYAFLGAMRSAAQVISYELAMGF
CCCCEEEEHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGE
HHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
SEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWL
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LLKIAIMLFFFLWFRATFPRYRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
LNLWF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]