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The map label for this gene is dapA

Identifier: 114330748

GI number: 114330748

Start: 748916

End: 749794

Strand: Reverse

Name: dapA

Synonym: Neut_0733

Alternate gene names: 114330748

Gene position: 749794-748916 (Counterclockwise)

Preceding gene: 114330749

Following gene: 114330747

Centisome position: 28.18

GC content: 51.42

Gene sequence:

>879_bases
ATGTTCAGAGGTAGTCATGTAGCGATCGTCACTCCCATGTTGGAAGACGGGGCATTGGATCTGGATAGATTCTGTGCCTT
GATCGACTTTCATATCGAACAGGGAACGGATGGCATCGTCGTAGTCGGTACCACAGGGGAGTCTCCCACCGTAGATTTTG
ATGAGCACGATCTGCTGATTCGAACAGCTGTTTCCTATGCAGACGGACGTATTCCGATCATCGCCGGCACTGGTGCCAAT
TCGACCCGAGAAGCAATCGAGCTCACCGTGTTTTCGAAGAATGCCGGCGCAGATGCCTGCCTGTCCGTCGCACCTTACTA
TAACAAGCCGACTCAGGAAGGGTTGTACCAGCATTTCAAGGCAATCGCCGAAGCAGTAGATATTCCGATGATTTTATATA
ACGTACCGGGGCGGACTGTAGCAGATATCAGTAATGAAACCACATTACGGCTGGCGCAGATTCCTGGTATCGTTGGCATC
AAGGATGCCACTGGCAATATTGCACGCGGATGTGATTTGGTGCAGCGTGTACCAGATAATTTTGCTGTTTACAGTGGCGA
TGATGCCACAGCACTGGCGCTGCTGTTGCTCGGTGGACACGGCATTATTTCGGTTACCGCCAACGTCGCCCCGCGATTGA
TGCACGAAATGTGTACTGCTGCTCTGTCCGGCGATCTGGCCCAGGCACGGGCAATCAATGCCCGATTATTCAAGCTGCAT
ATCGATTTGTTTGTCGAGGCCAATCCCATCCCGGTCAAATGGGCGGTGGCAAAAATGGGATTGATCAACGAAAACATACG
TCTGCCATTGACGGCTTTATCCAGCCAGCATCACGAACTGATCAGAAAAGCGATGCTGCAGGCTGGTATCACGGTTTAA

Upstream 100 bases:

>100_bases
ACAGCATTAAGCCTGGCTTATGGCCAATCGCTGAAATTGAATGAAAGCAGATTGTTTCGGGTAGAATAATGATTATTATT
ATTTATATAGACAAAGTGCC

Downstream 100 bases:

>100_bases
AGGTTTACCATGCTTAAGAAGCGTCCGAGCAGACGTCTGAGAAAATTTCTGATTGCAAATATTACGCTGGCGATCCTCGT
TTCGGGCTGCAACCTGCTAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFRGSHVAIVTPMLEDGALDLDRFCALIDFHIEQGTDGIVVVGTTGESPTVDFDEHDLLIRTAVSYADGRIPIIAGTGAN
STREAIELTVFSKNAGADACLSVAPYYNKPTQEGLYQHFKAIAEAVDIPMILYNVPGRTVADISNETTLRLAQIPGIVGI
KDATGNIARGCDLVQRVPDNFAVYSGDDATALALLLLGGHGIISVTANVAPRLMHEMCTAALSGDLAQARAINARLFKLH
IDLFVEANPIPVKWAVAKMGLINENIRLPLTALSSQHHELIRKAMLQAGITV

Sequences:

>Translated_292_residues
MFRGSHVAIVTPMLEDGALDLDRFCALIDFHIEQGTDGIVVVGTTGESPTVDFDEHDLLIRTAVSYADGRIPIIAGTGAN
STREAIELTVFSKNAGADACLSVAPYYNKPTQEGLYQHFKAIAEAVDIPMILYNVPGRTVADISNETTLRLAQIPGIVGI
KDATGNIARGCDLVQRVPDNFAVYSGDDATALALLLLGGHGIISVTANVAPRLMHEMCTAALSGDLAQARAINARLFKLH
IDLFVEANPIPVKWAVAKMGLINENIRLPLTALSSQHHELIRKAMLQAGITV
>Mature_292_residues
MFRGSHVAIVTPMLEDGALDLDRFCALIDFHIEQGTDGIVVVGTTGESPTVDFDEHDLLIRTAVSYADGRIPIIAGTGAN
STREAIELTVFSKNAGADACLSVAPYYNKPTQEGLYQHFKAIAEAVDIPMILYNVPGRTVADISNETTLRLAQIPGIVGI
KDATGNIARGCDLVQRVPDNFAVYSGDDATALALLLLGGHGIISVTANVAPRLMHEMCTAALSGDLAQARAINARLFKLH
IDLFVEANPIPVKWAVAKMGLINENIRLPLTALSSQHHELIRKAMLQAGITV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=249, Percent_Identity=28.1124497991968, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13540533, Length=237, Percent_Identity=29.1139240506329, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=54.639175257732, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI87082415, Length=273, Percent_Identity=35.1648351648352, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789620, Length=246, Percent_Identity=29.6747967479675, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_NITEC (Q0AI27)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746970.1
- ProteinModelPortal:   Q0AI27
- SMR:   Q0AI27
- STRING:   Q0AI27
- GeneID:   4273027
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0733
- NMPDR:   fig|335283.3.peg.2421
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q0AI27
- ProtClustDB:   PRK03170
- BioCyc:   NEUT335283:NEUT_0733-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31233; Mature: 31233

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGSHVAIVTPMLEDGALDLDRFCALIDFHIEQGTDGIVVVGTTGESPTVDFDEHDLLI
CCCCCEEEEEEEECCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEEE
RTAVSYADGRIPIIAGTGANSTREAIELTVFSKNAGADACLSVAPYYNKPTQEGLYQHFK
EEHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHH
AIAEAVDIPMILYNVPGRTVADISNETTLRLAQIPGIVGIKDATGNIARGCDLVQRVPDN
HHHHHHCCCEEEEECCCCEEECCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCC
FAVYSGDDATALALLLLGGHGIISVTANVAPRLMHEMCTAALSGDLAQARAINARLFKLH
CEEECCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEE
IDLFVEANPIPVKWAVAKMGLINENIRLPLTALSSQHHELIRKAMLQAGITV
EEEEEECCCCCEEEHHHHHCCCCCCCEEEHHHHCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFRGSHVAIVTPMLEDGALDLDRFCALIDFHIEQGTDGIVVVGTTGESPTVDFDEHDLLI
CCCCCEEEEEEEECCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEEE
RTAVSYADGRIPIIAGTGANSTREAIELTVFSKNAGADACLSVAPYYNKPTQEGLYQHFK
EEHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHH
AIAEAVDIPMILYNVPGRTVADISNETTLRLAQIPGIVGIKDATGNIARGCDLVQRVPDN
HHHHHHCCCEEEEECCCCEEECCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCC
FAVYSGDDATALALLLLGGHGIISVTANVAPRLMHEMCTAALSGDLAQARAINARLFKLH
CEEECCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEE
IDLFVEANPIPVKWAVAKMGLINENIRLPLTALSSQHHELIRKAMLQAGITV
EEEEEECCCCCEEEHHHHHCCCCCCCEEEHHHHCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA