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The map label for this gene is fadE [H]

Identifier: 114330718

GI number: 114330718

Start: 709830

End: 712166

Strand: Reverse

Name: fadE [H]

Synonym: Neut_0703

Alternate gene names: 114330718

Gene position: 712166-709830 (Counterclockwise)

Preceding gene: 114330719

Following gene: 114330717

Centisome position: 26.76

GC content: 52.5

Gene sequence:

>2337_bases
ATGTCAGAGTTTGTTTTGCTCCTGTTTGTCGCGTTGCTTGTCCTCATCGTGGCATTATTCACGGTGCCGTTTCTACGCCG
CAACATTGTCTCCAACCTTGCCTTGAGAGTTTTTTGCAAGCTGTTGCCACAAATTTCCCAAACCGAGCAGGAGGCGCTCG
ACGCCGGTACAGTTTGGTGGGAAGGTGAACTCTTCAGCGGCAAACCAAATTGGGACAAGCTGCTGGCCTATCCCAAACCA
ACTTTGAGTACGGAGGAACAGGCTTTTCTCGATGGCCCCGTTGAGCAGTTATGTGCCATGCTGGATGAATGGCATATCAC
GCATGAACGGCATGATCTTCCACCTGATGTCTGGCAATTTATCCGGGGAAACCGCTTTTTTGCGCTGATTATTCCCAAGG
AATACGGTGGGCTCGGCTTTTCTGCACTGGCACATTCAGCAGTGGTGATGAAAATTAGTTCGCGCAGCAACACCGCAGCG
GTTACGGTGATGGTGCCCAACTCACTCGGTCCGGCCGAGTTATTGCTGCATTATGGAACGGAAGAGCAGAAAAATCATTA
TTTGCCGCGCTTGGCCAATGGCACTGAAATCCCCTGTTTTGCATTGACCGGGCCGGAAGCCGGTTCGGATGCCGGATCCA
TTCCAGATGCAGGCATCGTCTGCCGCGCTGAATTTAATGGTCAGCCGGATGTACTGGGAATACGCATCAACTGGGAAAAA
CGCTATATCACGCTGGGGCCGGTTGCCACCTTGCTGGGGCTTGCATTCAGACTATATGATCCGGATGGATTGCTTGGCGG
TGAAAAAGATATCGGCATTACGCTGGCACTGATTCCGACCAATACACCGGGGATTGATATTGGTCGCAGACATTTTCCCC
TGAATGGTGTTTTCCAGAATGGGCCCAATTCCGGCAAGGATGTTTTCATTCCCATGGACTGGATCATTGGTGGACAGGAA
AAAGCAGGACAAGGCTGGCGCATGCTGATGAACAGTCTTTCCGTCGGCCGATCGATTTCGCTGCCGGCCACCAGTGTCGG
TGCAGCCAAGTTATCTGCCTGGAGCAGCGGTGCCTATGGTCGGGTACGCGTACAATTCAGATTGCCAATTGGTTATTTCG
AGGGGGTGGAGGAAGCACTTGCCCGCATCGCCGGCAACACCTATATGATGGATGCCGCACGCGTCATGACTGCCGGTGCA
GTTGATCTAGGCGAGGAGCCCTCGGTCATTTCAGCAATCGTCAAATATCATCTGACCGAACGCAGCCGCCAGGCGATTAA
CGATGCCATGGATATTCACGGCGGCAAGGGAATTTGTCTGGGGCCCTCCAATTATCTGGCACGCACCTATCAGCAGACAC
CGGTGGGAATCACCGTAGAAGGTGCCAATATCCTGACACGCAACATGATCATCTTTGGACAAGGTGCTATCCGTGCCCAT
CCTTTCACGCTGCAGGAAATCAGCGCAGCTTGGGATCAAGACAGGAAGCGCAGTCTGCAAGCGTTTGATAAGGCATTGAT
CGGACACGTAGCCTTTACCTTGCGCAATGCATTCTGCAGTCTGATTTTTGGTTTCAGTCTGCGATTGATCAAAGAAGTGC
CGGCAAATGCAGCCAGTGAAACTGTCAATTACTACCGACAGCTGACACGTTTCTCTGCTTCCTTTGCGCTGCTAACGGAT
GTTGCCATGCTGAAGCTGGGTGGCACACTCAAGCGGCGTGAACGTCTTTCCGCACGTCTGGGCGATGTGCTCAGCCAGTT
GTATCTTTGTTCAGCCACGCTTAAACGTTTTGAGGATGATGGCCGCCCTGCTGCCGATCTGCCATTTTTACACTGGTCCA
TGCAGGATGCACTCTACCGTATGCAGCAAGCACTCCATGAATTCCTGCTTAATTTCCCGGTCAGAAAAGTCACGCGGTGC
CTGTTGCGACTCATGGTTTTTCCGCGCGGCATGCGCTGCCAGCCGCCTCCTGATACGCTTTCACATCAAGTCGCCCGGCT
CATTCTGACCCCTGGAGAAGCACGTGATCGCCTGACAATGGGAATTTACCTGCCGGCTGACGAGGATGATCCTCTGGCAT
TACTCGGGCAAGCCATGGTTAGCGCCATCTCCTGCGAACCAATTGAAGCCAGACTGAGGCAAGCAGTCAAAGATAAAACC
CTGACTACCCACGAAGATGAACAAATCAATCAGGCGCTGGCGCAAGGCATTATTAGCGATAGAGAAGCTACTTTACTGGC
AGAAATGAAAGCCTTGCGCCACCGCGTCATCATGGTGGATGATTTCTCACCTGATTTGCAGCAGGTGGGTAATCCACAAG
GAGAAATTCCGGCATGA

Upstream 100 bases:

>100_bases
GTTTGTTGAGCATAAGTACGGATACAAACAAAATCTTGACAGCATCCTATTCTCGGGTAGTGTAACGATCAATAATCACT
AAAAATTCATGGAGAAAGCC

Downstream 100 bases:

>100_bases
ATCATATAACTGCCGCCACACCATCCCGGAACATAGACGTGATCCCCGTTGAAACGGCCCGGACGCTTGATGGGTTGTTC
CAAGAACGGGTCAGACGCAC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MSEFVLLLFVALLVLIVALFTVPFLRRNIVSNLALRVFCKLLPQISQTEQEALDAGTVWWEGELFSGKPNWDKLLAYPKP
TLSTEEQAFLDGPVEQLCAMLDEWHITHERHDLPPDVWQFIRGNRFFALIIPKEYGGLGFSALAHSAVVMKISSRSNTAA
VTVMVPNSLGPAELLLHYGTEEQKNHYLPRLANGTEIPCFALTGPEAGSDAGSIPDAGIVCRAEFNGQPDVLGIRINWEK
RYITLGPVATLLGLAFRLYDPDGLLGGEKDIGITLALIPTNTPGIDIGRRHFPLNGVFQNGPNSGKDVFIPMDWIIGGQE
KAGQGWRMLMNSLSVGRSISLPATSVGAAKLSAWSSGAYGRVRVQFRLPIGYFEGVEEALARIAGNTYMMDAARVMTAGA
VDLGEEPSVISAIVKYHLTERSRQAINDAMDIHGGKGICLGPSNYLARTYQQTPVGITVEGANILTRNMIIFGQGAIRAH
PFTLQEISAAWDQDRKRSLQAFDKALIGHVAFTLRNAFCSLIFGFSLRLIKEVPANAASETVNYYRQLTRFSASFALLTD
VAMLKLGGTLKRRERLSARLGDVLSQLYLCSATLKRFEDDGRPAADLPFLHWSMQDALYRMQQALHEFLLNFPVRKVTRC
LLRLMVFPRGMRCQPPPDTLSHQVARLILTPGEARDRLTMGIYLPADEDDPLALLGQAMVSAISCEPIEARLRQAVKDKT
LTTHEDEQINQALAQGIISDREATLLAEMKALRHRVIMVDDFSPDLQQVGNPQGEIPA

Sequences:

>Translated_778_residues
MSEFVLLLFVALLVLIVALFTVPFLRRNIVSNLALRVFCKLLPQISQTEQEALDAGTVWWEGELFSGKPNWDKLLAYPKP
TLSTEEQAFLDGPVEQLCAMLDEWHITHERHDLPPDVWQFIRGNRFFALIIPKEYGGLGFSALAHSAVVMKISSRSNTAA
VTVMVPNSLGPAELLLHYGTEEQKNHYLPRLANGTEIPCFALTGPEAGSDAGSIPDAGIVCRAEFNGQPDVLGIRINWEK
RYITLGPVATLLGLAFRLYDPDGLLGGEKDIGITLALIPTNTPGIDIGRRHFPLNGVFQNGPNSGKDVFIPMDWIIGGQE
KAGQGWRMLMNSLSVGRSISLPATSVGAAKLSAWSSGAYGRVRVQFRLPIGYFEGVEEALARIAGNTYMMDAARVMTAGA
VDLGEEPSVISAIVKYHLTERSRQAINDAMDIHGGKGICLGPSNYLARTYQQTPVGITVEGANILTRNMIIFGQGAIRAH
PFTLQEISAAWDQDRKRSLQAFDKALIGHVAFTLRNAFCSLIFGFSLRLIKEVPANAASETVNYYRQLTRFSASFALLTD
VAMLKLGGTLKRRERLSARLGDVLSQLYLCSATLKRFEDDGRPAADLPFLHWSMQDALYRMQQALHEFLLNFPVRKVTRC
LLRLMVFPRGMRCQPPPDTLSHQVARLILTPGEARDRLTMGIYLPADEDDPLALLGQAMVSAISCEPIEARLRQAVKDKT
LTTHEDEQINQALAQGIISDREATLLAEMKALRHRVIMVDDFSPDLQQVGNPQGEIPA
>Mature_777_residues
SEFVLLLFVALLVLIVALFTVPFLRRNIVSNLALRVFCKLLPQISQTEQEALDAGTVWWEGELFSGKPNWDKLLAYPKPT
LSTEEQAFLDGPVEQLCAMLDEWHITHERHDLPPDVWQFIRGNRFFALIIPKEYGGLGFSALAHSAVVMKISSRSNTAAV
TVMVPNSLGPAELLLHYGTEEQKNHYLPRLANGTEIPCFALTGPEAGSDAGSIPDAGIVCRAEFNGQPDVLGIRINWEKR
YITLGPVATLLGLAFRLYDPDGLLGGEKDIGITLALIPTNTPGIDIGRRHFPLNGVFQNGPNSGKDVFIPMDWIIGGQEK
AGQGWRMLMNSLSVGRSISLPATSVGAAKLSAWSSGAYGRVRVQFRLPIGYFEGVEEALARIAGNTYMMDAARVMTAGAV
DLGEEPSVISAIVKYHLTERSRQAINDAMDIHGGKGICLGPSNYLARTYQQTPVGITVEGANILTRNMIIFGQGAIRAHP
FTLQEISAAWDQDRKRSLQAFDKALIGHVAFTLRNAFCSLIFGFSLRLIKEVPANAASETVNYYRQLTRFSASFALLTDV
AMLKLGGTLKRRERLSARLGDVLSQLYLCSATLKRFEDDGRPAADLPFLHWSMQDALYRMQQALHEFLLNFPVRKVTRCL
LRLMVFPRGMRCQPPPDTLSHQVARLILTPGEARDRLTMGIYLPADEDDPLALLGQAMVSAISCEPIEARLRQAVKDKTL
TTHEDEQINQALAQGIISDREATLLAEMKALRHRVIMVDDFSPDLQQVGNPQGEIPA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=550, Percent_Identity=27.8181818181818, Blast_Score=137, Evalue=6e-32,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=28.1914893617021, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4557235, Length=414, Percent_Identity=24.8792270531401, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI76496475, Length=414, Percent_Identity=24.8792270531401, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=27.5204359673025, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI7656849, Length=404, Percent_Identity=24.009900990099, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI226958412, Length=331, Percent_Identity=26.5861027190332, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI187960098, Length=311, Percent_Identity=27.3311897106109, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=26.5861027190332, Blast_Score=77, Evalue=9e-14,
Organism=Homo sapiens, GI4557231, Length=311, Percent_Identity=27.3311897106109, Blast_Score=77, Evalue=9e-14,
Organism=Escherichia coli, GI87081702, Length=762, Percent_Identity=55.3805774278215, Blast_Score=855, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=418, Percent_Identity=27.511961722488, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538396, Length=324, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=366, Percent_Identity=27.0491803278689, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534899, Length=356, Percent_Identity=28.3707865168539, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=26.2162162162162, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=328, Percent_Identity=27.4390243902439, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=328, Percent_Identity=26.219512195122, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=345, Percent_Identity=24.3478260869565, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=27.8735632183908, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24666513, Length=366, Percent_Identity=28.4153005464481, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646207, Length=336, Percent_Identity=27.0833333333333, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24660351, Length=309, Percent_Identity=27.1844660194175, Blast_Score=83, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355753, Length=355, Percent_Identity=26.4788732394366, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 85827; Mature: 85696

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFVLLLFVALLVLIVALFTVPFLRRNIVSNLALRVFCKLLPQISQTEQEALDAGTVWW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
EGELFSGKPNWDKLLAYPKPTLSTEEQAFLDGPVEQLCAMLDEWHITHERHDLPPDVWQF
ECEEECCCCCHHHEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
IRGNRFFALIIPKEYGGLGFSALAHSAVVMKISSRSNTAAVTVMVPNSLGPAELLLHYGT
HCCCEEEEEEEECCCCCCCHHHHHCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHCCC
EEQKNHYLPRLANGTEIPCFALTGPEAGSDAGSIPDAGIVCRAEFNGQPDVLGIRINWEK
CHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
RYITLGPVATLLGLAFRLYDPDGLLGGEKDIGITLALIPTNTPGIDIGRRHFPLNGVFQN
EEEEECHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
GPNSGKDVFIPMDWIIGGQEKAGQGWRMLMNSLSVGRSISLPATSVGAAKLSAWSSGAYG
CCCCCCEEEEEEHEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCE
RVRVQFRLPIGYFEGVEEALARIAGNTYMMDAARVMTAGAVDLGEEPSVISAIVKYHLTE
EEEEEEEECCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RSRQAINDAMDIHGGKGICLGPSNYLARTYQQTPVGITVEGANILTRNMIIFGQGAIRAH
HHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCCEEC
PFTLQEISAAWDQDRKRSLQAFDKALIGHVAFTLRNAFCSLIFGFSLRLIKEVPANAASE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TVNYYRQLTRFSASFALLTDVAMLKLGGTLKRRERLSARLGDVLSQLYLCSATLKRFEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GRPAADLPFLHWSMQDALYRMQQALHEFLLNFPVRKVTRCLLRLMVFPRGMRCQPPPDTL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
SHQVARLILTPGEARDRLTMGIYLPADEDDPLALLGQAMVSAISCEPIEARLRQAVKDKT
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
LTTHEDEQINQALAQGIISDREATLLAEMKALRHRVIMVDDFSPDLQQVGNPQGEIPA
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SEFVLLLFVALLVLIVALFTVPFLRRNIVSNLALRVFCKLLPQISQTEQEALDAGTVWW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
EGELFSGKPNWDKLLAYPKPTLSTEEQAFLDGPVEQLCAMLDEWHITHERHDLPPDVWQF
ECEEECCCCCHHHEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
IRGNRFFALIIPKEYGGLGFSALAHSAVVMKISSRSNTAAVTVMVPNSLGPAELLLHYGT
HCCCEEEEEEEECCCCCCCHHHHHCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHCCC
EEQKNHYLPRLANGTEIPCFALTGPEAGSDAGSIPDAGIVCRAEFNGQPDVLGIRINWEK
CHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
RYITLGPVATLLGLAFRLYDPDGLLGGEKDIGITLALIPTNTPGIDIGRRHFPLNGVFQN
EEEEECHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
GPNSGKDVFIPMDWIIGGQEKAGQGWRMLMNSLSVGRSISLPATSVGAAKLSAWSSGAYG
CCCCCCEEEEEEHEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCE
RVRVQFRLPIGYFEGVEEALARIAGNTYMMDAARVMTAGAVDLGEEPSVISAIVKYHLTE
EEEEEEEECCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RSRQAINDAMDIHGGKGICLGPSNYLARTYQQTPVGITVEGANILTRNMIIFGQGAIRAH
HHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCCEEC
PFTLQEISAAWDQDRKRSLQAFDKALIGHVAFTLRNAFCSLIFGFSLRLIKEVPANAASE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TVNYYRQLTRFSASFALLTDVAMLKLGGTLKRRERLSARLGDVLSQLYLCSATLKRFEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GRPAADLPFLHWSMQDALYRMQQALHEFLLNFPVRKVTRCLLRLMVFPRGMRCQPPPDTL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
SHQVARLILTPGEARDRLTMGIYLPADEDDPLALLGQAMVSAISCEPIEARLRQAVKDKT
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
LTTHEDEQINQALAQGIISDREATLLAEMKALRHRVIMVDDFSPDLQQVGNPQGEIPA
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]