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The map label for this gene is gpmA [H]

Identifier: 114330922

GI number: 114330922

Start: 946406

End: 947155

Strand: Reverse

Name: gpmA [H]

Synonym: Neut_0919

Alternate gene names: 114330922

Gene position: 947155-946406 (Counterclockwise)

Preceding gene: 114330939

Following gene: 114330921

Centisome position: 35.59

GC content: 45.47

Gene sequence:

>750_bases
ATGAAAAAACTTGTTCTCCTACGTCATGGAGAAAGCACCTGGAATCAGGAAAATCGCTTTACAGGATGGACCGATGTTGA
TTTGACACCCAAAGGGTTCAAAGAAGCTAGAAATGCCGGAAGACTACTTCGCGAAAATGGCTTTACCTTCGACATTGCGC
ATACATCGCTACTCAAACGAGCCATCCGCACGCTGTGGATCGCACTGGATGAAATGGATCAGATGTGGACTCCGATCGAA
CTTAACTGGCGGCTCAATGAACGTCATTATGGCGCATTGCAAGGCTTGAACAAAGCAGAAACAGCCAAGGAGTATGGTGA
TGAACAGGTACTCATATGGCGACGCAGTTATGACACTCGCCCTCCTTCCATTACAACCGATGATAAGCGCTACCCTGGTT
TTGACATGCGTTATCGCGGCCTTCCCTCCGGTGATATTCCGGTTACTGAAAGTCTCAAGGATACCGTGGCAAGATTTCTT
CCCTATTGGAATCAGTCAATTGCCCCACAAATTAAGGCAGAAAAAAAAGTGATTATCACCGCTCACGGGAATTCGCTACG
CGCTCTGATTAAACATCTCGACAATATCTCAGATCAAGATATTTTGAACTGCAATATACCGACAGGAATTCCTCTGGTTT
ATGAGTTGGATAACAACCTGAAACCACTAACGAACTACTACTTGGGTAATGACAGTGTAATTGGGGAAGCAATATCAGCT
GTCGCGAATCAGGATAAAGCCGGAGCTTAA

Upstream 100 bases:

>100_bases
TCGGATCAGTCCTGATTTGCTGCACCTTAAGGTAAAATATATTAAACTACAAAAGTTACTTATATGTAATTTTCTCCCCC
CGCTCAACTCTAAGGCCGAC

Downstream 100 bases:

>100_bases
TGTTTGCTGGTTTCATTGCAGATTTCACATTAGCGCCACATTACTTCCCGGGGATAGGGAAGATATTATCCAGGACTGTT
TGTCTTCTGCTTTTAGTAAA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM 2; PGAM 2; Phosphoglyceromutase 2; dPGM 2 [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKKLVLLRHGESTWNQENRFTGWTDVDLTPKGFKEARNAGRLLRENGFTFDIAHTSLLKRAIRTLWIALDEMDQMWTPIE
LNWRLNERHYGALQGLNKAETAKEYGDEQVLIWRRSYDTRPPSITTDDKRYPGFDMRYRGLPSGDIPVTESLKDTVARFL
PYWNQSIAPQIKAEKKVIITAHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDNNLKPLTNYYLGNDSVIGEAISA
VANQDKAGA

Sequences:

>Translated_249_residues
MKKLVLLRHGESTWNQENRFTGWTDVDLTPKGFKEARNAGRLLRENGFTFDIAHTSLLKRAIRTLWIALDEMDQMWTPIE
LNWRLNERHYGALQGLNKAETAKEYGDEQVLIWRRSYDTRPPSITTDDKRYPGFDMRYRGLPSGDIPVTESLKDTVARFL
PYWNQSIAPQIKAEKKVIITAHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDNNLKPLTNYYLGNDSVIGEAISA
VANQDKAGA
>Mature_249_residues
MKKLVLLRHGESTWNQENRFTGWTDVDLTPKGFKEARNAGRLLRENGFTFDIAHTSLLKRAIRTLWIALDEMDQMWTPIE
LNWRLNERHYGALQGLNKAETAKEYGDEQVLIWRRSYDTRPPSITTDDKRYPGFDMRYRGLPSGDIPVTESLKDTVARFL
PYWNQSIAPQIKAEKKVIITAHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDNNLKPLTNYYLGNDSVIGEAISA
VANQDKAGA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate [H]

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily [H]

Homologues:

Organism=Homo sapiens, GI50593010, Length=251, Percent_Identity=55.3784860557769, Blast_Score=297, Evalue=8e-81,
Organism=Homo sapiens, GI4505753, Length=248, Percent_Identity=56.8548387096774, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI71274132, Length=248, Percent_Identity=55.6451612903226, Blast_Score=280, Evalue=8e-76,
Organism=Homo sapiens, GI4502445, Length=250, Percent_Identity=48.8, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI40353764, Length=250, Percent_Identity=48.8, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=59.0062111801242, Blast_Score=190, Evalue=1e-48,
Organism=Escherichia coli, GI1786970, Length=247, Percent_Identity=62.753036437247, Blast_Score=332, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6322697, Length=229, Percent_Identity=52.8384279475983, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324516, Length=280, Percent_Identity=36.0714285714286, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320183, Length=284, Percent_Identity=34.1549295774648, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646216, Length=249, Percent_Identity=53.0120481927711, Blast_Score=267, Evalue=4e-72,
Organism=Drosophila melanogaster, GI85725270, Length=249, Percent_Identity=51.8072289156626, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI85725272, Length=249, Percent_Identity=51.8072289156626, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24650981, Length=249, Percent_Identity=51.8072289156626, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI28571817, Length=222, Percent_Identity=38.7387387387387, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571815, Length=222, Percent_Identity=38.7387387387387, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648979, Length=222, Percent_Identity=38.7387387387387, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =5.4.2.1 [H]

Molecular weight: Translated: 28428; Mature: 28428

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLLRHGESTWNQENRFTGWTDVDLTPKGFKEARNAGRLLRENGFTFDIAHTSLLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIRTLWIALDEMDQMWTPIELNWRLNERHYGALQGLNKAETAKEYGDEQVLIWRRSYDTR
HHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCC
PPSITTDDKRYPGFDMRYRGLPSGDIPVTESLKDTVARFLPYWNQSIAPQIKAEKKVIIT
CCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
AHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDNNLKPLTNYYLGNDSVIGEAISA
ECCCHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCCCHHHEECCCCHHHHHHHHH
VANQDKAGA
HHCCCCCCC
>Mature Secondary Structure
MKKLVLLRHGESTWNQENRFTGWTDVDLTPKGFKEARNAGRLLRENGFTFDIAHTSLLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIRTLWIALDEMDQMWTPIELNWRLNERHYGALQGLNKAETAKEYGDEQVLIWRRSYDTR
HHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCC
PPSITTDDKRYPGFDMRYRGLPSGDIPVTESLKDTVARFLPYWNQSIAPQIKAEKKVIIT
CCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
AHGNSLRALIKHLDNISDQDILNCNIPTGIPLVYELDNNLKPLTNYYLGNDSVIGEAISA
ECCCHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCCCHHHEECCCCHHHHHHHHH
VANQDKAGA
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]